Navigation Links
LSTM Researchers demonstrate adaptive potential of hybridization in mosquito species
Date:6/25/2014

Researchers from LSTM have exploited a natural experiment created by insecticidal pressure to determine how the most important malaria vectors - A. gambiae s.s. and A. coluzzii respond rapidly to environmental change.

Working with genome analysis specialists from the Wellcome Trust Sanger Institute and field entomologists in Ghana, LSTM researchers sequenced the genomes of individual wild mosquitoes of each species from southern Ghana. The results, published in Nature Communications, reveal that transfer of a major insecticide resistance mutation (kdr) resulted in replacement of over 3 million surrounding DNA bases (1.5% of the genome) of A. coluzzii, with that of A. gambiae s.s. This is especially significant because the two species are very closely related and the region replaced is one of relatively few areas of their genomes that are substantially different. Surprisingly, this apparently huge genomic disruption has had no detectable impact on reproductive isolation with hybridisation rates between the species in Ghana remaining low and stable despite a dramatic rise in frequency of the kdr mutation in A. coluzzii.

Dr David Weetman, co-first author and LSTM Lecturer in Population Genomics, said: "Our work demonstrates amazing flexibility in the genomes of closely related species. The genomic section replaced is not only huge but was previously considered a major 'speciation island'; a probable location for genes driving reproductive isolation between the species. The findings not only call into question the general importance of 'speciation islands', but also importantly show that these closely-related mosquito species, can evolve largely separately but then interchange genetic variation to allow rapid adaptation to human-driven environmental changes.".

The two species, which co-occur throughout much of West and Central Africa, exhibit behavioural and ecological differences. Anopheles coluzzii is thought to be able to exploit relatively stable agricultural breeding sites, which can extend malaria transmission far into the dry season. A. gambiae s.s. has traditionally been the more insecticide resistant, but, with transfer of insecticide resistance mutations, this is changing. In addition to concerns for vector control, this presented a near-unique opportunity to investigate the popular theory that new species form through the development of pockets of divergence in the genome containing speciation genes. Driven by technological advances and early work on the Anopheles gambiae species pair, this has become a rapidly-growing area of research in evolutionary biology.

LSTM's Professor Martin Donnelly, senior author of the study, said: "Through our collaboration with the Wellcome Trust Sanger Institute we are learning how to use Anopheles genomic information to address questions of immense evolutionary and public health importance. This paper is just a foretaste of the studies that the vector community will be able to perform as the Anopheles gambiae 1000 Genome data sets become available (see http://www.malariagen.net/projects/vector/ag1000g)."

"This is a wonderful example of how new technologies for genome sequence analysis can elucidate specific biological questions in the field," says Professor Dominic Kwiatkowski, Head of the Malaria Programme at the Wellcome Trust Sanger Institute, whose team have worked closely with LSTM on this project.


'/>"/>

Contact: Clare Bebb
c.bebb@liv.ac.uk
44-015-170-53135
Liverpool School of Tropical Medicine
Source:Eurekalert

Related biology news :

1. CU-Boulder, NCAR researchers seek to reduce deadly air pollution from cooking emissions
2. BUSM researchers investigating ways to improve type 2 diabetes treatments
3. Researchers discover new genes that promote brain cancer
4. Researchers identify mitochondrial mutation linked to congenital myasthenic syndrome
5. Researchers develop genetic control mechanism for major livestock pest
6. Portable brain-mapping device allows UT Arlington researchers to see where memory fails
7. NJIT researchers probe links between vision problems and cognition in a pioneering study
8. Top Monash researchers recognised with NHMRC Excellence Awards
9. No link found between soy food and endometrial cancer risk, say researchers
10. Researchers use virus to reveal nanopore physics
11. Researchers identify regulation process of protein linked to bipolar disorder
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/11/2017)... Florida , April 11, 2017 ... a security technology company, announces the appointment of independent Directors ... Bendheim to its Board of Directors, furthering the company,s ... ... of NXT-ID, we look forward to their guidance and benefiting ...
(Date:4/5/2017)... 2017  The Allen Institute for Cell Science today ... one-of-a-kind portal and dynamic digital window into the human ... first application of deep learning to create predictive models ... and a growing suite of powerful tools. The Allen ... future publicly available resources created and shared by the ...
(Date:4/5/2017)... April 4, 2017 KEY FINDINGS ... expand at a CAGR of 25.76% during the forecast ... the primary factor for the growth of the stem ... https://www.reportbuyer.com/product/4807905/ MARKET INSIGHTS The global stem cell ... application, and geography. The stem cell market of the ...
Breaking Biology News(10 mins):
(Date:8/15/2017)... New York, NY (PRWEB) , ... August 15, 2017 , ... ... for the first time on Immuno-Oncology 360° (IO360°) programming through a series of upcoming ... to be held February 7-9, 2018, at The Roosevelt Hotel in New York City. ...
(Date:8/14/2017)... ... August 14, 2017 , ... ... antibodies. Key researchers in the antibody community have recently come together to address ... antibodies in the laboratory. , The team at Thermo Fisher ...
(Date:8/11/2017)... , Aug. 11, 2017  Market ... New York Times article regarding the telemedicine ... according to Kalorama Information.  The article, ... for That"  used information from Kalorama ... Monitoring & Telemedicine Market  (Sleep, Diabetes, ...
(Date:8/11/2017)... ... August 11, 2017 , ... “There is an ... natural alternatives to synthetic ingredients,” said Matt Hundt, President of Third Wave Bioactives. ... manufacturing presence and know-how of Biorigin will allow us to bring truly novel ...
Breaking Biology Technology: