Navigation Links
La Jolla Institute discovers novel tumor suppressor
Date:8/3/2009

SAN DIEGO (August 3, 2009) La Jolla Institute for Allergy & Immunology researchers studying an enzyme believed to play a role in allergy onset, instead have discovered its previously unknown role as a tumor suppressor that may be important in myeloproliferative diseases and some types of lymphoma and leukemia. Myeloproliferative diseases are a group of disorders characterized by an overproduction of blood cells by the bone marrow and include chronic myeloid leukemia. Lymphoma and leukemia are cancers of the blood.

"PLC-beta 3 is an enzyme, but the function we found was a completely different function that no one knew it had -- as a tumor suppressor," said the La Jolla Institute's Toshiaki Kawakami, M.D., Ph.D., who led the research team. The study, conducted in animal models, could eventually lead to the development of new therapies directed towards controlling this newly discovered cellular mechanism.

Tony Hunter, Ph.D., director of the Salk Institute Cancer Center and a professor in Salk's Molecular and Cell Biology Laboratory, called the finding an "important" step in advancing understanding of blood cancers. "It's very interesting that this molecule acts in this way independently of its enzyme activity," he said. "It's quite an unexpected finding and it definitely has the potential for helping the scientific community understand the mechanisms leading to some types of leukemia."

The findings are being published online today in the journal Cancer Cell in a paper entitled "Tumor Suppression by Phospholipase C- 3 via SHP-1-Mediated Dephosphorylation of STAT5." Researchers from UC San Diego Cancer Center, University of Alabama and the University of Western Ontario also contributed to the study.

Dr. Kawakami said he and his research team got their first inkling of something unexpected fairly early on in their experiments. "We wanted to better understand the PLC-beta 3 enzyme's possible role as a signalin
'/>"/>

Contact: Bonnie Ward
contact@liai.org
619-303-3160
La Jolla Institute for Allergy and Immunology
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. La Jolla Institute signs exclusive license agreement with Medimmune on major asthma discovery
2. Palm Beach County wants to establish a Max Planck Institute in Florida
3. Midlands Consortium delighted to be chosen to host £1 billion energy institute
4. $22 million gift from Alfred Taubman launches new biomedical research institute
5. 3 Columbia University Medical Center faculty elected to Institute of Medicine
6. Stowers Institutes Xie Lab demonstrates dual intrinsic and extrinsic control of stem cell aging
7. Weizmann Institute scientists discover: A risk distribution law for evolution
8. Ludwig Institute for Cancer Research to set up its first Asian branch in Singapore
9. Baker Institute finds increased domestic production wont make US self-sufficient in natural gas
10. Lupus Research Institute strategy delivers $30 million in national funding
11. Stowers Institutes Hawley Lab identifies factors responsible for restart of meiotic cycle
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/28/2014)... from North America, Europe and China have published a ... of Sciences that reveals important details about key ... planet., From strange and exotic algae, mosses, ferns, trees ... grains and vegetables we eat and the ornamental plants ... over a billion years of history., "Our study generated ...
(Date:10/28/2014)... be building a hybrid micro-grid which will integrate ... in the region, the hybrid micro-grid will test ... diesel, storage and power-to-gas technologies, and ensure these ... built under the new Renewable Energy Integration Demonstrator- ... located offshore at Semakau Landfill and is expected ...
(Date:10/27/2014)... in German . ... interior via electrical signals, they communicate with each other ... messenger substances, the neurotransmitters, are stored in vesicles at ... these vesicles fuse with the cell membrane and release ... lost, synapses always have some readily releasable vesicles on ...
Breaking Biology News(10 mins):New study uses DNA sequences to look back in time at key events in plant evolution 2New study uses DNA sequences to look back in time at key events in plant evolution 3NTU to build region's first renewable energy integration demonstration micro-grid 2NTU to build region's first renewable energy integration demonstration micro-grid 3Synapses always on the starting blocks 2Synapses always on the starting blocks 3
... Inc. (NYSE:,SXE), a leading provider of systems integration ... today that it has entered into a,definitive agreement ... operations and information technology services,company. The purchase price ... certain working capital and other adjustments as of ...
... of Food Research have detected subtle changes that may make ... With support from the Food Standards Agency and the ... diet could control these changes and delay or reverse the ... genes that play a role in the very earliest stages ...
... in dolphins from Port Phillip Bay and the Gippsland ... contributing factor to dolphin deaths. Researchers from ... mercury found in the dolphins were within a range ... were higher than mercury levels found in populations around ...
Cached Biology News:Stanley to Acquire Oberon Associates 2Stanley to Acquire Oberon Associates 3Stanley to Acquire Oberon Associates 4'Addicted' cells provide early cancer diagnosis 2Mercury contamination found in stranded Victorian dolphins 2
(Date:10/30/2014)... Ras Al Khaimah, UAE (PRWEB) October 30, 2014 ... the appointment of Dr. James A. Manganello, Chairman of the ... (NSCEC) of The Bahamas. The appointment was made by ... The Bahamas on September 24th, 2014. , More ... Cell Therapy and Research Bill , Prime Minister Perry Christie ...
(Date:10/30/2014)... BASKING RIDGE, N.J. , Oct. 30, 2014 /PRNewswire/ ... announced that it will hold a conference call and ... 8:30 a.m. EST to discuss its third quarter 2014 ... access the conference call by dialing (888) 347-1165 for ... conference call will be webcast live under the investor ...
(Date:10/27/2014)... 2014 Ryan Carfley , Managing Partner ... sit down with Bryan Hamilton, the publisher of the Triangle ... talent in the Research Triangle region of North Carolina. , ... at the roundtable include the role of social media ... work/life balance and the unique role that Millennials play in ...
(Date:10/27/2014)... and TORONTO , ... ( www.generex.com ) (OTCQB: GNBT) today announced two ... response triggered by its novel proprietary cancer immunotherapeutic ... in breast cancer patients. The AE37 cancer vaccine ... Antigen Express, Inc. ( www.antigenexpress.com ). The presentations ...
Breaking Biology Technology:Grace Century’s Stem Cell Biobank Project Announces Chairman’s Appointment to National Stem Cell Ethics Committee of The Bahamas 2Grace Century’s Stem Cell Biobank Project Announces Chairman’s Appointment to National Stem Cell Ethics Committee of The Bahamas 3Regado Biosciences to Provide Third Quarter 2014 Financial Results 2Personify's Ryan Carfley Talks Recruiting with Triangle Business Journal, RPG Solutions 2Personify's Ryan Carfley Talks Recruiting with Triangle Business Journal, RPG Solutions 3Generex Announces Presentations Correlating Immunological Response with Reduced Recurrence in Phase II Study of AE37 Breast Cancer Vaccine in Patients at the American College of Surgeons 2Generex Announces Presentations Correlating Immunological Response with Reduced Recurrence in Phase II Study of AE37 Breast Cancer Vaccine in Patients at the American College of Surgeons 3Generex Announces Presentations Correlating Immunological Response with Reduced Recurrence in Phase II Study of AE37 Breast Cancer Vaccine in Patients at the American College of Surgeons 4
... , , TUSTIN, Calif., Aug. 27 ... it will release its financial results for the first quarter of fiscal ... host a conference call and webcast to discuss the results at 11:30 ... senior management will discuss financial results for the first quarter ended July ...
... , , , SEATTLE, ... that the Company will hold an Analyst Day on Thursday, September 24, ... A live audio webcast of the presentation will be accessible through the ... are unable to listen to the live webcast, it will be archived ...
... , , , ... Aug. 27 Airo, recognized maker of the world,s best ... is available for delivery Q4 of 2009. Airo is releasing ... explosive environments like Petroleum, Chemicals, Fertilizer, Coal, Propane, Fuel Distribution, ...
Cached Biology Technology:Peregrine Pharmaceuticals to Report First Quarter FY 2010 Financial Results 2Airo Wireless Announces the Release of the Intrinsically Safe A25is Cell Phone/PDA 2
ICAD / DFF45 (NT) Affinity Purified Polyclonal Antibody...
Anti-Human IFN-Gamma Receptor Chain 2 (beta chain) [CD119], Rabbit serum, NON-neutralizing polyclonal antibody...
Anti-BAR Immunogen: Peptide of aa 3-21 from human Bar Available Date: 38226...
... UbcH7 interacts with the ... c-Cbl RING domain. Evidence suggests ... in both the degradation of ... of certain N-a -acetylated proteins ...
Biology Products: