Navigation Links
Killing cancer cells with acid reflux
Date:3/7/2013

A University of Central Florida chemist has come up with a unique way to kill certain cancer cells give them acid reflux.

Chemistry professor Kevin Belfield used a special salt to make cancer cells more acidic similar to the way greasy foods cause acid reflux in some people. He used a light-activated, acid-generating molecule to make the cells more acidic when exposed to specific wavelengths of light, which in turn kills the bad cells. The surrounding healthy cells stay intact.

The technique is a simple way around a problem that has frustrated researchers for years. For photodynamic therapy (the special laser-light treatment) to work, cancer cells loaded with photosensitizers need oxygen to trigger the fatal reaction. But by their very nature, most cancer cells lack oxygen. Nonetheless, scientists were intent on making the photodynamic system work because it offers a way to target cancer cells deep within human tissue without causing a lot of collateral damage.

Instead of focusing on oxygen, Belfield flipped the problem around and found another way to poison the bad cells, while protecting the healthy ones.

"It's the first time we've found a way around the oxygen problem," Belfield said. "This work is truly ground breaking. It should eventually provide a therapeutic means to treat certain types of cancers with minimal side effects. It should also be a very useful tool for cell biologists and biomedical researchers. It could even find a place in treating other diseases such as neurodegenerative diseases."

His work was recently published in the Journal of the American Chemical Society. (http://pubs.acs.org/doi/full/10.1021/ja3122312)

Belfield and his team at UCF used human colorectal carcinoma cells for the study, which was funded by the National Science Foundation and the National Institutes for Health. More research is needed to determine that there are no serious side affects in humans and whether the technique will work on a variety of cancers, but Belfield is optimistic.

"Predicting commercialization is difficult at best," he said. "But we are well situated to forge ahead".

So how did Belfield come up with such an "outside the box" approach? His other non-medical related research was the inspiration.

Belfield has developed a three-dimensional, optical data-storage system, which involves the use of acid generators. About six years ago he wondered if his approach could have applications in medical therapy.

"It took about five years to get someone in my research group interested to take on the unorthodox project," Belfield said. "But it seems to have paid off."

Other contributors to the research are Xiling Yue, Ciceron O. Yanez and Sheng Yao, researchers and students at UCF students focusing on chemistry or photonics.

Belfield is one of the pioneers in two-photon absorbing materials, two-photon photochemistry, and two-photon photophysics. His research spans a number of disciplines including organic, polymer, and physical chemistry, as well as optics, optical microscopy, and bioimaging. His research has potential applications in everything from the way people store data on DVDs to fighting cancer.


'/>"/>

Contact: Zenaida Gonzalez Kotala
zenaida.kotala@ucf.edu
407-823-6120
University of Central Florida
Source:Eurekalert  

Related biology news :

1. Novel combination therapy shuts down escape route, killing glioblastoma tumor cells
2. Decoys could blunt spread of ash-killing beetles
3. New, cost-cutting approach to formulating pest-killing fungi
4. Research finds novel airborne germ-killing oral spray effective in fighting colds and flu
5. Cystic fibrosis makes airways more acidic, reduces bacterial killing
6. UT Southwestern scientists make mouse model of human cancer, demonstrate cure
7. Study uncovers enzymes double life, critical role in cancer blood supply
8. Cancer vaccines self-sabotage, channel immune attack to injection site
9. Mechanisms regulating inflammation associated with type 2 diabetes, cancer identified
10. Trackable drug-filled nanoparticles -- a potential weapon against cancer
11. 11th International Congress on Targeted Anticancer Therapies
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Killing cancer cells with acid reflux
(Date:6/20/2016)... DALLAS , June 20, 2016 ... criminal justice technology solutions for public safety, investigation, ... by the prisons involved, it has secured the ... Corrections (DOC) facilities for Managed Access Systems (MAS) ... (4) additional facilities to be installed by October, ...
(Date:6/7/2016)... -- Syngrafii Inc. and San Antonio Credit Union (SACU) ... Syngrafii,s patented LongPen™ eSignature "Wet" solution into SACU,s ... in greater convenience for SACU members and operational ... document workflow and compliance requirements. Logo ... Highlights: ...
(Date:6/1/2016)... NEW YORK , June 1, 2016 ... Biometric Technology in Election Administration and Criminal Identification to ... According to a recently released TechSci Research report, " ... Sector, By Region, Competition Forecast and Opportunities, 2011 - ... $ 24.8 billion by 2021, on account of growing ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... June 24, 2016  Regular discussions on a range of ... between the two entities said Poloz. Speaking at ... Ottawa , he pointed to the country,s inflation target, ... government. "In certain ... institutions have common economic goals, why not sit down and ...
(Date:6/24/2016)... ... ... While the majority of commercial spectrophotometers and fluorometers use the z-dimension of ... higher end machines that use the more unconventional z-dimension of 20mm. Z-dimension ... of the cuvette holder. , FireflySci has developed several Agilent flow cell product ...
(Date:6/23/2016)... ... June 23, 2016 , ... ... its second eBook, “Clinical Trials Patient Recruitment and Retention Tips.” Partnering with experienced ... this eBook by providing practical tips, tools, and strategies for clinical researchers. , ...
(Date:6/23/2016)... 2016   Boston Biomedical , an industry ... to target cancer stemness pathways, announced that its ... Drug Designation from the U.S. Food and Drug ... including gastroesophageal junction (GEJ) cancer. Napabucasin is an ... cancer stemness pathways by targeting STAT3, and is ...
Breaking Biology Technology: