Navigation Links
Key protein revealed as trigger for stem cell development
Date:2/7/2013

A natural trigger that enables stem cells to become any cell-type in the body has been discovered by scientists.

Researchers have identified a protein that kick-starts the process by which stem cells can develop to into different cells in the body, for instance liver or brain cells.

Their discovery could help scientists improve techniques enabling them to turn stem cells into other cell types in the laboratory. These could then be used to test drugs or help create therapies for degenerative conditions such as Parkinson's disease, motor neurone disease, multiple sclerosis and liver disease.

Scientists from the Medical Research Council Centre for Regenerative Medicine at the University of Edinburgh, who studied embryonic stem cells in mice, also developed a technique enabling them to highlight the presence of the key protein Tcf15 in the cells.

This means that researchers can identify which cells have the protein and watch how it affects stem cells in real time to gain a better understanding of how it works.

The study, published in the journal Cell Reports, was funded by the Wellcome Trust and the Biotechnology and Biological Sciences Research Council,

Dr Sally Lowell, from the MRC Centre for Regenerative Medicine at the University of Edinburgh, said: "This gives us better insight into the crucially important first step stem cells take to differentiate into other cell types. Understanding how and when this happens could help to improve the way in which we are able to control this process."

Researchers pinpointed the protein by looking at how some stem cells are naturally prevented from specialising into other cell types.

They found two sets of proteins, one of which binds to the other blocking them from carrying out their various functions.

They were then able to screen the blocked proteins to find out which ones would enable stem cells to differentiate.


'/>"/>

Contact: Tara Womersley
tara.womersley@ed.ac.uk
44-131-650-9836
University of Edinburgh
Source:Eurekalert

Page: 1

Related biology news :

1. IU biologists offer clearer picture of how protein machine systems tweak gene expression
2. Making memories: How 1 protein does it
3. Embryonic development protein active in cancer growth
4. More effective method of imaging proteins
5. The loss of a protein makes jump the tumor to the lymph node
6. Gold nanoantennas detect proteins
7. The Japanese traditional therapy, honokiol, blocks key protein in inflammatory brain damage
8. New hope for treating Alzheimers Disease: A role for the FKBP52 protein
9. Protein jailbreak helps breast cancer cells live
10. Plant research reveals new role for gene silencing protein
11. Newly found protein helps cells build tissues
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/29/2017)... , March 29, 2017  higi, the health IT ... North America , today announced a ... the acquisition of EveryMove. The new investment and acquisition ... of tools to transform population health activities through the ... data. higi collects and secures data today ...
(Date:3/24/2017)... -- Research and Markets has announced the addition of ... - Industry Forecast to 2025" report to their offering. ... The Global Biometric Vehicle ... around 15.1% over the next decade to reach approximately $1,580 million ... estimates and forecasts for all the given segments on global as ...
(Date:3/22/2017)... Optimove , provider of the ... as 1-800-Flowers and AdoreMe, today announced two new ... Using Optimove,s machine learning algorithms, these features allow ... recommendations to their customers based not just on ... intent drawn from a complex web of data ...
Breaking Biology News(10 mins):
(Date:6/20/2017)... ... 20, 2017 , ... HorizonScan is providing food and ingredient ... likely threat to their products at the annual IFT conference in Las Vegas, ... expo attracts over 20,000 attendees representing food science professionals from over 90 countries ...
(Date:6/20/2017)... ... June 20, 2017 , ... ... antibody therapeutics from millions-diverse immune repertoires, announces launch of its new Surge(TM) ... Dave Johnson, PhD, CEO of GigaGen, will present on Surge at the conference. ...
(Date:6/19/2017)... ... June 19, 2017 , ... A colony of healthy ... cells and tissues by delivering pollen and nectar containing nutrients necessary for growth and ... stay healthy. , Many recent indicators point to a decline in honey bee health. ...
(Date:6/15/2017)... (PRWEB) , ... June 15, 2017 , ... ... synthetic auxin herbicides give farmers new options for managing Palmer amaranth and other ... America (WSSA) say special precautions are necessary. Auxin herbicides are known to drift ...
Breaking Biology Technology: