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'Knocking out' cell receptor may help block fat deposits in tissues, prevent weight gain
Date:10/25/2007

Although both groups of mice were fed the same low-fat diet, the LRP1 knockout mice stored less fat and experienced no significant weight gain.

This shows that LRP1 is a critical regulator of lipid absorption in fat cells. Functional disruption leads to fewer lipids being absorbed into the cells and transported throughout the body, explains Susanna Hofmann, first author of the study and pathology research instructor at UC. Preventing these interactions in our model prevented the onset of obesity and diabetes.

Because the genetically altered mice had smaller fat stores to provide warmth, muscular activity naturally increased to raise body temperature and may have also contributed to the lack of weight gain, Hui adds.

Prevailing scientific knowledge says that dietary factorsprimarily consumption of triglyceride-rich foods such as fried foodscontribute to obesity and diabetes. When energy intake surpasses energy expenditure, excess calories are deposited as fat in adipose tissue and cause people to gain weight.


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Contact: Amanda Harper
amanda.harper@uc.edu
513-659-6847
University of Cincinnati
Source:Eurekalert

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