Navigation Links
LEDs illuminate eye for ocular disease screening
Date:8/31/2010

College Park, MD (August 31, 2010) -- A new imaging system using six different wavelengths to illuminate the interior of the eyeball (ocular fundus) may pave the way for doctors to easily screen patients for common diseases of the eye, such as age-related macular degeneration and diabetic retinopathy. The system is described in the journal Review of Scientific Instruments, which is published by the American Institute of Physics.

Currently, when optometrists and ophthalmogists visualize the ocular fundus, they typically take snapshot images of the eye in two or three wavelengths (red, green and blue), which can reveal some visually-apparent abnormalities. But an added dimension made possible with the imaging system described by Nicholas L. Everdell of University College London allows doctors to distinguish between the different light absorbing characteristics of biological molecules called chromophores.

According to the paper's coauthor Iain Styles of the University of Birmingham, five of these light-absorbing compounds are prevalent in the eye: retinal hemoglobins, choroidal hemoglobins, choroidal melanin, RPE (retinal pigment epithelium) melanin, and macular pigment. In a separate paper (Medical Image Analysis 10 (2006) 578�), Styles said that each of these has been shown to give rise to distinct variations in tissue coloration that can be discriminated in multispectral images.

In the new work, Everdell and Styles describe a device combining a high-sensitivity CCD camera with wavelength-specific illumination from LEDs (light-emitting diodes) that provides multispectral images of the ocular fundus. The multispectral images, explains Styles, are affected differently by the pigments present in the eye, and through a sophisticated algorithm they can be used to generate a pixel-by-pixel "parametric map" of the distribution of substances in the eye. Such maps may allow primary care clinicians to screen for and identify pathologies at a much earlier stage of development than other imaging modalities.

An advantage the new system offers over other multispectral retinal imaging systems is its speed. It can acquire a sequence of multispectral images at a fast enough rate (0. 5 seconds) to reduce image shifts caused by natural eye movements. In contrast with snapshot systems, the system's images retain full spatial resolution. Also, the system uses only the specific wavebands that are required for the subsequent analysis, minimizing the total light exposure of the subject, ensuring patient safety and improving image quality.

"The long term goal," Everdell said, "is to develop a system for chromophore quantification that is an integral part of the standard fundus camera, and therefore could be used routinely by both optometrists and opthalmologists."


'/>"/>

Contact: Jason Socrates Bardi
jbardi@aip.org
301-209-3091
American Institute of Physics
Source:Eurekalert

Related biology news :

1. Blood stem cell, leukemia link illuminated in UCSF-led study
2. Discovery of stem cell illuminates human brain evolution, points to therapies
3. Using fish to illuminate the architecture of inherited disease
4. Fireflies and jellyfish help illuminate quest for cause of infertility
5. New discovery suggests our lungs are innately prone to silicosis and related diseases
6. New research shows how disease-causing parasite gets around human innate immunity
7. Researchers find gene responsible for neurodegenerative disease in dogs, possibly in humans
8. Low bone mineral density common in children and teenagers with inflammatory bowel disease
9. Researchers: Cures to diseases may live in our guts
10. Research targets basic metabolism of disease-causing fungi, bacteria
11. Boston Univ., Veterans Affairs find sports brain trauma may cause disease mimicking ALS
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/22/2016)... , June 22, 2016   ... management and verification solutions, has partnered with ... software solutions for Visitor Management, Self-Service Kiosks ... provides products that add functional enhancements to ... provides corporations and venues with an automated ...
(Date:6/15/2016)... 15, 2016 Transparency Market ... Recognition Market by Application Market - Global Industry Analysis Size ... to the report, the  global gesture recognition market ... and is estimated to grow at a CAGR ... 2024.  Increasing application of gesture recognition ...
(Date:6/2/2016)... 2016 The Department of Transport Management ... 44 million US Dollar project, for the , ... Personalization, Enrolment, and IT Infrastructure , to ... and implementation of Identity Management Solutions. Numerous renowned international vendors ... Decatur was selected for the most compliant and ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... , June 24, 2016  Regular discussions on a ... take place between the two entities said Poloz. ... Ottawa , he pointed to the country,s ... the federal government. ... said, "Both institutions have common economic goals, why not sit ...
(Date:6/24/2016)... ... June 24, 2016 , ... Researchers at the Universita Politecnica delle Marche in ... peritoneal or pleural mesothelioma. Their findings are the subject of a new article on ... biomarkers are signposts in the blood, lung fluid or tissue of mesothelioma patients that ...
(Date:6/23/2016)... 23, 2016   Boston Biomedical , an ... designed to target cancer stemness pathways, announced that ... Orphan Drug Designation from the U.S. Food and ... cancer, including gastroesophageal junction (GEJ) cancer. Napabucasin is ... inhibit cancer stemness pathways by targeting STAT3, and ...
(Date:6/23/2016)... 2016 Houston Methodist Willowbrook Hospital has ... Association to serve as their official health care ... Willowbrook will provide sponsorship support, athletic training services, ... coaches, volunteers, athletes and families. "We ... Association and to bring Houston Methodist quality services ...
Breaking Biology Technology: