Navigation Links
LSUHSC research reveals structure of master regulator and new drug target for autism, cervical cancer
Date:1/9/2014

New Orleans, LA A team of scientists at LSU Health Sciences Center New Orleans has discovered the structure of the active form of E6-associated protein (E6AP), an enzyme that acts as a master regulator in the body. They report, for the first time, that the active form of E6AP is composed of three distinct protein molecules. E6AP controls functions as diverse as the ability of nerve cells to "rewire" themselves in response to external stimuli and the mechanism by which certain viruses, like human papillomaviruses or HPV, hijack normal cellular processes in order to replicate a process that can ultimately lead to cancer. The research will be published in the January 10, 2014, issue of the Journal of Biological Chemistry.

"Because the assembly of cells is like an elaborate tinker toy set in which the parts can be used in different combinations to serve various roles, E6AP normally functions in nerve cells to direct brain development and in a functionally related process termed neuronal plasticity which allows nerve cells to alter their patterns of communication with neighboring cells during learning," notes Arthur Haas, PhD, the Roland Coulson Professor and Chairman of Biochemistry and Molecular Biology at LSU Health Sciences Center New Orleans and Director of the laboratory in which the work was performed.

The research team included lead investigator Dr. Virginia Ronchi, a postdoctoral fellow, and her colleagues, Jennifer Klein and Dr. Daniel Edwards, all of whom work in Dr. Haas's laboratory at LSU Health Sciences Center New Orleans School of Medicine.

Inherited loss of E6AP function in the brain results in the mild to severe neurodevelopmental defects of Angelman Syndrome which occur in 1 in 10,000-20,000 births. Angelman Syndrome is a developmental condition characterized by severe mental retardation in children because the brain is unable to "learn" by adapting its nerve connections to outside stimuli. In contrast, othe
'/>"/>

Contact: Leslie Capo
lcapo@lsuhsc.edu
504-568-4806
Louisiana State University Health Sciences Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. LSUHSC research finds inflammation linked to obesity in adults may be protective in young children
2. LSUHSC research finds combo of plant nutrients kills breast cancer cells
3. LSUHSCS OCHOA 1 of 10 chosen by NIH director for Transformative Research Award
4. LSUHSC researchers develop new system to better study behavior, cell function
5. LSUHSC researcher awarded NCI grant to study link between chronic inflammation and cancer
6. LSUHSC research identifies new risk factors for parasitic infection
7. LSUHSC research discovers new drug target for metastatic breast cancer
8. LSUHSC research identifies co-factors critical to PTSD development
9. LSUHSC scientist awarded nearly $2 million to determine role of biofilms in common fungal infection
10. LSUHSC research discovery provides therapeutic target for ALS
11. LSUHSCs Weiss chosen to help set national eye policy, research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/11/2014)... 2014 Research and Markets ... ( http://www.researchandmarkets.com/research/twhjll/biometrics_market ) has announced the addition of ... 2015-2019"  report to their offering. ... advances in technology. With continuous advances in technology, ... the latest standard that meets the needs and ...
(Date:12/10/2014)... You,ve been here before: you desperately need to sign into ... key or the answer to your secret question. What,s your ... Today, Hoyos Labs , a digital infrastructure security ... an end to the frustration that comes with usernames, passwords ... a user,s smartphone to acquire his or her biometrics to ...
(Date:12/10/2014)... --Research and Markets ( http://www.researchandmarkets.com/research/xclcvw/biometrics_market ) ... Market in Japan 2014-2018" report to their ... The integration of biometrics and smart ... upgradation of the driver,s license is one of ... the aforementioned projects, biometrics is being used as ...
Breaking Biology News(10 mins):Biometrics Market in the APAC Region 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 3Biometrics Market in Japan 2014-2018: Key Vendors are DDS, Fujitsu, Hitachi and NEC 2
... provider of scientific, technical and medical information products and ... study in Reproductive BioMedicine Online ... male couples and single men when using assisted reproduction ... single men using assisted reproduction assistance to have a ...
... an emerging treatment that aims to fight colorectal cancer ... the ESMO 15th World Congress on Gastrointestinal Cancer. ... called MGN1703 and suggest it may be possible to ... the treatment, reported Prof Hans-Joachim Schmoll from Martin Luther ...
... weeding out the bacteria that form the base of ... according to a new study. In climate change, ... atmospheric carbon dioxide levels and temperature rise globally, scientists ... which will perish in the environment of tomorrow. ...
Cached Biology News:Reproductive BioMedicine Online publishes study on assisted reproduction 2Immune-boosting colorectal cancer drug shows promise 2Greenhouse gas likely altering ocean foodchain 2
(Date:12/24/2014)... December 23, 2014 “Preparative & ... HPLC, Flash), Consumables (Columns, Solvents, Buffers, Valves, Guages, ... & Agriculture) - Forecasts to 2019” provides a ... opportunities, current market trends, and strategies impacting the ... estimates and forecasts of the revenue and share ...
(Date:12/24/2014)... 23, 2014 On Friday, December ... 83, the Omnibus and Continuing Resolution Appropriations Act ... hydrocephalus a condition eligible to receive funding through ... by the Department of Defense (DoD). The Hydrocephalus ... on Capitol Hill, is celebrating this victory for ...
(Date:12/24/2014)... report expects global cell isolation and expansion market to ... carefully analyzed data about the vital drivers, restraints, trends, ... Copy of Report @ http://bit.ly/1yUxy0T , According ... will keep witnessing growth at an impressive CAGR during ... by rapid technological advancements, government funding and investments, and ...
(Date:12/24/2014)... 23, 2014 PharmaBoardroom,s new ... today and available for free download , digs deep ... and growth in the sector today. One area ... has been in developing a homegrown pharmaceutical manufacturing base, even ... still remains some way off. A cursory comparison with neighboring ...
Breaking Biology Technology:Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 2Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 3Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 4Rare Brain Condition Now Eligible for Department of Defense Research Dollars 2The Cell Expansion Market is Expected to Reach $14.8 billion by 2019 - New Research Report by MarketsandMarkets 2The Cell Expansion Market is Expected to Reach $14.8 billion by 2019 - New Research Report by MarketsandMarkets 3PharmaBoardroom Releases New Algeria Pharmaceuticals Report 2PharmaBoardroom Releases New Algeria Pharmaceuticals Report 3
... SOMERSET, N.J., Oct. 4 Alfacell Corporation,(Nasdaq: ACEL ... chief financial officer and corporate secretary, will present an,overview ... PDT on,Oct. 11th, at BIO InvestorForum 2007 at the ... Webcast of the presentation will be available on,Alfacell,s Web ...
... Kendle (Nasdaq: KNDL ), a,leading, global full-service ... Operating Officer Christopher C. Bergen,will participate in the ... held at The Carlton on Madison Avenue in ... scheduled for Monday, Oct. 8 at,2:15 p.m. Eastern ...
... announced today that it has entered into a ... Cancer (IRIC) of the Universite de,Montreal. This collaboration, ... by Sigma-Aldrich, will leverage Sigma,s RNA,Interference (RNAi) technologies ... Sigma-Aldrich and the Universite de Montreal have ...
Cached Biology Technology:Alfacell to Present at BIO InvestorForum 2007 2Kendle to Present at the Natixis Bleichroeder Hidden Gems Conference 2Sigma-Aldrich and the Universite de Montreal Establish Collaboration for RNA Interference Studies 2
Umbilical cord blood CD14+ Monocytes, For immunohistochemistry (IHC) Cell Chip with Human Umbilical Cord Blood Monocytes, B Cells and NK Cells...
Umbilical cord blood basophils, For immunohistochemistry (IHC)...
Human peripheral blood neutrophils, For immunohistochemistry (IHC) Cell Chip with Human Peripheral Blood Granulocytes...
Human peripheral blood CD14+ monocytes, For immunohistochemistry (IHC) Cell Chip with Human Peripheral Blood Monocytes, B Cells, NK Cells and Stem Cells...
Biology Products: