Navigation Links
LSTM Researchers demonstrate adaptive potential of hybridization in mosquito species
Date:6/25/2014

Researchers from LSTM have exploited a natural experiment created by insecticidal pressure to determine how the most important malaria vectors - A. gambiae s.s. and A. coluzzii respond rapidly to environmental change.

Working with genome analysis specialists from the Wellcome Trust Sanger Institute and field entomologists in Ghana, LSTM researchers sequenced the genomes of individual wild mosquitoes of each species from southern Ghana. The results, published in Nature Communications, reveal that transfer of a major insecticide resistance mutation (kdr) resulted in replacement of over 3 million surrounding DNA bases (1.5% of the genome) of A. coluzzii, with that of A. gambiae s.s. This is especially significant because the two species are very closely related and the region replaced is one of relatively few areas of their genomes that are substantially different. Surprisingly, this apparently huge genomic disruption has had no detectable impact on reproductive isolation with hybridisation rates between the species in Ghana remaining low and stable despite a dramatic rise in frequency of the kdr mutation in A. coluzzii.

Dr David Weetman, co-first author and LSTM Lecturer in Population Genomics, said: "Our work demonstrates amazing flexibility in the genomes of closely related species. The genomic section replaced is not only huge but was previously considered a major 'speciation island'; a probable location for genes driving reproductive isolation between the species. The findings not only call into question the general importance of 'speciation islands', but also importantly show that these closely-related mosquito species, can evolve largely separately but then interchange genetic variation to allow rapid adaptation to human-driven environmental changes.".

The two species, which co-occur throughout much of West and Central Africa, exhibit behavioural and ecological differences. Anopheles coluzzii is thought to be able to exploit relatively stable agricultural breeding sites, which can extend malaria transmission far into the dry season. A. gambiae s.s. has traditionally been the more insecticide resistant, but, with transfer of insecticide resistance mutations, this is changing. In addition to concerns for vector control, this presented a near-unique opportunity to investigate the popular theory that new species form through the development of pockets of divergence in the genome containing speciation genes. Driven by technological advances and early work on the Anopheles gambiae species pair, this has become a rapidly-growing area of research in evolutionary biology.

LSTM's Professor Martin Donnelly, senior author of the study, said: "Through our collaboration with the Wellcome Trust Sanger Institute we are learning how to use Anopheles genomic information to address questions of immense evolutionary and public health importance. This paper is just a foretaste of the studies that the vector community will be able to perform as the Anopheles gambiae 1000 Genome data sets become available (see http://www.malariagen.net/projects/vector/ag1000g)."

"This is a wonderful example of how new technologies for genome sequence analysis can elucidate specific biological questions in the field," says Professor Dominic Kwiatkowski, Head of the Malaria Programme at the Wellcome Trust Sanger Institute, whose team have worked closely with LSTM on this project.


'/>"/>

Contact: Clare Bebb
c.bebb@liv.ac.uk
44-015-170-53135
Liverpool School of Tropical Medicine
Source:Eurekalert

Related biology news :

1. CU-Boulder, NCAR researchers seek to reduce deadly air pollution from cooking emissions
2. BUSM researchers investigating ways to improve type 2 diabetes treatments
3. Researchers discover new genes that promote brain cancer
4. Researchers identify mitochondrial mutation linked to congenital myasthenic syndrome
5. Researchers develop genetic control mechanism for major livestock pest
6. Portable brain-mapping device allows UT Arlington researchers to see where memory fails
7. NJIT researchers probe links between vision problems and cognition in a pioneering study
8. Top Monash researchers recognised with NHMRC Excellence Awards
9. No link found between soy food and endometrial cancer risk, say researchers
10. Researchers use virus to reveal nanopore physics
11. Researchers identify regulation process of protein linked to bipolar disorder
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/7/2017)... 2017 Brandwatch , the leading social intelligence company, ... Trust to uncover insights to support its reporting, help direct ... The UK,s leading youth charity will be using Brandwatch Analytics social ... a better understanding of the topics and issues that are a ... ...
(Date:3/2/2017)... 2, 2017 Summary This report ... Merck KGaA and its partnering interests and activities since ... Description The Partnering Deals and Alliance since 2010 ... of one of the world,s leading life sciences companies. ... purchase to ensure inclusion of the most up to ...
(Date:2/28/2017)...   Acuant , a leading provider of data ... to new and core technologies building upon the acquisition ... and desktop Acuant FRM TM facial recognition and ... time manual review of identity documents by accredited professionals. ... and most accurate capture software to streamline workflows by ...
Breaking Biology News(10 mins):
(Date:3/24/2017)... On Thursday, March 23, 2017, ... down 0.07%; the Dow Jones Industrial Average edged 0.02% ... closed at 2,345.96, marginally dropping 0.11%. US markets saw ... 4 sectors finished in red, and 1 sector ended ... reports coverage on the following Biotechnology equities: BioDelivery Sciences ...
(Date:3/23/2017)... ... ... is proud to announce it has become the premiere team-building cooking event company in San ... world, such as Illumina, HP and Qualcomm, and is ranked #1 in its category on ... to its new team building format, a way for teams to not only interact with ...
(Date:3/23/2017)...  GlobeImmune, Inc. today announced it has entered into ... shares of its common stock to NantCell, Inc., a ... the sale of its common stock, NantCell has agreed ... GlobeImmune 200,000 shares, an estimated $2.0 million in value, ... pleased to enter into this strategic agreement with NantCell," ...
(Date:3/23/2017)... , March 23, 2017 NetworkNewsWire Editorial ... ... putting significant strain on health care systems, in terms of ... rises, so too does the development of innovative and efficient ... effects. Among the many types of cancer treatments, a growing ...
Breaking Biology Technology: