Navigation Links
LSUHSC research increases understanding of drug metabolism
Date:3/17/2010

New Orleans, LA Research led by Wayne L. Backes, PhD, Professor of Pharmacology and Associate Dean for Research at LSU Health Sciences Center New Orleans School of Medicine, has found that drug metabolism depends not only upon which enzymes are present in an individual, but also how they interact, and that can be the difference in whether a drug is safely eliminated from the body or is converted into a toxic or carcinogenic byproduct. The paper will be published in the March 19, 2010 issue of the Journal of Biological Chemistry.

Dr. Backes and his LSUHSC research colleagues J. Robert Reed, PhD, Pharmacology Assistant Professor and Marilyn Eyer, Research Associate have been studying an enzyme called Cytochrome P450 which is responsible for the removal of the majority of drugs from the body by chemically breaking them down into inactive substances or metabolites. There are many different P450 enzymes capable of degrading many different drugs. Because there are so many, there is a high degree of variability in people's responses to a drug.

"Although most P450 reactions lead to metabolites that speed the excretion of drugs and pollutants, sometimes P450 enzymes can lead to the activation of a compound to a metabolite that can cause cancer or toxicity where the initial chemical in the drug does not," notes Dr. Backes. "This is a partial explanation of why some people are more resistant to cancer and other diseases and why it is very important to understand the reasons for the variability in drug metabolism."

The results reported in this paper show that P450 enzymes form complexes with each other in biological membranes, and that these complexes affect how the enzymes metabolize substances, making one of the P450s more active and the other less active. The researchers also showed that both of the P450 enzymes they studied (1A2 and 2B4) had to be in the same membrane inside the cell for that to happen.

"Our study shows that the P450s should not be tested alone, but need to be present in mixtures similar to those found in humans in order to better predict how rapidly a candidate drug is metabolized and eliminated or even whether it can produce toxic byproducts in some individuals," said Dr. Backes. "This information is crucial to the development of new drugs because differences in drug metabolism can lead to differences not only in potential toxicity, but also in the effectiveness of a candidate drug."


'/>"/>

Contact: Leslie Capo
lcapo@lsuhsc.edu
504-568-4806
Louisiana State University Health Sciences Center
Source:Eurekalert

Related biology news :

1. LSUHSC researcher finds first inherited prostate cancer genetic mutation in African-American men
2. LSUHSC awarded multi-million dollar grant to reduce pneumonia
3. LSUHSCs England plays key role in developing new ALS treatment guidelines
4. LSUHSC researchers working to prevent diabetic neuropathy
5. Grant supports LSUHSC research on how like cell receptor systems determine very different functions
6. LSUHSC shows for first time infant inhalation of ultrafine air pollution linked to adult lung disease
7. LSUHSCs Bazan awarded ARRA grant to preserve vision
8. LSUHSC research helps link schizophrenia to specific DNA region
9. LSUHSCs Kolls awarded $1.8 million to improve vaccine strategies for P. carinii pneumonia
10. LSUHSC research describes function of key protein in cancer spread
11. LSUHSC public health researcher finds reason for weight gain
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/23/2017)... March 23, 2017 The report "Gesture Recognition and Touchless ... and Geography - Global Forecast to 2022", published by MarketsandMarkets, the market is ... of 29.63% between 2017 and 2022. Continue Reading ... ... ...
(Date:3/22/2017)... NEW YORK , March 21, 2017 /PRNewswire/ ... Customer Marketing Cloud used by retailers such as ... in its platform — Product Recommendations and Replenishment. Using ... to give more personalized product and replenishment recommendations ... purchases, but also on predictions of customer intent ...
(Date:3/20/2017)... Pa. , March 20, 2017 PMD ... 2.0 personal spirometer and Wellness Management System (WMS), a ... Founded in 2010, PMD Healthcare is a Medical ... with a mission dedicated to creating innovative solutions that ... life. With that intent focus, PMD developed the first ...
Breaking Biology News(10 mins):
(Date:5/18/2017)... Mass. (PRWEB) , ... May 18, 2017 , ... ... the procedure on April 28, 2017 at the Prince Of Wales Private Hospital. ... cervical disc at level C6-C7. The patient failed conservative treatments prior to undergoing ...
(Date:5/18/2017)... VIRGINIA (PRWEB) , ... May 17, 2017 , ... NDA ... business executive and former CEO of Eurofins Advantar Laboratories and President of Pharmaceutical Development ... addition to his position at Eurofins and Cardinal Health, he was former Chief Operating ...
(Date:5/18/2017)... , ... May 17, 2017 , ... ... and business process optimization firm for the life sciences and healthcare industries, is ... UDIs and Traceability for Medical Devices conference in Brussels, Belgium. , Crowley played ...
(Date:5/18/2017)... ... May 17, 2017 , ... Many complicated neurological disorders ... develop Alzheimer’s disease, while men are at greater risk for Parkinson’s disease. Understanding ... is the aim of a research program at Worcester Polytechnic Institute (WPI) funded ...
Breaking Biology Technology: