Navigation Links
'Knocking out' cell receptor may help block fat deposits in tissues, prevent weight gain
Date:10/25/2007

CINCINNATIUniversity of Cincinnati (UC) pathologists have identified a new molecular target that one day may help scientists develop drugs to reduce fat transport to adipocytes (fat cells) in the body and prevent obesity and related disorders, like diabetes.

Detailed in the Oct. 18 online edition and the November 2007 print issue of the Journal of Clinical Investigation, the findings about a specific cell receptor, known as the adipocyte LDL receptor-related protein 1 (LRP1), provide important clues about the underlying biological mechanisms that control fat transport in the body.

Using genetically altered mice, David Hui, PhD, and his team demonstrated that knocking out the LRP1 in fat cells has a direct impact on how many lipids (fats and fat-like substances) are transferred and deposited to different tissues. Hui says the experimental mice gained less weight, stored less fat, tolerated glucose better and expended more energy (due to increased muscle activity) when compared with a control group.

This receptor is expressed in numerous tissues throughout the bodyincluding the heart, muscles, liver and vascular wallbut its specific functions in the different tissues are still relatively unknown, says Hui, corresponding author of the study and professor of pathology and laboratory medicine at UC. Our study has shown that this molecule directly impacts the rate of fat transport in the body, so with further study it could be a new target for drugs aimed at controlling obesity.

For the study, two independent groups of LPR1-knockout mice were developed: one studied by Hui and his team at UC, the second monitored by collaborator and co-senior author Joachim Herz, PhD, at the University of Texas Southwestern Medical Center.

Researchers discovered that when the LRP1 receptor was active, adipocytes absorbed more fat and triggered a series of cell-signaling activities that caused the body to increase overall fat storage.
'/>"/>

Contact: Amanda Harper
amanda.harper@uc.edu
513-659-6847
University of Cincinnati
Source:Eurekalert

Page: 1 2

Related biology news :

1. Knocking out survival protein could aid leukemia treatment
2. Activation of thermoreceptors mediates raw garlics burning pungency
3. Fox Chase study shows that weakened T-cell receptor signals change T-cell lineage
4. Small worm yields big clue on muscle receptor action
5. Evolution of taste receptor may have shaped human sensitivity to toxic compounds
6. Missing Receptor Molecule Causes Tumor Growth
7. Blocking the nerve receptor EP1 in mouse models reduces brain damage caused by stroke
8. Bats use touch receptors on wings to fly, catch prey, study finds
9. HIV accessory protein disables host immunity via receptor-protein intermediary
10. Manipulating single cell receptor alters animal behavior
11. Nano-keys bind cell receptors and trigger allergic reactions
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2014)... German . ... are fixated in a way so as to align ... and Fudan University researchers are planning on looking into ... findings are being published today in the scientific journal ... sensitive molecules. Everyone knows that at least from ...
(Date:8/22/2014)... strong antioxidants and can reduce free radical ... against oxidative stress? Jianbo Zhao and co-workers ... Medical University, China discovered that green tea ... neuronal apoptosis, indicating green tea polyphenols play ... under oxidative stress. The relevant study has ...
(Date:8/22/2014)... In 2015, American consumers will finally be able to ... Although touted as zero-emissions vehicles, most of the cars ... fossil fuel that contributes to global warming. , Now ... device that uses an ordinary AAA battery to produce ... electric current through two electrodes that split liquid water ...
Breaking Biology News(10 mins):Proteins: New class of materials discovered 2Stanford scientists develop a water splitter that runs on an ordinary AAA battery 2Stanford scientists develop a water splitter that runs on an ordinary AAA battery 3
... human genetics at Baylor College of Medicine, first published her ... starvation, sometimes resulting in a rare change that benefited the ... current issue of the journal Molecular Cell, she and her ... that this only occurs at a special time and place ...
... prediction. , Computers can predict the detailed structure of ... least some of the time, according to new studies ... which were reported in the September 16, 2005, issue ... that scientists eventually may be able to determine the ...
... led by University of California, San Diego biochemists has ... produce 10 trillion varieties of a single protein, a ... drugs. , In the September 18 advance on-line publication ... researchers describe the mechanism by which a virus that ...
Cached Biology News:Stressed cells spark DNA repair missteps and speed evolution 2Computers close in on protein structure prediction 2Computers close in on protein structure prediction 3Computers close in on protein structure prediction 4UCSD discovery may provide novel method to generate medically useful proteins 2UCSD discovery may provide novel method to generate medically useful proteins 3
(Date:8/22/2014)... the University of Surrey have discovered how the receptors ... clock genes. , The new study, published today in ... clock activity in turn regulates the cycle of all ... discovered that the local biological clock and its control ... the clock in bladder physiology and ageing. ...
(Date:8/22/2014)... are intensively investigated for application as catalysts, ... and components in photonics and molecular electronics. ... for understanding physical and chemical properties, has ... USA, have demonstrated that high-resolution electron microscopy ... structure in which all gold atoms are ...
(Date:8/22/2014)... Research and Markets has announced ... Permeation Chromatography (GPC) Industry Report 2014" report to ... Gel Permeation Chromatography (GPC) Industry Report is a professional ... global gel permeation chromatography industry with a focus on ... overview of the industry including definitions, classifications, applications and ...
(Date:8/22/2014)... 2014 Nerium International, the go-to, ... the spotlight again. Nerium will showcase its signature ... Body Contouring Cream to Hollywood’s elite at the ... the 66th Primetime Emmy® Awards. , Developed from ... clinical trials show that NeriumAD night cream dramatically ...
Breaking Biology Technology:Treatment for overactive bladder and irritable bowel syndrome advanced through pioneering research 2A breakthrough in imaging gold nanoparticles to atomic resolution by electron microscopy 2Global and China Gel Permeation Chromatography (GPC) Industry Report 2014 2Nerium International Joins Television’s Biggest Stars at Backstage Creations Giving Suite at the 66th Primetime Emmy Awards 2Nerium International Joins Television’s Biggest Stars at Backstage Creations Giving Suite at the 66th Primetime Emmy Awards 3
... Nectid, Inc. ( www.nectid.com ) announced today that ... patents and patents-applications to Grunenthal GmbH ( www.grunenthal.com ), ... in pain drug discovery and research. The patent portfolio ... Pain Drug Discovery program and two key drug delivery ...
... , COLUMBUS, Ohio Engineers at Ohio State University have ... from nine different angles at once to create a 3D ... that move around an object; the new lens is the ... itself. Allen Yi, associate professor of integrated systems engineering ...
... NEW YORK, March 21, 2011 Reportlinker.com announces ... available in its catalogue: ... http://www.reportlinker.com/p0459142/Global-Angiongenesis-Inhibitors-and-Stimulators-Industry.html ... Angiogenesis Inhibitors and Stimulators in US$ Million ...
Cached Biology Technology:Seeing in stereo: Engineers invent lens for 3-D microscope 2Reportlinker Adds Global Angiongenesis Inhibitors and Stimulators Industry 2Reportlinker Adds Global Angiongenesis Inhibitors and Stimulators Industry 3Reportlinker Adds Global Angiongenesis Inhibitors and Stimulators Industry 4Reportlinker Adds Global Angiongenesis Inhibitors and Stimulators Industry 5Reportlinker Adds Global Angiongenesis Inhibitors and Stimulators Industry 6Reportlinker Adds Global Angiongenesis Inhibitors and Stimulators Industry 7Reportlinker Adds Global Angiongenesis Inhibitors and Stimulators Industry 8Reportlinker Adds Global Angiongenesis Inhibitors and Stimulators Industry 9Reportlinker Adds Global Angiongenesis Inhibitors and Stimulators Industry 10Reportlinker Adds Global Angiongenesis Inhibitors and Stimulators Industry 11Reportlinker Adds Global Angiongenesis Inhibitors and Stimulators Industry 12Reportlinker Adds Global Angiongenesis Inhibitors and Stimulators Industry 13Reportlinker Adds Global Angiongenesis Inhibitors and Stimulators Industry 14Reportlinker Adds Global Angiongenesis Inhibitors and Stimulators Industry 15Reportlinker Adds Global Angiongenesis Inhibitors and Stimulators Industry 16Reportlinker Adds Global Angiongenesis Inhibitors and Stimulators Industry 17
...
Improve inventory management with stainless steel red cell canisters; ensure product safety with CO2 or LN2 backup systems. A complete solution for your blood banking needs....
... oligonucleotides: PTOs are internucleotide modifications, ... backbone is replaced by a sulphur atom. ... degradation. PTOs are available as ... Oligonucleotides with thio-caps ...
Improve inventory management with stainless steel red cell canisters; ensure product safety with CO2 or LN2 backup systems. A complete solution for your blood banking needs....
Biology Products: