Navigation Links
LSUHSC scientist awarded nearly $2 million to determine role of biofilms in common fungal infection
Date:2/6/2013

New Orleans, LA Mairi Noverr, PhD, Associate Professor in the Department of Prosthodontics at the LSU Health Sciences Center New Orleans School of Dentistry, has been awarded a $1.7 million grant over five years by the National Institute of Dental & Craniofacial Research of the National Institutes of Health to study the role of biofilms in infection and disease. This research will contribute to our understanding of how biofilms are involved in fungal disease development, leading to the discovery of new therapeutic targets.

Dr. Noverr, a microbiologist, is studying a model of dental stomatitis, a fungal infection affecting approximately 50-75% of otherwise healthy denture wearers, and C. albicans, the most common infection-causing yeast. C. albicans normally lives on the skin and mucous membranes without any problem. But its overgrowth can result in infection. C. albicans is the most common cause of denture stomatitis. C. albicans readily forms biofilm on denture materials; however, the role of biofilm formation in the disease development process of denture stomatitis is unknown. Biofilms are the sticky substances composed of microorganisms like yeasts, bacteria, etc. that form on and adhere to wet surfaces including teeth, dental prostheses, or implants. Dental plaque is an example of a biofilm.

The major goals of this grant are to determine the role of biofilm formation in Candida-associated denture stomatitis and determine how the immune response influences development of the disease.

"Information gathered in these studies can be applied to other Candida mucosal and device-related biofilm infections, which can cause systemic infection and significant illness and death," notes Dr. Noverr, who is also a member of the LSUHSC Center of Excellence in Oral Biology. "Because biofilms are not only resistant to antimicrobial drugs but also to immune defenses, this knowledge base can be used to dev
'/>"/>

Contact: Leslie Capo
lcapo@lsuhsc.edu
504-568-4806
Louisiana State University Health Sciences Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. LSUHSC research discovery provides therapeutic target for ALS
2. LSUHSCs Weiss chosen to help set national eye policy, research
3. LSUHSC research identifies new therapeutic target for Alzheimers disease
4. LSUHSC research finds ginkgo biloba doesn’t improve cognitive function in MS
5. LSUHSC research finds treating stress prevented new MS brain lesions
6. LSUHSC research finds HPV-related head & neck cancers rising, highest in middle-aged white men
7. Scientists turn toxic by-product into biofuel booster
8. Scientists find a key element of lupus, suggesting better drug targets
9. Scientists notch a win in war against antibiotic-resistant bacteria
10. Plant scientists at CSHL demonstrate new means of boosting maize yields
11. Listening to cells: Scientists probe human cells with high-frequency sound
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/9/2014)... the oils produced by algae may offer a low-cost ... optimization of cost effective strategies for large-scale algae cultivation, ... Energy has developed an innovative solution to the challenge ... in Industrial Biotechnology , a peer-reviewed journal from ... on the Industrial Biotechnology website . ...
(Date:7/9/2014)... Ill. With over 100 diseases that can attack ... top of the most wanted list? University of Illinois ... that more research is needed on the fungus that ... with cool, damp growing conditions but Macrophomina phaseolina ... and dry drought conditions. , "As the climate continues ...
(Date:7/9/2014)... a sparrow-sized fossil from China challenges the commonly held ... gained the ability to fly. The birdlike fossil is ... rather the remains of a tiny tree-climbing animal that ... Dinosaur Museum in Blanding, Utah, and Alan Feduccia of ... Springer,s Journal of Ornithology . , The fossil ...
Breaking Biology News(10 mins):Controlling contamination in open algae ponds for biofuels 2Climate change provides good growing conditions for charcoal rot in soybeans 2Climate change provides good growing conditions for charcoal rot in soybeans 3Researchers declassify dinosaurs as being the great-great-grandparents of birds 2
... An international research team led by Nanjing Agricultural ... of pear by an approach using the combination of ... only provides an invaluable new resource for breeding improvement ... on the genome evolution and other genome-wide comparative studies. ...
... 19, 2012 Medbox, Inc. (Ticker: MDBX) ( www.medboxinc.com ... they have received many inquiries from shareholders purchasing shares ... week,s volatile trading. These inquiries were responded to and ... rapport. In other news, the company ...
... person imagines moving a limb, cells in the part ... if trying to make the immobile limb work again. ... pathway between brain and muscle, the region where the ... recent years, neuroscientists and neuroengineers working in prosthetics have ...
Cached Biology News:Pear genome provides new insight into breeding improvement and evolutionary trace analysis 2Medbox Communicates with Shareholders, Comments on Pending Transition to OTC Bulletin Board, and Announces Appearance on Fox Business News Channel 2A better thought-controlled computer cursor 2A better thought-controlled computer cursor 3A better thought-controlled computer cursor 4A better thought-controlled computer cursor 5
(Date:1/15/2014)... This webinar will focus on EMA ... assessment in biosimilars. , Regulatory frameworks are evolving many ... however the complex nature of biopharmaceuticals makes the demonstration ... extremely challenging. Based on the specific aspects of biosimilar ...
(Date:1/15/2014)... January 15, 2014 DTS Language Services, ... Online Web Portal for Life Science organizations who need document ... the subject matter of their documents in advance with a ... reduce time-to-delivery of translations, often a critical factor in clinical ...
(Date:1/14/2014)... 2014 Date: Friday, April 11, 2014 , ... Club, 1360 Almshouse Road, Warrington, Pa. , Details: ... dedicated to finding a cure for hepatitis B and improving ... its annual Crystal Ball on Friday, April 11 at Warrington ...
(Date:1/14/2014)... York, NY (PRWEB) January 14, 2014 ... of Alliqua, Inc. (OTCQB: ALQA). Alliqua is an emerging ... to serve the wound care market. , Free report ... was restructured with a seasoned management team and Board, ...
Breaking Biology Technology:Xtalks Life Sciences Webinar Examines Safety Assessment of Biosimilars 2DTS Improves Efficiency for Life Science Document Translations 2Hepatitis B Foundation to Host Annual Crystal Ball Gala 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 3
... LA JOLLA, Calif., Feb. 23, 2011 ... to providing personalized treatment information to women with ... been appointed Executive Director, a new position for ... to lead the foundation as it increases its ...
... CITY, Calif., Feb. 23, 2011 Ingenuity® Systems, ... for life science researchers, today announced a research ... for next-generation sequencing (NGS) data analysis. Covance Genomics ... the drug discovery and development industry, and Ingenuity ...
... in German . , Further development of ... at reasonable costs. In the past, integration density of ... of this strategy, future components will have to reach ... Center for Functional Nanostructures (CFN) and IPCMS have now ...
Cached Biology Technology:The Clearity Foundation Hires Hillary Theakston as Executive Director 2The Clearity Foundation Hires Hillary Theakston as Executive Director 3Ingenuity Systems and Covance Collaborate to Support Next-Generation Sequencing Research 2Smallest magnetic field sensor in the world 2
... of SYBR Green I or FAM in ... fluorophores in the second channel including ... a multitude of applications such as RT-qPCR ... offers precision thermal control and a temperature ...
... identification and library manager ... that adds capabilities for ... identification of unknowns against ... of the same taxon ...
Fingerprinting II comparative quantification and polymorphism analysis is an optional module that adds comparative quantification and polymorphism analysis functions to the Fingerprinting II Basic so...
... or for use in an automated line. ... disposable manifold provides greater ease, speed, convenience, ... StatMatic II can be connected to a ... fill a microplate with one-handed operation -- ...
Biology Products: