Navigation Links
Key to burning fat faster discovered
Date:8/22/2012

Enzymes involved in breaking down fat can now be manipulated to work three times harder by turning on a molecular switch recently observed by chemists at the University of Copenhagen. Being able to control this chemical on/off button could have massive implications for curing diseases related to obesity including diabetes, cardio vascular disease, stroke and even skin problems like acne. But the implications may be wider.

The results suggest that the switch may be a common characteristic of many more enzymes. Since enzymes are miniscule worker-molecules that control a vast variety of functions in cells, if the switches are standard, it may well be one of the most important discoveries in enzymology.

"If many enzymes turn out to be switched on in the same way as the ones we've studied, this opens a door to understanding- and maybe curing, a wide range of diseases", says professor Dimitrios Stamou.

Stamou heads a multidisciplinary team of scientists at the Nanoscience Center and Department of Chemistry at the University of Copenhagen who published their discovery in the prominent scientific journal "Journal of the American Chemical Society".

Switch contradicts previous understanding

The discovery of the enzymatic ignition key contradicts previous ideas of how cells control the function of enzymes such as the fat eating lipase used in the current study.

Researchers used to think that these enzymes work continuously at varying levels of efficiency. But in fact they are quite lazy. Very much like construction workers they work at a fixed efficiency for a given amount of time (working hours), and then they rest. And that's good news for enzyme designers.

Tripping their newfound switch resulted in tripling the working hours of lipase enzymes, from 15 percent of the time to 45 percent by the Copenhagen team

Function follows form

In enzymes, function is decided by the shape of the molecule. So making the
'/>"/>

Contact: Jes Andersen
jean@science.ku.dk
45-30-50-65-82
University of Copenhagen
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Hyenas that think outside the box solve problems faster
2. Searching genomic data faster
3. Palladium-gold nanoparticles clean TCE a billion times faster than iron filings
4. Exome sequencing gives cheaper, faster diagnosis in heterogeneous disease
5. Faster, cheaper gas and liquid separation using custom designed and built mesoscopic structures
6. What does a tree growing faster than its neighbor look like from outer space?
7. Athletic frogs have faster-changing genomes
8. Tiny electrical sensors could signal faster MRSA diagnosis
9. From scourge to saint: E. coli bacteria becomes a factory - to make cheaper, faster pharmaceuticals
10. Oceans acidifying faster today than in past 300 million years
11. 2 new owls discovered in the Philippines
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Key to burning fat faster discovered
(Date:7/10/2014)... , June 27, 2014  Pomerantz LLP has ... Inc. ("Provectus" or the "Company")(NYSE-MKT: PVCT) and certain ... United States District Court, Middle District of ... behalf of a class consisting of all persons ... securities between December 17, 2013 and May 22, ...
(Date:7/10/2014)... Conn. , July 2, 2014 NXT-ID, Inc., (OTCQB: ... reports that CEO Mr. Gino Pereira was interviewed ... show in Tampa Florida . Mr. Pereira ... host Cedric Harris and how the Wocket™ aims ... alternative.  Cedric Harris tells Gino ...
(Date:7/10/2014)... Fingerprint Cards, (FPC,s) new ... (DW). An Asian OEM has selected FPC1021 for a flagship ... August 2014.   FPC is proud to announce ... planned date for start of mass production in August 2014. ... 5M, for delivery in the first half of July. The ...
Breaking Biology News(10 mins):SHAREHOLDER ALERT: Pomerantz Law Firm Announces the Filing of a Class Action against Provectus Biopharmaceuticals, Inc. and Certain Officers - PVCT 2SHAREHOLDER ALERT: Pomerantz Law Firm Announces the Filing of a Class Action against Provectus Biopharmaceuticals, Inc. and Certain Officers - PVCT 3Security and Your Money: Tampa Bay Radio Host Cedric Harris Talks to NXT-ID CEO Mr. Gino Pereira about the Wocket Smart Wallet 2Security and Your Money: Tampa Bay Radio Host Cedric Harris Talks to NXT-ID CEO Mr. Gino Pereira about the Wocket Smart Wallet 3Security and Your Money: Tampa Bay Radio Host Cedric Harris Talks to NXT-ID CEO Mr. Gino Pereira about the Wocket Smart Wallet 4FPC Wins DW and Initial Ramp Order for FPC1021 Touch Sensor for Flagship Smartphone from Asian OEM 2
... a looming water crisis, driven by climate change, growing ... of this issue, the National Science Foundation has selected ... Engineering Research Center (ERC) to address this challenge by ... initial grant is $18.5 million spread over five years, ...
... Scientists at the U.S. Department of Energy,s (DOE) Brookhaven ... the metabolic processes in rapeseed plants - particularly those ... Their goal is to find ways to optimize the ... renewable resources for fuel and industrial chemicals. The ...
... ,(Phoenix ... awarded Robert Garfield, PhD, a researcher at St. Joseph,s Hospital and Medical ... to prevent post-partum hemorrhage. The grant was one of 88 awarded ... help lower the barriers for testing innovative ideas in global health. Phase ...
Cached Biology News:Re-inventing America's urban water infrastructure 2Re-inventing America's urban water infrastructure 3Re-inventing America's urban water infrastructure 4Modeling plant metabolism to optimize oil production 2Modeling plant metabolism to optimize oil production 3
(Date:7/10/2014)... July 10, 2014 Research and Markets ... the "International Photonic Integrated Circuit (Monolithic Integration, ... 2019" report to their offering. ... concept of photonic integration traces its roots in ... promise of photonic integration went unexplored and unfulfilled ...
(Date:7/10/2014)... April 15, 2014 -- According to the International ... nuclear security comes from terrorists acquiring sufficient quantities ... construct a crude nuclear explosive device. The IAEA ... trafficking have involved gram-level quantities, which can be ... According to a new study appearing this week ...
(Date:7/10/2014)... June 17, 2014 Using microscopic polymer light ... gases, researchers at MIT,s Quantum Photonics Laboratory have ... in the parts-per-billion range. Optical sensors are ideal ... high signal-to-noise ratio, compact, lightweight nature, and immunity ... sensors had been developed before, the MIT team ...
(Date:7/10/2014)... psychiatric disorders has been extremely challenging because there are ... insufficient to cause disease. Now investigators reporting in the ... Cell Stem Cell describe a strategy that may ... other risk factors or environmental exposures to affect the ... genetic variant that may predispose individuals to schizophrenia. ...
Breaking Biology Technology:International Photonic Integrated Circuit (Monolithic Integration, Hybrid Integration, Module Integration) Market - Forecasts to 2019 2Sensitive detection method may help impede illicit nuclear trafficking 2Swell new sensors 2New strategy could uncover genes at the root of psychiatric illnesses 2
... 11 Idenix Pharmaceuticals, Inc., (Nasdaq: IDIX ... results for the fourth quarter of 2008 on Tuesday, ... conjunction with the issuance of the press release, Idenix ... ET on Tuesday, February 17, 2009 to discuss the ...
... XTL,Biopharmaceuticals Ltd. (Nasdaq: XTLB ; TASE: ... Shweiger have been appointed to XTL,s Board of,Directors, effective ... assuming,the role of Co-Chief Executive Officer, with no remuneration, ... Ron Bentsur, Co-Chief Executive Officer ...
... Victhom Human Bionics Inc., "Victhom" (TSX: VHB), announced today ... and treatment of a physiological disorder that most likely ... seizure. , Victhom has recently filed a patent application ... sudden unexpected death in epilepsy (SUDEP) using its neuromodulation ...
Cached Biology Technology:XTL Biopharmaceuticals Announces Appointment of David Grossman and Boaz Shweiger to Board of Directors 2XTL Biopharmaceuticals Announces Appointment of David Grossman and Boaz Shweiger to Board of Directors 3Victhom announces the filing of a patent application to address sudden unexplained death in epilepsy (SUDEP) 2Victhom announces the filing of a patent application to address sudden unexplained death in epilepsy (SUDEP) 3
Takara's Mutan-Super Express Km Kit is designed to achieve site-directed mutagenesis in just one day. It is based on Oligonucleotide-directed Dual Amber (ODA) method, using the advantages of LA (Long...
... TriEx Sf9 Cells and TriEx Insect ... from pTriEx baculovirus constructs. This cell/medium combination ... cell growth and high protein expression levels ... pTriEx-1.14 vectors. Please note that our Ready-Plaque ...
...
...
Biology Products: