Navigation Links
LSUHSC research discovers new drug target for metastatic breast cancer
Date:4/11/2013

New Orleans, LA Research led by Dr. Suresh Alahari, Professor of Biochemistry and Molecular Biology at LSU Health Sciences Center New Orleans, is the first to report that two specific tumor suppressor genes work in concert to inhibit the growth and spread of breast tumor cells to the lungs. The research is published this week online in the Journal of Biological Chemistry.

Working in a mouse model, the LSUHSC research team studied LKB1, an enzyme that functions as a tumor suppressor in the small intestine, and Nischarin, a novel protein that regulates breast cancer cell migration and movement discovered by Dr. Alahari in 2000. Thirty percent of lung adenocarcinomas have an LKB1 gene mutation, and high levels of the LKB1 protein in breast cancer cells have been shown to significantly inhibit tumor growth. The LKB1-interacting protein is also structurally similar to Nischarin. The researchers suspected that the two suppressors might relate to each other, and they did in fact discover a functional and biochemical link between them.

The researchers demonstrated that Nischarin and LKB1 regulate breast cancer cell migration, anchorage-independent growth, tumor growth, and metastasis. They also identified a new pathway by which LKB1 suppresses tumor cell movement.

Metastasis, a complex process involving cell growth, tumor cell migration, and invasion is a leading cause of cancer-related deaths. Therefore, it is important to identify the molecular targets that can prevent cancer metastasis.

"The molecular mechanisms of tumor suppressor genes are not clearly understood, and each discovery moves us another step closer to a treatment advance or cure," notes Dr. Alahari.

Excluding skin cancer, breast cancer is the most common type of cancer among women in the United States. The American Cancer Society estimates 232,340 new cases of invasive breast cancer among American women this year, and 2,240 among men in the US, with 39,620 death
'/>"/>

Contact: Leslie Capo
lcapo@lsuhsc.edu
504-568-4806
Louisiana State University Health Sciences Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. LSUHSC research finds HPV-related head & neck cancers rising, highest in middle-aged white men
2. LSUHSC research finds treating stress prevented new MS brain lesions
3. LSUHSC research finds ginkgo biloba doesn’t improve cognitive function in MS
4. LSUHSC research identifies new therapeutic target for Alzheimers disease
5. LSUHSCs Weiss chosen to help set national eye policy, research
6. LSUHSC research discovery provides therapeutic target for ALS
7. LSUHSC scientist awarded nearly $2 million to determine role of biofilms in common fungal infection
8. LSUHSC research identifies co-factors critical to PTSD development
9. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
10. Research reveals first evidence of hunting by prehistoric Ohioans
11. Diabetes Research Institute develops oxygen-generating biomaterial
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/16/2014)... for independence later this week, its Government could face ... fracking is necessary, research has revealed. , The University ... perception of shale gas extraction in the UK since ... of the border are the least supportive of fracking. ... the University,s School of Geography, said: "The clear move ...
(Date:9/16/2014)... Schizophrenia is associated with increased rates and intensity of ... that the relationship between schizophrenia and smoking stems, in ... to self-medicate symptoms and cognitive impairment associated with the ... issue of Biological Psychiatry , sheds light on ... nicotine receptors in the brain was lower in schizophrenia ...
(Date:9/16/2014)... in Spanish . ... published in the Journal of Cell Biology describes ... proper cell division , At this very moment thousands of ... mechanism by which the body repairs damaged tissues and regenerates ... process known as "mitosis", during which the cell duplicates its ...
Breaking Biology News(10 mins):Scottish people most sceptical on fracking, survey shows 2Scottish people most sceptical on fracking, survey shows 3Smoking and schizophrenia linked by alterations in brain nicotine signals 2Unraveling cell division 2Unraveling cell division 3
... resistance has put humans in an escalating 'arms race' with ... than the bacteria can evolve new resistance strategies. But ... a leg up in the race -- reproducing in the ... resistance. , A team of scientists in Argentina and Mexico ...
... Since passage of the Endangered Species Act in 1973, over ... and its territories. In the forthcoming issue of Ecology Letters, ... animal status trends and show that the length of time ... their conservation are key variables in explaining trends. , Overall, ...
... discovered how a gene that suppresses the development of melanoma ... to treatments based on the function of the gene. The ... Institute in Austin, Minn., have applied for a patent on ... 10 in the journal Nature Structural & Molecular Biology. , ...
Cached Biology News:Gaining ground in the race against antibiotic resistance 2Gaining ground in the race against antibiotic resistance 3
(Date:9/16/2014)... Toronto, Canada (PRWEB) September 16, 2014 ... Estate, the Toronto affiliate of ITRA Global, new development ... With the Toronto city council approving another 755 storeys ... buildings), it appears construction cranes will be dominating the ... that seems to have an unquenchable thirst for new ...
(Date:9/15/2014)... EnGeneIC, Ltd. , an emerging ... cancer through the targeted delivery of therapeutic agents ... the Asbestos Disease Research Institute (ADRI), it has ... (NSW) Premier,s Award for Excellence in Translational Cancer ... that will be involved in the clinical trial, ...
(Date:9/15/2014)... researchers led by Northeastern University has developed a ... and a variety of nanocarbon structures in carbon ... scalable, which will allow the researchers to tailor ... in applications ranging from electronic devices to CNT-reinforced ... sports equipment. , Their findings were published in ...
(Date:9/15/2014)... AUSTIN, Texas , Sept. 15, 2014 The ... changes in climate, says a new article published by the ... Ahmed , PhD, on climate change and its effects on ... part of an extensive study conducted by Dr. Ahmed in ... China and has implications for the future ...
Breaking Biology Technology:ITRA Global Reports Downtown Toronto Real Estate Development is in High Gear 2ITRA Global Reports Downtown Toronto Real Estate Development is in High Gear 3EnGeneIC Named a Recipient of the Cancer Institute NSW Premier's Award for Excellence in Translational Cancer Research 2EnGeneIC Named a Recipient of the Cancer Institute NSW Premier's Award for Excellence in Translational Cancer Research 3Northeastern University Researchers Develop Novel Method for Working with Nanotubes 2Tea Taste and Quality Affected by Climate Change 2Tea Taste and Quality Affected by Climate Change 3Tea Taste and Quality Affected by Climate Change 4
... , Toronto Stock Exchange Symbol: LRILAVAL, QC, Feb. 9 ... or the "Company"), a Canadian based global non-clinical contract ... Chief Executive Officer of the Company, will be presenting ... Wednesday February 11, 2009 at 9.30 am at the ...
... the leader in single-use bioprocessing for development ... today that it has recently completed a ... collaborative agreement, PacificGMP produced master cell and ... under cGMP (current good manufacturing practices) standards ...
... 9 , , ... Progen board , Call by over ... Significant funding shortfall identified in the Progen merger proposal ... , Late last week Progen Pharmaceuticals Limited (ASX: PGL) responded to ...
Cached Biology Technology:PacificGMP and LigoCyte Pharmaceuticals Announce cGMP Manufacturing Collaboration 2Cytopia and Other Progen Shareholders Maintain Call for Meeting 2Cytopia and Other Progen Shareholders Maintain Call for Meeting 3Cytopia and Other Progen Shareholders Maintain Call for Meeting 4
... The steadylite plus assay ... High assay sensitivity, Designed for ... Suitable for higher density microplates ... plates, Odor free, Convenient storage ...
Sf21 cells derived from Spodoptera frugiperda ovarian cells are recommended for high-level production of recombinant proteins. Higher expression levels of some proteins are seen due to the larger ce...
... assay system offers the following ... for batch-processing systems, Long lasting ... microplates such as 384-well and ... storage conditions ( 2 - ...
Sf9 cells derived from Spodoptera frugiperda ovarian cells (Sf21 cells) are commonly used to isolate and propagate recombinant AcMNPV viral stocks and to produce recombinant proteins....
Biology Products: