Navigation Links
La Jolla Institute discovers novel tumor suppressor
Date:8/3/2009

SAN DIEGO (August 3, 2009) La Jolla Institute for Allergy & Immunology researchers studying an enzyme believed to play a role in allergy onset, instead have discovered its previously unknown role as a tumor suppressor that may be important in myeloproliferative diseases and some types of lymphoma and leukemia. Myeloproliferative diseases are a group of disorders characterized by an overproduction of blood cells by the bone marrow and include chronic myeloid leukemia. Lymphoma and leukemia are cancers of the blood.

"PLC-beta 3 is an enzyme, but the function we found was a completely different function that no one knew it had -- as a tumor suppressor," said the La Jolla Institute's Toshiaki Kawakami, M.D., Ph.D., who led the research team. The study, conducted in animal models, could eventually lead to the development of new therapies directed towards controlling this newly discovered cellular mechanism.

Tony Hunter, Ph.D., director of the Salk Institute Cancer Center and a professor in Salk's Molecular and Cell Biology Laboratory, called the finding an "important" step in advancing understanding of blood cancers. "It's very interesting that this molecule acts in this way independently of its enzyme activity," he said. "It's quite an unexpected finding and it definitely has the potential for helping the scientific community understand the mechanisms leading to some types of leukemia."

The findings are being published online today in the journal Cancer Cell in a paper entitled "Tumor Suppression by Phospholipase C- 3 via SHP-1-Mediated Dephosphorylation of STAT5." Researchers from UC San Diego Cancer Center, University of Alabama and the University of Western Ontario also contributed to the study.

Dr. Kawakami said he and his research team got their first inkling of something unexpected fairly early on in their experiments. "We wanted to better understand the PLC-beta 3 enzyme's possible role as a signalin
'/>"/>

Contact: Bonnie Ward
contact@liai.org
619-303-3160
La Jolla Institute for Allergy and Immunology
Source:Eurekalert

0

GOOD

Page: 1 2 3

Related biology news :

1. La Jolla Institute signs exclusive license agreement with Medimmune on major asthma discovery
2. Palm Beach County wants to establish a Max Planck Institute in Florida
3. Midlands Consortium delighted to be chosen to host £1 billion energy institute
4. $22 million gift from Alfred Taubman launches new biomedical research institute
5. 3 Columbia University Medical Center faculty elected to Institute of Medicine
6. Stowers Institutes Xie Lab demonstrates dual intrinsic and extrinsic control of stem cell aging
7. Weizmann Institute scientists discover: A risk distribution law for evolution
8. Ludwig Institute for Cancer Research to set up its first Asian branch in Singapore
9. Baker Institute finds increased domestic production wont make US self-sufficient in natural gas
10. Lupus Research Institute strategy delivers $30 million in national funding
11. Stowers Institutes Hawley Lab identifies factors responsible for restart of meiotic cycle

Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/20/2009)...c obstructive pulmonary disease (COPD), a respirat...r emphysema, is the fourth leading cause of death ...while researchers have yet to find any real treatm...titute at The University of Western Ontario in Lon...o gain new insight into the disease. , Parra...
(Date:11/20/2009)...IGN, Ill. In a new study, researchers report that... can have a helpful, or harmful, effect on the hea... study, which appears in the journal Circulation ...th the alpha- and beta-receptors on the heart musc...le those that target only the beta-receptors can a...
(Date:11/19/2009)...N Roughly 15,000 years ago, at the end of the las...e animals including such iconic creatures as mamm... giant beavers began their precipitous slide to e... emptying a land whose diversity of large animals ...eti plains then or now, an entirely novel ecosyste...
Breaking Biology News(10 mins):Gaining a better picture of lung disease 2Carvedilol shown to have unique characteristics among beta blockers 2After mastodons and mammoths, a transformed landscape 2After mastodons and mammoths, a transformed landscape 3Small mechanical forces have big impact on embryonic stem cells 10410 1Small mechanical forces have big impact on embryonic stem cells 10410 2New chromosomal abnormality identified in leukemia associated with Down syndrome 10408 1New chromosomal abnormality identified in leukemia associated with Down syndrome 10408 2New chromosomal abnormality identified in leukemia associated with Down syndrome 10408 3Time in a bottle 3A Scientists watch evolution unfold 10406 1Time in a bottle 3A Scientists watch evolution unfold 10406 2Time in a bottle 3A Scientists watch evolution unfold 10406 3
... AMES, Iowa -- Stress may indeed be a direct contr... new Iowa State University study finding that incr...ed with a greater likelihood of them being overwei...ged 10-15) and their mothers from low income famil...San Antonio -- was posted online by the Journal o...
... Oxford, UK, 14 May 2009 - A new article published...ww.elsevier.com/bihy ) suggests that our feelings ...labe Bucay suggests that a wide range of chemicals... moods could affect ,germ cells, (eggs and sperm),...tion. Such natural chemicals could affect the way ...
... Bacterial vaginosis (BV) is the most common vagin...is common in pregnant women. BV occurs when the no...d and replaced by an overgrowth of certain bacteri...k for a variety of complications, such as preterm ... how it can be prevented. Vitamin D may play a rol...
Other Biology News:Study finds link between individual stress and adolescent obesity 2Study finds link between individual stress and adolescent obesity 3Vitamin D insufficiency linked to bacterial vaginosis in pregnant women 2
(Date:11/19/2009)...FirstCall/ -- Spherix Incorporated (Nasdaq: SPEX ...apy, and a provider of technical and regulatory co...gy and pharmaceutical companies, today announced t...ders. ,, At the meeting, shareholders of Spheri...ing members to the Board of Directors: ,, Doug...
(Date:11/19/2009)...nd recognized refractive and cataract surgery expe...their fellow surgeons up-to-date on the latest dev...urgery, and ophthalmology in general at the recent...O) annual meeting in San Francisco, California. Dr... Huang, MD, Dr. Randy Epstein, Dr. William Trattle...
(Date:11/18/2009)...-- Marrone Bio Innovations (MBI), a leader in the ...fective and environmentally responsible pest manag...n IC20 company by the Investors, Circle, the Unite...ing group. ,, Companies named to the IC20 excel...ll stakeholders, including investors, the environm...
(Date:11/18/2009)... developing new sensors to detect chemical agents ...inst the threat of terrorist attacks. , The devi...dual or crime scene to gather a sample which is th...ct the presence of chemicals within seconds. This ...response to terrorist threats. , The scanning i...
Breaking Biology Technology:Spherix Announces Results of Annual Shareholders Meeting 2Spherix Announces Results of Annual Shareholders Meeting 3Spherix Announces Results of Annual Shareholders Meeting 4Experts Listed at Trusted LASIK Surgeons Bring Peers Up to Date on Vision Correction and Cataract Surgery at Annual AAO Meeting 2Experts Listed at Trusted LASIK Surgeons Bring Peers Up to Date on Vision Correction and Cataract Surgery at Annual AAO Meeting 3Experts Listed at Trusted LASIK Surgeons Bring Peers Up to Date on Vision Correction and Cataract Surgery at Annual AAO Meeting 4Experts Listed at Trusted LASIK Surgeons Bring Peers Up to Date on Vision Correction and Cataract Surgery at Annual AAO Meeting 5Experts Listed at Trusted LASIK Surgeons Bring Peers Up to Date on Vision Correction and Cataract Surgery at Annual AAO Meeting 6Experts Listed at Trusted LASIK Surgeons Bring Peers Up to Date on Vision Correction and Cataract Surgery at Annual AAO Meeting 7Experts Listed at Trusted LASIK Surgeons Bring Peers Up to Date on Vision Correction and Cataract Surgery at Annual AAO Meeting 8Experts Listed at Trusted LASIK Surgeons Bring Peers Up to Date on Vision Correction and Cataract Surgery at Annual AAO Meeting 9Marrone Bio Innovations Named an IC20 Company 2New technology detects chemical weapons in seconds 2
...PALO ALTO, Calif., Dec. 16 Jazz Pharmaceuticals,I...in force of 71 employees, or,approximately 24 perc.... The,company expects to record a charge of appro...8 related to this workforce reduction. Separately...ief Financial Officer, Matt Fust,has decided to le...
...LAWRENCE, Mass.Dec. 16 NxStage Medical, Inc. (Nas...e dialysis products, today announced that Jeffrey ...wn, Chief Financial Officer, will be presenting at...January 14, 2009 at the Westin St. Francis Hotel i...ntation is scheduled for Wednesday, January 14th a...
...PRINCETON, NJ, Dec. 16 /PRNewswire/ - DNP Green Te...r Bioamber joint venture has obtained the necessar...rst production plant for bio-based succinic acid. ...tion capacity of 2,000 metric tons and will be int...omacle, France. The plant, which is being financed...
Other Biology Technology:Jazz Pharmaceuticals Announces Reduction in Force to Reflect Streamlined Operations 2NxStage to Present at the JPMorgan Healthcare Conference 2Bioamber announces world's first bio-based succinic acid plant: helping to reduce dependence on fossil fuels 2Bioamber announces world's first bio-based succinic acid plant: helping to reduce dependence on fossil fuels 3
...mbines world-class performance hardware, Cerity Ne...gilents world-renowned support and columns, as wel...ombination that lets you reach uncompromising resu...pendable data. The Agilent 6820 GC system is not a...
7890A GC from Agilent Technologies
RF-5301 Fluorescence Spectrophotometer from Shimadzu
Kit for BASE20/50 dual control unit KIT50EHTD from Wave Biotech now part of GE Healthcare
Biology Products: