Navigation Links
LSUHSC research discovers new drug target for metastatic breast cancer
Date:4/11/2013

New Orleans, LA Research led by Dr. Suresh Alahari, Professor of Biochemistry and Molecular Biology at LSU Health Sciences Center New Orleans, is the first to report that two specific tumor suppressor genes work in concert to inhibit the growth and spread of breast tumor cells to the lungs. The research is published this week online in the Journal of Biological Chemistry.

Working in a mouse model, the LSUHSC research team studied LKB1, an enzyme that functions as a tumor suppressor in the small intestine, and Nischarin, a novel protein that regulates breast cancer cell migration and movement discovered by Dr. Alahari in 2000. Thirty percent of lung adenocarcinomas have an LKB1 gene mutation, and high levels of the LKB1 protein in breast cancer cells have been shown to significantly inhibit tumor growth. The LKB1-interacting protein is also structurally similar to Nischarin. The researchers suspected that the two suppressors might relate to each other, and they did in fact discover a functional and biochemical link between them.

The researchers demonstrated that Nischarin and LKB1 regulate breast cancer cell migration, anchorage-independent growth, tumor growth, and metastasis. They also identified a new pathway by which LKB1 suppresses tumor cell movement.

Metastasis, a complex process involving cell growth, tumor cell migration, and invasion is a leading cause of cancer-related deaths. Therefore, it is important to identify the molecular targets that can prevent cancer metastasis.

"The molecular mechanisms of tumor suppressor genes are not clearly understood, and each discovery moves us another step closer to a treatment advance or cure," notes Dr. Alahari.

Excluding skin cancer, breast cancer is the most common type of cancer among women in the United States. The American Cancer Society estimates 232,340 new cases of invasive breast cancer among American women this year, and 2,240 among men in the US, with 39,620 death
'/>"/>

Contact: Leslie Capo
lcapo@lsuhsc.edu
504-568-4806
Louisiana State University Health Sciences Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. LSUHSC research finds HPV-related head & neck cancers rising, highest in middle-aged white men
2. LSUHSC research finds treating stress prevented new MS brain lesions
3. LSUHSC research finds ginkgo biloba doesn’t improve cognitive function in MS
4. LSUHSC research identifies new therapeutic target for Alzheimers disease
5. LSUHSCs Weiss chosen to help set national eye policy, research
6. LSUHSC research discovery provides therapeutic target for ALS
7. LSUHSC scientist awarded nearly $2 million to determine role of biofilms in common fungal infection
8. LSUHSC research identifies co-factors critical to PTSD development
9. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
10. Research reveals first evidence of hunting by prehistoric Ohioans
11. Diabetes Research Institute develops oxygen-generating biomaterial
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... , July 2, 2014 It is a ... announce the appointment of the world-renowned Thoracic and Cardiovascular ... Directors. Dr. Ginsburg, with over 34 years ... Presbyterian Hospital and Good Samaritan Regional Medical Center. Dr. ... the late 1980,s and is considered an expert in ...
(Date:7/10/2014)... -- According to the new market research ... Material (Optical Prism, Pizeoelectric, Capacitive, and Adhesives), Application (Mobile ... Finance), and Geography - Global Trends & Forecasts to ... Sensors Market is projected to cross $14.35 Billion by ... 2014 to 2020. Browse more than 78 ...
(Date:7/10/2014)... July 7, 2014 Fingerprint Cards, (FPC,s) ... design win (DW). A Chinese Top 5 smartphone OEM has ... of mass production in October 2014.   FPC ... 5 smartphone OEM, which has a planned date for the ... sales volume for this phone of 3 million units. The ...
Breaking Biology News(10 mins):Avery Biomedical Devices, Inc. announces the appointment of Mark E Ginsburg, M.D. to its Board of Directors 2Fingerprint Sensors Market worth $14.35 Billion by 2020 2Fingerprint Sensors Market worth $14.35 Billion by 2020 3FPC Wins DW for 1021 Touch Sensor for Flagship Smartphone from Chinese Top 5 Smartphone OEM 2
... is little doubt that alcohol-related disorders in humans are ... remains unclear. Given that studies of humans are ... researchers in the March issue of Alcoholism: Clinical ... genetic and environmental influences on alcohol consumption. Results ...
... think you've got a bad boss, one who loves to chew ... you are not a wasp. , If you were, chances are ... to leave the nest and forage for the colony, according to ... a way that workers in a colony of the social wasp ...
... Minnesota researcher has found a universal rule that regulates the ... may also offer a key to calculating their carbon dioxide ... to construct valid models of global carbon dioxide cycling. ... animals through the process of respiration; Peter Reich, a professor ...
Cached Biology News:Genetic and environmental influences on alcohol consumption among rhesus monkeys 2Taking a bite out of a fellow worker helps wasps recruit new foragers 2Of mice, men, trees and the global carbon cycle 2Of mice, men, trees and the global carbon cycle 3
(Date:7/10/2014)... Understanding the need for better quality and higher ... that currently exists in this area, ChanTest has recently ... validated ion channel and GPCR cell lines. ChanTest’s ... channels control many critical physiological functions throughout the body. ... to treat a variety of human diseases. , ...
(Date:7/10/2014)... EvoDerma ’s NOOME Anti-Aging Motion has been upgraded for ... a second treatment cup to help prevent and smooth skin ... thinner on the edges for a softer contact with the ... surfaces on the face, neck and décolleté. Choose to use ... such as the cheeks and neck, or opt for the ...
(Date:7/10/2014)... 10, 2014 /PRNewswire-iReach/ -- Tute Genomics, the ... announced an agreement with Lineagen, Inc., to ... NextStep Dx PLUS.  Lineagen, focused on ... disorders, currently offers FirstStep Dx PLUS, ... used by healthcare providers as a first-line ...
(Date:7/10/2014)... Using microscopic polymer light resonators that expand in ... Quantum Photonics Laboratory have developed new optical sensors ... Optical sensors are ideal for detecting trace gas ... lightweight nature, and immunity to electromagnetic interference. , ... before, the MIT team conceived an extremely sensitive, ...
Breaking Biology Technology:Leader in Ion Channel Research Announces Newly Validated and Re-Engineered Cells 2Leader in Ion Channel Research Announces Newly Validated and Re-Engineered Cells 3Introducing a New Bonus Treatment Cup for EvoDerma’s NOOME Anti-Aging Motion 2Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 2Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 3Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 4Swell new sensors 2
... Calif., March 2 Pearl Therapeutics, a biopharmaceutical ... prevalent respiratory diseases, announced today the appointment of ... to attract a corporate leader with such an ... Ph.D., Venture Partner at 5AM Ventures and Executive ...
... March 2 /PRNewswire-Asia/ -- Sinovac Biotech Ltd.,(NYSE Alternext ... China, today,announced that it has received the Good ... and packaging production,facility. The certificate of compliance has ... Food and Drug Administration (SFDA) following a site ...
... involved in Asia Pacific,s largest homeland security Conference and Exhibition. ... ... and most comprehensive homeland security and counter terrorism Conference and Exhibition, ... from 17th to 19th March. The event will showcase the ...
Cached Biology Technology:Pearl Therapeutics Appoints Perry Karsen as Chief Executive Officer 2Sinovac Receives GMP Certification for its New Filling and Packaging Production Facility 2News Release: Homeland Security to Take Centre Stage with Global Security Asia 2009 2News Release: Homeland Security to Take Centre Stage with Global Security Asia 2009 3
Rat monoclonal [20d5] to NKG2A + C+ E ( Abpromise for all tested applications). Antigen: Tissue / cell preparation (Mouse): CHO transfected cells expressing the B6 allele of NKG2A. Entrez Gen...
... Ascent FL is equipped ... luminometric measurement technologies that ... of advanced features of ... Ascent. Fluoroskan Ascent FL ...
... Forma's stainless steel rack ... adjustable mechanism that permits ... shaking angles, and "snap-in" ... universal rack holder will ...
... The dotLab System brings together ... diffraction and immobilized capture surfaces. This ... simple technique for the detection of ... of fluorescent labels. , Protein-specific capture ...
Biology Products: