Navigation Links
LCSB discovers endogenous antibiotic in the brain
Date:5/6/2013

Luxembourg, 6 May 2013 Scientists from the Luxembourg Centre for Systems Biomedicine (LCSB) of the University of Luxembourg have discovered that immune cells in the brain can produce a substance that prevents bacterial growth: namely itaconic acid. Until now, biologists had assumed that only certain fungi produced itaconic acid. A team working with Dr. Karsten Hiller, head of the Metabolomics Group at LCSB, and Dr. Alessandro Michelucci has now shown that even so-called microglial cells in mammals are also capable of producing this acid. "This is a ground breaking result," says Prof. Dr. Rudi Balling, director of LCSB: "It is the first proof of an endogenous antibiotic in the brain." The researchers have now published their results in the prestigious scientific journal PNAS.

Alessandro Michelucci is a cellular biologist, with focus on neurosciences. This is an ideal combination for LCSB with its focus on neurodegenerative diseases, and Parkinson's disease especially i.e. changes in the cells of the human nervous system. "Little is still known about the immune responses of the brain," says Michelucci.

"However, because we suspect there are connections between the immune system and Parkinson's disease, we want to find out what happens in the brain when we trigger an immune response there." For this purpose, Michelucci brought cell cultures of microglial cells, the immune cells in the brain, into contact with specific constituents of bacterial membranes. The microglial cells exhibited a response and produced a cocktail of metabolic products.

This cocktail was subsequently analysed by Karsten Hillers metabolomics group. Upon closer examination, the scientists discovered that production of one substance in particular - itaconic acid - was upregulated. "Itaconic acid plays a central role in the plastics production. Industrial bioreactors use fungi to mass-produce it," says

Hiller: "The realisation that mammalian cells synthesise itaconic acid
'/>"/>

Contact: karsten.hiller@uni.lu
karsten.hiller@uni.lu
352-466-644-6136
University of Luxembourg
Source:Eurekalert

Page: 1 2

Related biology news :

1. Team discovers how bacteria resist a Trojan horse antibiotic
2. Study discovers genetic pathway impacting the spread of cancer cells
3. NOAA discovers way to detect low-level exposure to seafood toxin in marine animals
4. New study discovers powerful function of single protein that controls neurotransmission
5. La Jolla Institute scientist discovers key step in immune system-fueled inflammation
6. NUS-led research team discovers how bacteria sense salt stress
7. Team discovers how western corn rootworm resists crop rotation
8. Team discovers reason that male moths can keep finding females
9. Study in mice discovers injection of heat-generating cells reduces belly fat
10. CSHL-led team discovers new way in which plants control flower production
11. International team discovers likely basis of birth defect causing premature skull closure in infants
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/11/2015)... 2015   The Sync Project™ today ... measure and harness music to improve health. The ... objective measurements of physiology, enabling the study of ... large populations. It is designed for medical and ... rigorous studies and accelerate the discovery of the ...
(Date:3/10/2015)... , March 10, 2015 ... "Personalized Medicine in Human Space Flight" ... Thomas J. Goodwin , Ph.D. was recently featured ... the past two years. Specifically, "Personalized Medicine ... downloaded scientific papers published in 2013 and 2014 from ...
(Date:3/10/2015)... OXFORD, Conn. , March 10, 2015 /PRNewswire/ ... NXTDW) ("NXT-ID" or the "Company"), a biometric authentication ... reports the company,s Wocket™ smart wallet has been ... 2015" by Rethink Modern. Rethink Modern ... sharing modern and innovative items for your home and lifestyle that ...
Breaking Biology News(10 mins):Introducing The Sync Project, a Global Collaboration Harnessing the Scientific Potential of Music for Health 2Introducing The Sync Project, a Global Collaboration Harnessing the Scientific Potential of Music for Health 3"Personalized Medicine in Human Space Flight" Listed Among Most Influential Papers of 2013 and 2014 2NXT-ID's Wocket Smart Wallet Named Number One Best Tech Gift for 2015 by Rethink Modern 2NXT-ID's Wocket Smart Wallet Named Number One Best Tech Gift for 2015 by Rethink Modern 3NXT-ID's Wocket Smart Wallet Named Number One Best Tech Gift for 2015 by Rethink Modern 4
... and Building Media Inc. (BMI), a DuPont subsidiary, will ... help dramatically improve the energy efficiency of American homes ... 15 teams, appointed by the U.S. Department of Energy ... million for the initial 18 months to deliver innovative ...
... flu are common occurrences during pregnancy, and research has ... flu, viruses and other infections during pregnancy have about ... A new study out of Temple University examines what,s ... month in Schizophrenia Research , Temple University psychologist ...
... University researchers conducting zooarchaeological and archaeometric analyses of four ... Project in northeastern Ethiopia within walking distance of ... afarensis ) confirm that unusual marks on the ... in on findings reported in the Aug. 12 journal ...
Cached Biology News:NJIT to help lead public/private partnership to develop high-efficiency homes 2Immune responses during pregnancy linked to schizophrenia among offspring 2Immune responses during pregnancy linked to schizophrenia among offspring 3Animal bone markings show evidence that 'Lucy' species used stone tools, ate meat 2Animal bone markings show evidence that 'Lucy' species used stone tools, ate meat 3Animal bone markings show evidence that 'Lucy' species used stone tools, ate meat 4
(Date:3/27/2015)... 2015 The consumption of compound fertilizers ... recession and high prices in 2008. However, the situation ... keeps on gaining momentum now. , To date, the ... than 100,000 thousand tonnes. No considerable growth was registered ... capacity rocketed during 2012-2013, registering 11% growth as against ...
(Date:3/27/2015)... , March 27, 2015 Working ... Free Hospital in London , Richmond Pharmacology ... a global Phase 3 study for an investigational RNAi therapeutic ... orphan disease affecting the nerves and heart. ... Detail Based at St Georges University of ...
(Date:3/26/2015)... PRC Clinical, a Silicon-Valley based contract ... executive appointments effective immediately. , Mike Catelani will assume ... of the Board of Directors. Daniel Head is appointed ... will assume the position of Senior Director of Clinical ... (COO), has been appointed to the position of President ...
(Date:3/26/2015)... Neogen Corporation (NASDAQ: NEOG ) announced today that ... 2015, which ended Feb. 28, increased 13% to $7,454,000, ... share in the current quarter were $0.20, compared to ... 17% over prior year to $24,142,000, or $0.65 per ... the same period a year ago. Revenues ...
Breaking Biology Technology:World NPK Fertilizers Market Keeps On Gaining Momentum, According to BAC Reports Study Available at MarketPublishers.com 2World NPK Fertilizers Market Keeps On Gaining Momentum, According to BAC Reports Study Available at MarketPublishers.com 3PRC Clinical Announces Key Management Appointments and Launches East Coast Operations 2PRC Clinical Announces Key Management Appointments and Launches East Coast Operations 3Neogen reports 13% increase in net income 2Neogen reports 13% increase in net income 3Neogen reports 13% increase in net income 4Neogen reports 13% increase in net income 5Neogen reports 13% increase in net income 6Neogen reports 13% increase in net income 7Neogen reports 13% increase in net income 8
... Corporation, a,subsidiary of KV Pharmaceutical (NYSE: KVa/KVb), is ... January 26, 2009, a nationwide,voluntary recall of the ... at a wholesale or a retail level as ... under conditions that did not,sufficiently comply with current ...
... Scientific business of Thomson Reuters today announced the results ... of scientific research output continues to shrink while Asia-Pacific,s ... a healthy footing globally in the relative impact of ... Watch , Thomson Reuters analyzes 12 year,s worth of ...
... 28 Medarex, Inc. (Nasdaq: MEDX ) ... (IND) application filed with the U.S. Food & Drug ... (ADC) candidate generated from its proprietary technology. MDX-1203 is ... a fully human anti-CD70 antibody. CD70 is expressed in ...
Cached Biology Technology:ETHEX Corporation Issues Nationwide Voluntary Recall of Products 2ETHEX Corporation Issues Nationwide Voluntary Recall of Products 3ETHEX Corporation Issues Nationwide Voluntary Recall of Products 4ETHEX Corporation Issues Nationwide Voluntary Recall of Products 5ETHEX Corporation Issues Nationwide Voluntary Recall of Products 6Despite Decline in Share of Global Output, U.S. Science Impact Still Strong, Says Thomson Reuters 2Medarex Announces Allowance of Investigational New Drug Application for Company's First Antibody-Drug Conjugate, MDX-1203 2Medarex Announces Allowance of Investigational New Drug Application for Company's First Antibody-Drug Conjugate, MDX-1203 3
... 20 cm, is used for vertical slab gel ... gels. The cell is supplied without spacers and ... with gaskets, lower buffer chamber, lid with cables, ... upper buffer dam, casting stand with gaskets, leveling ...
CleanCut agarose is used to prepare genomic DNA plugs for use in pulsed field gel electrophoresis (PFGE) applications. Supplied as a 12 ml solution of 2% agarose....
... groove-binding probe for DNA. Binds to the ... AT rich DNA), forming a stable complex ... DAPI alone. DAPI is several times more ... in agarose gels. It may be used ...
...
Biology Products: