Navigation Links
La Jolla Institute discovers new player critical to unleashing T cells against disease
Date:6/23/2013

SAN DIEGO (June 23, 2013) A major study from researchers at the La Jolla Institute for Allergy and Immunology provides new revelations about the intricate pathways involved in turning on T cells, the body's most important disease-fighting cells, and was published today in the prestigious scientific journal Nature.

The La Jolla Institute team is the first to prove that a certain type of protein, called septins, play a critical role in activating a calcium channel on the surface of the T cell. The channel is the portal through which calcium enters T cells from the blood stream, an action essential for the T cell's survival, activation, and ability to fight disease.

Patrick Hogan and Anjana Rao, Ph.D.s, are senior authors on the paper and Sonia Sharma and Ariel Quintana, Ph.D.s, are co-first authors. Drs. Sharma, Rao and Hogan are former researchers at Harvard Medical School with high-level genetics expertise who joined the La Jolla Institute in 2010. Dr. Quintana conducted advanced microscopy that was a major aspect of the study.

Dr. Hogan describes the discovery as another important step in understanding the overall functioning of T cells knowledge from which new, more precisely targeted drugs to treat diseases ranging from cancer to viral infections can emerge. "It's like working on an engine, you have to know what all the parts are doing to repair it," he says. "We want to understand the basic machinery inside a T cell. This will enable us to target the specific pressure points to turn up a T cell response against a tumor or virus or to turn it down in the case of autoimmune diseases."

The findings were published in a Nature paper entitled "An siRNA screen for NFAT activation identifies septins as coordinators of store-operated Ca2+ entry."

"We have found that the septin protein is a very strong regulator of the calcium response, which is essential for activating immune cells," says Dr
'/>"/>

Contact: Bonnie Ward
contact@liai.org
619-991-0868
La Jolla Institute for Allergy and Immunology
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. La Jolla Institute identifies molecular switch enabling immune cells to better fight disease
2. La Jolla institute identifies critical cell in fighting E. coli infection
3. La Jolla Institute scientist discovers key step in immune system-fueled inflammation
4. La Jolla Institute discovery could lead to new way to screen drugs for adverse reactions
5. National Institutes of Health to fund research probing proteins linked to cancer, diabetes
6. Roy J. Carver Charitable Trust funds new research focus at Institute for Genomic Biology
7. The DOE Joint Genome Institute expands capabilities via new partnerships
8. St. Jude scientist named Howard Hughes Medical Institute investigator
9. Feinstein Institute collaborates with GSK, UPenn, MIT to research bodys electrical impulses
10. DOE Joint Genome Institute 8th Annual Meeting on March 26-28, 2013
11. Forsyth Institute receives $4.1 million grant for new center
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... and the Quebec government have discovered microplastics (in ... of Fisheries and Aquatic Sciences . , The ... industrial cleansers, to which they are commonly added ... buoyancy, they may readily pass through sewage treatment ... the world,s oceans, but have only recently been ...
(Date:9/18/2014)... ability to acquire and creatively manipulate spoken language is ... the past 6 million years of human evolution to ... the best candidate gene we now have," says Wolfgang ... In his efforts to understand the molecular biological basis ... forward. The results of his latest study, undertaken in ...
(Date:9/18/2014)... 2014Many Americans across racial and ethnic groups describe ... on their day-to-day life, more so than other ... speech (57% of African-Americans, 49% of non-Hispanic whites, ... asked which disease or ailment is the worst ... among African-Americans followed by AIDS/HIV. Hispanics and ...
Breaking Biology News(10 mins):Microplastic pollution discovered in St. Lawrence River sediments 2Language evolution: Quicker on the uptake 2Language evolution: Quicker on the uptake 3Americans rate losing eyesight as having greatest impact on their lives 2Americans rate losing eyesight as having greatest impact on their lives 3
... A current controversy raging in evolutionary biology is ... many genes, each of relatively small effect, or just ... published in Molecular Ecology strongly supports the ... from the Department of Biology and the Redpath Museum, ...
... Robot squirrels from the University of California, Davis, ... a research project on the interaction between squirrels and ... how squirrels signal to snakes with heat and tail ... University and UC Davis aim to learn more about ...
... April 3, 2012 A team led by scientists ... prevent infection from widely differing strains of hepatitis C virus ... very high rate of mutation normally helps it to evade ... to sites on the viral envelope that seldom mutate. One ...
Cached Biology News:Robosquirrels versus rattlesnakes 2Robosquirrels versus rattlesnakes 3Scripps Research Institute scientists find promising vaccine targets on hepatitis C virus 2Scripps Research Institute scientists find promising vaccine targets on hepatitis C virus 3Scripps Research Institute scientists find promising vaccine targets on hepatitis C virus 4
(Date:9/18/2014)... MA (PRWEB) September 18, 2014 ... Molecule Sequencing (tSMS™) technology, announced today the closing ... of investment, led by Genomic Diagnostic Technologies, will ... and diagnostic applications. , Founded in March 2013 ... and Bioinformatics Analyst at Helicos BioSciences, SeqLL has ...
(Date:9/18/2014)... Artificial sweeteners, promoted as aids to weight loss and ... intolerance and metabolic disease; and they do it in ... of the gut microbiota the substantial population of ... of experiments in mice and humans, were published today ... Eran Elinav of the Weizmann Institute,s Immunology Department, who ...
(Date:9/18/2014)... The quest for the ultimate memory device for computing ... at The City College of New York led by ... exhibit both magnetic and ferroelectric properties. , Combining both ... can occur between them and for the devices that ... Combining these two properties in a single material, however, ...
(Date:9/18/2014)... September 18, 2014 September 24 marks ... MX. ASEA is the manufacturer of the world's first ... care product, RENU28. , The Mexico City event ... Duvan Botero, and ASEA Field Leader Shawn Catmull from ... PhD in Atomic/Medical Physics from the University of Utah ...
Breaking Biology Technology:SeqLL Closes Series-A Funding Round for Expansion of Single Molecule Sequencing 2Gut bacteria, artificial sweeteners and glucose intolerance 2Gut bacteria, artificial sweeteners and glucose intolerance 3Oxides discovered by CCNY team could advance memory devices 2Announcing the ASEA Mexico Grand Opening Tour Beginning September 18th 2
... , Strategic Examination and Consolidation of Services Recommended ... 27 Little uniformity exists in the structure or functions of ... to Clinical Trials Offices: What,s New in Research Administration?, ... (AAHC). Emerging centralized clinical trial offices (CTOs) are among the ...
... , , ATLANTA, Aug. 27 ... million extension of its Series C financing which was originally completed in ... $5 million in Series C preferred stock received warrants for an additional ... have up to 30 days from the delivery of Phase III top-line ...
... , , , ... ATLANTA, Aug. 27 Airo, recognized maker of the ... Safe handset is available for delivery Q4 of 2009. Airo ... in potentially explosive environments like Petroleum, Chemicals, Fertilizer, Coal, Propane, ...
Cached Biology Technology:Clinical Trials Offices Changing Academic Health Center Research Infrastructure 2Alimera Sciences Closes $5 Million in Extended Series C Financing 2Airo Wireless Announces the Release of the Intrinsically Safe A25is Cell Phone/PDA 2
... Polynucleotide Kinase catalyzes the transfer ... to the 5-terminus of polynucleotides ... 5-hydroxyl group. The enzyme, purified ... be used to phosphorylate RNA, ...
... Freezers for IVF are designed for human ... ease of setup and operation, and convenience. ... are continuously displayed on the control panel. ... are printed by way of the thermal ...
... adamanteus venom Description: Phosphodiesterase I ... in studying nucleic acid structure ... hydrolyzes 5'-mononucleotides from 3'-hydroxy-terminated ribo-oligonucleotides ... I cleaves ADP-ribosylated proteins at ...
... Life Science Rotarods are used to assess the ... fatigue resistance on mice and rats using one ... user friendly; the animals are placed on textured ... onto the individual sensing platforms below, its test ...
Biology Products: