Navigation Links
Key mutations discovered for most common childhood brain cancer
Date:7/22/2012

the biological basis of the tumor's variability. "For the first time, we'll be able to classify and treat medulloblastoma based on molecular typing, providing the best therapy with the fewest long-term consequences."

In this new study, Pomeroy and his team used next generation sequencing technologies to read the full complement of protein-coding genes (also called the exome) of tumors from 92 patients. Within these tumors the team discovered that somatic (that is, non-heritable) mutations occur at very low frequency, one-tenth to one-hundredth of that seen in cancers of adults. Specific gene mutations clustered neatly into the four molecular subtypes, although the majority of genes (88%) were mutated only once in the entire tumor collection. Only 12 genes were mutated in more than one tumor, illustrating medulloblastoma's genetic heterogeneity.

Functionally, the mutated genes fell into two broad categories: genes like Shh and Wnt that play direct roles in molecular pathways controlling cell growth, and genes like DDX3X and GPS2 that play more of a coaching role, modulating the activity of other genes.

Taken as a whole, the study's results confirm the view of medulloblastoma as a family of tumors driven by disruptions in just a few common mechanisms. However, the form those disruptions takethe actual mutations or genomic changescan vary from tumor to tumor.

"The results reflect two emerging genetic themes seen throughout childhood tumors," Pomeroy noted. "First, very low mutation rates, much lower than those seen in adult tumors, and second, the importance of mutations in genes that regulate the function of the cell's growth pathways but which aren't direct components of those pathways."

Some of the study's findings could be translated to patients relatively quickly. For instance, with the main mutations of each subtype in hand, it should soon be possible to rapidly classify individual medulloblastoma patients' tumors an
'/>"/>

Contact: Meghan Weber
meghan.weber@childrens.harvard.edu
617-919-3110
Children's Hospital Boston
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. New gene mutations linked to ALS and nerve cell growth dysfunction
2. UMMS researchers isolate gene mutations in patients with inherited amyotrophic lateral sclerosis
3. Mutations in autism susceptibility gene increase risk in boys
4. Interacting mutations promote diversity
5. Gene mutations cause massive brain asymmetry
6. BRG1 mutations confer resistance to hormones in lung cancer
7. Virus discovered in Cultus Lake sport fish
8. Genetic link to rapid weight gain from antipsychotics discovered
9. Fossil egg discovered in Lleida (Spain) links dinosaurs to modern birds
10. Can you hear me now? New strategy discovered to prevent hearing loss
11. Feathered saurians -- downy dinosaur discovered
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2014)... Food and Drug Administration (FDA) for other purposes can ... human cells, including those that cause Legionnaires, disease, brucellosis, ... mBio , the online open-access journal of the American ... non-antibiotic drugs that could one day help curb bacterial ... list inhibit the growth of at least three of ...
(Date:7/28/2014)... coral communities showing signs of damage from the Deepwater Horizon ... in the Gulf of Mexico. The discovery was made by ... Penn State University. A paper describing this work and additional ... Mexico will be published during the last week of July ... Proceedings of the National Academy of Sciences . , "The ...
(Date:7/28/2014)... the South Pole in 1911, but new research shows ... , Using data from 16 ice cores collected from ... South Pole, a group led by Joe McConnell of ... the most accurate and precise reconstruction to date of ... described in an article published today in the online ...
Breaking Biology News(10 mins):New route to identify drugs that can fight bacterial infections 2Impact of Deepwater Horizon oil spill on coral is deeper and broader than predicted 2Lead pollution beat explorers to South Pole, persists today 2Lead pollution beat explorers to South Pole, persists today 3
... NOAA scientists report the discovery of the first known colony of ... A report on the discovery was published last month in the ... name due to its flat-topped, table-like shape, table coral ( Acropora ... of the tropical Pacific, but it has never been observed in ...
... online by the Nature journal Leukemia suggests ... some types of leukemia resist treatment can increase the ... Cincinnati Children,s Hospital Medical Center report that their experimental ... along with chemotherapy was particularly effective at stopping ...
... Calif. , Aug. 8, 2013 The radio frequency ... moving slowly mainly due to high costs and the criticality ... related to food safety and drug traceability in the U.S. ... into the market. New analysis from Frost & ...
Cached Biology News:Study suggests way to fight therapy resistant leukemia by blocking DNA repair 2Study suggests way to fight therapy resistant leukemia by blocking DNA repair 3Frost & Sullivan: Government Mandates Create Momentum in Uptake of Radio Frequency Identification in Global Cold Chain 2Frost & Sullivan: Government Mandates Create Momentum in Uptake of Radio Frequency Identification in Global Cold Chain 3Frost & Sullivan: Government Mandates Create Momentum in Uptake of Radio Frequency Identification in Global Cold Chain 4
(Date:7/29/2014)... (PRWEB) July 29, 2014 The first ... a next generation approach to robotics. What sets Droidles ... patent pending technology that allows them to communicate, share ... wirelessly over the internet. , “The invention is the ... the little Droidles a life of their own, both ...
(Date:7/29/2014)... Eppendorf Centrifuge 5427 R has ... R is geared towards high-end applications like genomic, atomic, ... towards work requiring high sample throughput. Pipette.com is excited ... their extensive 16, 48, and 64 multichannel pipettes as ... tubes, PCR strip tubes, and more. , Introducing ...
(Date:7/29/2014)... The prestigious "Discovery or Exploration in History ... to Juliana Hillis and Kaylie O’Connell, students at Stoneham ... an Egg, Everything: America’s First IVF Baby". This project ... National History Day program during a week-long final competition ... Washington, D.C. , The growing popularity of the assisted ...
(Date:7/29/2014)... Dr. Jason Wendel – recipient of a ... of the Top 10 Plastic Surgeon Specialists for Nashville, TN ... His complete line includes a Hydration Booster, Retexturing Night Crème, ... and skin a younger, more radiant appearance while protecting them ... different, that is why at Dr. J. J. Wendel Plastic ...
Breaking Biology Technology:Droidles, the Social Network of Robots and Open Source Platform for the Internet of Things, Launches for Crowd Funding on IndieGoGo.com 2International Pipette Distributor, Pipette.com Announces the Addition of the Eppendorf Centrifuge 5427 R to Their Product Portfolio 2In Vitro Fertilization (IVF) was the Subject of This Year’s Winning Entry for the Prestigious Library of Congress “Discovery or Exploration in History Award” 2In Vitro Fertilization (IVF) was the Subject of This Year’s Winning Entry for the Prestigious Library of Congress “Discovery or Exploration in History Award” 3Dr. J. J. Wendel Launches New Line of Skin Care Products 2
... MONTREAL and KIEL, Germany, ... researchers at the Kiel- based Collagen,Research Institute (CRI) ... peptides (FORTIGEL(R)) in the context of cell experiments.,Last ... the congress of the,Osteoarthritis Research Society International (OARSI) ...
... , BOZEN, Italy, September 14 ... CytoCare(TM) and i.v.STATION(TM) Robots to,be deployed across all of its ... "After multi-year due diligence on 2 ... on this exciting new technology [due to RIVA,s,publicly announced multi-year ...
... , , , ... Inc. (Nasdaq: CALP ), a leading provider of ... today introduced the IVIS Lumina XR in vivo imaging system, ... XR system combines highly sensitive bioluminescence and fluorescence molecular optical ...
Cached Biology Technology:Important Step Forward in Osteoarthritis Research: Bioactive Collagen Peptides Stimulate the Regeneration of Cartilage Tissue 2Important Step Forward in Osteoarthritis Research: Bioactive Collagen Peptides Stimulate the Regeneration of Cartilage Tissue 3Dr M Group Selects Health Robotics' Technology Over RIVA for all of its I.V. Compounding Centers in South East Asia 2Dr M Group Selects Health Robotics' Technology Over RIVA for all of its I.V. Compounding Centers in South East Asia 3Dr M Group Selects Health Robotics' Technology Over RIVA for all of its I.V. Compounding Centers in South East Asia 4Caliper Life Sciences Launches IVIS(R) In Vivo Imaging System with X-Ray 2Caliper Life Sciences Launches IVIS(R) In Vivo Imaging System with X-Ray 3
... Dot Blot Kits overcome this limitation and ... a wide range in low-density protein array ... They are ideal for performing reverse-phase protein ... for the presence of low abundant antigens. ...
AC input: 50-60 Hz 115-120 V...
... is an aqueous solution that contains ... non-toxic stabilizing chemicals in a MES ... 6.5. This product contains a ... bromonitrodioxane as a preservative. StabilZyme ...
... [3D12] to Lambda Free Light Chain ... light chains of human immunoglobulin. ... constantly expressed epitope of lambda chain. ... of free lambda chains but not ...
Biology Products: