Navigation Links
LSUHSC awarded $4 million to understand effect of THC on HIV
Date:7/7/2010

New Orleans, LA Patricia Molina, MD, PhD, Professor and Head of Physiology at LSU Health Sciences Center New Orleans, has been awarded a $4 million grant over five years by the National Institute on Drug Abuse of the National Institutes of Health to study how cannabinoids, the principal psychoactive component of marijuana, produce subtle changes in gene activity that affect how a person responds to HIV infection.

As the grant's principal investigator, Dr. Molina will lead a team of geneticists, microbiologists, pharmacologists, and physiologists to explore the mechanisms involved in the anti-inflammatory effects and suppression of viral replication associated with prolonged survival in a model of HIV. The hypothesis will be tested with the following specific aims:

  • Demonstrate that chronic cannabinoid treatment decreases tissue inflammation
  • Identify the mechanisms of cannabinoid-induced suppression of inflammation
  • Examine the direct and indirect mechanisms by which cannabinoids decrease viral replication

While the ability of cannabinoids to suppress inflammation and viral replication has been reported by others and confirmed by ongoing studies in Dr. Molina's lab, the mechanisms involved are not known.

"The expected results will have a profound impact on the potential development of targeted therapeutic interventions to ameliorate HIV disease progression," notes Dr. Molina.


'/>"/>

Contact: Leslie Capo
lcapo@lsuhsc.edu
504-568-4806
Louisiana State University Health Sciences Center
Source:Eurekalert

Page: 1

Related biology news :

1. LSUHSC researcher finds surprising link between sugar in drinks and blood pressure
2. LSUHSC research increases understanding of drug metabolism
3. LSUHSC researcher finds first inherited prostate cancer genetic mutation in African-American men
4. LSUHSC awarded multi-million dollar grant to reduce pneumonia
5. LSUHSCs England plays key role in developing new ALS treatment guidelines
6. LSUHSC researchers working to prevent diabetic neuropathy
7. Grant supports LSUHSC research on how like cell receptor systems determine very different functions
8. LSUHSC shows for first time infant inhalation of ultrafine air pollution linked to adult lung disease
9. LSUHSCs Bazan awarded ARRA grant to preserve vision
10. LSUHSC research helps link schizophrenia to specific DNA region
11. LSUHSCs Kolls awarded $1.8 million to improve vaccine strategies for P. carinii pneumonia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/20/2017)... At this year,s CeBIT Chancellor Dr. Angela Merkel ... came to the DERMALOG stand together with the Japanese Prime Minster Shinzo ... At the largest German biometrics company the two government leaders could see ... as well as DERMALOGĀ“s multi-biometrics system.   Continue ... ...
(Date:3/16/2017)... 2017 CeBIT 2017 - Against identity fraud with DERMALOG solutions "Made ... ... Used combined in one project, multi-biometric solutions provide a crucial contribution against identity ... Used combined in one project, multi-biometric ... ...
(Date:3/9/2017)... MELBOURNE , Australia , March ... clinical study data at the prestigious World Lung Imaging ... Dr. Andreas Fouras , was invited to deliver ... and pulmonary medicine. This globally recognised event brings together ... and share the latest developments in lung imaging. ...
Breaking Biology News(10 mins):
(Date:4/25/2017)... ... 25, 2017 , ... Franz Inc ., an early ... and market leader for Semantic Graph Database technology, today announced ... most effective system for developing and deploying applications to solve the challenges developers ...
(Date:4/25/2017)... ... April 25, 2017 , ... Dr. Robert G. ... , proudly announced today that acclaimed physiatrist Matthew Terzella, MD, has joined the ... 2017. , Dr. Terzella completed his residency in Physical Medicine and Rehabilitation at ...
(Date:4/24/2017)... ... April 24, 2017 , ... ... denaturation in a cellular milieu; however, the broad application of this cellular target ... platforms with sensitive quantitative readouts. Cell-based thermal stabilization assays are valuable methods for ...
(Date:4/21/2017)... ... April 21, 2017 , ... Having worked on the design of the ... to introduce it to top lab design architects from around the country at the ... of Industrial Design and Engineering Greg Casey will be at the show, where they ...
Breaking Biology Technology: