Navigation Links
LA BioMed's Dr. John Torday examines evolution from a cellular perspective

LOS ANGELES (Jan. 25, 2012) The evolutionary processes of unicellular and multicellular organisms are continually under debate. John Torday, Ph.D., a lead investigator at Los Angeles Biomedical Research Institute (LA BioMed), has recently co-authored a book entitled Evolutionary Biology, Cell-Cell Communication and Complex Disease, which incorporates cell biology into evolutionary biology. Rather than focusing on multicellular organisms, the book concentrates on the cell as the smallest unit of biologic structure and function. This is the first time that evolution has been looked at from the cellular mechanistic perspective, making evolution more accessible and relevant to all of biology and medicine.

According to Dr. Torday, "Understanding evolutionary biology is key to integrating biology. To accomplish this, we need a mechanism for the process of Natural Selection that explains how novelty in vertebrate evolution is generated, how selection pressure has made wings from limbs, lungs from swim bladders, and integrated physiologic regulatory mechanisms like lipid metabolism and respiration, photoreception and circadian rhythms, water balance and erythropoiesis," said Dr. Torday. "Evolutionary-developmental biology provides an opportunity to exploit contemporary cell-molecular developmental biology, yet it has not been used effectively because we don't have an algorithm to convert genes into phenotypes. That leaves a huge gap in evolutionary biology that must be filled to provide plausible answers for how evolution has generated physiologic phenotypes. Since cells generate phenotypes from genes, this is a logical way to understanding evolution that's been 'trumped' by our zeal to reduce everything in biology to genes. Evolution, like cell biology, is a process, not a thing."

Evolutionary Biology, Cell-Cell Communication and Complex Disease is focused on the scientific evidence that unicellular organisms are the origins of metazoans, and that metabolic cellular cooperativity is the central evolutionary mechanism being selected for. By examining the Gene Regulatory Networks (GRNs) that mediate these processes, the mechanisms underlying the evolution of a particular group of organisms (phylogeny) using the developmental history of an individual organism (ontogeny) can be leveraged, and visa versa, filling in the missing links using a mathematical algorithm like the Periodic Table.

The power of this novel approach is exemplified by focusing on GRNs that mediate cell-cell communication common to both ontogeny and phylogeny (independent of time), merging them into one common data set to determine the ultimate physiologic principles. The concept of cell-cell communication spans all of biology, from its initial conditions to preventive medicine. Evolutionary Biology will clarify this perspective, providing insights to experimental evolution.

In addition to being a lead investigator at LA BioMed, Dr. Torday is a Professor of Pediatrics and Obstetrics/Gynecology at the David Geffen School of Medicine at UCLA. He is a pioneer in the field of developmental lung biology, with current research interests in the developmental/phylogenetic origins of lung cell phenotypic heterogeneity and the gene regulatory network determinants of lung evolution. He is particularly interested in using evolutionary biology of the lung as an approach to clinical diagnosis and treatment of chronic lung disease, and as a prototype for predictive and preventive medicine.


Contact: Diana Soltesz
Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center (LA BioMed)

Related biology news :

1. Study examines how diving marine mammals manage decompression
2. Rutgers-Camden researcher examines how the brain perceives shades of gray
3. New NJIT book examines hemophilia and consequences of medical progress
4. Book examines how trees change as they age and grow: What do these clues tell us?
5. Research examines how to apply conductive nanocoatings to textiles
6. Study examines folic acid absorption rates from softgel capsule and standard tablet
7. K-State doctoral graduate examines food bioterrorism for dissertation
8. New study examines immunity in emerging species of a major mosquito carrer of malaria
9. New book examines health and environmental impacts of common (and not-so-common) chemicals
10. Study examines risk of heterosexual HIV transmission in China
11. Physicist examines game theory on microbial level as part of UH Tenneco lecture series
Post Your Comments:
(Date:11/12/2015)... Nov. 12, 2015  Arxspan has entered into ... and Harvard for use of its ArxLab cloud-based ... tools. The partnership will support the institute,s efforts ... chemical research information internally and with external collaborators. ... for managing the Institute,s electronic laboratory notebook, compound ...
(Date:11/9/2015)... DUBLIN , Nov. 09, 2015 /PRNewswire/ ... announced the addition of the "Global ... to their offering. --> ... "Global Law Enforcement Biometrics Market 2015-2019" ... Research and Markets ( ) ...
(Date:10/29/2015)... 2015  The J. Craig Venter Institute (JCVI) policy ... and Biosecurity: Lessons Learned and Options for the Future," ... Human Services guidance for synthetic biology providers has worked ... --> --> Synthetic biology promises ... to pose unique biosecurity threats. It now is easier ...
Breaking Biology News(10 mins):
(Date:11/30/2015)... ... 2015 , ... Imagine Exhibitions and Universal Partnerships & Licensing ... March 2016 at Melbourne Museum in Melbourne, Australia. Immediately following the Australia premiere, ... dates. The Exhibition is based on Universal Pictures’ Jurassic World, one of the ...
(Date:11/30/2015)... SAN DIEGO , Nov. 30, 2015 ... today that the company has acquired Cypher Genomics, Inc., ... and robust human genomic interpretation software solutions. The ... who will join HLI including Cypher CEO and Co-founder, ... head of HLI,s Pediatric Business.  Financial details of the ...
(Date:11/30/2015)... DIEGO , Nov. 30, 2015  HUYA Bioscience ... China,s pharmaceutical innovations, today announced it ... Drug Development Fund (KDDF) to foster collaboration between KDDF ... development and commercialization of healthcare products for the global ... as an important source of new innovative preclinical and ...
(Date:11/30/2015)... Ill. , Nov. 30, 2015  AbbVie, is ... program that focuses on a daily routine for managing ... take their medication can affect the way the body ... follow to their a daily routine are important. The ... to help patients better manage their hypothyroidism by establishing ...
Breaking Biology Technology: