Navigation Links
LSUHSC research helps link schizophrenia to specific DNA region

New Orleans, LA For the first time, an international group of researchers has found genetic evidence linking schizophrenia to a specific region of DNA on chromosome 6. This is the same area where key genes for immune function are located. The LSUHSC research team was led by Nancy Buccola, APRN, PMH CNS-BC, Assistant Professor of Clinical Nursing at LSU Health Sciences Center New Orleans, who also coordinated the ten clinical sites. The work, Common variants on chromosome 6p22.1 are associated with schizophrenia, along with two related papers, is published in the July 1, 2009 issue of the journal Nature.

The researchers recruited study participants, people with diagnoses of schizophrenia or schizoaffective disorder, plus controls from the general population. They analyzed data collected and also conducted a meta-analysis of data from the Molecular Genetics of Schizophrenia, International Schizophrenia Consortium and SGENE data sets thousands of DNA samples.

While a single gene does not appear to be the source of the development of schizophrenia, the researchers found variations on chromosome 6 that appear to be associated with higher risk. These variations were found most often in people with schizophrenia, leading the scientists to believe that these common variations contribute to the development of schizophrenia. This area of chromosome 6, in the same area where genes important to the immune system function, provokes questions about whether or not treatments for autoimmune disorders might also be helpful in treating schizophrenia.

"Schizophrenia can be a devastating disease, and while treatments are improving, there are still people who do not respond or only partially respond," notes Buccola, principal investigator on the LSUHSC study. "Understanding the underpinnings of this illness will open doors to new and potentially better treatments."

According to the National Institute of Mental Health, schizophrenia is a chronic, severe, and disabling brain disorder that affects about 1.1 percent of the U.S. population age 18 and older in a given year. People with schizophrenia sometimes hear voices others don't hear, believe that others are broadcasting their thoughts to the world, or become convinced that others are plotting to harm them. These experiences can make them fearful and withdrawn and cause difficulties when they try to have relationships with others.

The LSUHSC research team, which included LSUHSC Assistant Professor of Clinical Psychiatry, Margaret Baier, MD, and Erich Conrad, MD, LSUHSC Assistant Professor of Psychiatry, as well as Sherri Chalona, completed the work while evacuated from New Orleans after Hurricane Katrina to LSUHSC's temporary campuses in Baton Rouge.

The research was supported by funding from the National Institute of Mental Health and the National Alliance for Research on Schizophrenia and Depression.

"Scientists have been looking for schizophrenia susceptibility genes since the early 1900s," says Buccola. "This study shows that these genes can be found and sets the stage for future research."


Contact: Leslie Capo
Louisiana State University Health Sciences Center

Related biology news :

1. LSUHSCs Kolls awarded $1.8 million to improve vaccine strategies for P. carinii pneumonia
2. LSUHSC research describes function of key protein in cancer spread
3. LSUHSC public health researcher finds reason for weight gain
4. LSUHSC student awarded top national honor for diabetes research
5. LSUHSC research identifies key contributor to Alzheimers disease process
6. LSUHSC awarded patent for compound inhibiting cancer and other diseases
7. LSUHSC research reports new method to protect brain cells from diseases like Alzheimers
8. LSUHSCs Lazartigues awarded $1.2 million grant
9. LSUHSC awarded $10M+ COBRE grant
10. Shaw to receive prestigious honor for plant pathology research
11. Protein can help cells or cause cancer, Purdue researcher finds
Post Your Comments:
(Date:5/9/2016)... 9, 2016 Elevay is currently ... expanding freedom for high net worth professionals seeking travel ... globally connected world, there is still no substitute for ... duplicate sealing your deal with a firm handshake. This ... taking advantage of citizenship via investment programs like those ...
(Date:4/26/2016)... 27, 2016 Research and ... Biometrics Market 2016-2020"  report to their offering.  , ... The analysts forecast the global multimodal biometrics ... during the period 2016-2020.  Multimodal biometrics ... such as the healthcare, BFSI, transportation, automotive, and ...
(Date:4/13/2016)... physicians supporting Medicaid patients in Central Florida ... telehealth thanks to a new partnership with higi.   ... can routinely track key health measurements, such as blood ... they opt in, share them with IMPOWER clinicians through ... location at no cost. By leveraging this data, IMPOWER ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... -- The Biodesign Challenge (BDC), a university competition that asks ... systems and biotechnology, announced its winning teams at the ... York City . The teams, chosen ... MoMA,s Celeste Bartos Theater during the daylong summit. Keynote ... of architecture and design, and Suzanne Lee , ...
(Date:6/23/2016)... ... June 23, 2016 , ... STACS DNA Inc., the sample tracking software company, ... Crime Laboratory, has joined STACS DNA as a Field Application Specialist. , “I ... President and COO of STACS DNA. “In further expanding our capacity as a scientific ...
(Date:6/23/2016)... , June 23, 2016  Blueprint Bio, a company ... to the medical community, has closed its Series A ... Nunez . "We have received a commitment ... capital we need to meet our current goals," stated ... us the runway to complete validation on the current ...
(Date:6/23/2016)... , ... June 23, 2016 , ... ... exhibiting at the Pennsylvania Convention Center and will showcase its product’s latest features ... will also be presenting a scientific poster on Disrupting Clinical Trials in The ...
Breaking Biology Technology: