Navigation Links
Knee protectors can form allergenic substances on the skin
Date:1/11/2011

"Substances that appear at first glance to be harmless can cause allergic reactions since skin enzymes may help to form new, allergenic substances from them, giving rise to dermatitis and other skin problems. This is the case for isothiocyanates, which are formed on the skin following repeated contact with rubber", says Kristin Samuelsson of the Department of Chemistry at the University of Gothenburg.

Around one in five adults in Europe suffers from contact allergy against one or several chemical substances to which they are exposed. The most common allergy is against nickel, while many people suffer from contact allergy against, for example, perfume. A substance must bind to proteins in the skin before it can give rise to an allergy. This means that substances must be chemically reactive, if they are to cause an allergic reaction. Isothiocyanates are potent contact allergens that occur naturally in vegetables. They are used also in technical products.

Kristin Samuelsson has used fluorescent isothiocyanates to study how allergenic substances are absorbed by the skin and lymph nodes, after being applied to the skin. The results show that the reactive isothiocyanates are mainly restricted to the outermost layer of skin (known as the "stratum corneum"), which consists of dead cells. Even so, the isothiocyanates that were tested were potent allergens.

Diphenylthiourea is a substance that is used in the production of rubber, including the neoprene rubber that is used in mouse mats, wetsuits, knee protectors and other products with which we have close and frequent contact. Isothiocyanates are among the substances that are formed from diphenylthiourea when it is applied to skin.

The number of patients with reported allergies against neoprene rubber is not actually very high, but this may be because it is difficult to confirm such allergies. The results presented in the thesis have led to the initiation of a new study at the Skin Clinic, Sahlgrenska University Hospital, in which patients with suspected allergy against neoprene rubber will be tested using the isothiocyanate that is formed in the skin. Testing with the active allergen increases the chances of detecting cases of rubber allergy, and thus providing the appropriate treatment and advice for the patients. Identifying allergenic substances in common products will also make it possible to reduce the exposure of the general population to such substances.

The thesis: Isothiocyanates as skin sensitizers. Bioactivation and distributor in skin and draining lymph nodes has been successfully defended.


'/>"/>

Contact: Kristin Samuelsson
Samuelsson.kristin@gmail.com
46-070-753-7474
University of Gothenburg
Source:Eurekalert  

Related biology news :

1. Airway cells use tasting mechanism to detect and clear harmful substances
2. Exposure to alkaline substances can result in damaged teeth
3. Smokeless tobacco called moist snuff is contaminated with harmful substances
4. Invasive fish and mussels team up to transfer toxic substances into Great Lakes walleyes
5. Healing haze: Substances in smoke left over from forest fires speed plant growth
6. Health Robotics i.v.STATION Certified as the Only Robot to Comply with Security Guidelines for Controlled Substances
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Knee protectors can form allergenic substances on the skin
(Date:3/2/2017)... , March 2, 2017 Australian stem cell ... (ASX: CYP), has signed an agreement with the Monash ... Monash Biomedicine Discovery Institute and Department of Pharmacology at ... a further preclinical study to support the use of ... asthma.  Asthma is a chronic, long ...
(Date:2/27/2017)...   Strategic Cyber Ventures , the industry,s first ... $3.5 million investment in  Polarity , the first commercial ... DC based and is led by cybersecurity veterans ... Ron Gula , also a longtime cybersecurity veteran and ... series A round of funding. This new funding will ...
(Date:2/21/2017)... -- Der weltweite Biobanking-Sektor wird bis zum ... mit mehr als 50 Vertretern aus verschiedenen Branchen wurde aber ... diese Prognose zu realisieren. ... Zu den Schwierigkeiten für ... für die Biobank, die Implementierung Zeit sparender Technologien, ein ...
Breaking Biology News(10 mins):
(Date:3/24/2017)... March 24, 2017 On Thursday, ... session at 5,817.69, down 0.07%; the Dow Jones Industrial ... the S&P 500 closed at 2,345.96, marginally dropping 0.11%. ... closed in green, 4 sectors finished in red, and ... Stock-Callers.com has initiated reports coverage on the following Biotechnology ...
(Date:3/24/2017)... 24, 2017 Agenus Inc. (NASDAQ: AGEN), an ... and cancer vaccines, today announced participation at the following ... William Blair and Maidstone Life Sciences conference "Cancer Immunotherapy ... New York, NY . Agenus will ... at 9:40 am: Robert B. Stein , M.D., ...
(Date:3/23/2017)... ... ... Lajollacooks4u is proud to announce it has become the premiere team-building cooking event company in ... the world, such as Illumina, HP and Qualcomm, and is ranked #1 in its category ... due to its new team building format, a way for teams to not only interact ...
(Date:3/23/2017)... 23, 2017  Northwest Biotherapeutics (OTCQB: NWBO) (NW ... therapies for solid tumor cancers, today announced that ... it announced last Friday, March 17, 2017. ... investors securities totaling 28,843,692 shares, comprised of 18,843,692 ... shares of Class C Warrants pre-funded at the ...
Breaking Biology Technology: