Navigation Links
LSUHSC contributes to work identifying new DNA regions associated with schizophrenia
Date:7/22/2014

New Orleans, LA -- Nancy Buccola, MSN, APRN, PMHCNS-BC, CNE, Assistant Professor of Clinical Nursing at LSU Health Sciences Center New Orleans School of Nursing, contributed samples used in a study reporting new locations of genetic material associated with schizophrenia and also suggesting a possible link between the immune system and schizophrenia. The study, Biological insights from 108 schizophrenia-associated genetic loci, was published online July 22, 2014 in Nature, available at http://www.nature.com/nature/journal/vaop/ncurrent/full/nature13595.html.

Buccola collected samples as part of the Molecular Genetics of Schizophrenia (MGS) study. A large international collaboration, called the Schizophrenia Working Group of the Psychiatric Genomics Consortium, combined these previously collected samples with published or unpublished genome-wide association study genotypes into a single, systematic analysis. To the Consortiums knowledge this is the largest molecular genetic study of schizophrenia ever conducted.

The researchers not only identified previously unknown areas associated with schizophrenia, but also show that the associations are not random; rather they converge upon genes active in certain tissues and cell types, including those that play important roles in immune function. They report 128 independent associations spanning 108 regions of DNA, 83 of which have not been previously reported. The findings provoke the question of whether or not treatments for autoimmune disorders might also be helpful in treating schizophrenia, or at least provide new targets for drug development.

According to the National Institute of Mental Health, which funded the research, approximately 2.4 million American adults, or about 1.1 percent of the population age 18 and older in a given year, have schizophrenia. Schizophrenia is a chronic, severe, and disabling brain disorder. People with the disorder may hear voices other people don't hear. They may believe other people are reading their minds, controlling their thoughts, or plotting to harm them. This can terrify people with the illness and make them withdrawn or extremely agitated.

While treatments are available, they are not effective for many patients. All of the currently used antipsychotic drugs work by a mechanism discovered more than 60 years ago. No new effective drugs have been developed since partly due to lack of knowledge about how the disease develops.

Buccola, Principal Investigator at LSU Health Sciences Center New Orleans for the MGS study, says The lead authors have done a tremendous job of coordinating the analysis of a vast amount of data. This study brings us closer to understanding the cause of schizophrenia as well as potential treatments.


'/>"/>
Contact: Leslie Capo
lcapo@lsuhsc.edu
504-568-4806
Louisiana State University Health Sciences Center
Source:Eurekalert  

Related biology news :

1. LSUHSCS Sothern pens new book on safe exercise for overweight kids
2. LSUHSC research reveals structure of master regulator and new drug target for autism, cervical cancer
3. LSUHSC research finds inflammation linked to obesity in adults may be protective in young children
4. LSUHSC research finds combo of plant nutrients kills breast cancer cells
5. LSUHSCS OCHOA 1 of 10 chosen by NIH director for Transformative Research Award
6. LSUHSC researchers develop new system to better study behavior, cell function
7. LSUHSC researcher awarded NCI grant to study link between chronic inflammation and cancer
8. LSUHSC research identifies new risk factors for parasitic infection
9. LSUHSC research discovers new drug target for metastatic breast cancer
10. LSUHSC research identifies co-factors critical to PTSD development
11. LSUHSC scientist awarded nearly $2 million to determine role of biofilms in common fungal infection
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
LSUHSC contributes to work identifying new DNA regions associated with schizophrenia
(Date:4/13/2017)... 13, 2017 UBM,s Advanced Design and Manufacturing ... feature emerging and evolving technology through its 3D Printing ... run alongside the expo portion of the event and ... demonstrations focused on trending topics within 3D printing and ... manufacturing event will take place June 13-15, 2017 at the ...
(Date:4/11/2017)... 11, 2017 Research and Markets has announced ... report to their offering. ... global eye tracking market to grow at a CAGR of 30.37% ... Tracking Market 2017-2021, has been prepared based on an in-depth market ... landscape and its growth prospects over the coming years. The report ...
(Date:4/6/2017)... LONDON , April 6, 2017 ... Control, RFID, ANPR, Document Readers, by End-Use (Transportation & ... Energy Facility, Oil, Gas & Fossil Generation Facility, Nuclear ... Healthcare, Educational, Other) Are you looking for ... Authentication sector? ...
Breaking Biology News(10 mins):
(Date:4/27/2017)... ... , ... Mitotech S.A, a Luxembourg based clinical stage biotechnology company, announced positive ... a rare devastating genetic disease that leads to a sudden and rapid loss of ... patients carrying 11778, 14484 and 3460 mutations and having experienced the onset of symptoms ...
(Date:4/27/2017)... , ... April 27, 2017 , ... ... practicing internist, who will review how testing for 1,25-Dihydroxyvitamin D can enhance clinical ... of 25-OH-vitamin D and 1,25 dihydroxyvitamin D. , Dr. Gregory Plotnikoff, senior consultant ...
(Date:4/27/2017)... (PRWEB) , ... April 27, 2017 , ... ... and photonics , joined other scientists, researchers, engineers, and industry professionals in visiting ... strengthen America's ability to compete in the world photonics industry. , This year, ...
(Date:4/27/2017)... , April 27, 2017  Kinexum, a distinguished resource ... today announces the appointment of Thomas C. Seoh ... ("Zan") Fleming, M.D., Kinexum founder, who becomes Executive Chairman ... to Kinexum clients. Thomas Seoh ... the Kinexum mission and lead the firm,s remarkable team ...
Breaking Biology Technology: