Navigation Links
La Jolla Institute researchers identify pivotal immune cell in Type 1 diabetes in humans
Date:1/12/2012

SAN DIEGO (January 12, 2012) Researchers at the La Jolla Institute for Allergy & Immunology have proven for the first time in human tissues -- the specific immune system T cells which trigger the destruction of type 1 diabetes in the pancreas. The finding is an important advance that verifies in humans several important disease characteristics shown in mouse studies and provides a key focal point for interrupting the disease process.

"This study marks the first time that the presence of beta cell-reactive T cells has been directly proven in pancreas tissues from type 1 diabetes patients," explained Ken Coppieters, Ph.D., first author on the study published online January 2nd in the in the Journal of Experimental Medicine. "Previously, it was only known in plastic dishes or mouse models. What is unique about this study is the use of human tissue."

Human pancreatic tissue for the studies was provided through a collaborative type 1 diabetes research consortium funded by JDRF, a leading charitable supporter of type 1 diabetes research. The JDRF's Network for Pancreatic Organ Donors with Diabetes (nPOD) provides rare and difficult to obtain pancreatic tissues to carefully selected research organizations worldwide. Participating institutions are chosen based on their history and quality of type 1 diabetes research.

"Mice represent an excellent model for disease, but eventually it is important to confirm in human tissues the things that you learn in mice," said Matthias von Herrath, M.D., a world- renowned type 1 diabetes researcher, who led the scientific team. "The use of this tissue from the nPOD consortium was critical to our ability to prove which T cells are most important in destroying beta cells in humans, which leads to type 1 diabetes, and where these cells are located in the pancreas." The study was published in a paper entitled, "Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients." Dr. von Herrath was senior author.

Previously, the research community had assumed, based on lab and mouse studies, that T cells the body's soldier-like attack cells -- recognize and react against certain molecular structures on the beta cells and then kill the beta cells. The La Jolla Institute study confirmed this occurrence and showed the T cells location in the islets of the pancreas, which house the beta cells. The team is also is the first to identify the specific T cells -- CD8 -- as being key in the destruction of beta cells. This destruction eventually leads to the beta cell's inability to produce insulin, the hallmark of type 1 diabetes.

Dr. Coppieters, formerly of the La Jolla Institute and now at Ghent University, Belgium, said the study serves to clarify an important step in the type 1 diabetes process in humans. "It points to the CD8 T cells as being one of the most important cells that we should focus on to stop type 1 diabetes progression, once it is already underway."

In addition, the research team identified the places on the beta cells that trigger the T cell attack. T cells come in several different types and, in type 1 diabetes, react against a variety of substances produced within the body.

"Knowing which pieces of the molecules the T cells react against is a crucial prerequisite to design therapies that attempt to restore balance within the immune system," said Dr. Coppieters.

Teodora Staeva, Ph.D., director of JDRF's Immune Therapies Program, called the paper "very important" for the diabetes field. "We are certainly very pleased that nPOD enabled this study through the supply of human tissue," she said. "It is a perfect example of the kind of cutting-edge research that JDRF is proud to support to catalyze major research advances in type 1 diabetes."

She said the findings are the latest of several important papers resulting from collaborations between researchers around the world and nPOD, since the project was launched in 2007. nPOD currently supports over 70 type 1 diabetes-related scientific studies at various institutions.


'/>"/>

Contact: Bonnie Ward
contact@liai.org
619-303-3160
La Jolla Institute for Allergy and Immunology
Source:Eurekalert

Related biology news :

1. La Jolla Institute signs exclusive license agreement with Medimmune on major asthma discovery
2. La Jolla Institute discovers novel tumor suppressor
3. Visionary concept earns La Jolla Institute scientist prestigious NIH Pioneer Award
4. La Jolla Institute scientist leads team which discovers important new player in diabetes onset
5. La Jolla Institute scientist Klaus Ley receives Malpighi award
6. La Jolla Institute validates Type 1 diabetes computer models predictive success through lab testing
7. La Jolla Institute-led team illuminates cell pathway key to insulin resistance in Type 2 diabetes
8. La Jolla Institute identifies new therapeutic target for asthma, COPD and other lung disorders
9. La Jolla Institute opens major RNAi center for identifying genetic triggers of disease
10. La Jolla Institute discovers previously unknown cell interaction key in immune system attacks
11. La Jolla Institute discovers novel mechanism for preventing infection via bodys mucosal borders
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/16/2016)... June 16, 2016 The ... expected to reach USD 1.83 billion by 2024, ... Research, Inc. Technological proliferation and increasing demand in ... expected to drive the market growth. ... The development of advanced multimodal techniques for ...
(Date:6/9/2016)... -- Perkotek an innovation leader in attendance control systems is proud to announce the introduction ... to make sure the right employees are actually signing in, and to even control ... ... ... ...
(Date:6/7/2016)... June 7, 2016  Syngrafii Inc. and San ... relationship that includes integrating Syngrafii,s patented LongPen™ eSignature ... This collaboration will result in greater convenience for ... union, while maintaining existing document workflow and compliance ... ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... June 24, 2016  Regular discussions on a range of ... between the two entities said Poloz. Speaking at ... Ottawa , he pointed to the country,s inflation target, ... government. "In certain ... institutions have common economic goals, why not sit down and ...
(Date:6/24/2016)... , ... June 24, 2016 , ... Researchers at the ... commonly-identified miRNAs in people with peritoneal or pleural mesothelioma. Their findings are the subject ... it now. , Diagnostic biomarkers are signposts in the blood, lung fluid or ...
(Date:6/23/2016)... Mass. , June 23, 2016   ... development of novel compounds designed to target cancer ... napabucasin, has been granted Orphan Drug Designation from ... the treatment of gastric cancer, including gastroesophageal junction ... stemness inhibitor designed to inhibit cancer stemness pathways ...
(Date:6/23/2016)... Houston Methodist Willowbrook Hospital has signed ... to serve as their official health care provider. ... will provide sponsorship support, athletic training services, and ... volunteers, athletes and families. "We are ... and to bring Houston Methodist quality services and ...
Breaking Biology Technology: