Navigation Links
Killing drug-resistant melanoma requires combination therapy
Date:12/13/2010

cells that became resistant to one type of BRAF drug became resistant to all of them, which suggests that the cells were biochemically "rewired" in such a way that they no longer needed BRAF to form tumors.

"Cells are complex machines that work, essentially, through chains of biochemical reactions that we refer to as signaling pathways," said Jessie Villanueva, Ph.D., senior author on the study and staff scientist in the Herlyn laboratory.

"Knocking out mutant BRAF shuts a major pathway down, but if some cells can use an alternate pathway, then they can survive."

To find out which alternate pathways the drug-resistant cells use, Villanueva and her colleagues looked for signs of increased activation among proteins along the pathways BRAF uses, as well as other pathways.

Their hunt turned up two paths that worked together to aid survival. First, they found that resistant cells used a protein similar to BRAF to carry the signal down the chain. Second, they found these cells received an additional boost from the IGF-1 receptor, a protein that sits on the surface of cells and sends signals that prevent cells from being killed. The resistant cells re-route the signal around BRAF by switching to an alternate protein (CRAF or ARAF), which promotes tumor cell growth, while IGF-1R signaling promotes survival of the resistant cells.

Fortunately, there are a number compounds in clinical development that could block signals along both these pathways. So-called MEK inhibitors target a protein along the same pathway as BRAF, and IGF-1 receptor inhibitors (and inhibitors of P13K, a protein that can be activated by the IGF-1 receptor pathway) block the cancer-enabling survival signal. To test these drug combinations in the BRAF-inhibitor resistant cells, the Herlyn laboratory used a tool they developed to simulate the real-world environment of human cells: 3-D melanoma tumor spheroids. Their 3-D tissue cultures allow melanoma cells to gr
'/>"/>

Contact: Greg Lester
glester@wistar.org
215-898-3943
The Wistar Institute
Source:Eurekalert  

0

GOOD

Page: 1 2 3

Related biology news :

1. Modern genetics vs. ancient frog-killing fungus
2. Stanford researchers: Global warming is killing frogs and salamanders in Yellowstone Park
3. Scripps research team defines new painkilling chemical pathway
4. Scientists fool bacteria into killing themselves to survive
5. Twin nanoparticle shown effective at targeting, killing breast cancer cells
6. New Southern California beetle killing oaks
7. Estrogen-dependent switch tempers killing activity of immune cells
8. Tracking new cancer-killing particles with MRI
9. Bacteria-killing proteins cover blood type blind spot
10. Killing in the name of conservation
11. Ultraviolet radiation not culprit killing amphibians, research shows
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Killing drug-resistant melanoma requires combination therapy
(Date:6/18/2013)... Adelaide shows that weight gain and increased head size in ... higher IQ at early school age. , The study was led ... more than 13,800 children who were born full-term. , The results, ... babies who put on 40% of their birthweight in the first ... they were six years of age, compared with babies who only ...
(Date:6/17/2013)... other locations with central nervous system infections may well ... virus, according to a study to be published in ... American Society for Microbiology. Researchers have detected the virus ... with central nervous system infections of unknown cause, and ... from pigs and poultry, suggesting animals may serve as ...
(Date:6/17/2013)... June 17, 2013 An international team led ... Howard Hughes Medical Institute and Albert Einstein College of ... new anti-tuberculosis compound that attacks the tuberculosis (TB) bacterium ... effort to help solve one of the major global ... its dangerous drug-resistant strains," said Peter G. Schultz, the ...
Breaking Biology News(10 mins):IQ link to baby's weight gain in first month 2New virus discovered in patients with central nervous system infections 2New virus discovered in patients with central nervous system infections 3New compound excels at killing persistent and drug-resistant tuberculosis 2New compound excels at killing persistent and drug-resistant tuberculosis 3New compound excels at killing persistent and drug-resistant tuberculosis 4
... CITY -- Climate change spells trouble for many tropical ... and relatively small areas and the damage will ... and competition among species. That is among the ... relevant to the topic. The review was scheduled for ...
... whether long periods of hot weather, such as last year,s ... or July, August or September? Scientists studying the subtle ... events happen makes a big difference. Based on more ... (NSF) Konza Prairie Long-Term Ecological Research (LTER) site in Kansas--one ...
... assistant professor of biochemistry at Virginia Tech, has ... administered by the Ministry of Science and Technology ... is "a significant contribution to the diagnosis and ... a release distributed my MICIT. Sobrado, an ...
Cached Biology News:Climate change threatens tropical birds 2Climate change threatens tropical birds 3Climate change threatens tropical birds 4Climate change threatens tropical birds 5Time of year important in projections of climate change effects on ecosystems 2Contributions to diagnosis, treatment of tropical diseases recognized 2
(Date:6/18/2013)... 2013) A million electric cars could be on roads ... the help of research by the United States Department of ... , Professor Zhongwei Chen is part of a team led ... materials to replace the expensive platinum catalysts in fuel cells. ... fuel cells in vehicles is the cost of the units. ...
(Date:6/18/2013)... (PRWEB) June 18, 2013 ExakTime, ... in North America, has introduced AccountLinx Plus, a ... payroll records between ExakTime’s software and industry-leading payroll ... software setup and keeps employee databases up-to-date in ... a business’ current payroll software, directly into ExakTime’s ...
(Date:6/18/2013)... June 18, 2013 The human skin is ... as an important human body part. Similar to the liver, ... order to function, repair and grow. Recent reports from the ... supplements, is just as important as other life supporting organs. ... aid in skin cell reproduction, increase the appearance of skin, ...
(Date:6/18/2013)... 2013 RegeneCure announced today ... AMCA Guided Bone Regeneration (GBR) Dental Membrane as a bone ... common problem encountered when patients have a tooth replaced with ... to house the implant. Consequently there is often a need ... natural bone regenerates. The bone substitute material, in turn, needs ...
Breaking Biology Technology:US and Canadian researchers drive towards cheaper fuel cells for electric cars 2ExakTime Introduces AccountLinx Plus 2Natural Acne Remedies Through Diet, Probiotic Action Shares New Insight on What Foods May Help Lead to Clear Skin 2RegeneCure Starts Clinical Study Using Polymeric Bone Stimulating Membrane for Dental Implants 2RegeneCure Starts Clinical Study Using Polymeric Bone Stimulating Membrane for Dental Implants 3
... University of Wisconsin Medical Foundation is initiating ... Foundation's clinical data and to improve the reliability of ... QDX Platform V Integration Services from Quovadx, ... in Englewood, Colorado. , ,The Medical Foundations growth ...
... of single-molecule DNA analysis technology, announced Thursday it has commenced ... tumor, known as oligodendroglioma. OpGen, based in Madison, is working ... of genetics and chemistry at the University of Wisconsin-Madison and ... mapping, invented by Schwartz, will enable researchers to determine how ...
... weeks ago, I referred to offshore outsourcing as an ... an issue de lannee (an election year at that ... questions about the economic future of the U.S. Prominent ... the contenders for the Democratic presidential nomination to the ...
Cached Biology Technology:UW Medical Foundation Integrates Medical Records 2OpGen joins UW, Henry Ford Heath in Improving Brain Tumor Treatment 2The Great Offshore Outsourcing Debate 2
The F40 pump maintenance kit is used to service one F40 pump of a BioLogic DuoFlow workstation. It includes 2 piston seals, 4 check valves, seal removal tool, and 2 O-rings....
... Mouse monoclonal [HDAC8-48] to HDAC8 ... by several mechanisms such as DNA ... translational modifications of histones, which include ... epsilon-amino groups of lysine residues present ...
...
Mouse monoclonal antibody raised against a partial recombinant PUM2. NCBI Entrez Gene ID = PUM2...
Biology Products: