Navigation Links
Key to 'curing' obesity may lie in worms that destroy their own fat: McGill researchers
Date:12/8/2008

This release is available in French.

A previously unknown mutation discovered in a common roundworm holds the promise of new treatments for obesity in humans, McGill University researchers say. Their study was published Dec. 3 in the journal Nature, and was funded by the Canadian Cancer Society and the Canadian Institutes of Health Research.

In lean times, a normal Caenorhabditis elegans worm goes into a form of suspended animation called "dauer" that slows its metabolism and allows it to survive for extended periods without food.

"When they go into dauer, these worms radically alter their metabolism," said Dr. Richard Roy, a cancer researcher at McGill's Department of Biology specializing in the control of cell division. "They shut down everything energy-consuming, which includes foraging, cell division and reproduction."

Unlike other "hibernating" organisms, C. elegans maintains a degree of mobility during dauer by stocking up on energy in the form of fats or lipids which they store in special cells or reserves.

"This allows them to live up to six months without eating, instead of the two weeks they would otherwise have," Roy explained. A worm with the newly discovered mutation, however, will usually die within a week of going into dauer

"These mutants somehow cannot shut down the process of cell division, which is why we noticed them in the first place," Roy said. "However, that's not what kills them. They cannot adjust their metabolism correctly. They store up their six-month lipid reserves, but as soon as they shift into dauer they use them up within a few days. This is because they lack an enzyme that blocks the activity of a very important triglyceride lipase. Without this regulation the lipase burns up all the fat it encounters and destroys the worm's energy reserves."

This discovery w
'/>"/>

Contact: Mark Shainblum
mark.shainblum@mcgill.ca
514-398-2189
McGill University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Securing the future of Europes biological data resources
2. Childrens National convenes first childhood obesity symposium
3. Persistent pollutant may promote obesity
4. Adiponectin is a metabolic link between obesity and bone mineral density
5. UNC study: Text messaging may help children fight off obesity
6. 15-state Southern obesity summit to focus on deadly epidemic
7. A new weapon in the fight against obesity and diabetes
8. Scientists from Granada find a potential treatment to prevent diabetes and obesity
9. Color My Pyramid nutrition education program battles obesity in DC schools
10. Making metabolism more inefficient can reduce obesity
11. Scientists discover why a mothers high-fat diet contributes to obesity in her children
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/16/2014)... infections and worldwide claims the lives of 160,000 ... University have succeeded in developing a promising vaccination ... , Xavier Saelens (VIB/UGent): "We discovered a new ... development of a novel approach to vaccination against ... small children and elderly people." , RSV: ...
(Date:10/15/2014)... pandemic risk from strains of influenza virus increases with ... to become complacent that the most substantial threats have ... Influenza pandemics arise when a new virus strain – ... – spreads in the human population. There have been ... worst of which – the 1918 Spanish Flu – ...
(Date:10/15/2014)... in female mice to an enzyme activated by the ... resistant to respiratory infections than males. Now, an international ... bacterial pneumonia in female mice is linked to the ... that this enzyme is ultimately activated by the release ... lead by Professor Lester Kobzik at the Harvard University ...
Breaking Biology News(10 mins):New perspectives for development of an RSV vaccine 2Scientists 'must not become complacent' when assessing pandemic threat from flu viruses 2
... , This release is available in German ... and spokesman for Solar Energy Research at Helmholtz-Zentrum Berlin (HZB), ... Solar Energy Conference and Exhibition" in Valencia. The EU Commission ... field of photovoltaics. The award ceremony took place ...
... Pine trees, scientists have shown that the iconic pine forests ... that colonised Britain after the end of the last Ice ... according to new results published in the journal Heredity ... team from the Centre for Ecology & Hydrology, the Polish ...
... Cotton growers can produce more cotton if they ... of an article published in the September-October 2010 ... of Agronomy. Bill Pettigrew, a scientist with the ... of cotton under irrigated and non-irrigated plots, with half ...
Cached Biology News:Untiring dedication to solar energy 2Scots Pine shows its continental roots 2Early cotton planting requires irrigation 2
(Date:10/20/2014)... October 20, 2014 Earle ... LLC, announced today that Ellen Teplitzky, an experienced ... for the pharmaceutical industry, has joined the firm ... its legal services practice. NDA Partners provides ... witness and testimony, to top law firms and ...
(Date:10/19/2014)... The Asia-Pacific Bromine Market report defines and ... and forecast of revenue. , Browse through the ... to get an idea of the in-depth analysis ... segmentation in the Asia-Pacific bromine market, and is ... http://www.micromarketmonitor.com/market/asia-pacific-bromine-6741503144.html , Bromine is a volatile ...
(Date:10/19/2014)... October 19, 2014 The report ... & Homeland Security), Technology, Payload, Type & by ... segments the global unmanned ground vehicle market into ... forecasting of market sizes. The report also identifies ... opportunities impacting it along with the adoption trends. ...
(Date:10/18/2014)... The Asian arthroscopic devices report defines and ... forecast of revenue. The arthroscopic devices market in Asia ... at a CAGR of 6.5% from 2013 to 2018. ... devices market, to get an idea of the in-depth ... segmentation of arthroscopic devices market in the same region, ...
Breaking Biology Technology:NDA Partners Appoints Ellen Teplitzky, JD as Director of its Legal Services Practice 2The Asia-Pacific Bromine Market is estimated to grow to $4,080.1 million by 2018 - New Report by MicroMarket Monitor 2The Asia-Pacific Bromine Market is estimated to grow to $4,080.1 million by 2018 - New Report by MicroMarket Monitor 3Unmanned Ground Vehicle (UGV) Market Estimated to Reach $8.26 Billion by 2020 - New Research Report by MarketsandMarkets 2Unmanned Ground Vehicle (UGV) Market Estimated to Reach $8.26 Billion by 2020 - New Research Report by MarketsandMarkets 3Unmanned Ground Vehicle (UGV) Market Estimated to Reach $8.26 Billion by 2020 - New Research Report by MarketsandMarkets 4Unmanned Ground Vehicle (UGV) Market Estimated to Reach $8.26 Billion by 2020 - New Research Report by MarketsandMarkets 5The Asian arthroscopic devices market is estimated to grow to $712.3 million by 2018 - New Report by MicroMarket Monitor 2The Asian arthroscopic devices market is estimated to grow to $712.3 million by 2018 - New Report by MicroMarket Monitor 3The Asian arthroscopic devices market is estimated to grow to $712.3 million by 2018 - New Report by MicroMarket Monitor 4
... EntreMed, Inc. (Nasdaq: ENMD ), a ... cancer today announced the presentation of clinical data for ... cancer patients.   The data were presented by the ... medical director of gynecologic oncology at Dana-Farber Cancer Institute ...
... LifeVantage Corporation (OTCBB: LFVN), the maker of ... reduction of oxidative stress by the synergistic activation ... review article involving Protandim® was published in the ... (Logo:   http://photos.prnewswire.com/prnh/20090930/LIFEVANTAGELOGO ) ...
... Houston researchers have developed a method for creating single-crystal ... the possibility of a replacement for silicon in high-performance ... their collaborators is featured on the cover of the ... a one-atom-thick layer of carbon that was first fabricated ...
Cached Biology Technology:EntreMed's ENMD-2076 Demonstrates Clinical Activity in Recurrent, Platinum-Resistant Ovarian Cancer Patients 2EntreMed's ENMD-2076 Demonstrates Clinical Activity in Recurrent, Platinum-Resistant Ovarian Cancer Patients 3EntreMed's ENMD-2076 Demonstrates Clinical Activity in Recurrent, Platinum-Resistant Ovarian Cancer Patients 4LifeVantage's Nrf2 Activator Reviewed for Tumor Prevention and Suppression in New Peer-Reviewed Article 2LifeVantage's Nrf2 Activator Reviewed for Tumor Prevention and Suppression in New Peer-Reviewed Article 3LifeVantage's Nrf2 Activator Reviewed for Tumor Prevention and Suppression in New Peer-Reviewed Article 4LifeVantage's Nrf2 Activator Reviewed for Tumor Prevention and Suppression in New Peer-Reviewed Article 5University of Houston develops method for creating single-crystal arrays of graphene 2
... Super-Sensitive, Super-Dark, Super-Small! ... with the ChemiDoc-It Imaging System. High-sensitivity ... produces low-background noise and wide dynamic ... a short exposure time. The light-tight ...
Mouse monoclonal [X223] to Lamin B1 + B2 - Nuclear Envelope Marker ( Abpromise for all tested applications). entrezGeneID: 4001 SwissProtID: P20700...
... Evidence Based Oligonucleotide) Genome Set and MEEBO ... Set contain a collection of open source ... exons, allowing interrogation of thousands of genes. ... Stanford University and UCSF, the sets enable ...
odz, odd Oz/ten-m homolog 1 [Source:RefSeq_peptide;Acc:NP_055068] Antigen: Recombinant Protein Epitope Signature Tag (PrEST)....
Biology Products: