Navigation Links
LSUHSC research identifies key contributor to Alzheimer's disease process
Date:11/13/2008

Walter J. Lukiw, PhD, Associate Professor of Neuroscience and Ophthalmology at LSU Health Sciences Center New Orleans, is the lead author of a paper identifying, for the first time, a specific function of a fragment of ribonucleic acid (RNA), once thought to be no more than a byproduct, in regulating inflammation and the development of Alzheimer's disease. The paper, An NF-kB-sensitive micro RNA-146a-mediated inflammatory circuit in Alzheimer's disease and in stressed human brain cells, will be published in the November 14, 2008 issue of The Journal of Biological Chemistry.

Dr. Lukiw's lab at the LSU Health Sciences Center New Orleans Neuroscience Center of Excellence has shown that this tiny piece of RNA, or microRNA, called miRNA-146a is found in increased amounts in stressed human brain cells and in Alzheimer's disease, and that it plays a crucial role in the regulation of inflammation and disease-related neuropathology thought to be integral to the Alzheimer's disease process. Dr. Lukiw's research team, which also included LSUHSC's Jian Guo Cui, MD, PhD and Yuhai Zhao, a post doctoral student in the lab, demonstrated in human brain cells in primary culture that MiRNA-146a targets the messenger RNA of an important anti-inflammatory regulator called complement factor H (CFH). Testing both control cells and Alzheimer's disease-affected tissues, they found that miRNA-164a appears to reduce the amount and bioavailability of CFH, promoting the inflammation of brain cells and contributing to the development of Alzheimer's disease.

The most common form of dementia, Alzheimer's Disease is a fatal, age-related neurodegenerative disorder characterized clinically by the progressive erosion of cognition and memory, and neuropathologically by defective gene expression and increased inflammatory cell signaling. According to the Alzheimer's Foundation of America, it is estimated that Alzheimer's disease currently affects more than 5 million Amer
'/>"/>

Contact: Leslie Capo
lcapo@lsuhsc.edu
504-568-4806
Louisiana State University Health Sciences Center
Source:Eurekalert

1

GOOD

Page: 1 2

Related biology news :

1. LSUHSC awarded patent for compound inhibiting cancer and other diseases
2. LSUHSC research reports new method to protect brain cells from diseases like Alzheimers
3. LSUHSCs Lazartigues awarded $1.2 million grant
4. LSUHSC awarded $10M+ COBRE grant
5. Compact research freezers to debut in space
6. Space researchers developing tool to help disoriented pilots
7. Montana State researchers receive grant to study algae as a source of biofuel
8. Einstein researchers develop a new way to study how breast cancer spreads
9. Queens University Belfast researchers trace octopuses family tree
10. K-State research: Freshwater pollution costs US at least $4.3 billion a year
11. UD researchers show that plants can accumulate nanoparticles in tissues
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/18/2013)... 2013 Joshua Obar, Ph.D., Department of Immunology and ... a 2013 ICAAC Young Investigator Award for his research ... responses to infection. , Obar earned his B.A. ... went on to complete his Ph.D. in Microbiology and ... his Ph.D. thesis research in Edward Usherwood,s laboratory at ...
(Date:6/18/2013)... Methylation refers to a chemical modification of DNA ... positions in the DNA sequence. Until now, scientists ... expression of certain genes. Today, a team of ... led by Emmanouil Dermitzakis, Louis-Jeantet Professor at the ... always the case and that DNA methylation may ...
(Date:6/17/2013)... other locations with central nervous system infections may well ... virus, according to a study to be published in ... American Society for Microbiology. Researchers have detected the virus ... with central nervous system infections of unknown cause, and ... from pigs and poultry, suggesting animals may serve as ...
Breaking Biology News(10 mins):The American Society for Microbiology honors Joshua Obar 2The secret of DNA methylation 2New virus discovered in patients with central nervous system infections 2New virus discovered in patients with central nervous system infections 3
... 2011 The American Chemical Society (ACS) today released ... Solutions " podcast series showcasing a discovery that ... a key ingredient used to make everything from paint ... focus on a new way to make acrylic acid, ...
... in German . , Trichomes, hair-like projections ... herbivores: they can be obstacles, traps, or reservoirs for ... attenuata contain primarily acyl sugars, which are composed ... aliphatic acids, compounds that give baby vomit its distinctive ...
... around the world have forced many species to the brink ... multiple causes that are still not fully understood, researchers conclude ... causative factor is often missing the larger picture, they said, ... don,t consider the totality of causes or could even ...
Cached Biology News:Lollipops with side effects 2Lollipops with side effects 3Lollipops with side effects 4Catastrophic amphibian declines have multiple causes, no simple solution 2Catastrophic amphibian declines have multiple causes, no simple solution 3
(Date:6/18/2013)... KONG, June 18, 2013 China Cord Blood ... "Company"), China,s leading provider of cord blood collection, laboratory ... services, today announced its preliminary unaudited financial results for ... 2013 ended March 31, 2013. Fourth ... the fourth quarter of fiscal 2013 increased by 33.3% ...
(Date:6/18/2013)... Rockville, MD, USA (PRWEB) June 18, 2013 ... today announced the opening of two new offices in ... office in Singapore will serve as RAPS’ Pan-Asia ... Shanghai office will be more focused on audiences within ... after RAPS announced its partnership with five Singapore government ...
(Date:6/18/2013)... June 18, 2013 DuPont welcomes 48 ... 11th annual DuPont National AgriScience Teachers Ambassador Academy this ... in Chestertown, Md. , The NATAA “Ag ... and is a special project of the National ... Agricultural Educators (NAAE) . The highly recommended agriscience ...
(Date:6/18/2013)... , June 18, 2013 ... release of the HELM biomolecular representation standard software ... MIT licence. HELM (Hierarchical Editing Language ... range of biomolecules (e.g. proteins, nucleotides, antibody drug ... and sequence-based informatics methodologies impractical or unusable. HELM ...
Breaking Biology Technology:China Cord Blood Corporation Reports Financial Results for the Fourth Quarter and Full Year of Fiscal 2013 2China Cord Blood Corporation Reports Financial Results for the Fourth Quarter and Full Year of Fiscal 2013 3China Cord Blood Corporation Reports Financial Results for the Fourth Quarter and Full Year of Fiscal 2013 4China Cord Blood Corporation Reports Financial Results for the Fourth Quarter and Full Year of Fiscal 2013 5China Cord Blood Corporation Reports Financial Results for the Fourth Quarter and Full Year of Fiscal 2013 6China Cord Blood Corporation Reports Financial Results for the Fourth Quarter and Full Year of Fiscal 2013 7China Cord Blood Corporation Reports Financial Results for the Fourth Quarter and Full Year of Fiscal 2013 8China Cord Blood Corporation Reports Financial Results for the Fourth Quarter and Full Year of Fiscal 2013 9China Cord Blood Corporation Reports Financial Results for the Fourth Quarter and Full Year of Fiscal 2013 10China Cord Blood Corporation Reports Financial Results for the Fourth Quarter and Full Year of Fiscal 2013 11China Cord Blood Corporation Reports Financial Results for the Fourth Quarter and Full Year of Fiscal 2013 12China Cord Blood Corporation Reports Financial Results for the Fourth Quarter and Full Year of Fiscal 2013 13RAPS Opens Offices in Singapore and China 2RAPS Opens Offices in Singapore and China 3DuPont Sponsors National AgriScience Ambassador Academy 2DuPont Sponsors National AgriScience Ambassador Academy 3The Pistoia Alliance Releases HELM Biomolecular Representation Standard Open Source Tools 2
... Ontario, April 30, 2012  IGY Immune Technology & ... its proprietary IgY products.  IgY from chicken egg ... its immune enhancing benefits in humans as well ... fight sickness and maintain good health.  Until now, ...
... Therapeutics Inc ., a biopharmaceutical company leading the discovery ... the appointment of Bruce Carter, Ph.D. to its Board ... member of the Board of Directors of Immune Design ... and as a board member of additional scientific organizations. ...
... Lawrence Berkeley National Laboratory (Berkeley Lab) and the ... first self-assembly of nanoparticles into device-ready materials. Through ... blending nanoparticles with block co-polymer supramolecules, the researchers ... one-, two- and three-dimensional arrays of gold nanoparticles. ...
Cached Biology Technology:IGY Immune Technology & Life Sciences Purchases Manufacturing Facility to Produce Purified Immunoglobulin Y (IgY) 2Regulus Therapeutics Appoints Bruce Carter to its Board of Directors 2Regulus Therapeutics Appoints Bruce Carter to its Board of Directors 3Regulus Therapeutics Appoints Bruce Carter to its Board of Directors 4Golden potential for gold thin films 2Golden potential for gold thin films 3
Formulation: Phosphate-buffered saline, pH 7.2, containing 0.09% sodium azide....
... 100 Instrument System is ideal for ... Upstate's Beadlyte reagents. The Luminex 100 ... with software version 1.7, the XY ... Upstate offers $2000 in free Beadlyte ...
normal human fibroblasts Source: Cell Lysate Form: Ready to Use Application: Western Blotting Control...
Purified anti-Fanconi anemia D2-Phosphorylated (Ser222)...
Biology Products: