Navigation Links
Key piece of puzzle sheds light on function of ribosomes
Date:1/13/2010

When ribosomes produce protein in all living cells, they do so through a chemical reaction that happens so fast that scientists have been puzzled. Using large quantum mechanical calculations of the reaction center of the ribosome, researchers at Uppsala University in Sweden can now provide the first detailed picture of the reaction. The findings are published in the Web edition of Proceedings of the National Academy of Sciences, PNAS.

It was previously known how the chemical reaction goes about adding amino acids to the growing protein. Both computer simulations and x-ray crystallographic experiments have identified a hydrogen bonding network that appears to be the main explanation for the high speed of the reaction. What is especially remarkable is the presence of a couple of "trapped" water molecules seem to be the only parts of the ribosome that are in contact with the reacting chemical groups.

Doctoral candidate Gran Wallin and Professor Johan qvist at the Department of Cell and Molecular Biology at Uppsala University have carried out large-scale calculations of the ribosome reaction center, and this has enabled them to monitor the changes electronic structure during the reaction. With about a thousand quantum mechanical optimizations, they have succeeded in establishing exactly what the highest point of the energy surface looks like, the point that determines the speed of the reaction.

"Our calculations provide a detailed picture of the reaction and show that the two water molecules play a central role in ribosome catalysis. One of the molecules participates directly in the reaction by 'shuffling' protons around, while the other one helps increase the speed of the reaction," explains Johan qvist.

The findings surprisingly show that it is just a few components in the ribosome's reaction center that induce the catalytic effect, whereas the surrounding structure mainly holds them in place.

"An exciting question for future research is whether these components are a vestige of a primordial and much simpler ribosome," says Johan qvist.


'/>"/>

Contact: Johan qvist
johan.aqvist@icm.uu.se
46-018-471-4109
Uppsala University
Source:Eurekalert

Related biology news :

1. Researchers uncover new piece to the puzzle of human height
2. Iowa State researchers help piece together the corn genomes first draft
3. Hopkins researchers piece together gene network linked to schizophrenia
4. Researchers solve piece of large-scale gene silencing mystery
5. Missing piece of plant clock found
6. Learning how the pieces responsible for interpreting the human genome work
7. Aerosol: A key piece of the climate change puzzle
8. New piece found in the puzzle of epigenetics
9. Prehistoric aesthetics explains snail biogeography puzzle
10. UC San Diego physicists tackle knotty puzzle
11. Chloroform provides clue to 150 year old medical puzzle
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/2/2016)... -- The Department of Transport Management (DOTM) of ... US Dollar project, for the , Supply and ... and IT Infrastructure , to Decatur ... of Identity Management Solutions. Numerous renowned international vendors participated in ... was selected for the most compliant and innovative solution. ...
(Date:5/20/2016)... , May 20, 2016  VoiceIt is excited ... with VoicePass. By working together, VoiceIt ...  Because VoiceIt and VoicePass take slightly different approaches ... increases both security and usability. ... about this new partnership. "This marketing ...
(Date:4/28/2016)... and BANGALORE, India , April ... EdgeVerve Systems, a product subsidiary of Infosys (NYSE: ... today announced a global partnership that will provide ... to use mobile banking and payment services.      ... a key innovation area for financial services, but it also ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... Durham, NC (PRWEB) , ... June 23, 2016 , ... ... Odense University Hospital in Denmark detail how a patient who developed lymphedema after being ... (fat) tissue. The results could change the paradigm for dealing with this debilitating, frequent ...
(Date:6/23/2016)... , June 23, 2016  Blueprint Bio, a company ... to the medical community, has closed its Series A ... Nunez . "We have received a commitment ... capital we need to meet our current goals," stated ... us the runway to complete validation on the current ...
(Date:6/23/2016)... YORK , June 23, 2016 ... trading session at 4,833.32, down 0.22%; the Dow Jones Industrial ... S&P 500 closed at 2,085.45, down 0.17%. Stock-Callers.com has initiated ... INFI ), Nektar Therapeutics (NASDAQ: NKTR ), ... Therapeutics Inc. (NASDAQ: BIND ). Learn more about ...
(Date:6/23/2016)... , ... June 23, 2016 , ... ... quality, regulatory and technical consulting, provides a free webinar on Performing ... July 13, 2016 at 12pm CT at no charge. , Incomplete investigations are ...
Breaking Biology Technology: