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Kill the cancer, not the patient: New toxicity testing approach could make chemo drugs safer
Date:11/18/2009

clophosphamide, docetaxelwere chosen because of their well-known myelotoxic effects. Myelotoxicity or bone marrow suppression reduces the production of blood cells, hampering the body's ability to fight infection and causing anemia and other severe problems.

"We have chosen myelosuppression as the physiological response for this study," Churchill says, "because this adverse effect is a major contributor to morbidity, mortality and costs associated with cancer treatment. Mice are known to respond to these agents in a manner similar to humans, and the response can be measured using standard clinical hematological methods."

Imogen Hurley, Ph.D., an associate research scientist in Churchill's laboratory, notes that the approach behind these experiments will be relevant to all types of drugs. "Cancer drugs are an important test case. We expect to show that researchers will be able to use the genetic diversity of these mice to understand why individuals have different reactions to a wide range of drugs."


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Contact: Joyce Peterson
joyce.peterson@jax.org
207-288-6058
Jackson Laboratory
Source:Eurekalert

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