Navigation Links
LSTM and UoL secure £1.4m ($2m) to develop new 'magic bullet' antimalarial drug
Date:2/24/2009

The Liverpool School of Tropical Medicine (LSTM) and the University of Liverpool (UoL) have secured a 1.4 million project grant to begin the development of new drugs to combat malaria.

The project, funded by the Wellcome Trust, aims to develop new antimalarial drug candidates which work by targeting a novel enzyme in the respiratory chain of Plasmodium falciparum the parasite that causes malaria.

The enzyme within the parasite is not found in humans, thereby fulfilling the most important prerequisite of a target for a 'magic bullet' - a drug capable of targeting an organism without affecting its host.

Having identified this enzyme, project PI Professor Steve Ward (LSTM), Professor Paul O'Neill (UoL) and Dr Giancarlo Biagini (LSTM) are now assembling a team of biochemists, pharmacologists, medicinal chemists and computational chemists to design new compounds that will successfully inhibit its operation. Drug candidates from this stage of the project will be put forward for further pre-clinical development.

Professor Steve Ward explained: "New drugs to treat malaria are urgently required because the parasite has evolved to develop resistance to traditional drugs and consequently more people die from malaria now than they did twenty years ago. This project is seeking to develop a drug which works differently.

"Our initial research indicates that if we can knock out this enzyme in the parasite we can stop the disease progressing through its usual stages within the body thereby eliminating the clinical symptoms of malaria and reducing the possibility of transmission to other people through mosquito bites."

Professor Paul O'Neill added: "This exciting project will further strengthen links between the University's Chemistry department and LSTM. In addition to the synthesis of inhibitors, a team of molecular modellers, led by Dr N Berry (UoL), will use various computational techniques such as virtual screening to facilitate and inform the discovery process.

"This approach will provide a platform for future activities in this area of medicinal chemistry."


'/>"/>

Contact: Alan Hughes
a.p.hughes@liv.ac.uk
44-151-705-3308
Liverpool School of Tropical Medicine
Source:Eurekalert

Related biology news :

1. Voice Biometrics Gains Traction as Most Accurate and Convenient Technology to Secure Customer Privacy
2. Silicon Valley Technology Leaders LaserCard Corporation and Tesla Motors Sign LaserPass Secure Access Deal
3. IdentiPHI Re Launches SAFmodule Software to Secure Novell(R) Networks
4. IdentiPHI Re Launches SAFmodule Software to Secure Novell(R) Networks
5. Ultraviolet light helps to secure water supply
6. Secure Services Corp. Achieves Milestone in United States Identity Protection with the Launch of the SSC SHAPE Card Management Solution
7. Life-saving clean water project secures $13M from Bill & Melinda Gates Foundation
8. Synaptics SecurePad(TM) Selected as CES Innovations 2008 Design and Engineering Award Honoree
9. New study finds biodiversity conservation secures ecosystem services for people
10. UT Southwestern secures $5 million NIH grant for lupus research
11. Entrust Digital Signatures Help Secure More Than 18 Million U.S. ePassports
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/26/2016)... , April 27, 2016 ... the  "Global Multi-modal Biometrics Market 2016-2020"  report to ... ) , The analysts forecast the ... CAGR of 15.49% during the period 2016-2020.  ... number of sectors such as the healthcare, BFSI, ...
(Date:4/13/2016)... -- IMPOWER physicians supporting Medicaid patients in Central ... in telehealth thanks to a new partnership with higi. ... patients can routinely track key health measurements, such as ... when they opt in, share them with IMPOWER clinicians ... retail location at no cost. By leveraging this data, ...
(Date:3/22/2016)... , March 22, 2016 ... research report "Electronic Sensors Market for Consumer Industry by ... & Others), Application (Communication & IT, Entertainment, ... - Global Forecast to 2022", published by ... is expected to reach USD 26.76 Billion ...
Breaking Biology News(10 mins):
(Date:4/28/2016)... ... 28, 2016 , ... As part of an ongoing global ... expanding its LATAM network and logistics capabilities. Enhancements have been made to ... trial projects. , The expansion will provide unmatched clinical trial logistics services for ...
(Date:4/27/2016)... (PRWEB) , ... April 27, 2016 , ... ... of cannabis testing technology at the Spring 2016 Marijuana Business Conference and Expo. ... pesticides, residual solvents, heavy metals, and more. Expo attendees can stop by booth ...
(Date:4/27/2016)... April 27, 2016 NanoStruck ... (OTCPink: NSKQB) ( Frankfurt : 8NSK) ... Pressemitteilung vom 13. August 2015 die Genehmigung von ... um zusätzliche 200.000.000 Einheiten auf 400.000.000 Einheiten zu ... bringen. Davon wurden 157.900.000 Einheiten mit dem ersten ...
(Date:4/27/2016)... , ... April 27, 2016 , ... ... Jon Clark has joined the company as an Expert Consultant. Mr. Clark ... industry collaborations and managing the development of small molecule monographs based on analytical ...
Breaking Biology Technology: