Navigation Links
La Jolla Institute scientist discovers key step in immune system-fueled inflammation
Date:7/1/2012

/p>

In his Nature paper entitled "'Slings' enable neutrophil rolling at high shear," Dr. Ley revealed how neutrophils use sling-like membrane tethers to latch on to the blood vessel wall during periods when blood flow is very fast. In making the discovery, Dr. Ley and Prithu Sundd, Ph.D., a researcher at La Jolla Institute, used "dynamic footprinting," a pioneering imaging technique they developed in 2010 that uses special microscopes and total internal reflection microscopy to see and photograph the neutrophil adhesion process with unprecedented clarity. Alex Groisman, Ph.D., an associate professor in UCSD's Department of Physics, was instrumental in developing and constructing the microfluidic device in which these experiments were conducted and collaborated on the Nature paper.

Sussan Nourshargh, Ph.D., professor of Microvascular Pharmacology and head of the Center for Microvascular Research at Barts and The London Medical School, University of London, said the work provides another "major insight" from Dr. Ley whose discoveries, over the years, have repeatedly enhanced scientific understanding of the role of neutrophils in causing inflammation. In particular, she cited Dr. Ley's groundbreaking work on the discovery of the leukocyte adhesion cascade, which explained the sequential steps used by neutrophils to clamp onto the blood vessel wall as they prepare to migrate to sites of infection. His latest finding reveals another important step in that process.

"This is a completely new cellular concept that will now be added as an additional step to the leukocyte adhesion cascade that describes the sequential cellular responses involved in guiding neutrophils to sites of inflammation," she said. "This pioneering work will without doubt pave the way for other researchers to explore the occurrence of "slings" in a wide range of inflammatory scenarios."

Like other immune cells, neutrophils travel throughout the body via the blood s
'/>"/>

Contact: Bonnie Ward
contact@liai.org
619-303-3160
La Jolla Institute for Allergy and Immunology
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. La Jolla Institute discovery could lead to new way to screen drugs for adverse reactions
2. Diabetes Research Institute develops oxygen-generating biomaterial
3. Space research institute honors Sen. Hutchison with Pioneer Award
4. Scripps Research Institute scientists find promising vaccine targets on hepatitis C virus
5. Minneapolis Heart Institute selected to participate in Cardiovascular Cell Therapy Research Network
6. Cary Institute Hydrofracking Forum
7. Scripps Research Institute Professor Gerald F. Joyce elected to American Academy of Arts & Sciences
8. Scripps Research Institute scientists develop antidote for cocaine overdose
9. NJIT, Chinas Bengbu Glass Institute sign agreement for R&D, training
10. Merkin Family Foundation to fund next generation of Broad Institute scientists
11. TGen leads new National Institutes of Health study of brain tumors
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... N.C. , Jan. 22, 2015 Infinisource has launched ... of the G2 model. The G2 sets a higher standard ... iSolved human capital management solution. With plug-and-play installation, touch screen ... time clock provides a robust time collection solution for the ...
(Date:12/19/2014)... Research and Markets ( http://www.researchandmarkets.com/research/8kmfcn/iphone_5s ) has ... Sensor - Apple/AuthenTec TMDR92 & Sapphire - Technology Report" ... http://photos.prnewswire.com/prnh/20130307/600769 Following the acquisition of ... feature with the iPhone 5S. It is currently the ...
(Date:12/17/2014)... , Dec. 15, 2014 The Defense Logistics Agency ... detect and prevent counterfeit microcircuits from entering into its ... an in-house microcircuit anti-counterfeit initiative dubbed DNA marking. The ... increasing their reliability throughout the supply chain. The new ...
Breaking Biology News(10 mins):Infinisource's NXG series sets new time clock standard 2iPhone 5S Fingerprint Sensor - Apple/AuthenTec TMDR92 & Sapphire - Technology Report 2Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 2Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 3
... Genetic Medicine at Johns Hopkins have invented a cost-effective ... termed "junk" DNA and identified regions critical for controlling ... regions from different species don't have to look alike ... online at Science Express March 23. , The researchers ...
... The human body has a unique immune system response ... viruses are detected by different mechanisms, Yale School of ... researchers also found that DNA recognition might be used ... to Daniel Stetson, a post doctoral fellow in the ...
... Ernst Mayr's theory of genetic revolution , introduced in ... many detractors. , Mayr believed that genes interacted with ... led to an interaction of natural selection with genetic ... evolutionary change. , Detractors of the theory object to ...
Cached Biology News:Junk DNA may not be so junky after all 2Junk DNA may not be so junky after all 3Immune system response to viral DNA is unique 2Ernst Mayr's theory illustrated in genetic epidemiology studies 2Ernst Mayr's theory illustrated in genetic epidemiology studies 3Ernst Mayr's theory illustrated in genetic epidemiology studies 4
(Date:1/23/2015)... 2015 Portal Solutions , a technology ... Microsoft Office 365 and SharePoint platforms , today announces ... for being one of the region’s fastest-growing mid-sized companies based ... , “To be recognized a second year in a ...
(Date:1/22/2015)... | RBJ today announces the firm brokered a long-term lease ... leading biopharmaceutical company, at Two Ledgemont Center in ... , president, and Brian Cohen , senior vice president, ... at 95 Hayden Ave. Photo - http://photos.prnewswire.com/prnh/20150122/170765 ...
(Date:1/22/2015)... Cambridge Semantics, the leading provider of smart ... 2014 was a record-breaking year across the board for the ... Smart Data Platform and our Smart Data solutions, our customers ... data which led to record growth for the company in ...
(Date:1/22/2015)... 2015 Crystal Diagnostics (CDx) Xpress System, a ... received AOAC-PTM Certifications for the six non-O157 Shiga toxin-producing E. ... referred to as STEC or the “Big-6”) as well as ... (cfu) per 325 g of raw ground beef and raw ...
Breaking Biology Technology:Washington SmartCEO Announces Portal Solutions as 2015 Future 50 Award Winner Second Year in a Row 2Washington SmartCEO Announces Portal Solutions as 2015 Future 50 Award Winner Second Year in a Row 3Transwestern | RBJ Advises Shire in 202,000 SF Lease, Creating Boston's Largest Suburban Biotech Campus 2Cambridge Semantics Announces Record Results for 2014 2Crystal Diagnostics Awarded AOAC-PTM Accreditation for the Rapid Detection of “Big 6” E.coli Food Pathogens 2
... housands of engineers and ... applications: test and measurement, process control and automation, ... choice due to its unparalleled connectivity to instruments, powerful ... interface, scalability, and overall function completeness. One need ...
... Today, as a research or design engineer, you are ... As you quickly perform tests to validate designs and analyze ... collected measurement data has become quite complicated. Often, large amounts ... making it extremely difficult to locate and analyze to improve product ...
... , , Abstract , ... neural gene expression requires procurement of specific cell types. ... using Laser Capture Microdissection (LCM) and in-vivo labeling to ... brain region HVC of the songbird Taeniopygia guttata. HVC ...
Cached Biology Technology:LabVIEW for Measurement and Data Analysis 2LabVIEW for Measurement and Data Analysis 3LabVIEW for Measurement and Data Analysis 4LabVIEW for Measurement and Data Analysis 5LabVIEW for Measurement and Data Analysis 6LabVIEW for Measurement and Data Analysis 7LabVIEW for Measurement and Data Analysis 8LabVIEW for Measurement and Data Analysis 9LabVIEW for Measurement and Data Analysis 10LabVIEW for Measurement and Data Analysis 11LabVIEW for Measurement and Data Analysis 12LabVIEW for Measurement and Data Analysis 13LabVIEW for Measurement and Data Analysis 14LabVIEW for Measurement and Data Analysis 15National Instruments DIAdem -- Complete Your Technical Data Management Framework with Powerful Off-line Analysis, Visualization, and Report Generation 2National Instruments DIAdem -- Complete Your Technical Data Management Framework with Powerful Off-line Analysis, Visualization, and Report Generation 3National Instruments DIAdem -- Complete Your Technical Data Management Framework with Powerful Off-line Analysis, Visualization, and Report Generation 4National Instruments DIAdem -- Complete Your Technical Data Management Framework with Powerful Off-line Analysis, Visualization, and Report Generation 5National Instruments DIAdem -- Complete Your Technical Data Management Framework with Powerful Off-line Analysis, Visualization, and Report Generation 6National Instruments DIAdem -- Complete Your Technical Data Management Framework with Powerful Off-line Analysis, Visualization, and Report Generation 7National Instruments DIAdem -- Complete Your Technical Data Management Framework with Powerful Off-line Analysis, Visualization, and Report Generation 8National Instruments DIAdem -- Complete Your Technical Data Management Framework with Powerful Off-line Analysis, Visualization, and Report Generation 9National Instruments DIAdem -- Complete Your Technical Data Management Framework with Powerful Off-line Analysis, Visualization, and Report Generation 10National Instruments DIAdem -- Complete Your Technical Data Management Framework with Powerful Off-line Analysis, Visualization, and Report Generation 11National Instruments DIAdem -- Complete Your Technical Data Management Framework with Powerful Off-line Analysis, Visualization, and Report Generation 12National Instruments DIAdem -- Complete Your Technical Data Management Framework with Powerful Off-line Analysis, Visualization, and Report Generation 13Laser Capture Microdissection (LCM) and Expression Profiling of Long-Range Projection Neurons 2Laser Capture Microdissection (LCM) and Expression Profiling of Long-Range Projection Neurons 3Laser Capture Microdissection (LCM) and Expression Profiling of Long-Range Projection Neurons 4Laser Capture Microdissection (LCM) and Expression Profiling of Long-Range Projection Neurons 5Laser Capture Microdissection (LCM) and Expression Profiling of Long-Range Projection Neurons 6Laser Capture Microdissection (LCM) and Expression Profiling of Long-Range Projection Neurons 7Laser Capture Microdissection (LCM) and Expression Profiling of Long-Range Projection Neurons 8Laser Capture Microdissection (LCM) and Expression Profiling of Long-Range Projection Neurons 9Laser Capture Microdissection (LCM) and Expression Profiling of Long-Range Projection Neurons 10