Navigation Links
LSUHSC contributes to work identifying new DNA regions associated with schizophrenia
Date:7/22/2014

New Orleans, LA -- Nancy Buccola, MSN, APRN, PMHCNS-BC, CNE, Assistant Professor of Clinical Nursing at LSU Health Sciences Center New Orleans School of Nursing, contributed samples used in a study reporting new locations of genetic material associated with schizophrenia and also suggesting a possible link between the immune system and schizophrenia. The study, Biological insights from 108 schizophrenia-associated genetic loci, was published online July 22, 2014 in Nature, available at http://www.nature.com/nature/journal/vaop/ncurrent/full/nature13595.html.

Buccola collected samples as part of the Molecular Genetics of Schizophrenia (MGS) study. A large international collaboration, called the Schizophrenia Working Group of the Psychiatric Genomics Consortium, combined these previously collected samples with published or unpublished genome-wide association study genotypes into a single, systematic analysis. To the Consortiums knowledge this is the largest molecular genetic study of schizophrenia ever conducted.

The researchers not only identified previously unknown areas associated with schizophrenia, but also show that the associations are not random; rather they converge upon genes active in certain tissues and cell types, including those that play important roles in immune function. They report 128 independent associations spanning 108 regions of DNA, 83 of which have not been previously reported. The findings provoke the question of whether or not treatments for autoimmune disorders might also be helpful in treating schizophrenia, or at least provide new targets for drug development.

According to the National Institute of Mental Health, which funded the research, approximately 2.4 million American adults, or about 1.1 percent of the population age 18 and older in a given year, have schizophrenia. Schizophrenia is a chronic, severe, and disabling brain disorder. People with the disorder may hear voices other people don't hear. They may believe other people are reading their minds, controlling their thoughts, or plotting to harm them. This can terrify people with the illness and make them withdrawn or extremely agitated.

While treatments are available, they are not effective for many patients. All of the currently used antipsychotic drugs work by a mechanism discovered more than 60 years ago. No new effective drugs have been developed since partly due to lack of knowledge about how the disease develops.

Buccola, Principal Investigator at LSU Health Sciences Center New Orleans for the MGS study, says The lead authors have done a tremendous job of coordinating the analysis of a vast amount of data. This study brings us closer to understanding the cause of schizophrenia as well as potential treatments.


'/>"/>
Contact: Leslie Capo
lcapo@lsuhsc.edu
504-568-4806
Louisiana State University Health Sciences Center
Source:Eurekalert  

Related biology news :

1. LSUHSCS Sothern pens new book on safe exercise for overweight kids
2. LSUHSC research reveals structure of master regulator and new drug target for autism, cervical cancer
3. LSUHSC research finds inflammation linked to obesity in adults may be protective in young children
4. LSUHSC research finds combo of plant nutrients kills breast cancer cells
5. LSUHSCS OCHOA 1 of 10 chosen by NIH director for Transformative Research Award
6. LSUHSC researchers develop new system to better study behavior, cell function
7. LSUHSC researcher awarded NCI grant to study link between chronic inflammation and cancer
8. LSUHSC research identifies new risk factors for parasitic infection
9. LSUHSC research discovers new drug target for metastatic breast cancer
10. LSUHSC research identifies co-factors critical to PTSD development
11. LSUHSC scientist awarded nearly $2 million to determine role of biofilms in common fungal infection
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
LSUHSC contributes to work identifying new DNA regions associated with schizophrenia
(Date:4/19/2016)... -- The new GEZE SecuLogic access control ... system solution for all door components. It can be ... interface with integration authorization management system, and thus fulfills ... dimensions of the access control and the optimum integration ... considerable freedom of design with regard to the doors. ...
(Date:4/14/2016)... BioCatch ™, the global ... the appointment of Eyal Goldwerger as CEO. ... Goldwerger,s leadership appointment comes at a time of significant ... of its platform at several of the world,s largest ... unique cognitive and physiological factors, is a winner of ...
(Date:3/31/2016)... PROVIDENCE, R.I. , March 31, 2016  Genomics ... leadership of founding CEO, Barrett Bready , M.D., ... addition, members of the original technical leadership team, including ... Vice President of Product Development, Steve Nurnberg and Vice ... have returned to the company. Dr. Bready ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... 27, 2016  Global demand for enzymes is ... 2020 to $7.2 billion.  This market includes enzymes ... products, biofuel production, animal feed, and other markets) ... biocatalysts). Food and beverages will remain the largest ... consumption of products containing enzymes in developing regions.  ...
(Date:6/27/2016)... , ... June 27, 2016 , ... ... bring innovative medical technologies, services and solutions to the healthcare market. The company's ... of various distribution, manufacturing, sales and marketing strategies that are necessary to help ...
(Date:6/24/2016)... 2016 Epic Sciences unveiled a liquid ... to PARP inhibitors by targeting homologous recombination deficiency ... new test has already been incorporated into numerous ... types. Over 230 clinical trials are ... including PARP, ATM, ATR, DNA-PK and WEE-1. Drugs ...
(Date:6/23/2016)... 2016   Boston Biomedical , an industry ... to target cancer stemness pathways, announced that its ... Drug Designation from the U.S. Food and Drug ... including gastroesophageal junction (GEJ) cancer. Napabucasin is an ... cancer stemness pathways by targeting STAT3, and is ...
Breaking Biology Technology: