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LSUHSC researchers develop new system to better study behavior, cell function
Date:9/5/2013

any of the limitations of switch-based approaches.

Using genetic technology, the research team developed DREADD receptors in the flies' neuronal circuits, which they selectively activated by feeding the flies a drug that only activates the DREADD receptors in their food. There were three DREADD flavors two activating and one inhibitory. Depending on which DREADD was expressed where, distinct neural circuits could either be activated or suppressed. Because the researchers activated DREADDs with drugs in the food, the degree of activation could be precisely controlled by just changing the amount of drug in the food.

"We have successfully translated this technology to the fly and in this paper report reversible and dose responsive control of many behaviors including sensory perception, learning and memory, and courtship," says Dr. Nichols. "Our new pharmacogenetic approach fills an important and unmet need in our ability to understand fly behaviors by allowing us for the first time to conveniently examine behaviors in only partially activated neurons to uncover more subtle roles for particular neurons and circuits in behaviors." A better understanding of fly behaviors will translate to a better understanding of human biology and diseases.

A unique feature of this DREADD system not found in other methods is that it is not limited to the control of neurons activity levels of certain enzymes in almost every tissue type can be controlled to probe mechanisms of basic cellular function. The researchers demonstrated this ability by stopping the fly heart with activation of the inhibiting DREADD expressed in the heart, and then restarting the heart simply by washing away the drug.


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Contact: Leslie Capo
lcapo@lsuhsc.edu
504-568-4806
Louisiana State University Health Sciences Center
Source:Eurekalert

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