Navigation Links
Kidney dopamine regulates blood pressure, life span
Date:7/19/2011

The neurotransmitter dopamine is best known for its roles in the brain in signaling pathways that control movement, motivation, reward, learning and memory.

Now, Vanderbilt University Medical Center investigators have demonstrated that dopamine produced outside the brain in the kidneys is important for renal function, blood pressure regulation and life span. Their studies, published in the July Journal of Clinical Investigation, suggest that the kidney-specific dopamine system may be a therapeutic target for treating hypertension and kidney diseases such as diabetic nephropathy.

Previous studies had suggested a role for dopamine in regulating kidney function and total body fluid volume, "but how that mechanism works was not clear," said Raymond Harris, M.D., chief of the Division of Nephrology and Hypertension at Vanderbilt.

To explore dopamine's role in the kidney, Harris and Ming-Zhi Zhang, M.D., assistant professor of Medicine at Vanderbilt, eliminated kidney-specific dopamine production in mice (by knocking out a dopamine-generating enzyme only in the kidney) and studied the outcome.

They found that mice lacking kidney dopamine had high blood pressure at baseline and became more hypertensive when they consumed a high-salt diet, suggesting they may be a good model of salt-sensitive (essential) hypertension, Harris said. Alterations in the kidney dopamine system may predispose individuals to hypertension, he noted.

The investigators also showed that elimination of kidney dopamine increased renin production, which activates the angiotensin II system to increase salt and water reabsorption and produce hypertension.

"These animals retain salt and water when they don't have sufficient dopamine production in the kidney," Harris said. "Our studies highlight this whole other hormonal system that appears to balance or put the brakes on the renin-angiotensin system."

Currently, the renin-angiotensin system is the major target for treating chronic kidney diseases. Discovering another target the kidney dopamine system is exciting, the researchers said. They are exploring whether specific drugs that enhance the kidney dopamine system are effective in blocking hypertension and treating progressive kidney diseases.

The investigators predicted changes in kidney function in the mouse model, but they were "very surprised" to discover that the modified mice only lived about half as long as normal mice (15 months versus 30 months). They found increases in stress-related proteins in the kidney, heart and vasculature, suggesting that elimination of kidney dopamine causes systemic effects, Harris said.

"This kidney-specific dopamine system is not only important for kidney function and blood pressure regulation, but also for the overall health of the animal," Harris said. "If the dopamine system in the kidney is altered, the animals have a markedly shortened life span."


'/>"/>

Contact: Leigh MacMillan
leigh.macmillan@vanderbilt.edu
615-322-4747
Vanderbilt University Medical Center
Source:Eurekalert

Related biology news :

1. A mothers salt intake could be key to prenatal kidney development
2. New evidence of the benefits of home dialysis for kidney patients
3. UofL researchers replicate human kidney gene changes in mouse model
4. TGen findings contribute to understanding of diabetic kidney disease
5. Gene variant influences chronic kidney disease risk
6. Study shows pine bark naturally improves kidney function in patients with metabolic syndrome
7. Common congenital defect a prickly problem for the kidney
8. Stem cell transplants help kidney damage
9. Researchers unlock the potential for exploring kidney regeneration
10. Seeing kidney injury, as it happens
11. Kidney gene implicated in increased heart failure risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/5/2017)... KEY FINDINGS The global market for stem ... 25.76% during the forecast period of 2017-2025. The rise ... growth of the stem cell market. Download ... The global stem cell market is segmented on the ... cell market of the product is segmented into adult ...
(Date:3/30/2017)... 2017  On April 6-7, 2017, Sequencing.com will host ... hackathon at Microsoft,s headquarters in Redmond, ... on developing health and wellness apps that provide a ... Genome is the first hackathon for personal genomics ... companies in the genomics, tech and health industries are ...
(Date:3/29/2017)... , March 29, 2017  higi, the health ... in North America , today announced ... and the acquisition of EveryMove. The new investment and ... set of tools to transform population health activities through ... lifestyle data. higi collects and secures data ...
Breaking Biology News(10 mins):
(Date:4/27/2017)... and RESEARCH TRIANGLE PARK, N.C. , ... UTHR ) today announced that its Board ... million of the company,s common stock. This program will ... 31, 2017. Purchases may be made in the open ... from time to time as determined by United Therapeutics, ...
(Date:4/27/2017)... ... April 27, 2017 , ... Arrowhead Publishers ... http://www.paintherapeuticsummit.com ) is coming to San Diego, CA on September 27-28, 2017. Leaders ... about the latest advances in the treatment of various types of pain. There ...
(Date:4/27/2017)... ... April 27, 2017 , ... The ... Communication Award goes to Jayson Lusk, a consummate communicator who promotes agricultural science ... advocate for science, as he explains how innovation and growth in agriculture are ...
(Date:4/26/2017)... ... April 26, 2017 , ... ... for phase I clinical trials comes to Tampa, San Francisco and Boston in ... professionals representing FDA regulated organizations such as Pfizer Inc., Teva Pharmaceuticals, Advaxis, Inc., ...
Breaking Biology Technology: