Navigation Links
LSUHSC shows for first time infant inhalation of ultrafine air pollution linked to adult lung disease
Date:7/22/2009

New Orleans, LA Stephania Cormier, PhD, Associate Professor of Pharmacology at LSU Health Sciences Center New Orleans, has shown for the first time that early exposure to environmentally persistent free radicals (present in airborne ultrafine particulate matter) affects long-term lung function. She recently presented her latest research data at the 11th International Congress on Combustion By-Products and Their Health Effects at the Environmental Protection Agency Conference Center in Research Triangle Park, N.C.

Dr. Cormier, a 2006 National Institute of Environmental Health Sciences Outstanding New Environmental Scientist awardee, is conducting research to determine how inhalation exposure to environmental factors such as allergens, pollutants, and respiratory viruses during infancy leads to pulmonary inflammatory diseases, such as chronic obstructive pulmonary disease (COPD) and asthma later in life.

Using protein profiling techniques, Dr. Cormier's lab was able to determine that early exposure to these ultrafine pollutants caused genes to produce a number of proteins, including one associated with COPD and steroid-resistant asthma, and also caused proteins to misfold, rendering them dysfunctional. These genetic defects are linked to structural changes in the lung, airflow limitations, and permanent changes in immune responses.

"It is no surprise that elevations in airborne particulate matter (PM) are associated with increased hospital admissions for respiratory symptoms including asthma exacerbations," notes Dr. Cormier. "What has come as a surprise is that early exposure to elevated levels of PM elicits long-term effects on lung function and lung development in children."

These results could be especially important because the US Environmental Protection Agency does not currently regulate ultrafine PM emissions.

According to the National Institutes of Health, more than 12 million Americans are currently diagnosed with COPD and another 12 million probably have it and don't know it. Asthma is now the most common chronic disorder of childhood, affecting an estimated 6.2 million US children under the age of 18.

"Glucocorticoid (steroid) treatment is the foundation of asthma treatment; however, while the majority of patients with asthma respond to glucocorticoid treatment there are a number of patients who do not," says Dr. Cormier. "In cells, a protein called cofilin-1 appears to inhibit glucocorticoid function. We are currently testing whether cofilin-1 also does this in the body. If it does, then it is possible to envision the development of therapeutics aimed at inhibiting cofilin-1 for use in steroid-resistant asthmatics."


'/>"/>

Contact: Leslie Capo
lcapo@lsuhsc.edu
504-568-4806
Louisiana State University Health Sciences Center
Source:Eurekalert

Related biology news :

1. LSUHSC awarded $10M+ COBRE grant
2. LSUHSCs Lazartigues awarded $1.2 million grant
3. LSUHSC research reports new method to protect brain cells from diseases like Alzheimers
4. LSUHSC awarded patent for compound inhibiting cancer and other diseases
5. LSUHSC research identifies key contributor to Alzheimers disease process
6. LSUHSC student awarded top national honor for diabetes research
7. LSUHSC public health researcher finds reason for weight gain
8. LSUHSC research describes function of key protein in cancer spread
9. LSUHSCs Kolls awarded $1.8 million to improve vaccine strategies for P. carinii pneumonia
10. LSUHSC research helps link schizophrenia to specific DNA region
11. LSUHSCs Bazan awarded ARRA grant to preserve vision
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/20/2017)... ALLENTOWN, Pa. , March 20, 2017 ... PD 2.0 personal spirometer and Wellness Management System (WMS), ... Founded in 2010, PMD Healthcare is a ... Company with a mission dedicated to creating innovative solutions ... of life. With that intent focus, PMD developed the ...
(Date:3/13/2017)... Future of security: Biometric Face Matching software  ... ... Matching enables to match face pictures against each other or against large databases. ... Systems) ... the fastest software for biometric Face Matching on the market. The speed is ...
(Date:3/9/2017)... VIEW, Calif. , March 9, 2017 ... 23andMe , the leading personal genetics company, are using ... now provide customers with personalized nutrition plans that consider ... but also genetic markers impacting how their body may ... food decision support platform uses biometrics such as Body ...
Breaking Biology News(10 mins):
(Date:5/16/2017)... Telehealth has long been a standalone ... has been kept completely separate from discussions about ...   Logicalis Healthcare Solutions , the healthcare-focused arm ... managed services provider ( www.us.logicalis.com ), there is ... between telehealth, imaging, and EHR optimization that healthcare ...
(Date:5/16/2017)... ... ... On Tuesday, May 23 at 10:30 AM, James Sherley, Director of Asymmetrex ... that his company has recently achieved in collaboration with its partner, AlphaSTAR Corporation ... first partnering conference, Cell & Gene Exchange 2017 . In addition to ...
(Date:5/15/2017)... ... 15, 2017 , ... Catalent Pharma Solutions, the leading global ... health products, today announced that it has signed an agreement with Therachon AG, ... clinical development of TA-46, a novel protein addressing achondroplasia, which is the most ...
(Date:5/15/2017)... ... May 15, 2017 , ... Continuing to build off ... has today launched its first-ever cross-medium campaign, #StandFirm, with high-visibility social and digital ... social media channels, emphasizing Algenist’s stance on individuality and disruption: , We ...
Breaking Biology Technology: