Navigation Links
Key protein revealed as trigger for stem cell development
Date:2/7/2013

A natural trigger that enables stem cells to become any cell-type in the body has been discovered by scientists.

Researchers have identified a protein that kick-starts the process by which stem cells can develop to into different cells in the body, for instance liver or brain cells.

Their discovery could help scientists improve techniques enabling them to turn stem cells into other cell types in the laboratory. These could then be used to test drugs or help create therapies for degenerative conditions such as Parkinson's disease, motor neurone disease, multiple sclerosis and liver disease.

Scientists from the Medical Research Council Centre for Regenerative Medicine at the University of Edinburgh, who studied embryonic stem cells in mice, also developed a technique enabling them to highlight the presence of the key protein Tcf15 in the cells.

This means that researchers can identify which cells have the protein and watch how it affects stem cells in real time to gain a better understanding of how it works.

The study, published in the journal Cell Reports, was funded by the Wellcome Trust and the Biotechnology and Biological Sciences Research Council,

Dr Sally Lowell, from the MRC Centre for Regenerative Medicine at the University of Edinburgh, said: "This gives us better insight into the crucially important first step stem cells take to differentiate into other cell types. Understanding how and when this happens could help to improve the way in which we are able to control this process."

Researchers pinpointed the protein by looking at how some stem cells are naturally prevented from specialising into other cell types.

They found two sets of proteins, one of which binds to the other blocking them from carrying out their various functions.

They were then able to screen the blocked proteins to find out which ones would enable stem cells to differentiate.


'/>"/>

Contact: Tara Womersley
tara.womersley@ed.ac.uk
44-131-650-9836
University of Edinburgh
Source:Eurekalert

Page: 1

Related biology news :

1. IU biologists offer clearer picture of how protein machine systems tweak gene expression
2. Making memories: How 1 protein does it
3. Embryonic development protein active in cancer growth
4. More effective method of imaging proteins
5. The loss of a protein makes jump the tumor to the lymph node
6. Gold nanoantennas detect proteins
7. The Japanese traditional therapy, honokiol, blocks key protein in inflammatory brain damage
8. New hope for treating Alzheimers Disease: A role for the FKBP52 protein
9. Protein jailbreak helps breast cancer cells live
10. Plant research reveals new role for gene silencing protein
11. Newly found protein helps cells build tissues
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2020)... ... ... Today CJ BIO announced the first in a series of Food Ingredient ... that is revolutionizing ingredient mixes, nutritional content and flavor profiles across a range of ... 2020 at11:00 AM (CDT) during SHIFT20, the virtual edition of the IFT Annual Meeting ...
(Date:7/2/2020)... ... July 01, 2020 , ... AltruBio Inc. http://www.altrubio.com ... a biologic for the treatment of steroid-refractory acute graft-versus-host disease (SR-aGVHD), at European ... J Martin of the Fred Hutchinson Cancer Research Center, this single-arm, open-label Phase ...
(Date:7/1/2020)... ... July 01, 2020 , ... Catalent, ... the purchase of Teva-Takeda Pharmaceuticals’ packaging facility in Minakuchi, located in the Shiga ... supply facility located in Kakegawa, the new 60,000-square-foot facility will provide customers with ...
Breaking Biology News(10 mins):
(Date:7/10/2020)... (PRWEB) , ... July 09, ... ... biotechnology company, announced today that Massachusetts Institute of Technology (MIT) has expanded ... broader license allows PathSensors to move into the point-of-care diagnostic market, focusing ...
(Date:7/7/2020)... ... 06, 2020 , ... R3 International is now offering stem cell therapy for ... cells. Depending on the patient's condition, treatment may be offered IV, intrathecal or with ... form of Alzheimers dementia, and the incidence continues to increase as individuals live longer. ...
(Date:7/1/2020)... ... June 29, 2020 , ... The Interlocal Purchasing System ... its membership, recently named BioFit Engineered Products an Awarded Vendor. Awarded ... ergonomic seating, cafeteria tables, book trucks and carts at discounted pricing without the ...
(Date:6/28/2020)... ... June 25, 2020 , ... ... to develop a vaccine or drug treatment. In an effort to better understand ... publicly released the world’s largest imaging dataset portraying therapeutic compound effects from over ...
Breaking Biology Technology: