Navigation Links
LSTM Researchers demonstrate adaptive potential of hybridization in mosquito species
Date:6/25/2014

Researchers from LSTM have exploited a natural experiment created by insecticidal pressure to determine how the most important malaria vectors - A. gambiae s.s. and A. coluzzii respond rapidly to environmental change.

Working with genome analysis specialists from the Wellcome Trust Sanger Institute and field entomologists in Ghana, LSTM researchers sequenced the genomes of individual wild mosquitoes of each species from southern Ghana. The results, published in Nature Communications, reveal that transfer of a major insecticide resistance mutation (kdr) resulted in replacement of over 3 million surrounding DNA bases (1.5% of the genome) of A. coluzzii, with that of A. gambiae s.s. This is especially significant because the two species are very closely related and the region replaced is one of relatively few areas of their genomes that are substantially different. Surprisingly, this apparently huge genomic disruption has had no detectable impact on reproductive isolation with hybridisation rates between the species in Ghana remaining low and stable despite a dramatic rise in frequency of the kdr mutation in A. coluzzii.

Dr David Weetman, co-first author and LSTM Lecturer in Population Genomics, said: "Our work demonstrates amazing flexibility in the genomes of closely related species. The genomic section replaced is not only huge but was previously considered a major 'speciation island'; a probable location for genes driving reproductive isolation between the species. The findings not only call into question the general importance of 'speciation islands', but also importantly show that these closely-related mosquito species, can evolve largely separately but then interchange genetic variation to allow rapid adaptation to human-driven environmental changes.".

The two species, which co-occur throughout much of West and Central Africa, exhibit behavioural and ecological differences. Anopheles coluzzii is thought to be able to exploit relatively stable agricultural breeding sites, which can extend malaria transmission far into the dry season. A. gambiae s.s. has traditionally been the more insecticide resistant, but, with transfer of insecticide resistance mutations, this is changing. In addition to concerns for vector control, this presented a near-unique opportunity to investigate the popular theory that new species form through the development of pockets of divergence in the genome containing speciation genes. Driven by technological advances and early work on the Anopheles gambiae species pair, this has become a rapidly-growing area of research in evolutionary biology.

LSTM's Professor Martin Donnelly, senior author of the study, said: "Through our collaboration with the Wellcome Trust Sanger Institute we are learning how to use Anopheles genomic information to address questions of immense evolutionary and public health importance. This paper is just a foretaste of the studies that the vector community will be able to perform as the Anopheles gambiae 1000 Genome data sets become available (see http://www.malariagen.net/projects/vector/ag1000g)."

"This is a wonderful example of how new technologies for genome sequence analysis can elucidate specific biological questions in the field," says Professor Dominic Kwiatkowski, Head of the Malaria Programme at the Wellcome Trust Sanger Institute, whose team have worked closely with LSTM on this project.


'/>"/>

Contact: Clare Bebb
c.bebb@liv.ac.uk
44-015-170-53135
Liverpool School of Tropical Medicine
Source:Eurekalert

Related biology news :

1. CU-Boulder, NCAR researchers seek to reduce deadly air pollution from cooking emissions
2. BUSM researchers investigating ways to improve type 2 diabetes treatments
3. Researchers discover new genes that promote brain cancer
4. Researchers identify mitochondrial mutation linked to congenital myasthenic syndrome
5. Researchers develop genetic control mechanism for major livestock pest
6. Portable brain-mapping device allows UT Arlington researchers to see where memory fails
7. NJIT researchers probe links between vision problems and cognition in a pioneering study
8. Top Monash researchers recognised with NHMRC Excellence Awards
9. No link found between soy food and endometrial cancer risk, say researchers
10. Researchers use virus to reveal nanopore physics
11. Researchers identify regulation process of protein linked to bipolar disorder
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/2/2016)... Technology Enhancements Accelerate Growth of X-ray Imaging ... and computed radiography markets in Thailand ... Indonesia (TIM). It provides an in-depth analysis ... as regional market drivers and restraints. The study offers ... market attractiveness, both for digital and computed radiography. Market ...
(Date:2/1/2016)... smart wallet ( www.wocketwallet.com ) announces the launch of a new video ... Las Vegas , where Joey appeared at the Wocket ... Vegas , where Joey appeared at the Wocket booth to meet ... filmed at the Consumer Electronics Show (CES2016) in Las Vegas ... greet fans. --> --> The ...
(Date:1/22/2016)... DUBLIN , January 22, 2016 ... has announced the addition of the  ... to their offering. --> ... of the  "Global Behavioral Biometric Market ... --> Research and Markets ( http://www.researchandmarkets.com/research/4lmf2s/global_behavioral ...
Breaking Biology News(10 mins):
(Date:2/12/2016)... 2016 MedGenome,s Commitment Will ... Understanding of Complex Diseases Such as Cancer, Metabolic ... --> --> MedGenome, the ... a leading provider of genomics research services globally, ... the GenomeAsia 100K consortium as a founding member. ...
(Date:2/11/2016)... Feb. 11, 2016  Bioethics International, a not-for-profit organization focused ... developed, marketed and made accessible to patients around the world, ... had named the publication of the Good Pharma Scorecard ... is also featured as one of BMJ Open ,s ... year that are most frequently read. Ed Sucksmith ...
(Date:2/11/2016)... DELRAY BEACH, Florida , February 11, 2016 ... --> PositiveID Corporation ("PositiveID" or "Company") (OTCQB: ... and diagnostics, announced today that its Thermomedics subsidiary, ... significant progress on its growth plan in January ... healthcare products distributors, increasing sequential monthly sales growth, ...
(Date:2/10/2016)... - BioAmber Inc. (NYSE: BIOA ), a leader ... & Co. Ltd., its partner in the ... an additional CDN$25 million in the joint venture for ... to 40%.  Mitsui will also play a stronger role ... Sarnia , providing dedicated resources alongside BioAmber,s ...
Breaking Biology Technology: