Navigation Links
Kids born small should get moving
Date:8/8/2013

HOUSTON (Aug. 8, 2013) Female mice who were growth restricted in the womb were born at a lower birth weight, but were less active and prone to obesity as adults, said researchers from Baylor College of Medicine and the USDA/ARS Children's Nutrition Research Center (CNRC) at BCM and Texas Children's Hospital in a report that appears online in the International Journal of Obesity.

"Given that human studies also show female-specific obesity following early growth restriction," said Dr. Robert Waterland, associate professor of pediatrics nutrition at BCM, and a member of the CNRC faculty, "it may be prudent to encourage parents of a low birth weight child to promote healthy physical activity particularly if that child is a girl."

"These findings were a bit of a surprise," said Waterland, corresponding author of the report.

He had already shown that genetically normal female offspring of obese female mice of a specific type (prone to obesity and marked with a yellow coat) were themselves prone to obesity and inactivity. However, he realized he also had data on the mice's weight at birth. The birth weight data showed that the offspring of these overweight females were growth restricted in the uterus.

This was surprising because babies born to obese human women tend to be larger at birth, although there is a slightly elevated risk of low birth weight as well, said Waterland. When he looked at historical reports of people who had been born in famine conditions, he found that women but not men who had been growth-restricted in early life were more likely to be obese.

These included women born during the Dutch Hunger Winter near the end of World War II, the great famine in China from 1959 to 1961 and the Biafran famine during the Nigerian civil war (1967-1970).

Once it was considered important to help infants born small to "catch up and achieve a normal weight for their age," said Waterland. "Increasingly, these and other epidemiologic data show that it might not be a good thing. It might set you up for bad outcomes in the long term."

Their studies of the growth-restricted mice show definitively that they are not prone to overeat but become obese because they are less active. (Similar changes were not seen in male mice that were growth restricted in utero.)

That could make evolutionary sense, said Waterland. In times of food scarcity, it might be more important for females to be developmentally 'programmed' to conserve their energy for future bearing of offspring.

"Millions of low birth weight babies are born every year, so this could be an important factor in the worldwide obesity epidemic," said Waterland.

Others who took part in this research include Dr. Maria S. Baker, Dr. Ge Li, and John J. Kohorst, all of BCM. Kohorst is now with the Mayo Clinic in Rochester, Minn.


'/>"/>

Contact: Dipali Pathak
pathak@bcm.edu
713-798-6826
Baylor College of Medicine
Source:Eurekalert

Related biology news :

1. Turning off small RNA
2. New analysis helps guide use of erlotinib in advanced non-small cell lung cancer
3. Laparoscopy reduces the risk of small-bowel obstruction
4. A small cut with a big impact
5. New evidence that many genes of small effect influence economic decisions and political attitudes
6. AcelRx Pharmaceuticals Receives First U.S. Patent for Small-Volume Oral Transmucosal Dosage Forms
7. U-M forecasters predict second-smallest Gulf of Mexico dead zone
8. Smallest and largest fetuses at greater risk of being stillborn, research finds
9. Do the worlds smallest flies decapitate tiny ants?
10. Small molecule may play big role in Alzheimers disease
11. Protein involved in DNA replication, centrosome regulation linked to dwarfism, small brain size
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/2/2017)... Who risk to be deprived of its imprint in ... https://www.reportbuyer.com/product/4313699/ WILL APPLE AND SAMSUNG CONFRONT EACH ... using capacitive technology represent a fast growing market, especially ... increase of 360% of the number of fingerprint sensor ... market between 2014 and 2017 (source : N+1 Singer, ...
(Date:2/28/2017)...  EyeLock LLC, ein marktführendes Unternehmen im Bereich ... Lösung zur Iris-Erkennung auf der neuesten Mobilplattform ... dem Mobile World Congress 2017 (27. Februar ... 3, Stand 3E10, vorstellen. Der ... – eine Kombination aus Hardware, Software und ...
(Date:2/21/2017)... and PORTLAND, Ore. , Feb. ... the Avamere Family of Companies (Avamere Health Services, Infinity ... a six-month research study that will apply the power ... at senior living and health centers. By analyzing data ... to gain insights into physical and environmental conditions, and ...
Breaking Biology News(10 mins):
(Date:3/23/2017)... (PRWEB) , ... March 23, 2017 , ... ... monitoring solutions, today announced the hire of Dr. Sigmund “Sig” Floyd as Vice ... applications, strategic partnerships and joint development activities. , “Dr. Floyd’s career has spanned ...
(Date:3/22/2017)...  Ascendis Pharma A/S (Nasdaq: ASND), a biopharmaceutical ... address significant unmet medical needs in rare diseases, ... ended December 31, 2016. "2016 ... we broadened our pipeline and pursued our vision ... with an initial focus on endocrinology," said ...
(Date:3/22/2017)... JERUSALEM , March 22, 2017 ... ( www.oramed.com ), ... of oral drug delivery systems, announced today that ... Officer, will deliver a presentation titled, "Oral Insulin ... upcoming Cambridge Healthtech Institute,s Oligonucleotide and Peptide Therapeutics ...
(Date:3/22/2017)... Florida , March 22, 2017 ... ... various cancer conditions are being pressured as of late due ... for cancer pain management has a dramatic impact on patient,s ... research and development activities for identifying new forms of opioid ...
Breaking Biology Technology: