Navigation Links
LCSB discovers endogenous antibiotic in the brain
Date:5/6/2013

Luxembourg, 6 May 2013 Scientists from the Luxembourg Centre for Systems Biomedicine (LCSB) of the University of Luxembourg have discovered that immune cells in the brain can produce a substance that prevents bacterial growth: namely itaconic acid. Until now, biologists had assumed that only certain fungi produced itaconic acid. A team working with Dr. Karsten Hiller, head of the Metabolomics Group at LCSB, and Dr. Alessandro Michelucci has now shown that even so-called microglial cells in mammals are also capable of producing this acid. "This is a ground breaking result," says Prof. Dr. Rudi Balling, director of LCSB: "It is the first proof of an endogenous antibiotic in the brain." The researchers have now published their results in the prestigious scientific journal PNAS.

Alessandro Michelucci is a cellular biologist, with focus on neurosciences. This is an ideal combination for LCSB with its focus on neurodegenerative diseases, and Parkinson's disease especially i.e. changes in the cells of the human nervous system. "Little is still known about the immune responses of the brain," says Michelucci.

"However, because we suspect there are connections between the immune system and Parkinson's disease, we want to find out what happens in the brain when we trigger an immune response there." For this purpose, Michelucci brought cell cultures of microglial cells, the immune cells in the brain, into contact with specific constituents of bacterial membranes. The microglial cells exhibited a response and produced a cocktail of metabolic products.

This cocktail was subsequently analysed by Karsten Hillers metabolomics group. Upon closer examination, the scientists discovered that production of one substance in particular - itaconic acid - was upregulated. "Itaconic acid plays a central role in the plastics production. Industrial bioreactors use fungi to mass-produce it," says

Hiller: "The realisation that mammalian cells synthesise itaconic acid
'/>"/>

Contact: karsten.hiller@uni.lu
karsten.hiller@uni.lu
352-466-644-6136
University of Luxembourg
Source:Eurekalert

Page: 1 2

Related biology news :

1. Team discovers how bacteria resist a Trojan horse antibiotic
2. Study discovers genetic pathway impacting the spread of cancer cells
3. NOAA discovers way to detect low-level exposure to seafood toxin in marine animals
4. New study discovers powerful function of single protein that controls neurotransmission
5. La Jolla Institute scientist discovers key step in immune system-fueled inflammation
6. NUS-led research team discovers how bacteria sense salt stress
7. Team discovers how western corn rootworm resists crop rotation
8. Team discovers reason that male moths can keep finding females
9. Study in mice discovers injection of heat-generating cells reduces belly fat
10. CSHL-led team discovers new way in which plants control flower production
11. International team discovers likely basis of birth defect causing premature skull closure in infants
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/11/2014)... DUBLIN , Dec. 09, 2014 Research ... http://photos.prnewswire.com/prnh/20130307/600769 ( http://www.researchandmarkets.com/research/twhjll/biometrics_market ) ... Market in the APAC Region 2015-2019"  report to ... emerging in this market is advances in technology. ... to upgrade biometric solutions to the latest standard ...
(Date:12/10/2014)... , Dec. 8, 2014 You,ve been here before: ... but can,t remember your password, site key or the answer ... your first grade teacher? Today, Hoyos ... app that will finally put an end to the ... 1U TM . 1U leverages a user,s smartphone to ...
(Date:12/10/2014)... 08, 2014 Research and Markets ... the "Biometrics Market in Japan 2014-2018" ... http://photos.prnewswire.com/prnh/20130307/600769 The integration of ... rural banking and upgradation of the driver,s license ... the market. Besides the aforementioned projects, biometrics is ...
Breaking Biology News(10 mins):Biometrics Market in the APAC Region 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 3Biometrics Market in Japan 2014-2018: Key Vendors are DDS, Fujitsu, Hitachi and NEC 2
... German . Toxins from Bacillus thuringiensis ... conventional farming to manage pest insects. Sprayed as pesticides or ... in pest control since 1938, minimize herbivory in crops, such ... producing transgenic crops have been grown, which successfully control pests ...
... at the San Diego Supercomputer Center (SDSC) and ... (Calit2) at the University of California, San Diego, ... from the National Science Foundation (NSF) to create ... will develop new tools to help manage ever-growing ...
... 18, 2011 Acclaimed UC Irvine geneticist Francisco J. Ayala, ... and evolution, will donate $10 million to the School of ... faculty member, will be funded with profits from flourishing vineyards ... things, you should do them," said the University Professor and ...
Cached Biology News:New bacteria toxins against resistant insect pests 2SDSC, Calit2 awarded $1.4 million NSF grant for new bioinformatics tools 2SDSC, Calit2 awarded $1.4 million NSF grant for new bioinformatics tools 3Francisco J. Ayala gives $10 million to UCI, largest gift ever by campus faculty member 2
(Date:12/17/2014)... (PRWEB) December 17, 2014 Xeno ... Excellence following its most recent COLA inspection. Xeno ... COLA, a national healthcare accreditation organization. Accreditation is ... of quality in day-to-day operations, demonstrate continued accuracy ... a rigorous on-site laboratory survey. , ...
(Date:12/17/2014)... 16, 2014  Vermillion, Inc. (NASDAQ: VRML ... today announced the next step in its expanded strategy ... provider with the naming of current Chief Operating Officer, ... Officer, while current Chairman of the Board and CEO ... Chairman. These changes are effective January 1, 2015. ...
(Date:12/17/2014)... Calif. , Dec. 17, 2014 ... a Phase 2 study evaluating the investigational oral ... of patients with severe, chronic itch who are ... of care, including topical steroids and antihistamines. ... change in Visual Analog Scale (VAS) itch score ...
(Date:12/15/2014)... & PETACH TIKVAH, Israel , Dec. ... BCLI ), a leading developer of adult stem ... subsidiary Brainstorm Cell Therapeutics Ltd. was awarded a grant ... Office of the Chief Scientist (OCS).  This is ... of grant support from the Office of the Chief ...
Breaking Biology Technology:Xeno Diagnostics Receives 3rd Award for Laboratory Excellence 2Vermillion Names Valerie Palmieri CEO; James LaFrance to continue as Chairman of Board 2Vermillion Names Valerie Palmieri CEO; James LaFrance to continue as Chairman of Board 3Vermillion Names Valerie Palmieri CEO; James LaFrance to continue as Chairman of Board 4Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 2Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 3Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 4BrainStorm Receives $1,100,000 for its 8th Annual Non-Dilutive Grant from Israel's Chief Scientist Office 2BrainStorm Receives $1,100,000 for its 8th Annual Non-Dilutive Grant from Israel's Chief Scientist Office 3
... Reports Financial Results for the 12 Months Ended December ... A/S,(OMX: GEN) announced today results for the financial year ... (approximately USD 104 million) compared to,DKK 136 million (approximately ... of DKK 437 million (approximately USD 86 million).,This compares ...
... (OTC Bulletin Board: IMYN), a biotechnology firm that ... to,the biopharmaceutical SF-1019, has announced its results for ... the year ended December 31, 2007, the company ... in interest expense which,was funded from advances by ...
... Elbit Imaging Ltd.,(Nasdaq: EMITF ) ("EI" or ... year 2007., Transition to IFRS, Through ... been,prepared in accordance with generally accepted accounting principles ... provisions of Standard 29 of the Israeli,Accounting Standard ...
Cached Biology Technology:Genmab Announces Year End 2007 Financial Results 2Genmab Announces Year End 2007 Financial Results 3Genmab Announces Year End 2007 Financial Results 4Genmab Announces Year End 2007 Financial Results 5Immunosyn Corporation Announces 2007 Results, Files 10KSB 2Immunosyn Corporation Announces 2007 Results, Files 10KSB 3Elbit Imaging Ltd. Announces Results For Fiscal Year 2007 2Elbit Imaging Ltd. Announces Results For Fiscal Year 2007 3Elbit Imaging Ltd. Announces Results For Fiscal Year 2007 4Elbit Imaging Ltd. Announces Results For Fiscal Year 2007 5Elbit Imaging Ltd. Announces Results For Fiscal Year 2007 6Elbit Imaging Ltd. Announces Results For Fiscal Year 2007 7Elbit Imaging Ltd. Announces Results For Fiscal Year 2007 8Elbit Imaging Ltd. Announces Results For Fiscal Year 2007 9Elbit Imaging Ltd. Announces Results For Fiscal Year 2007 10Elbit Imaging Ltd. Announces Results For Fiscal Year 2007 11Elbit Imaging Ltd. Announces Results For Fiscal Year 2007 12Elbit Imaging Ltd. Announces Results For Fiscal Year 2007 13Elbit Imaging Ltd. Announces Results For Fiscal Year 2007 14Elbit Imaging Ltd. Announces Results For Fiscal Year 2007 15Elbit Imaging Ltd. Announces Results For Fiscal Year 2007 16
Request Info...
Prepared by multi-temperature ethanol fractionation with extensive charcoal treatment and dialysis.• Assay: ≥ 95 % (HPCE)• pH ~5.2 (10 mg/mL in 0.15 M NaCl)...
Collected from animals that are 16 to 18 months old. Sterile, Cell culture tested, ID clarifier: USA Origin...
Contact us for more information...
Biology Products: