Navigation Links
LSUHSC research identifies key contributor to Alzheimer's disease process
Date:11/13/2008

Walter J. Lukiw, PhD, Associate Professor of Neuroscience and Ophthalmology at LSU Health Sciences Center New Orleans, is the lead author of a paper identifying, for the first time, a specific function of a fragment of ribonucleic acid (RNA), once thought to be no more than a byproduct, in regulating inflammation and the development of Alzheimer's disease. The paper, An NF-kB-sensitive micro RNA-146a-mediated inflammatory circuit in Alzheimer's disease and in stressed human brain cells, will be published in the November 14, 2008 issue of The Journal of Biological Chemistry.

Dr. Lukiw's lab at the LSU Health Sciences Center New Orleans Neuroscience Center of Excellence has shown that this tiny piece of RNA, or microRNA, called miRNA-146a is found in increased amounts in stressed human brain cells and in Alzheimer's disease, and that it plays a crucial role in the regulation of inflammation and disease-related neuropathology thought to be integral to the Alzheimer's disease process. Dr. Lukiw's research team, which also included LSUHSC's Jian Guo Cui, MD, PhD and Yuhai Zhao, a post doctoral student in the lab, demonstrated in human brain cells in primary culture that MiRNA-146a targets the messenger RNA of an important anti-inflammatory regulator called complement factor H (CFH). Testing both control cells and Alzheimer's disease-affected tissues, they found that miRNA-164a appears to reduce the amount and bioavailability of CFH, promoting the inflammation of brain cells and contributing to the development of Alzheimer's disease.

The most common form of dementia, Alzheimer's Disease is a fatal, age-related neurodegenerative disorder characterized clinically by the progressive erosion of cognition and memory, and neuropathologically by defective gene expression and increased inflammatory cell signaling. According to the Alzheimer's Foundation of America, it is estimated that Alzheimer's disease currently affects more than 5 million Amer
'/>"/>

Contact: Leslie Capo
lcapo@lsuhsc.edu
504-568-4806
Louisiana State University Health Sciences Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. LSUHSC awarded patent for compound inhibiting cancer and other diseases
2. LSUHSC research reports new method to protect brain cells from diseases like Alzheimers
3. LSUHSCs Lazartigues awarded $1.2 million grant
4. LSUHSC awarded $10M+ COBRE grant
5. Compact research freezers to debut in space
6. Space researchers developing tool to help disoriented pilots
7. Montana State researchers receive grant to study algae as a source of biofuel
8. Einstein researchers develop a new way to study how breast cancer spreads
9. Queens University Belfast researchers trace octopuses family tree
10. K-State research: Freshwater pollution costs US at least $4.3 billion a year
11. UD researchers show that plants can accumulate nanoparticles in tissues
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/18/2014)... YORK , Nov. 18, 2014   ... identity authentication solutions, and MorphoTrust USA ... and services, today announced a strategic partnership to ... enterprise, motor vehicle administration (MVA), airport screening and ... in identity-related solutions, MorphoTrust serves consumers through a ...
(Date:11/10/2014)... pods began appearing on U.S. store shelves in early ... ever since. The small packets can be tossed into ... a liquid or powder. The convenience, though, has come ... from researchers at Nationwide Children,s Hospital found that from ... of 17,230 children younger than 6 years of age ...
(Date:11/6/2014)... -- A groundbreaking paper from a team of Florida ... of how plants could adapt to and survive environmental ... published in the latest issue of the journal ... (the complex of DNA and proteins) is organized in ... that some genes are turned on and others are ...
Breaking Biology News(10 mins):EyeLock, MorphoTrust Form Strategic Partnership to Pursue Commercial Enterprise Deployments 2EyeLock, MorphoTrust Form Strategic Partnership to Pursue Commercial Enterprise Deployments 3Study finds laundry detergent pods, serious poisoning risk for children 2Maize analysis yields whole new world of genetic science 2
... Society meetingA chemical catalyst developed at Carnegie Mellon ... according to Arani Chanda, a doctoral student who ... at the 230th meeting of the American Chemical ... and Engineering Chemistry, Convention Center Hall A). , ...
... the physical proportions of our bodies. The most familiar sensations, ... our own shirt sleeve, serve to constantly remind the brain ... is known as proprioception. In a new study, researchers report ... and update its sense of bodily self is more dynamic ...
... Department of Geology and Geophysics at Yale and his ... dioxide between 45 - 25 million years ago based ... Foundation study reported in Science Express. , "Through the ... to increasing greenhouse gasses, such as carbon dioxide and ...
Cached Biology News:Green catalyst destroys pesticides and munitions toxins, finds Carnegie Mellon University 2To translate touch, the brain can quickly rearrange its sense of the body 2Stem cells grown in lab mirror normal developmental steps 2
(Date:11/24/2014)... November 24, 2014 2014 Deep ... Industry is a professional and in-depth research report ... Dihydrazide information, like its definition, classification, application, and ... This report covers the international market analysis, including ... as the US, Europe, Asia, China, Japan etc. ...
(Date:11/23/2014)... (PRWEB) November 23, 2014 Apiscent ... supplier of fine chemical ingredients to the global ... launch of its new website, Apiscent.com. , The ... Apiscent Labs, clean design, easy navigation, rotating images ... Apiscent Labs stand out. , The ...
(Date:11/22/2014)... CannLabs, Inc. (OTCQB: CANL), ... scientific testing methodologies relating to cannabis, today announced that ... of credit from an existing stockholder of the Company. ... this commitment from one of our existing stockholders,” stated ... capital will help accelerate our planned expansions into the ...
(Date:11/22/2014)... 22, 2014 Respiratory therapy students ... proper management of life-like respiratory ailments using the ... . Grand Rapids-based, Michigan Instruments Inc. developers of ... of the respiratory simulation units to the pro-gram, ... Valley and Muskegon Community College are collaborating to ...
Breaking Biology Technology:Adipic Dihydrazide Industry 2019 Research Forecasts on Worldwide, China Regions Now Available at ReportsnReports.com 2Adipic Dihydrazide Industry 2019 Research Forecasts on Worldwide, China Regions Now Available at ReportsnReports.com 3CannLabs Secures $750,000 Line Of Credit 2Michigan Instruments Donates Two Respiratory Simulation Training and Test Lung (TTL) Devices to Grand Valley State University 2Michigan Instruments Donates Two Respiratory Simulation Training and Test Lung (TTL) Devices to Grand Valley State University 3
... China , July 6 /PRNewswire-Asia-FirstCall/ -- ... Company"), the,Xianyang-based manufacturer of a leading over-the-counter Hepatitis B ... that Mr. Deyin "Bill" Chen has been ... Mr. Chen replaces Ms. Elaine Zhao , ...
... ... ... a live, interactive Webinar to discuss its successful move to paperless environmental monitoring (EM) using ... The Webinar will offer two optional times: 8:00 AM EST (International) and 11:00 AM EST ...
... BEIJING , ... YONG ), ("Yongye" or the "Company") a ... and animal nutrient products in, China , today ... annual,production capacity of its existing plant nutrient production ...
Cached Biology Technology:Biostar Pharmaceuticals, Inc. Appoints New Chief Financial Officer 2Biostar Pharmaceuticals, Inc. Appoints New Chief Financial Officer 3Live Webinar: Lonza's Paperless EM Success and Acquisition of MODA 2Live Webinar: Lonza's Paperless EM Success and Acquisition of MODA 3Yongye International Expands Its Existing Production Capacity by 50% and Provides Updates on Customer List Acquisition 2Yongye International Expands Its Existing Production Capacity by 50% and Provides Updates on Customer List Acquisition 3Yongye International Expands Its Existing Production Capacity by 50% and Provides Updates on Customer List Acquisition 4
SlowFade Antifade Kit with DAPI...
...
... SAGE (serial analysis of ... genome-wide expression analysis. Expression profiles ... enough to detect low-abundance transcripts ... novel genes. The I-SAGE Kit ...
Mycoplasma tested...
Biology Products: