Navigation Links
LSUHSC study IDs proteins regulating water retention in salt-sensitive hypertension
Date:10/22/2010

New Orleans, LA Research conducted by scientists at LSU Health Sciences Center New Orleans has found that two proteins in the brain act as valves to turn the hormone that regulates water retention in the body on and off. Their findings may lead to advances in treatment for diseases like high blood pressure, congestive heart failure, and cirrhosis of the liver. The research is published in the November 1, 2010 issue of Endocrinology.

Daniel Kapusta, PhD, Professor of Pharmacology at LSU Health Sciences Center New Orleans, and Richard Wainford, PhD, LSUHSC Instructor of Pharmacology, report the role of these brain proteins, called Gαq and Gαz, in producing elevated secretion of the hormone, vasopressin, and water retention in salt-sensitive hypertension, a condition in which blood pressure becomes elevated when salt is consumed. It is estimated that salt-sensitive hypertension occurs in about 26% of Americans with normal blood pressure and in 58% of those whose blood pressure is already high.

"Throughout the day, vasopressin, a peptide hormone produced by the hypothalamus, is released into the circulation from the pituitary gland and plays a vital role as the flood-gate keeper to prevent excessive loss of water from the kidneys," notes Dr. Kapusta. "Under most conditions, the water-retaining action of vasopressin is vital for survival. However, it has remained essentially a black box as to why, in susceptible individuals, the regulatory mechanisms that control vasopressin secretion cannot turn off when the body already has elevated water content."

For 21-days, the research team fed groups of male salt-resistant and salt-sensitive rats a diet containing either normal or high salt. Then they measured how the treatments influenced the animal's ability to excrete water and how the salt stress altered levels of vasopressin, Gαq and Gαz.

The consumption of high salt triggered a decrease in Gαq proteins in the br
'/>"/>

Contact: Leslie Capo
lcapo@lsuhsc.edu
504-568-4806
Louisiana State University Health Sciences Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. LSUHSC awarded patent for compound inhibiting cancer and other diseases
2. LSUHSC research identifies key contributor to Alzheimers disease process
3. LSUHSC student awarded top national honor for diabetes research
4. LSUHSC public health researcher finds reason for weight gain
5. LSUHSC research describes function of key protein in cancer spread
6. LSUHSCs Kolls awarded $1.8 million to improve vaccine strategies for P. carinii pneumonia
7. LSUHSC research helps link schizophrenia to specific DNA region
8. LSUHSCs Bazan awarded ARRA grant to preserve vision
9. LSUHSC shows for first time infant inhalation of ultrafine air pollution linked to adult lung disease
10. Grant supports LSUHSC research on how like cell receptor systems determine very different functions
11. LSUHSC researchers working to prevent diabetic neuropathy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/14/2014)... fly genome for the first time, revealing robust immune ... thrives in pathogen-rich dung piles and garbage heaps. , ... Genome Biology , will increase understanding of house fly ... to resist insecticides, which could lead to novel control ... transmit more than 100 human and animal diseases, including ...
(Date:10/14/2014)... new kind of stem cell that can become either a ... according to a study published today in the journal ... type contradicts current theory on how organs arise from cell ... of, and future treatment for, liver cancer., Thanks to stem ... being made up of more than 200 cell types. The ...
(Date:10/14/2014)... LA JOLLA, CA – October 14, 2014 – Scientists ... $6.6 million from the National Institutes of Health (NIH) ... most prevalent virus-induced hemorrhagic fever disease in Africa. The ... disease and why some patients die, while others survive ... researchers to understand the basic mechanism of how Lassa ...
Breaking Biology News(10 mins):House fly genome reveals expanded immune system 2Stem cell discovery challenges dogma on how fetus develops; holds insights for liver cancer and reg 2Stem cell discovery challenges dogma on how fetus develops; holds insights for liver cancer and reg 3Scripps Research Institute team receives $6.6 million to investigate deadly Lassa virus 2
... pioneering stem cell bandage, believed to be the world,s first ... heal torn meniscal cartilage, can now take the technology to ... the UK,s most successful entrepreneurs. Mr Hugh Osmond, a ... into the UK,s largest sit-down restaurant chain and founded one ...
... The possibility that functional, three-dimensional tissues and organs ... stem cells (ESCs) and induced pluripotent stem cells (iPSCs), ... research, but is also one of the fundamental goals ... has played a central role in informing such efforts, ...
... November 14, 2011 DERMALOG Identification Systems ... a new world record in the identification of fingerprints. ... is capable of correctly identifying the ten fingerprints of ... more than 129 million fingerprints. The renowned international SGS ...
Cached Biology News:World's first stem cell bandage in human clinical trials 2Self-organized pituitary-like tissue from mouse ES cells 2Self-organized pituitary-like tissue from mouse ES cells 3Self-organized pituitary-like tissue from mouse ES cells 4World Record in Fingerprint Identification: DERMALOG Correctly Identifies 129 Million Fingerprints in one Second 2World Record in Fingerprint Identification: DERMALOG Correctly Identifies 129 Million Fingerprints in one Second 3
(Date:10/22/2014)... , Oct. 22, 2014  Actavis plc (NYSE: ... company, and Rhythm, a biopharmaceutical company, today announced that ... Rhythm,s wholly owned subsidiary, Rhythm Health, Inc., which is ... treatment of diabetic gastroparesis and other GI functional disorders. ... 2 trial of relamorelin for the treatment of diabetic ...
(Date:10/22/2014)... The North American crystal oscillator market ... with analysis and forecast of revenue. This market was ... to reach $623.6 million by 2018, at a CAGR ... the TOC of the North American crystal oscillator market ... provided. This also provides a glimpse of the segmentation ...
(Date:10/22/2014)... Arlington, Massachusetts (PRWEB) October 22, 2014 ... recently announced the release of a new infographic, ... was to create a beautifully designed, easy to follow ... Ebola's transmission, areas of outbreak, symptoms and prevention. , ... have discovered that the 2014 Ebola outbreak represents not ...
(Date:10/22/2014)... 22, 2014 Currently offering a ... & D Weighing, Rice Lake, and Ohaus, Pipette.com ... . The Sartorius CPA Semi-Micro Balance is ideal ... precise, and user-friendly laboratory balance. , Sartorius is ... their laboratory balances are well known for their ...
Breaking Biology Technology:Actavis Signs Option to Acquire Rhythm Subsidiary and its GI Development Product, Relamorelin 2Actavis Signs Option to Acquire Rhythm Subsidiary and its GI Development Product, Relamorelin 3Actavis Signs Option to Acquire Rhythm Subsidiary and its GI Development Product, Relamorelin 4Actavis Signs Option to Acquire Rhythm Subsidiary and its GI Development Product, Relamorelin 5The North American crystal oscillator market is expected to reach $623.6 million by 2018 - New Report by MicroMarket Monitor 2The North American crystal oscillator market is expected to reach $623.6 million by 2018 - New Report by MicroMarket Monitor 3The North American crystal oscillator market is expected to reach $623.6 million by 2018 - New Report by MicroMarket Monitor 4Involution Studios' Ebola Infographic Provides Key Disease Information and Statistics at a Glance 2Pipette.com Launches the Addition of Sartorius CPA Semi-Micro Balance to Their Product Portfolio with Special Promotional Pricing 2Pipette.com Launches the Addition of Sartorius CPA Semi-Micro Balance to Their Product Portfolio with Special Promotional Pricing 3
... Terumo Americas Holding, Inc., a U.S. subsidiary of Japan,s ... manufacturers with $3.4 billion in sales and operations in ... entered into a Stock Purchase Agreement to acquire all ... company working to commercialize the world,s first point-of-care technology ...
... make it possible to improve photoelectrochemical cells. In the ... into energy, these cells use sunlight to drive chemical ... involves using a light-sensitive semi-conducting material such as cuprous ... reaction. Although it is not expensive, the oxide is ...
... 2011 Biocept, Inc., a privately-held laboratory testing ... of circulating tumor cells (CTCs) in cancer patients, ... the identification of different CTC phenotypes using its ... paper, appearing in the Journal of Oncology ...
Cached Biology Technology:Terumo Americas Holding, Inc., Agrees to Acquire Harvest Technologies Corporation, a Leader in the Development of Point-of-Care Cellular Therapy 2Terumo Americas Holding, Inc., Agrees to Acquire Harvest Technologies Corporation, a Leader in the Development of Point-of-Care Cellular Therapy 3Terumo Americas Holding, Inc., Agrees to Acquire Harvest Technologies Corporation, a Leader in the Development of Point-of-Care Cellular Therapy 4Harnessing the energy of the Sun: New technique improves artificial photosynthesis 2Biocept Demonstrates Multiple Phenotypes of Circulating Tumor Cells (CTCs) in Cancer Patients 2Biocept Demonstrates Multiple Phenotypes of Circulating Tumor Cells (CTCs) in Cancer Patients 3
Recognizes the ~115 kDa NMDA receptor NR1 subunit in rat cortex tissue extracts....
... T4 DNA Ligase catalyzes the formation of ... between double-stranded DNAs with 3' hydroxyl and ... Ligase buffer optimizes ligation which can be ... acids are not substrates for this enzyme. ...
Porcine Coronary Artery Smooth Muscle Cells (PCASMC) (>500,000 cells)...
Sulfadimethoxine (CH-2027)...
Biology Products: