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La Jolla Institute identifies new therapeutic target for asthma, COPD and other lung disorders
Date:4/17/2011

re detailed in a scientific paper entitled, "Herpesvirus entry mediator (TNFRSF14) regulates the persistence of T helper memory cell populations."

Dr. Croft said he is excited about his findings on LIGHT and its impact on both airway remodeling and inflammation in asthma. "Identifying these molecules (LIGHT and its receptors) as regulators of processes associated with several lung diseases may be an important advantage in efforts to develop new and better therapies," he said.

LIGHT was initially discovered in 1998 by former La Jolla Institute scientist Carl Ware, Ph.D. The TNF family of molecules has proven to be important players in inflammation-driven autoimmune diseases and is a particular focus of the La Jolla Institute.

"The fact that LIGHT appears to be important in Crohn's disease and colitis, and now may have an indication in asthma, is a continued demonstration of the TNF family's critical role in inflammatory diseases," said Dr. Kronenberg. "We are thrilled that both of these findings originated from our Institute. It is a reflection that our Institute is one of the world's leaders in TNF research, which is a hotbed of therapeutic potential for autoimmune diseases."


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Contact: Bonnie Ward
contact@liai.org
619-303-3160
La Jolla Institute for Allergy and Immunology
Source:Eurekalert

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