Navigation Links
Krumlauf Lab demonstrates modulation of gene expression by protein coding regions
Date:12/23/2008

A research team at the Stowers Institute has discovered how the expression of one of the Hox master control genes is regulated in a specific segment of the developing brain. The findings provide important insight into how and where the brain develops some of its unique and important structures.

The findings were posted to the online Early Edition of the Proceedings of the National Academy of Science today.

The team led by Robb Krumlauf and Leanne Wiedemann set out to understand the "instruction manual" for a Hox gene that tells the early brain which genes to turn on and in what order, to specify critical regions of the adult brain. Their studies discovered how expression of the key regulatory protein, encoded by the Hoxa2 gene, is controlled. Surprisingly, the DNA sequence that contains the instructions about when and where to express Hoxa2 in a segment of the developing brain overlaps with sequences that code for amino acids of the Hoxa2 protein.

"In the mammalian genome, sequences that encode proteins and those that control gene expression are usually separate from each other," explained Robb Krumlauf, Ph.D., Scientific Director. "Most approaches to the identification of DNA elements that control gene expression utilize methods that exclude protein coding domains. Our group has now discovered that protein coding regions can also play a role in modulating gene expression. This work has important implications for identifying the regulatory logic contained in mammalian genomes."

"Our findings provide important insight into the regulation of the formation of the anterior hindbrain," said Leanne Wiedemann, Ph.D., a co-investigator in the Krumlauf Lab and senior author on the publication. "Additionally, because we now understand that regulatory input from coding regions needs to be considered, our findings have broader implications in helping to design tests and interpret data from large-scale analyses of gene regulation."

Expanding on this work, their lab will continue to dissect the regulatory networks and integrate the genes that play a role in hindbrain development using evolutionary comparisons, bioinformatics approaches, and experimental analyses.


'/>"/>

Contact: Marie Jennings
mfj@stowers-institute.org
816-926-4015
Stowers Institute for Medical Research
Source:Eurekalert

Related biology news :

1. Geron Demonstrates hESC-derived cardiomyocytes improve heart function after myocardial infarction
2. Stowers Institutes Xie Lab demonstrates dual intrinsic and extrinsic control of stem cell aging
3. Pourquie Lab demonstrates role of growth factor in vertebrae formation
4. JDRF-funded clinical trial demonstrates continuous glucose monitoring improves blood sugar control
5. Experiment demonstrates 110 years of sustainable agriculture
6. Nature study demonstrates that bacterial clotting depends on clustering
7. Tolerance to inhalants may be caused by changes in gene expression
8. Unique pattern of gene expression can indicate acetaminophen overdose
9. Powerful integration of lipid metabolic profiling with gene expression analysis
10. Gene-environment interaction in yeast gene expression
11. Scientists discover small RNAs that regulate gene expression and protect the genome
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/29/2016)... Nearly one billion matches per second with DERMALOG,s high-speed AFIS    ... ... DERMALOG is Germany's largest Multi-Biometric supplier: The company's ... Systems) ... largest Multi-Biometric supplier: The company's Fingerprint Identification System is part of an ...
(Date:11/22/2016)... 22, 2016   MedNet Solutions , an innovative ... of clinical research, is pleased to announce that the ... and Life Sciences Awards as "Most Outstanding in ... unprecedented year of recognition and growth for MedNet, which ... years. iMedNet ™ , MedNet,s ...
(Date:11/17/2016)... 17, 2016  AIC announces that it has just released a new white paper ... high-performance scale-out plus high speed data transfer storage solutions. Photo - ... ... ... Setting up a high performance computing or HPC ...
Breaking Biology News(10 mins):
(Date:12/4/2016)... ... December 02, 2016 , ... ... and -operated small businesses in federally funded research and development is welcome news ... for optics and photonics . , As part of the National Defense Authorization ...
(Date:12/4/2016)... SAN DIEGO , Dec. 3, 2016  In ... Society of Hematology (ASH) Annual Meeting and Exposition in ... advanced biomedical engineering methods to improve the delivery of ... conditions. These new methods are designed to carry therapies ... are needed most, which could provide a substantial advantage ...
(Date:12/2/2016)... ... 2016 , ... In anticipation of AxioMed’s exclusive cleanroom manufacturing ... President, Jake Lubinski will be traveling to Switzerland from December 5-10. Mr. Lubinski ... and Zurich to discuss the benefits of a viscoelastic disc. AxioMed received CE ...
(Date:12/2/2016)... -- The Multiple Myeloma Research Foundation (MMRF) today announced that ... —the largest and most comprehensive study driving new genomic ... presented at the 58 th American Society of ... San Diego from December 3-6. The new ... as identify pathways and targets for new drug development. ...
Breaking Biology Technology: