Navigation Links
Killing cancer cells with acid reflux
Date:3/7/2013

A University of Central Florida chemist has come up with a unique way to kill certain cancer cells give them acid reflux.

Chemistry professor Kevin Belfield used a special salt to make cancer cells more acidic similar to the way greasy foods cause acid reflux in some people. He used a light-activated, acid-generating molecule to make the cells more acidic when exposed to specific wavelengths of light, which in turn kills the bad cells. The surrounding healthy cells stay intact.

The technique is a simple way around a problem that has frustrated researchers for years. For photodynamic therapy (the special laser-light treatment) to work, cancer cells loaded with photosensitizers need oxygen to trigger the fatal reaction. But by their very nature, most cancer cells lack oxygen. Nonetheless, scientists were intent on making the photodynamic system work because it offers a way to target cancer cells deep within human tissue without causing a lot of collateral damage.

Instead of focusing on oxygen, Belfield flipped the problem around and found another way to poison the bad cells, while protecting the healthy ones.

"It's the first time we've found a way around the oxygen problem," Belfield said. "This work is truly ground breaking. It should eventually provide a therapeutic means to treat certain types of cancers with minimal side effects. It should also be a very useful tool for cell biologists and biomedical researchers. It could even find a place in treating other diseases such as neurodegenerative diseases."

His work was recently published in the Journal of the American Chemical Society. (http://pubs.acs.org/doi/full/10.1021/ja3122312)

Belfield and his team at UCF used human colorectal carcinoma cells for the study, which was funded by the National Science Foundation and the National Institutes for Health. More research is nee
'/>"/>

Contact: Zenaida Gonzalez Kotala
zenaida.kotala@ucf.edu
407-823-6120
University of Central Florida
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Novel combination therapy shuts down escape route, killing glioblastoma tumor cells
2. Decoys could blunt spread of ash-killing beetles
3. New, cost-cutting approach to formulating pest-killing fungi
4. Research finds novel airborne germ-killing oral spray effective in fighting colds and flu
5. Cystic fibrosis makes airways more acidic, reduces bacterial killing
6. UT Southwestern scientists make mouse model of human cancer, demonstrate cure
7. Study uncovers enzymes double life, critical role in cancer blood supply
8. Cancer vaccines self-sabotage, channel immune attack to injection site
9. Mechanisms regulating inflammation associated with type 2 diabetes, cancer identified
10. Trackable drug-filled nanoparticles -- a potential weapon against cancer
11. 11th International Congress on Targeted Anticancer Therapies
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Killing cancer cells with acid reflux
(Date:11/11/2014)... Inc., a Chicago -based digital forensics ... of Yaniv Schiff from Senior Computer Forensics ... role as Director, he will lead company efforts to ... provide leadership within the company,s digital forensics practice area.  ... Schiff joined Forensicon in 2006 and has ...
(Date:11/6/2014)... a team of Florida State University biologists could lead ... to and survive environmental swings such as droughts or ... of the journal The Plant Cell , sheds ... proteins) is organized in a cell and how plants ... on and others are turned off. , "If you ...
(Date:11/5/2014)... career to understanding the Earth,s climate and communicating ... deputy director and regional climatologist for the Western ... Redmond has more than three decades of experience ... data to the general public. , At its ... December 15-19, 2014 the American Geophysical Union (AGU) ...
Breaking Biology News(10 mins):Yaniv Schiff Promoted to Director of Digital Forensics at Forensicon, Inc. 2Maize analysis yields whole new world of genetic science 2Nevada climatologist to be honored at AGU Fall Meeting for lifetime of public outreach 2
... with support from the National Institutes of Health ... dedicated to solving a wide range of challenging ... capable of 2.6 trillion mathematical operations per second, ... will be used to analyze everything from the ...
... Nonlinear Dynamics Ltd, a leading provider of bioinformatics ... OEM partnership with PerkinElmer, Inc. (NYSE: PKI), a ... and analytical solutions. , As detailed in a ... Nonlinear's full range of 1D, 2D and array ...
... By studying animals, Johns Hopkins researchers have discovered that ... on the brain and central nervous system, problems that ... elsewhere in the body. , Five monkeys infected with ... HIV, and treated with minocycline had less damage to ...
Cached Biology News:Supercomputer Dedicated To Bioengineering, Computational Biology Installed 2Supercomputer Dedicated To Bioengineering, Computational Biology Installed 3Antibiotic might fight HIV-induced neurological problems 2Antibiotic might fight HIV-induced neurological problems 3
(Date:11/22/2014)... Grand Rapids, MI (PRWEB) November 22, 2014 ... the opportunity to simulate the proper management of ... training and test lung devices . Grand Rapids-based, ... Lung” plans to donate two of the respiratory ... $12,000 to $15,000 each. Grand Valley and Muskegon ...
(Date:11/21/2014)... Washington, USA (PRWEB) November 19, 2014 ... in our lives was shared with more than 200 ... and postgraduate students from the University of Otago Physics ... Grant . The Otago students, members of the university’s ... New Zealand in early September, giving children from small, ...
(Date:11/21/2014)... 20, 2014 The November 2014 issue ... an open access journal featuring the following articles:, ... to preserve photoresponsiveness in the retina , ... situ hybridization using chromogenic substrates in zebrafish , ... and protein electrophoresis , Nuclear LC3-positive puncta ...
(Date:11/21/2014)... DIEGO , Nov. 20, 2014 ... has been dosed in its Phase 1 trial ... cisplatin for the treatment of malignant pleural mesothelioma ... Group is conducting clinical trials on ADI-PEG 20, ... agents, for the treatment of several other indications, ...
Breaking Biology Technology:Michigan Instruments Donates Two Respiratory Simulation Training and Test Lung (TTL) Devices to Grand Valley State University 2Michigan Instruments Donates Two Respiratory Simulation Training and Test Lung (TTL) Devices to Grand Valley State University 3Optics and photonics outreach programs share science, spark fascination with light 2Optics and photonics outreach programs share science, spark fascination with light 3BioTechniques: The International Journal of Life Science Methods Announces the Publication of the November 2014 Issue—Available in Print and Online 2BioTechniques: The International Journal of Life Science Methods Announces the Publication of the November 2014 Issue—Available in Print and Online 3Polaris Group Announces Treatment of First Patient in Phase 1 Study of ADI-PEG 20 plus Pemetrexed and Cisplatin in Malignant Pleural Mesothelioma And Non-Squamous Non-Small Cell Lung Carcinoma 2
... CARLSBAD, Calif., Dec. 20 Ardea Biosciences,Inc. (Nasdaq: ... discovery and development of,small-molecule therapeutics for the treatment ... that it has entered into a,securities purchase agreement ... from the private placement of approximately 3.0,million newly ...
... WALTHAM, Mass., Dec. 20 Thermo Fisher,Scientific ... leader in serving science, today,announced it has ... chromatography consumables and related accessories, based in ... La-Pha-Pack will allow,Thermo Fisher to offer customers ...
... Continues Growth Strategy ... MOUNTAIN VIEW, Calif., Dec. 20 Pharsight,Corporation (Nasdaq: ... strategic,consulting, and regulatory services for optimizing clinical drug,development, ... audits of its Reporting and Analysis Services (RAS) ...
Cached Biology Technology:Ardea Biosciences Announces $40 Million Private Placement 2Ardea Biosciences Announces $40 Million Private Placement 3Thermo Fisher Scientific Acquires Leading Chromatography Consumables Provider, La-Pha-Pack 2Thermo Fisher Scientific Acquires Leading Chromatography Consumables Provider, La-Pha-Pack 3Thermo Fisher Scientific Acquires Leading Chromatography Consumables Provider, La-Pha-Pack 4Pharsight's Reporting and Analysis Services Business Reaches Quality Assurance Milestone 2Pharsight's Reporting and Analysis Services Business Reaches Quality Assurance Milestone 3Pharsight's Reporting and Analysis Services Business Reaches Quality Assurance Milestone 4
Anti-Mouse D011.10 TCR, Biotin (Clone KJ1-26) (mouse IgG2a)...
... Abpromise for all tested applications). ... QTEEEDVELP conjugated to KLH, corresponding to amino ... SARA. Conserved sequence unique to SARA. ... 9372 Swiss Protein ID: ...
Rabbit monoclonal [E227] to ZAP70 (phospho Y319) ( Abpromise for all tested applications). Antigen: Synthetic phospho peptide corresponding to residues surrounding Tyr319 of human ZAP70 Entre...
C/EBPalpha Antibody Shipping Temperature: Cold Storage Temperature: -20C...
Biology Products: