Navigation Links
LSUHSC awarded multi-million dollar grant to reduce pneumonia
Date:1/7/2010

New Orleans, LA Dr. Jay Kolls, Professor and Chairman of Genetics at the LSU Health Sciences Center New Orleans School of Medicine, has been awarded a $2.1 million grant over five years by the National Heart, Lung, and Blood Institute of the National Institutes of Health to further his work on a discovery that plays a critical role in the body's defense against pneumonia.

Bacterial pneumonia is an important clinical problem and defense mechanisms against it are not fully understood. Dr. Kolls and his research team have identified a unique group of white blood cells that play a critical role in defense against pneumonia. These cells rapidly produce two new cytokines (small proteins in the immune system that affect how cells communicate and function) to increase resistance to infection in the lung. The first is interleukin-17 which helps recruit white blood cells into the sight of infection. The second is interleukin-22 which increases the barrier function of the epithelium (tissue lining the lungs). The research funded under this grant will use genetically engineered mice to see which cells need to receive these cytokine signals. Specifically, the researchers will investigate the role of the lung epithelium itself as the primary recipient of these signals. This application will also explore how these cells are generated and how they control infection defense in the lung.

"This work will help advance prevention and treatment of pneumonia and also advance vaccine development against lung infections," said Dr. Kolls. "It will also have broader application because mucous tissues like the lung are also the primary sites of emerging infections such as H1N1 influenza and MRSA (Methicillin-Resistant Staphylococcus aureus)."

According to the Centers for Disease Control and Prevention, in 2006, 1.2 million people in the U.S. were hospitalized with pneumonia and 55,477 people died from the disease.

Globally, pneumonia kills more than 4 million people every year half of these deaths occur among children less than 5 years of age. This is greater than the number of deaths from any other infectious disease, such as AIDS, malaria or tuberculosis. The CDC also reports that recent data show that Americans visit the doctor approximately 12 million times each year to get checked for suspected Staph or MRSA skin infection.

A study of the first population-based nationwide estimates of the burden of invasive MSRA disease from active cases published in 2007 found the incidence in 2005 was 31.8 cases per 100,000 persons, with a mortality rate of about 20%.


'/>"/>

Contact: Leslie Capo
lcapo@lsuhsc.edu
504-568-4806
Louisiana State University Health Sciences Center
Source:Eurekalert

Related biology news :

1. LSUHSCs England plays key role in developing new ALS treatment guidelines
2. LSUHSC researchers working to prevent diabetic neuropathy
3. Grant supports LSUHSC research on how like cell receptor systems determine very different functions
4. LSUHSC shows for first time infant inhalation of ultrafine air pollution linked to adult lung disease
5. LSUHSCs Bazan awarded ARRA grant to preserve vision
6. LSUHSC research helps link schizophrenia to specific DNA region
7. LSUHSCs Kolls awarded $1.8 million to improve vaccine strategies for P. carinii pneumonia
8. LSUHSC research describes function of key protein in cancer spread
9. LSUHSC public health researcher finds reason for weight gain
10. LSUHSC student awarded top national honor for diabetes research
11. LSUHSC research identifies key contributor to Alzheimers disease process
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/3/2016)... DUBLIN , Feb. 3, 2016 /PRNewswire/ ... announced the addition of the "Emotion ... NLP, Machine Learning, and Others), Software Tools ... Application Areas, End Users,and Regions - Global ... offering. --> http://www.researchandmarkets.com/research/d8zjcd/emotion_detection ) ...
(Date:2/2/2016)... 2016 This BCC Research report provides ... reviewing the recent advances in high throughput ‘omic ... field forward. Includes forecast through 2019. ... and opportunities that exist in the bioinformatic market. ... as well as IT and bioinformatics service providers. ...
(Date:2/2/2016)... 2016 Technology Enhancements Accelerate Growth of X-ray Imaging ... digital and computed radiography markets in Thailand ... Indonesia (TIM). It provides an in-depth ... well as regional market drivers and restraints. The study ... and market attractiveness, both for digital and computed radiography. ...
Breaking Biology News(10 mins):
(Date:2/4/2016)... 2016 Strasbourg, France , ... --> Strasbourg, France , to the US ... is pleased to announce that it acted as an advisor ... in Strasbourg, France , to the US ... --> Transgene (Euronext: TNG), a member of ...
(Date:2/3/2016)... 3, 2016  With the growing need for ... is underway, therapies such as monoclonal antibodies, recombinant ... host of indications are in high demand. Conventionally ... development and production of these therapeutics. However, due ... high costs, novel approaches and novel expression systems ...
(Date:2/3/2016)... ... February 03, 2016 , ... Aerocom, a world-leading supplier of ... North American healthcare market. , Aerocom Healthcare, LLC will be based in Denver, ... provide new pneumatic tube systems or expand existing systems within the U.S. and ...
(Date:2/3/2016)... Mass. , Feb. 3, 2016  Silk Therapeutics, Inc., ... financing round. Silk Therapeutics has now raised a total of ... made by the company. The Series A2 round was led ... Massachusetts , with participation from new investors Lear Corporation ... Sheri and Roy P. Disney ; Richard Sackler , ...
Breaking Biology Technology: