Navigation Links
La Jolla Institute identifies molecular switch enabling immune cells to better fight disease
Date:1/20/2013

SAN DIEGO (January 20th, 2013) A research team led by the La Jolla Institute for Allergy & Immunology has discovered the mechanism that enables CD4 helper T cells to assume the more aggressive role of killer T cells in mounting an immune attack against viruses, cancerous tumors and other damaged or infected cells. The finding, made in collaboration with researchers from the RIKEN Institute in Japan, could enable the development of more potent drugs for AIDS, cancer and many other diseases based on using this mechanism to trigger larger armies of killer T cells against infected or damaged cells.

CD4 helper T cells, which normally assist other cells of the immune system during an infection, and CD8 killer T cells, which directly attack and eliminate infected cells, are two of the body's most important immune cells for defending against diseases. Earlier research studies have shown that helper T cells can become killer cells in some instances. However, the specific mechanism of action that allowed this to occur was not known until now.

"We have identified the molecular switch that enables CD4 T cells to override their programming as helper cells and transform into cytolytic (killer) cells," said La Jolla Institute scientist and study co-leader Hilde Cheroutre, Ph.D. "Our team also showed that these transformed helper T cells represent a separate and distinct population of cells. They are not a subset of TH-1 helper cells as previously thought."

Jay A. Berzofsky, M.D., Ph.D., chief of the Vaccine Branch at the National Cancer Institute's Center for Cancer Research, called the finding "a major advance" that provides new understanding about the cell's lineage and basic mechanisms. Dr. Berzofsky was among the researchers whose work in the 1980s first demonstrated that helper cells could convert to killer cells. "Understanding how these cells derive and what causes them to switch from helper T cells to cytolytic T cells is an imp
'/>"/>

Contact: Bonnie Ward
contact@liai.org
619-303-3160
La Jolla Institute for Allergy and Immunology
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. La Jolla Institute discovery could lead to new way to screen drugs for adverse reactions
2. La Jolla Institute scientist discovers key step in immune system-fueled inflammation
3. La Jolla institute identifies critical cell in fighting E. coli infection
4. Diabetes Research Institute develops oxygen-generating biomaterial
5. Space research institute honors Sen. Hutchison with Pioneer Award
6. Scripps Research Institute scientists find promising vaccine targets on hepatitis C virus
7. Minneapolis Heart Institute selected to participate in Cardiovascular Cell Therapy Research Network
8. Cary Institute Hydrofracking Forum
9. Scripps Research Institute Professor Gerald F. Joyce elected to American Academy of Arts & Sciences
10. Scripps Research Institute scientists develop antidote for cocaine overdose
11. NJIT, Chinas Bengbu Glass Institute sign agreement for R&D, training
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... face a suite of perilous threats in today,s ... and climate change, fragile coral ecosystems are disappearing ... trend, some species of corals surrounding the island ... protector in their tropical environment: coral guard-crabs. New ... Smithsonian Marine Station scientist Seabird McKeon and the ...
(Date:9/29/2014)... tar tended to be lower for smokers of slim ... nicotine tended to be lower. , Slim cigarettes are ... around the world. Previous studies have shown that the ... these cigarettes are lower than those in regular cigarettes. ... are not necessarily linked to a reduced exposure to ...
(Date:9/29/2014)... new Food and Brand Lab pilot study, published in ... the National School Lunch Program (NSLP) by 9% and ... Chefs Move to Schools (CMTS), an initiative of Michelle ... order to provide nutrition instruction to students and culinary ... CMTS event was held in an Upstate New York ...
Breaking Biology News(10 mins):Smithsonian scientists discover coral's best defender against an army of sea stars 2Slim cigarette smokers not exposed to more harmful chemicals 2Chefs move to schools can increase school meal participation and vegetable intake among students 2
... or amplification of particular DNA regions contributes to the development ... DNA changes have a high likelihood of dying from the ... journal of the American Cancer Society, the study provides valuable ... into which patients should be treated aggressively. Cells can ...
... half of all strokes are the results of advanced atherosclerosis ... In 2009, the direct and indirect annual cost of heart ... the total cost of heart disease to increase from $523 ... it is expected that there will be more than 148 ...
... disability with more than 350 million people globally affected ... mental health, depression predisposes an individual to physiological disease ... the risk of depression. According to the World ... depression will be the number one and number two ...
Cached Biology News:Particular DNA changes linked with prostate cancer development and lethality 2Development of novel therapies for endothelial damage may heal atherosclerotic plaques 2Social stress and the inflamed brain 2
(Date:9/30/2014)... Boston, MA (PRWEB) September 30, 2014 ... communications (UC) and collaboration company is dedicated to ... data connectivity needs. Julie Power, a ... team to ensure collaboration solutions stays connected and ... response to the increased movement of businesses to ...
(Date:9/30/2014)... September 30, 2014 UFP Technologies, ... specialty packaging has recently introduced a custom insulated ... Pack . The new insulated shipper solves the ... distribution process. UFP Technologies’ BioShell is a universal ... during storage, handling and shipping. The insulated shipper ...
(Date:9/30/2014)... and Pittsburgh PA (PRWEB) September 30, 2014 ... Research Nurses ( IACRN), a non-profit organization ... for Clinical Research Excellence and Safety (ACRES), ... signing of a strategic alliance agreement, setting the ... vision is to enhance clinical research quality and ...
(Date:9/29/2014)... the start of the military conflicts in Iraq and ... United States with traumatic brain injury caused by exposure ... improvised explosive devices, or IEDs. Symptoms of traumatic brain ... headaches and nausea, to more severe impairments in memory ... of Defense has recognized the critical importance and complexity ...
Breaking Biology Technology:SoundConnect Expands Carrier Services Division 2UFP Technologies Introduces Insulated Shipping Container For Bulk Drug Transportation 2UFP Technologies Introduces Insulated Shipping Container For Bulk Drug Transportation 3IACRN and ACRES to Support Clinical Research Nurses 2IACRN and ACRES to Support Clinical Research Nurses 3Modeling shockwaves through the brain 2Modeling shockwaves through the brain 3Modeling shockwaves through the brain 4
... of Patients Compensation Fund could be illegal , ... expressed support yesterday for Gov. Jim Doyles Grow Wisconsin ... expressed support, but takes issue with the provisions for ... strongest criticism for Doyles proposed use of funds from ...
... EAU CLAIRE, WI- Efforts at improving communication and technology ... outlook of the Chippewa Valley. , ,Thanks in large ... several Chippewa Falls-area companies are in line to receive ... bill, which was passed by the House and the ...
... WI-Patrick O'Malley, D.O. established his practice, O'Malley Family ... envisioned that practicing ndependently would enable him to ... can a solo practitioner build a thriving practice ... is essential," says O'Malley. "That's why I sought ...
Cached Biology Technology:Republicans criticize Doyles growth package 2Republicans criticize Doyles growth package 3Republicans criticize Doyles growth package 4Chippewa Valley Draws Defense Dollars 2Chippewa Valley Draws Defense Dollars 3Computer Card Supports Solo Doctor 2
...
...
... The newest member of Wyatt Technology's ... fits inside of your high temperature chromatograph ... scattering data from thermoplastic polymers. The HTmD ... any Waters 150C, PL220C or Alliance 2000 ...
... The FDSS6000 System is an imaging ... assay development and high throughput screening ... luminescence modalities., The Hamamatsu light sources ... our companys decades-long experience in photon ...
Biology Products: