Navigation Links
Key protein revealed as trigger for stem cell development
Date:2/7/2013

A natural trigger that enables stem cells to become any cell-type in the body has been discovered by scientists.

Researchers have identified a protein that kick-starts the process by which stem cells can develop to into different cells in the body, for instance liver or brain cells.

Their discovery could help scientists improve techniques enabling them to turn stem cells into other cell types in the laboratory. These could then be used to test drugs or help create therapies for degenerative conditions such as Parkinson's disease, motor neurone disease, multiple sclerosis and liver disease.

Scientists from the Medical Research Council Centre for Regenerative Medicine at the University of Edinburgh, who studied embryonic stem cells in mice, also developed a technique enabling them to highlight the presence of the key protein Tcf15 in the cells.

This means that researchers can identify which cells have the protein and watch how it affects stem cells in real time to gain a better understanding of how it works.

The study, published in the journal Cell Reports, was funded by the Wellcome Trust and the Biotechnology and Biological Sciences Research Council,

Dr Sally Lowell, from the MRC Centre for Regenerative Medicine at the University of Edinburgh, said: "This gives us better insight into the crucially important first step stem cells take to differentiate into other cell types. Understanding how and when this happens could help to improve the way in which we are able to control this process."

Researchers pinpointed the protein by looking at how some stem cells are naturally prevented from specialising into other cell types.

They found two sets of proteins, one of which binds to the other blocking them from carrying out their various functions.

They were then able to screen the blocked proteins to find out which ones would enable stem cells to differentiate.


'/>"/>

Contact: Tara Womersley
tara.womersley@ed.ac.uk
44-131-650-9836
University of Edinburgh
Source:Eurekalert

Page: 1

Related biology news :

1. IU biologists offer clearer picture of how protein machine systems tweak gene expression
2. Making memories: How 1 protein does it
3. Embryonic development protein active in cancer growth
4. More effective method of imaging proteins
5. The loss of a protein makes jump the tumor to the lymph node
6. Gold nanoantennas detect proteins
7. The Japanese traditional therapy, honokiol, blocks key protein in inflammatory brain damage
8. New hope for treating Alzheimers Disease: A role for the FKBP52 protein
9. Protein jailbreak helps breast cancer cells live
10. Plant research reveals new role for gene silencing protein
11. Newly found protein helps cells build tissues
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/20/2016)... DALLAS , June 20, 2016 ... criminal justice technology solutions for public safety, investigation, ... by the prisons involved, it has secured the ... Corrections (DOC) facilities for Managed Access Systems (MAS) ... (4) additional facilities to be installed by October, ...
(Date:6/15/2016)... June 15, 2016 Transparency ... titled "Gesture Recognition Market by Application Market - Global Industry Analysis ... 2024". According to the report, the  global gesture recognition ... 2015 and is estimated to grow at a ... by 2024.  Increasing application of gesture ...
(Date:6/9/2016)... TURKU, Finland , June 9, 2016 ... French National Police deploy Teleste,s video security solution to ensure ... France during the major tournament ... and data communications systems and services, announced today that its ... Police Prefecture to back up public safety across ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... on a range of subjects including policies, debt and investment ... Speaking at a lecture to the Canadian Economics ... the country,s inflation target, which is set by both the ... "In certain areas there needs to be frequent ... not sit down and address strategy together?" He ...
(Date:6/23/2016)... ... June 23, 2016 , ... ... of its second eBook, “Clinical Trials Patient Recruitment and Retention Tips.” Partnering with ... in this eBook by providing practical tips, tools, and strategies for clinical researchers. ...
(Date:6/23/2016)... Md. , June 23, 2016 A person ... from the crime scene to track the criminal down. ... the U.S. Food and Drug Administration (FDA) uses DNA evidence ... Sound far-fetched? It,s not. The FDA ... sequencing to support investigations of foodborne illnesses. Put as simply ...
(Date:6/23/2016)... June, 23, 2016  The Biodesign Challenge (BDC), a ... ways to harness living systems and biotechnology, announced its ... in New York City . ... students, showcased projects at MoMA,s Celeste Bartos Theater during ... , MoMA,s senior curator of architecture and design, and ...
Breaking Biology Technology: