Navigation Links
LSUHSC awarded $4 million to understand effect of THC on HIV

New Orleans, LA Patricia Molina, MD, PhD, Professor and Head of Physiology at LSU Health Sciences Center New Orleans, has been awarded a $4 million grant over five years by the National Institute on Drug Abuse of the National Institutes of Health to study how cannabinoids, the principal psychoactive component of marijuana, produce subtle changes in gene activity that affect how a person responds to HIV infection.

As the grant's principal investigator, Dr. Molina will lead a team of geneticists, microbiologists, pharmacologists, and physiologists to explore the mechanisms involved in the anti-inflammatory effects and suppression of viral replication associated with prolonged survival in a model of HIV. The hypothesis will be tested with the following specific aims:

  • Demonstrate that chronic cannabinoid treatment decreases tissue inflammation
  • Identify the mechanisms of cannabinoid-induced suppression of inflammation
  • Examine the direct and indirect mechanisms by which cannabinoids decrease viral replication

While the ability of cannabinoids to suppress inflammation and viral replication has been reported by others and confirmed by ongoing studies in Dr. Molina's lab, the mechanisms involved are not known.

"The expected results will have a profound impact on the potential development of targeted therapeutic interventions to ameliorate HIV disease progression," notes Dr. Molina.


Contact: Leslie Capo
Louisiana State University Health Sciences Center

Page: 1

Related biology news :

1. LSUHSC researcher finds surprising link between sugar in drinks and blood pressure
2. LSUHSC research increases understanding of drug metabolism
3. LSUHSC researcher finds first inherited prostate cancer genetic mutation in African-American men
4. LSUHSC awarded multi-million dollar grant to reduce pneumonia
5. LSUHSCs England plays key role in developing new ALS treatment guidelines
6. LSUHSC researchers working to prevent diabetic neuropathy
7. Grant supports LSUHSC research on how like cell receptor systems determine very different functions
8. LSUHSC shows for first time infant inhalation of ultrafine air pollution linked to adult lung disease
9. LSUHSCs Bazan awarded ARRA grant to preserve vision
10. LSUHSC research helps link schizophrenia to specific DNA region
11. LSUHSCs Kolls awarded $1.8 million to improve vaccine strategies for P. carinii pneumonia
Post Your Comments:
(Date:4/26/2016)... , April 27, 2016 ... the  "Global Multi-modal Biometrics Market 2016-2020"  report to ... ) , The analysts forecast the ... CAGR of 15.49% during the period 2016-2020.  ... number of sectors such as the healthcare, BFSI, ...
(Date:4/13/2016)... , April 13, 2016  IMPOWER physicians supporting ... are setting a new clinical standard in telehealth thanks ... By leveraging the higi platform, IMPOWER patients can routinely ... pulse and body mass index, and, when they opt ... and convenient visit to a local retail location at ...
(Date:3/22/2016)... 22, 2016 According ... Market for Consumer Industry by Type (Image, Motion, ... (Communication & IT, Entertainment, Home Appliances, & ... to 2022", published by MarketsandMarkets, the market ... reach USD 26.76 Billion by 2022, at ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... 2016   EpiBiome , a precision microbiome engineering ... debt financing from Silicon Valley Bank (SVB). The financing ... advance its drug development efforts, as well as purchase ... "SVB has been an incredible strategic partner to us ... bank would provide," said Dr. Aeron Tynes Hammack ...
(Date:6/23/2016)... LOUISVILLE, Ky. , June 23, 2016 /PRNewswire/ ... from two Phase 1 clinical trials of its ... double-blind, placebo-controlled, single and multiple ascending dose studies ... and pharmacodynamics (PD) of subcutaneous injection in healthy ... APL-2 subcutaneously (SC) either as a single dose ...
(Date:6/23/2016)... ... June 23, 2016 , ... ClinCapture, the only free ... and will showcase its product’s latest features from June 26 to June 30, ... poster on Disrupting Clinical Trials in The Cloud during the conference. DIA ...
(Date:6/23/2016)... 23, 2016 adds ... to its pharmaceuticals section with historic and forecast ... much more. Complete report on the ... profiling 15 companies and supported with 261 tables ... . The Global Cell Culture ...
Breaking Biology Technology: