Navigation Links
LSUHSC research increases understanding of drug metabolism

New Orleans, LA Research led by Wayne L. Backes, PhD, Professor of Pharmacology and Associate Dean for Research at LSU Health Sciences Center New Orleans School of Medicine, has found that drug metabolism depends not only upon which enzymes are present in an individual, but also how they interact, and that can be the difference in whether a drug is safely eliminated from the body or is converted into a toxic or carcinogenic byproduct. The paper will be published in the March 19, 2010 issue of the Journal of Biological Chemistry.

Dr. Backes and his LSUHSC research colleagues J. Robert Reed, PhD, Pharmacology Assistant Professor and Marilyn Eyer, Research Associate have been studying an enzyme called Cytochrome P450 which is responsible for the removal of the majority of drugs from the body by chemically breaking them down into inactive substances or metabolites. There are many different P450 enzymes capable of degrading many different drugs. Because there are so many, there is a high degree of variability in people's responses to a drug.

"Although most P450 reactions lead to metabolites that speed the excretion of drugs and pollutants, sometimes P450 enzymes can lead to the activation of a compound to a metabolite that can cause cancer or toxicity where the initial chemical in the drug does not," notes Dr. Backes. "This is a partial explanation of why some people are more resistant to cancer and other diseases and why it is very important to understand the reasons for the variability in drug metabolism."

The results reported in this paper show that P450 enzymes form complexes with each other in biological membranes, and that these complexes affect how the enzymes metabolize substances, making one of the P450s more active and the other less active. The researchers also showed that both of the P450 enzymes they studied (1A2 and 2B4) had to be in the same membrane inside the cell for that to happen.

"Our study shows that the P450s should not be tested alone, but need to be present in mixtures similar to those found in humans in order to better predict how rapidly a candidate drug is metabolized and eliminated or even whether it can produce toxic byproducts in some individuals," said Dr. Backes. "This information is crucial to the development of new drugs because differences in drug metabolism can lead to differences not only in potential toxicity, but also in the effectiveness of a candidate drug."


Contact: Leslie Capo
Louisiana State University Health Sciences Center

Related biology news :

1. LSUHSC researcher finds first inherited prostate cancer genetic mutation in African-American men
2. LSUHSC awarded multi-million dollar grant to reduce pneumonia
3. LSUHSCs England plays key role in developing new ALS treatment guidelines
4. LSUHSC researchers working to prevent diabetic neuropathy
5. Grant supports LSUHSC research on how like cell receptor systems determine very different functions
6. LSUHSC shows for first time infant inhalation of ultrafine air pollution linked to adult lung disease
7. LSUHSCs Bazan awarded ARRA grant to preserve vision
8. LSUHSC research helps link schizophrenia to specific DNA region
9. LSUHSCs Kolls awarded $1.8 million to improve vaccine strategies for P. carinii pneumonia
10. LSUHSC research describes function of key protein in cancer spread
11. LSUHSC public health researcher finds reason for weight gain
Post Your Comments:
(Date:10/29/2015)... 29, 2015 Daon, a global leader in ... released a new version of its IdentityX Platform ... North America have already installed IdentityX v4.0 ... a FIDO UAF certified server component as ... activate FIDO features. These customers include some of the ...
(Date:10/29/2015)... -- Connected health pioneer, Joseph C. Kvedar , MD, ... and wellness, and the business opportunities that arise from ... of Healthy Things . Long before health and ... Kvedar, vice president, Connected Health, Partners HealthCare, was creating ... from the hospital or doctor,s office into the day-to-day ...
(Date:10/29/2015)... YORK , Oct. 29, 2015 ... technology, announced a partnership with 2XU, a global ... to deliver a smart hat with advanced bio-sensing ... and other athletes to monitor key biometrics to ... the strategic partnership, the two companies will bring together ...
Breaking Biology News(10 mins):
(Date:11/30/2015)... and MAGDEBURG, Germany , November 30, ... (ECNR) in Vienna, Austria to ... Congress of NeuroRehabilitation (ECNR) in Vienna, Austria ... NovaVision, a wholly owned subsidiary of Vycor Medical, Inc. ... of its Internet-delivered NovaVision Therapy Suite at the 3rd ...
(Date:11/28/2015)... ... November 28, 2015 , ... • Jeon Jin Bio Corp, ... and rodent control solutions , Bird Free, ... works across all sensory modalities including visual, smell, taste and touch, enabling safe, effective ...
(Date:11/26/2015)... 26, 2015 ... Accutest Research Laboratories, a leading independent ... (CRO), has formed a strategic partnership ... Temple Health for joint work on ... ) , --> ...
(Date:11/25/2015)... -- 2 nouvelles études permettent d , ... entre les souches bactériennes retrouvées dans la plaque ... . Ces recherches  ouvrent une nouvelle voie ... efficace de l,un des problèmes de santé les ...    --> 2 nouvelles études permettent d ...
Breaking Biology Technology: