Navigation Links
Kidney stone mystery solved
Date:4/18/2012

Kidney stones strike an estimated 1 million Americans each year, and those who have experienced the excruciating pain say it is among the worst known to man (or woman).

Now, new research by scientists at Washington University School of Medicine in St. Louis provides evidence to explain why some people are more prone to develop the condition than others. Their discovery opens the door to finding effective drug treatments and a test that could assess a person's risk of kidney stones.

"Now, we finally have a more complete picture detailing why some people develop kidney stones and others do not," says senior author Jianghui Hou, PhD, assistant professor of medicine. "With this information, we can begin to think about better treatments and ways to determine a person's risk of the condition, which typically increases with age."

The research, in mice, is now available online in the EMBO Journal, published by the European Molecular Biology Organization.

Because kidneys function the same way in mice as in humans, the new findings can help scientists understand the root causes of kidney stones in patients. The mouse model used in the study can also serve as a platform for the preclinical testing of novel treatments for the condition, the researchers say.

Most kidney stones form when the urine becomes too concentrated, allowing minerals like calcium to crystallize and stick together. Diet plays a role in the condition not drinking enough water or eating too much salt (which binds to calcium) also increases the risk of stones.

But genes are partly to blame. A common genetic variation in a gene called claudin-14 recently has been linked to a substantial increase in risk roughly 65 percent of getting kidney stones. In the new study, the researchers have shown how alterations in the gene's activity influence the development of stones.

Typically, the claudin-14 gene is not active in the kidney. The
'/>"/>

Contact: Caroline Arbanas
arbanasc@wustl.edu
314-286-0109
Washington University School of Medicine
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Scientists identify cell changes leading to impaired artificial kidney function
2. Kidney function discovery sheds light on genetic complexity of disease
3. UC San Diego researchers use metagene portraits to reveal distinct stages of kidney formation
4. UC Davis discovery offers hope for treating kidney cancer
5. Gene mutation increases drug toxicity, rejection risk in pediatric kidney transplants
6. Shorter wait means longer life for kidney transplant candidates
7. Updated formula measures kidney function more accurately
8. Freezing kidney cancer: Hot treatment should be new gold standard for destroying small tumors
9. Is it really only our kidneys that control blood pressure?
10. UT Southwestern researchers probe kidney damage, protection in lupus
11. Drinking diet soda may reduce the risk of forming kidney stones
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Kidney stone mystery solved
(Date:11/21/2014)... , November 18, 2014 According ... Market by Systems (Video, RFID, Access Control, Intrusion Detection, ... Hotels, Banks, Government), Component Service Geography - Global Forecasts ... Market is projected to be around $25 Billion in ... 2020, growing at a CAGR of 8.69%. ...
(Date:11/21/2014)... JOSE, Calif. , Nov. 20, 2014   ... global leader in microcontroller (MCU) and touch technology solutions, ... digital temperature sensors with the widest V cc ... delivers higher temperature accuracy and faster I 2 C ... registers and serial EEPROM memory making them ideal for ...
(Date:11/18/2014)... 18, 2014   EyeLock Inc. , a ... MorphoTrust USA (Safran), a leading U.S. ... a strategic partnership to offer comprehensive biometric identity ... (MVA), airport screening and financial services markets. ... serves consumers through a nationwide network of 1,100 ...
Breaking Biology News(10 mins):Industrial Security Systems Market Worth $38 Billion by 2020 2Industrial Security Systems Market Worth $38 Billion by 2020 3Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 2Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 3Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 4EyeLock, MorphoTrust Form Strategic Partnership to Pursue Commercial Enterprise Deployments 2EyeLock, MorphoTrust Form Strategic Partnership to Pursue Commercial Enterprise Deployments 3
... Massey Cancer Center studying the interaction between the ... gamma as one of the signaling proteins involved ... researchers develop tailored vaccines and other immunotherapeutic strategies ... the manipulation of the immune system ?by introducing ...
... M.D. and Ami Klin are part of a global research ... region of a chromosome that may lead to autism in ... Genetics and also will be published in the journal’s March ... scan. Over 120 scientists from over 50 institutions who formed ...
... cause of high blood pressure lies within the brain, and ... by scientists at the University of Bristol, UK, and is ... Waki, working in a research group led by Professor Julian ... (junctional adhesion molecule-1), which is located in the walls of ...
Cached Biology News:Mechanisms involved with tumor relapse identified 2Autism gene identified by researchers at Yale working with a global research consortium 2Blame the brain for high blood pressure 2
(Date:12/19/2014)... Dec. 18, 2014 Relmada Therapeutics, Inc. (OTCQB: ... treatment of chronic pain, announced the results of its ... "This was a transformational year in Relmada,s history and ... our company," said Sergio Traversa , chief executive ... executed on key financial, human resource and clinical development ...
(Date:12/17/2014)... 16, 2014 “Never say, ‘I ... Universität Marburg’s Department of Physics, advises young women ... newly released SPIE Women in Optics 18-month ... shy to ask questions.” , In the annual ... mathematics) occupations ranging from university professor and laboratory ...
(Date:12/17/2014)... Once more, EMAAR has selected ... waste water treatment plant to phase one of BayLaSun, ... Two years ago Bioshaft successfully supplied and operated a ... residential towers with an occupancy of 900 residences. ... gallons per day and was signed on September 16th, ...
(Date:12/17/2014)... CA (PRWEB) December 17, 2014 ... today that it has entered into a technology ... Company (ADM) to apply DNA2.0’s proprietary protein engineering ... engineering process. , “We are extremely excited that ... engineering platform. This proprietary bioengineering technology has ...
Breaking Biology Technology:Relmada Therapeutics Announces Results of Annual Shareholders Meeting 2Network, Multitask, Persevere: SPIE Women in Optics Planner Subjects Share from Experience 2Network, Multitask, Persevere: SPIE Women in Optics Planner Subjects Share from Experience 3ADM and DNA2.0 Enter Into Protein Engineering Technology Access and Service Agreement 2
... - Los Angeles has been selected as a member of ... year alliance, as a provider of the DuPont™ Tyvek® LifeCycle ... of 17 national printers that met DuPont Graphics strict criteria ... New York - Los Angeles continues to be an industry ...
... ISRAEL, July 13, 2011 A new system using video ... used to prevent Sudden Infant Death Syndrome (SIDS), as ... students at Ben-Gurion University of the Negev (BGU). The ... BGU Departments of Electrical Engineering and Computer Sciences. It ...
... particles emitted by diesel exhaust fumes could raise the risk ... that ultrafine particles produced when diesel burns are harmful to ... forming in arteries, leading to a heart attack or stroke. ... impact of diesel exhaust fumes on healthy volunteers at levels ...
Cached Biology Technology:Coloredge New York - Los Angeles Joins DuPont™ Tyvek® Graphics Authorized Printer Network 2Computerized system to prevent SIDS developed by Ben-Gurion University students 2Diesel fumes pose risk to heart as well as lungs, study shows 2
... siRNA --- a cocktail of 3 siRNAs ... interestis our most popular product. The siTrio ... knockdown of your target gene when used ... transfection and confirmation of optimal transfection with ...
... siRNA --- a cocktail of 3 siRNAs ... interestis our most popular product. The siTrio ... knockdown of your target gene when used ... transfection and confirmation of optimal transfection with ...
... kit #27295 has improved stability and convenience from ... not only has overcome this problem but also ... have changed the formulation of HRP conjugated antibody ... By this change, the stability of the conjugate ...
... IDS EIA kit is a complete assay ... D (1,25D) in human serum or plasma. ... system found in the IDS 1,25D RIA ... assay comes with ready to use reagents, ...
Biology Products: