Navigation Links
LSUHSC scientist awarded nearly $2 million to determine role of biofilms in common fungal infection
Date:2/6/2013

New Orleans, LA Mairi Noverr, PhD, Associate Professor in the Department of Prosthodontics at the LSU Health Sciences Center New Orleans School of Dentistry, has been awarded a $1.7 million grant over five years by the National Institute of Dental & Craniofacial Research of the National Institutes of Health to study the role of biofilms in infection and disease. This research will contribute to our understanding of how biofilms are involved in fungal disease development, leading to the discovery of new therapeutic targets.

Dr. Noverr, a microbiologist, is studying a model of dental stomatitis, a fungal infection affecting approximately 50-75% of otherwise healthy denture wearers, and C. albicans, the most common infection-causing yeast. C. albicans normally lives on the skin and mucous membranes without any problem. But its overgrowth can result in infection. C. albicans is the most common cause of denture stomatitis. C. albicans readily forms biofilm on denture materials; however, the role of biofilm formation in the disease development process of denture stomatitis is unknown. Biofilms are the sticky substances composed of microorganisms like yeasts, bacteria, etc. that form on and adhere to wet surfaces including teeth, dental prostheses, or implants. Dental plaque is an example of a biofilm.

The major goals of this grant are to determine the role of biofilm formation in Candida-associated denture stomatitis and determine how the immune response influences development of the disease.

"Information gathered in these studies can be applied to other Candida mucosal and device-related biofilm infections, which can cause systemic infection and significant illness and death," notes Dr. Noverr, who is also a member of the LSUHSC Center of Excellence in Oral Biology. "Because biofilms are not only resistant to antimicrobial drugs but also to immune defenses, this knowledge base can be used to develop novel immunotherapies that target biofilm growth."


'/>"/>

Contact: Leslie Capo
lcapo@lsuhsc.edu
504-568-4806
Louisiana State University Health Sciences Center
Source:Eurekalert

Related biology news :

1. LSUHSC research discovery provides therapeutic target for ALS
2. LSUHSCs Weiss chosen to help set national eye policy, research
3. LSUHSC research identifies new therapeutic target for Alzheimers disease
4. LSUHSC research finds ginkgo biloba doesn’t improve cognitive function in MS
5. LSUHSC research finds treating stress prevented new MS brain lesions
6. LSUHSC research finds HPV-related head & neck cancers rising, highest in middle-aged white men
7. Scientists turn toxic by-product into biofuel booster
8. Scientists find a key element of lupus, suggesting better drug targets
9. Scientists notch a win in war against antibiotic-resistant bacteria
10. Plant scientists at CSHL demonstrate new means of boosting maize yields
11. Listening to cells: Scientists probe human cells with high-frequency sound
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2017)... Mar 24, 2017 Research and Markets has ... Market Analysis & Trends - Industry Forecast to 2025" report ... ... at a CAGR of around 15.1% over the next decade to ... report analyzes the market estimates and forecasts for all the given ...
(Date:3/22/2017)... 2017 Vigilant Solutions , a vehicle ... agencies, announced today the appointment of retired FBI special ... safety business development. Mr. Sheridan brings more ... a focus on the aviation transportation sector, to his ... Mr. Sheridan served as the Aviation Liaison Agent Coordinator ...
(Date:3/9/2017)... Australia , March 9, 2017 4Dx ... prestigious World Lung Imaging Workshop at the University of ... was invited to deliver the latest data to world ... recognised event brings together leaders at the forefront of ... in lung imaging. "The quality of ...
Breaking Biology News(10 mins):
(Date:4/20/2017)... SANTA BARBARA, CALIFORNIA (PRWEB) , ... April 20, 2017 , ... ... process optimization firm for the life sciences and healthcare industries, is pleased to announce ... of the new established USDM subsidiary “USDM Europe GmbH” based in Germany. , ...
(Date:4/20/2017)... CA (PRWEB) , ... April 20, 2017 , ... ... of clinical trials worldwide, announced today that they were named one of the ... which covers the latest developments in the pharmaceutical industry. , “We take pride in ...
(Date:4/19/2017)... ... 2017 , ... The Vibrating Orifice Aerosol Generator (VOAG) was ... droplets of known diameters for research applications such as for calibrating droplet measuring ... monodisperse droplets. , The VOAG requires forcing liquid out of an orifice ...
(Date:4/19/2017)... Waltham, MA (PRWEB) , ... April 19, 2017 ... ... of a $1.5M Series A-1 financing round. This event adds to several other ... establishment of its’ Executive and Scientific Teams. , ThermaGenix will use ...
Breaking Biology Technology: