Navigation Links
LSTM and UoL secure £1.4m ($2m) to develop new 'magic bullet' antimalarial drug
Date:2/24/2009

The Liverpool School of Tropical Medicine (LSTM) and the University of Liverpool (UoL) have secured a 1.4 million project grant to begin the development of new drugs to combat malaria.

The project, funded by the Wellcome Trust, aims to develop new antimalarial drug candidates which work by targeting a novel enzyme in the respiratory chain of Plasmodium falciparum the parasite that causes malaria.

The enzyme within the parasite is not found in humans, thereby fulfilling the most important prerequisite of a target for a 'magic bullet' - a drug capable of targeting an organism without affecting its host.

Having identified this enzyme, project PI Professor Steve Ward (LSTM), Professor Paul O'Neill (UoL) and Dr Giancarlo Biagini (LSTM) are now assembling a team of biochemists, pharmacologists, medicinal chemists and computational chemists to design new compounds that will successfully inhibit its operation. Drug candidates from this stage of the project will be put forward for further pre-clinical development.

Professor Steve Ward explained: "New drugs to treat malaria are urgently required because the parasite has evolved to develop resistance to traditional drugs and consequently more people die from malaria now than they did twenty years ago. This project is seeking to develop a drug which works differently.

"Our initial research indicates that if we can knock out this enzyme in the parasite we can stop the disease progressing through its usual stages within the body thereby eliminating the clinical symptoms of malaria and reducing the possibility of transmission to other people through mosquito bites."

Professor Paul O'Neill added: "This exciting project will further strengthen links between the University's Chemistry department and LSTM. In addition to the synthesis of inhibitors, a team of molecular modellers, led by Dr N Berry (UoL), will use various computational techniques such as virtual screening to facilitate and inform the discovery process.

"This approach will provide a platform for future activities in this area of medicinal chemistry."


'/>"/>

Contact: Alan Hughes
a.p.hughes@liv.ac.uk
44-151-705-3308
Liverpool School of Tropical Medicine
Source:Eurekalert

Related biology news :

1. Voice Biometrics Gains Traction as Most Accurate and Convenient Technology to Secure Customer Privacy
2. Silicon Valley Technology Leaders LaserCard Corporation and Tesla Motors Sign LaserPass Secure Access Deal
3. IdentiPHI Re Launches SAFmodule Software to Secure Novell(R) Networks
4. IdentiPHI Re Launches SAFmodule Software to Secure Novell(R) Networks
5. Ultraviolet light helps to secure water supply
6. Secure Services Corp. Achieves Milestone in United States Identity Protection with the Launch of the SSC SHAPE Card Management Solution
7. Life-saving clean water project secures $13M from Bill & Melinda Gates Foundation
8. Synaptics SecurePad(TM) Selected as CES Innovations 2008 Design and Engineering Award Honoree
9. New study finds biodiversity conservation secures ecosystem services for people
10. UT Southwestern secures $5 million NIH grant for lupus research
11. Entrust Digital Signatures Help Secure More Than 18 Million U.S. ePassports
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/12/2017)... PUNE, India , January 12, 2017 A new report ... 2022," projects that the global biometric technology market is expected to generate revenue of ... Continue Reading ... Allied ...      (Logo: http://photos.prnewswire.com/prnh/20140911/647229) ...
(Date:1/6/2017)... Jan. 6, 2017  Privately-held CalciMedica, Inc., announced ... healthy volunteers of a novel calcium release-activated calcium ... pancreatitis. Acute pancreatitis, sudden painful ... disorder, but can be very serious.  In severe cases ... where extended hospital stays, time in the ICU ...
(Date:1/4/2017)... Jan. 4, 2017  For the thousands of attendees at this year,s ... in connected health and biometric measurement devices and services, will be featuring ... On display in A&D Medical,s special CES Exhibit Suite , the ... expansion of the company,s WellnessConnected product platform.  ... ...
Breaking Biology News(10 mins):
(Date:1/19/2017)... Jan. 18, 2017 Acupath Laboratories, Inc., a ... formation of an Executive Committee that will guide the ... John Cucci , a 15-year veteran of ... of Business Development to Chief Sales Officer .  ... served in senior sales leadership roles at several leading ...
(Date:1/18/2017)... (PRWEB) , ... January 18, 2017 , ... ... provide essential device-to-computer interconnect using USB or PCI Express, announced the ZEM5310 USB ... V E FPGA into a compact business-card sized form factor suitable for prototyping, ...
(Date:1/18/2017)...   Boston Biomedical , an industry leader in ... stemness pathways, will feature data from two clinical studies ... ASCO Gastrointestinal Cancers Symposium, held from January 19-21, in ... Napabucasin is an orally-administered investigational agent designed to inhibit ... stem cells (CSCs) possess the property of stemness – ...
(Date:1/18/2017)... HACKENSACK, N.J. , Jan. 18, 2017   ... leading the fight to end Duchenne muscular dystrophy ... awarded to the New Jersey Institute of Technology (NJIT) ... ongoing exploration of robotic technology to assist ... study to incorporate NJIT,s technology – an embedded computer, ...
Breaking Biology Technology: