Navigation Links
LSUHSC awarded multi-million dollar grant to reduce pneumonia

New Orleans, LA Dr. Jay Kolls, Professor and Chairman of Genetics at the LSU Health Sciences Center New Orleans School of Medicine, has been awarded a $2.1 million grant over five years by the National Heart, Lung, and Blood Institute of the National Institutes of Health to further his work on a discovery that plays a critical role in the body's defense against pneumonia.

Bacterial pneumonia is an important clinical problem and defense mechanisms against it are not fully understood. Dr. Kolls and his research team have identified a unique group of white blood cells that play a critical role in defense against pneumonia. These cells rapidly produce two new cytokines (small proteins in the immune system that affect how cells communicate and function) to increase resistance to infection in the lung. The first is interleukin-17 which helps recruit white blood cells into the sight of infection. The second is interleukin-22 which increases the barrier function of the epithelium (tissue lining the lungs). The research funded under this grant will use genetically engineered mice to see which cells need to receive these cytokine signals. Specifically, the researchers will investigate the role of the lung epithelium itself as the primary recipient of these signals. This application will also explore how these cells are generated and how they control infection defense in the lung.

"This work will help advance prevention and treatment of pneumonia and also advance vaccine development against lung infections," said Dr. Kolls. "It will also have broader application because mucous tissues like the lung are also the primary sites of emerging infections such as H1N1 influenza and MRSA (Methicillin-Resistant Staphylococcus aureus)."

According to the Centers for Disease Control and Prevention, in 2006, 1.2 million people in the U.S. were hospitalized with pneumonia and 55,477 people died from the disease.

Globally, pneumonia kills more than 4 million people every year half of these deaths occur among children less than 5 years of age. This is greater than the number of deaths from any other infectious disease, such as AIDS, malaria or tuberculosis. The CDC also reports that recent data show that Americans visit the doctor approximately 12 million times each year to get checked for suspected Staph or MRSA skin infection.

A study of the first population-based nationwide estimates of the burden of invasive MSRA disease from active cases published in 2007 found the incidence in 2005 was 31.8 cases per 100,000 persons, with a mortality rate of about 20%.


Contact: Leslie Capo
Louisiana State University Health Sciences Center

Related biology news :

1. LSUHSCs England plays key role in developing new ALS treatment guidelines
2. LSUHSC researchers working to prevent diabetic neuropathy
3. Grant supports LSUHSC research on how like cell receptor systems determine very different functions
4. LSUHSC shows for first time infant inhalation of ultrafine air pollution linked to adult lung disease
5. LSUHSCs Bazan awarded ARRA grant to preserve vision
6. LSUHSC research helps link schizophrenia to specific DNA region
7. LSUHSCs Kolls awarded $1.8 million to improve vaccine strategies for P. carinii pneumonia
8. LSUHSC research describes function of key protein in cancer spread
9. LSUHSC public health researcher finds reason for weight gain
10. LSUHSC student awarded top national honor for diabetes research
11. LSUHSC research identifies key contributor to Alzheimers disease process
Post Your Comments:
(Date:11/12/2015)... 11, 2015   Growing need for low-cost, ... has been paving the way for use of ... discrete analytes in clinical, agricultural, environmental, food and ... used in medical applications, however, their adoption is ... to continuous emphasis on improving product quality and ...
(Date:11/10/2015)... 2015 About signature verification ... to identify and verify the identity of an ... the secure and accurate method of authentication and ... individual because each individual,s signature is highly unique. ... dynamic signature of an individual is compared and ...
(Date:11/4/2015)... 2015 --> ... by Transparency Market Research "Home Security Solutions Market - Global ... - 2022", the global home security solutions market is expected to ... The market is estimated to expand at a CAGR ... 2022. Rising security needs among customers at homes, the ...
Breaking Biology News(10 mins):
(Date:11/24/2015)... -- Cepheid (NASDAQ: CPHD ) today announced that ... and invited investors to participate via webcast. ... 1, 2015 at 11.00 a.m. Eastern Time --> ... 1, 2015 at 11.00 a.m. Eastern Time --> ... NY      Tuesday, December 1, 2015 at 11.00 ...
(Date:11/24/2015)... Nov. 24, 2015 /PRNewswire/ - Aeterna Zentaris Inc. (NASDAQ: ... on behalf of the Toronto Stock Exchange, confirms that ... are no corporate developments that would cause the recent ... --> --> About Aeterna Zentaris Inc. ... --> Aeterna Zentaris is a specialty biopharmaceutical ...
(Date:11/24/2015)... , November 24, 2015 SHPG ) ... participate in the Piper Jaffray 27 th Annual Healthcare Conference ... December 1, 2015, at 8:30 a.m. EST (1:30 p.m. GMT). ... Chief Financial Officer, will participate in the Piper Jaffray 27 th ... , NY on Tuesday, December 1, 2015, at 8:30 a.m. EST ...
(Date:11/24/2015)... ... November 24, 2015 , ... ... are paramount. Insertion points for in-line sensors can represent a weak spot where ... InTrac 781/784 series of retractable sensor housings , which are designed to tolerate ...
Breaking Biology Technology: