Navigation Links
LA BioMed's Dr. John Torday examines evolution from a cellular perspective
Date:1/25/2012

LOS ANGELES (Jan. 25, 2012) The evolutionary processes of unicellular and multicellular organisms are continually under debate. John Torday, Ph.D., a lead investigator at Los Angeles Biomedical Research Institute (LA BioMed), has recently co-authored a book entitled Evolutionary Biology, Cell-Cell Communication and Complex Disease, which incorporates cell biology into evolutionary biology. Rather than focusing on multicellular organisms, the book concentrates on the cell as the smallest unit of biologic structure and function. This is the first time that evolution has been looked at from the cellular mechanistic perspective, making evolution more accessible and relevant to all of biology and medicine.

According to Dr. Torday, "Understanding evolutionary biology is key to integrating biology. To accomplish this, we need a mechanism for the process of Natural Selection that explains how novelty in vertebrate evolution is generated, how selection pressure has made wings from limbs, lungs from swim bladders, and integrated physiologic regulatory mechanisms like lipid metabolism and respiration, photoreception and circadian rhythms, water balance and erythropoiesis," said Dr. Torday. "Evolutionary-developmental biology provides an opportunity to exploit contemporary cell-molecular developmental biology, yet it has not been used effectively because we don't have an algorithm to convert genes into phenotypes. That leaves a huge gap in evolutionary biology that must be filled to provide plausible answers for how evolution has generated physiologic phenotypes. Since cells generate phenotypes from genes, this is a logical way to understanding evolution that's been 'trumped' by our zeal to reduce everything in biology to genes. Evolution, like cell biology, is a process, not a thing."

Evolutionary Biology, Cell-Cell Communication and Complex Disease is focused on the scientific evidence that unicellular organisms are the origins of metazoans, and that metabolic cellular cooperativity is the central evolutionary mechanism being selected for. By examining the Gene Regulatory Networks (GRNs) that mediate these processes, the mechanisms underlying the evolution of a particular group of organisms (phylogeny) using the developmental history of an individual organism (ontogeny) can be leveraged, and visa versa, filling in the missing links using a mathematical algorithm like the Periodic Table.

The power of this novel approach is exemplified by focusing on GRNs that mediate cell-cell communication common to both ontogeny and phylogeny (independent of time), merging them into one common data set to determine the ultimate physiologic principles. The concept of cell-cell communication spans all of biology, from its initial conditions to preventive medicine. Evolutionary Biology will clarify this perspective, providing insights to experimental evolution.

In addition to being a lead investigator at LA BioMed, Dr. Torday is a Professor of Pediatrics and Obstetrics/Gynecology at the David Geffen School of Medicine at UCLA. He is a pioneer in the field of developmental lung biology, with current research interests in the developmental/phylogenetic origins of lung cell phenotypic heterogeneity and the gene regulatory network determinants of lung evolution. He is particularly interested in using evolutionary biology of the lung as an approach to clinical diagnosis and treatment of chronic lung disease, and as a prototype for predictive and preventive medicine.


'/>"/>

Contact: Diana Soltesz
diana@dsmmedia.com
818-592-6747
Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center (LA BioMed)
Source:Eurekalert

Related biology news :

1. Study examines how diving marine mammals manage decompression
2. Rutgers-Camden researcher examines how the brain perceives shades of gray
3. New NJIT book examines hemophilia and consequences of medical progress
4. Book examines how trees change as they age and grow: What do these clues tell us?
5. Research examines how to apply conductive nanocoatings to textiles
6. Study examines folic acid absorption rates from softgel capsule and standard tablet
7. K-State doctoral graduate examines food bioterrorism for dissertation
8. New study examines immunity in emerging species of a major mosquito carrer of malaria
9. New book examines health and environmental impacts of common (and not-so-common) chemicals
10. Study examines risk of heterosexual HIV transmission in China
11. Physicist examines game theory on microbial level as part of UH Tenneco lecture series
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/16/2016)...   EyeLock LLC , a market leader of ... an IoT Center of Excellence in Austin, ... of embedded iris biometric applications. EyeLock,s iris ... security with unmatched biometric accuracy, making it the most ... EyeLock,s platform uses video technology to deliver a fast ...
(Date:4/28/2016)... BANGALORE, India , April 28, 2016 ... of Infosys (NYSE: INFY ), and Samsung SDS, ... partnership that will provide end customers with a more ... payment services.      (Logo: http://photos.prnewswire.com/prnh/20130122/589162 ) ... financial services, but it also plays a fundamental part in ...
(Date:4/19/2016)... The new GEZE SecuLogic access ... "all-in-one" system solution for all door components. It can ... door interface with integration authorization management system, and thus ... minimal dimensions of the access control and the optimum ... offer considerable freedom of design with regard to the ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... ... June 27, 2016 , ... Newly created 4Sight Medical ... to the healthcare market. The company's primary focus is on new product introductions, ... strategies that are necessary to help companies efficiently bring their products to market. ...
(Date:6/24/2016)... on a range of subjects including policies, debt and investment ... Speaking at a lecture to the Canadian Economics ... the country,s inflation target, which is set by both the ... "In certain areas there needs to be frequent ... not sit down and address strategy together?" He ...
(Date:6/23/2016)... ... June 23, 2016 , ... ... of its second eBook, “Clinical Trials Patient Recruitment and Retention Tips.” Partnering with ... in this eBook by providing practical tips, tools, and strategies for clinical researchers. ...
(Date:6/23/2016)... Md. , June 23, 2016 A person ... from the crime scene to track the criminal down. ... the U.S. Food and Drug Administration (FDA) uses DNA evidence ... Sound far-fetched? It,s not. The FDA ... sequencing to support investigations of foodborne illnesses. Put as simply ...
Breaking Biology Technology: