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LA BioMed's Dr. John Torday examines evolution from a cellular perspective
Date:1/25/2012

that metabolic cellular cooperativity is the central evolutionary mechanism being selected for. By examining the Gene Regulatory Networks (GRNs) that mediate these processes, the mechanisms underlying the evolution of a particular group of organisms (phylogeny) using the developmental history of an individual organism (ontogeny) can be leveraged, and visa versa, filling in the missing links using a mathematical algorithm like the Periodic Table.

The power of this novel approach is exemplified by focusing on GRNs that mediate cell-cell communication common to both ontogeny and phylogeny (independent of time), merging them into one common data set to determine the ultimate physiologic principles. The concept of cell-cell communication spans all of biology, from its initial conditions to preventive medicine. Evolutionary Biology will clarify this perspective, providing insights to experimental evolution.

In addition to being a lead investigator at LA BioMed, Dr. Torday is a Professor of Pediatrics and Obstetrics/Gynecology at the David Geffen School of Medicine at UCLA. He is a pioneer in the field of developmental lung biology, with current research interests in the developmental/phylogenetic origins of lung cell phenotypic heterogeneity and the gene regulatory network determinants of lung evolution. He is particularly interested in using evolutionary biology of the lung as an approach to clinical diagnosis and treatment of chronic lung disease, and as a prototype for predictive and preventive medicine.


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Contact: Diana Soltesz
diana@dsmmedia.com
818-592-6747
Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center (LA BioMed)
Source:Eurekalert

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