Navigation Links
LSUHSC awarded multi-million dollar grant to reduce pneumonia
Date:1/7/2010

New Orleans, LA Dr. Jay Kolls, Professor and Chairman of Genetics at the LSU Health Sciences Center New Orleans School of Medicine, has been awarded a $2.1 million grant over five years by the National Heart, Lung, and Blood Institute of the National Institutes of Health to further his work on a discovery that plays a critical role in the body's defense against pneumonia.

Bacterial pneumonia is an important clinical problem and defense mechanisms against it are not fully understood. Dr. Kolls and his research team have identified a unique group of white blood cells that play a critical role in defense against pneumonia. These cells rapidly produce two new cytokines (small proteins in the immune system that affect how cells communicate and function) to increase resistance to infection in the lung. The first is interleukin-17 which helps recruit white blood cells into the sight of infection. The second is interleukin-22 which increases the barrier function of the epithelium (tissue lining the lungs). The research funded under this grant will use genetically engineered mice to see which cells need to receive these cytokine signals. Specifically, the researchers will investigate the role of the lung epithelium itself as the primary recipient of these signals. This application will also explore how these cells are generated and how they control infection defense in the lung.

"This work will help advance prevention and treatment of pneumonia and also advance vaccine development against lung infections," said Dr. Kolls. "It will also have broader application because mucous tissues like the lung are also the primary sites of emerging infections such as H1N1 influenza and MRSA (Methicillin-Resistant Staphylococcus aureus)."

According to the Centers for Disease Control and Prevention, in 2006, 1.2 million people in the U.S. were hospitalized with pneumonia and 55,477 people died from the disease.

Globally, pneumonia kills more than 4 million people every year half of these deaths occur among children less than 5 years of age. This is greater than the number of deaths from any other infectious disease, such as AIDS, malaria or tuberculosis. The CDC also reports that recent data show that Americans visit the doctor approximately 12 million times each year to get checked for suspected Staph or MRSA skin infection.

A study of the first population-based nationwide estimates of the burden of invasive MSRA disease from active cases published in 2007 found the incidence in 2005 was 31.8 cases per 100,000 persons, with a mortality rate of about 20%.


'/>"/>

Contact: Leslie Capo
lcapo@lsuhsc.edu
504-568-4806
Louisiana State University Health Sciences Center
Source:Eurekalert

Related biology news :

1. LSUHSCs England plays key role in developing new ALS treatment guidelines
2. LSUHSC researchers working to prevent diabetic neuropathy
3. Grant supports LSUHSC research on how like cell receptor systems determine very different functions
4. LSUHSC shows for first time infant inhalation of ultrafine air pollution linked to adult lung disease
5. LSUHSCs Bazan awarded ARRA grant to preserve vision
6. LSUHSC research helps link schizophrenia to specific DNA region
7. LSUHSCs Kolls awarded $1.8 million to improve vaccine strategies for P. carinii pneumonia
8. LSUHSC research describes function of key protein in cancer spread
9. LSUHSC public health researcher finds reason for weight gain
10. LSUHSC student awarded top national honor for diabetes research
11. LSUHSC research identifies key contributor to Alzheimers disease process
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/31/2016)... RATON, Florida , March 31, 2016 ... LEGX ) ("LegacyXChange" or the "Company") ... for potential users of its soon to be launched ... video ( https://www.youtube.com/channel/UCyTLBzmZogV1y2D6bDkBX5g ) will also provide ... the use of DNA technology to an industry that ...
(Date:3/22/2016)... and SANDY, Utah , ... which operates the highest sample volume laboratory in ... Genomics and UNIConnect, leaders in clinical sequencing informatics and ... launch of a project to establish the informatics infrastructure ... NSO has been contracted by the Ontario ...
(Date:3/15/2016)... 15, 2016 Yissum Research Development Company ... company of the Hebrew University, announced today the formation ... technology of various human biological indicators. Neteera Technologies has ... from private investors. ... detection of electromagnetic emissions from sweat ducts, enables reliable ...
Breaking Biology News(10 mins):
(Date:4/27/2016)... ... , ... Shimadzu Scientific Instruments (SSI) will be showcasing a ... and Expo. Shimadzu’s high-performance instruments enable laboratories to test cannabis products for potency, ... by booth 1021 to learn how Shimadzu’s instruments can help improve QA/QC testing, ...
(Date:4/27/2016)... ... April 27, 2016 , ... Most consumers engage with ... recognition for secure access, voice recognition for hands-free communication, and facial recognition to ... with biometrics technology today. But if they asked Joey Pritikin, Vice President ...
(Date:4/27/2016)... SILVER SPRING, Md. and RESEARCH ... -- United Therapeutics Corporation (NASDAQ: UTHR ) announced ... Co-Chief Executive Officer, of United Therapeutics will provide an ... Deutsche Bank 41 st Annual Health Care Conference. ... May 5, 2016, at 10:00 a.m. Eastern Time, and ...
(Date:4/27/2016)... ... April 27, 2016 , ... NDA ... joined the company as an Expert Consultant. Mr. Clark was formerly a ... managing the development of small molecule monographs based on analytical methods. NDA ...
Breaking Biology Technology: