Navigation Links
Krumlauf Lab demonstrates modulation of gene expression by protein coding regions
Date:12/23/2008

A research team at the Stowers Institute has discovered how the expression of one of the Hox master control genes is regulated in a specific segment of the developing brain. The findings provide important insight into how and where the brain develops some of its unique and important structures.

The findings were posted to the online Early Edition of the Proceedings of the National Academy of Science today.

The team led by Robb Krumlauf and Leanne Wiedemann set out to understand the "instruction manual" for a Hox gene that tells the early brain which genes to turn on and in what order, to specify critical regions of the adult brain. Their studies discovered how expression of the key regulatory protein, encoded by the Hoxa2 gene, is controlled. Surprisingly, the DNA sequence that contains the instructions about when and where to express Hoxa2 in a segment of the developing brain overlaps with sequences that code for amino acids of the Hoxa2 protein.

"In the mammalian genome, sequences that encode proteins and those that control gene expression are usually separate from each other," explained Robb Krumlauf, Ph.D., Scientific Director. "Most approaches to the identification of DNA elements that control gene expression utilize methods that exclude protein coding domains. Our group has now discovered that protein coding regions can also play a role in modulating gene expression. This work has important implications for identifying the regulatory logic contained in mammalian genomes."

"Our findings provide important insight into the regulation of the formation of the anterior hindbrain," said Leanne Wiedemann, Ph.D., a co-investigator in the Krumlauf Lab and senior author on the publication. "Additionally, because we now understand that regulatory input from coding regions needs to be considered, our findings have broader implications in helping to design tests and interpret data from large-scale analyses of gene regu
'/>"/>

Contact: Marie Jennings
mfj@stowers-institute.org
816-926-4015
Stowers Institute for Medical Research
Source:Eurekalert

Page: 1 2

Related biology news :

1. Geron Demonstrates hESC-derived cardiomyocytes improve heart function after myocardial infarction
2. Stowers Institutes Xie Lab demonstrates dual intrinsic and extrinsic control of stem cell aging
3. Pourquie Lab demonstrates role of growth factor in vertebrae formation
4. JDRF-funded clinical trial demonstrates continuous glucose monitoring improves blood sugar control
5. Experiment demonstrates 110 years of sustainable agriculture
6. Nature study demonstrates that bacterial clotting depends on clustering
7. Tolerance to inhalants may be caused by changes in gene expression
8. Unique pattern of gene expression can indicate acetaminophen overdose
9. Powerful integration of lipid metabolic profiling with gene expression analysis
10. Gene-environment interaction in yeast gene expression
11. Scientists discover small RNAs that regulate gene expression and protect the genome
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/20/2015)... Conn. , March 20, 2015 NXT-ID, ... a biometric authentication company focused on the growing mobile ... smart wallet is one of the products featured in ... March 20th at 11:00 PM EST on the DIY ... to Las Vegas , site of ...
(Date:3/18/2015)... March 18, 2015 As mobile payments ... revolutionary smart wallets and apps continue to be introduced into ... in the mobile payment industry in focus today are:  NXT-ID, ... (NYSE: BABA ), Apple Inc. (NASDAQ: ... Facebook Inc. (NASDAQ: FB ) NXT-ID, ...
(Date:3/17/2015)... NEW YORK , March 17, 2015 /PRNewswire/ ... , the largest exhibition for service robots ever ... . RoboUniverse takes place on May 11-13, 2015 ... Sponsors and exhibitors for the event include: Acorn ... Motion Control; EZ-Robot; Infranor; Kinova Robotics; Littler; NewBotic ...
Breaking Biology News(10 mins):NXT-ID's Wocket Biometric Smart Wallet to Air on "I Want That" International CES Special 2NXT-ID's Wocket Biometric Smart Wallet to Air on "I Want That" International CES Special 3Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 2Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 3Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 4Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 5Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 6MecklerMedia's RoboUniverse New York Announces Sponsors and Exhibitors, May 11-13, 2015 2
... This press release is available in ... have found that unmanned aerial vehicles (UAVs), a tool used ... on changing land-use patterns across vast tracts of western rangeland. ... to survey vast, remote rangelands to see how they are ...
... sorghum hybrid that does not flower and accumulates as much ... may help the bioenergy industry, according to a study appearing ... Sciences. A team at Texas AgriLife Research has ... proceedings. "For energy crops, we want to prevent plants ...
... DigitalPersona, Inc. , a global provider of ... portfolio of fingerprint biometric Civil ID solutions ... Tampa, Fla. Supported by the National Institute of Standards ... the Biometric Consortium Conference is focused on biometric technologies ...
Cached Biology News:A labor saving way to monitor vast rangelands 2Gene controlling flowering boosts energy production from sorghum 2Gene controlling flowering boosts energy production from sorghum 3DigitalPersona Showcases Fingerprint Biometrics for Civil ID Applications at the Biometric Consortium Conference 2DigitalPersona Showcases Fingerprint Biometrics for Civil ID Applications at the Biometric Consortium Conference 3
(Date:4/16/2015)... 2015 /CNW/ - Bioenterprise Corporation is pleased to announce that ... Charlottetown , PEI.  Bioenterprise has established a ... Council for the commercialization of agricultural technologies and innovations. ... PEI ADAPT.  They have been at the heart of ... explains Dave Smardon , President & CEO of ...
(Date:4/16/2015)... DIEGO , April 16, 2015  AnaptysBio, ... development of therapeutic antibodies, today announced the ... antibody program into IND-enabling studies. The Company,s ... novel treatment for generalized pustular psoriasis (GPP), ... unmet medical need. ANB019 is wholly owned within ...
(Date:4/16/2015)... 2015  EMD Serono today announced the US ... Germany , appointed Alise Reicin , ... Clinical Development.  Dr. Reicin brings extensive research and ... and Immunology. She is an accomplished pharmaceutical executive ... Vice President in various capacities across R&D at ...
(Date:4/16/2015)... 16, 2015 Fairleigh Dickinson University ... Gulfo to become the Executive Director of the ... announced the kick-off of the Initiative for Patient ... Dr. Gulfo, under the Rothman Institute of Innovation ... and in collaboration with FDU’s School of Pharmacy’s ...
Breaking Biology Technology:Bioenterprise Corporation Expands into the Maritimes 2AnaptysBio Advances First-In-Class Anti-IL-36 Receptor Antibody Program To Treat Orphan Inflammatory Disease 2Alise Reicin Joins the Biopharmaceutical Business of Merck KGaA, Darmstadt, Germany as Head of Global Clinical Development 2Alise Reicin Joins the Biopharmaceutical Business of Merck KGaA, Darmstadt, Germany as Head of Global Clinical Development 3Dr. Joseph V. Gulfo Named Executive Director of Fairleigh Dickinson University’s Rothman Institute to Spearhead New Initiative for Patient-Centered Innovation (iPCI) 2Dr. Joseph V. Gulfo Named Executive Director of Fairleigh Dickinson University’s Rothman Institute to Spearhead New Initiative for Patient-Centered Innovation (iPCI) 3
... DIEGO, Nov. 6 Halozyme Therapeutics, Inc.,(Nasdaq: ... targeting the extracellular matrix for the drug delivery,endocrinology, ... the three and nine months ended September 30, ... been stronger and I am,pleased with the initiation ...
... 6 /PRNewswire-FirstCall/ - Dr. Brad Thompson, President,and CEO of ... a,corporate overview of the Company at the Rodman & ... at 11:10 a.m. ET. The,event will be held at ... A live audio webcast of the presentation will ...
... Highlights:, * Submitted NDA with FDA for NGX-4010 for management of pain ... ... EMEA,s scheduled Day 120 questions regarding MAA under ... SAN MATEO, Calif., Nov. 6 NeurogesX, Inc.,(Nasdaq: NGSX ), a biopharmaceutical ...
Cached Biology Technology:Halozyme Therapeutics Reports 2008 Third Quarter Financial Results 2Halozyme Therapeutics Reports 2008 Third Quarter Financial Results 3Halozyme Therapeutics Reports 2008 Third Quarter Financial Results 4Halozyme Therapeutics Reports 2008 Third Quarter Financial Results 5Halozyme Therapeutics Reports 2008 Third Quarter Financial Results 6Halozyme Therapeutics Reports 2008 Third Quarter Financial Results 7Halozyme Therapeutics Reports 2008 Third Quarter Financial Results 8Media Advisory - Oncolytics Biotech Inc. to Present at Rodman & Renshaw 10th Annual Healthcare Conference 2NeurogesX Reports Third Quarter 2008 Results 2NeurogesX Reports Third Quarter 2008 Results 3NeurogesX Reports Third Quarter 2008 Results 4NeurogesX Reports Third Quarter 2008 Results 5NeurogesX Reports Third Quarter 2008 Results 6NeurogesX Reports Third Quarter 2008 Results 7NeurogesX Reports Third Quarter 2008 Results 8NeurogesX Reports Third Quarter 2008 Results 9
Required to perform reference file generation, flatfield calibration and performance verification processes on the GSD-501...
Applications: Immunohistochemistry, ISH, FISH, CISH....
Applications: Immunohistochemistry, ISH, FISH, CISH....
Polypropylene test tube racks, used in Thermo Forma's line of Test Tube Rack holders...
Biology Products: