Navigation Links
Key mechanism identified in metastatic breast cancer
Date:5/4/2010

etastasis in breast cancer.

Using a protein purification approach, Zhou and his colleagues found that Snail interacts and teams up with its "partner in crime," an enzyme called LSD1, inside the cell. LSD1 is known to change the structure of DNA and shut down the expression of many genes.

LSD1, which stands for lysine-specific demethylase-1 (and is chemically unrelated to the hallucinogen LSD), regulates the structure of the chromosome by removing a key methylation at histone H3, a core component that warps the DNA into compact conformation. This event triggers the "closure" of DNA structure and shuts down gene expression, such as E-cadherin. Zhou's team showed that the N-terminal portion of Snail molecular functions as a "molecular hook" for recruiting LSD1 to the E-cadherin gene, which, in turn, shuts down the expression of E-cadherin and induces tumor cell invasion and metastasis.

"This finding has significant clinical ramification, because chemical compounds or agents that can disrupt the interaction of Snail with LSD1 will have a great therapeutic potential of treating metastatic breast cancer," Zhou said. "Scientists at the Markey Cancer Center are currently exploring this idea and are keen to develop drugs that can treat metastatic cancer."

Breast cancer is the most common cancer in women. Approximately 90 percent of breast cancer deaths are caused by local invasion and distant metastasis of tumor cells, and the average survival after documentation of metastasis is approximately two years.

"An understanding of the mechanism underlying the biology of breast cancer metastasis will provide novel therapeutic approaches to combat this life-threatening disease," Zhou said.


'/>"/>

Contact: Keith Hautala
klhaut2@uky.edu
859-257-1754
University of Kentucky
Source:Eurekalert

Page: 1 2

Related biology news :

1. Carnegie Mellon scientists investigate initial molecular mechanism that triggers neuronal firing
2. Scientists find clue to mechanisms of gene signaling and regulation
3. Neural stem cell study reveals mechanism that may play role in cancer
4. New insight into the mechanisms of voltage sensing and transduction in biological processes
5. Mechanism for the in-vivo transport of siRNA
6. Scientists decipher mechanism behind antimicrobial hole punchers
7. Enhanced DNA-repair mechanism can cause breast cancer
8. Scientists enhance Mother Natures carbon handling mechanism
9. A mechanism to explain biological cross-talk between 24-hour body cycle and metabolism
10. Mechanism for regulation of growth and differentiation of adult muscle stem cells is revealed
11. Pathogens use previously undescribed mechanism to sabotage host immune system
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/14/2015)... 2015 NXT-ID, Inc. (NASDAQ: NXTD ) ... on the growing mobile commerce market, announces that its ... New York Design Awards under the category  ,Product Design ... Design Awards are part of a global multi-disciplinary awards ... from the marketplace, industry and judging panel. Winners will ...
(Date:4/10/2015)... DUBLIN , April 10, 2015 ... the addition of the "Security Competitive Profiles - ... (Logo: http://photos.prnewswire.com/prnh/20130307/600769) , NEC will continue to ... solutions to the market, with a company focus on ... solution anticipated. Winning opportunities in the ...
(Date:4/6/2015)... NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" ... on the growing mobile commerce market, announced today ... MINIATURE, MULTI-PURPOSE ANTENNA METHOD AND SYSTEM FOR ... introduces a new revolutionary method and system to ... of miniature antenna modules for multiple purposes including ...
Breaking Biology News(10 mins):NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 2NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 3NEC Security Competitive Profile 2015 2NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 2NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 3NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 4
... In findings that should finally put to rest a decade ... The Scripps Research Institute has found decisive evidence that a ... known to play a key role in the processing of ... shows that this system can dampen the effects of alcohol, ...
... CINCINNATIAn international team led by a University of Cincinnati ... survive hostile host defenses in the body. The team, led ... biochemistry and microbiology department, analyzed the evolution over time of ... GAS or Strep A), a bacterium often found in the ...
... "European Inorganic Membrane Research Alliance" (EIMRA) aims to ... In this way, EIMRA will contribute to the ... carbon dioxide emissions. Collaboration with industrial partners ... seeks to support the industrial implementation of membrane ...
Cached Biology News:Scripps Research study overturns decade-old findings in neurobiology 2Scripps Research study overturns decade-old findings in neurobiology 3Research team shows how bacterial community evolves to survive 2
(Date:4/17/2015)... 2015 Reed Technology and Information ... data management, preparation, and submission to the U.S. Food ... a new Lot Distribution Report (LDR) service for manufacturers ... compliant with the FDA’s new rule on electronic submission ... monitor the volume and timing of particular biologics introduced ...
(Date:4/17/2015)... 2015  Guggenheim Securities, the investment banking and capital ... of William Tanner as a Managing Director ... will start work at Guggenheim in May 2015 in ... "Bill brings a wealth of biotech experience, ... and highly acclaimed healthcare team," said Matthew Johnson ...
(Date:4/17/2015)... April 17, 2015 LC Sciences ... technologies, announced today that it is seeking beta ... innovative multiplex PCR based targeted sequencing technology. The ... analysis, that enables accurate detection of rare variants. ... Omega-Primer™ technologies. The company will collaborate with beta ...
(Date:4/16/2015)... and OSAKA, Japan , April ... Application (CiRA) of Kyoto University and Takeda Pharmaceutical ... work together to develop clinical applications of induced ... failure, diabetes mellitus, neurological disorders and cancer immunotherapy. ... (T-CiRA) is designed to expedite multiple research projects ...
Breaking Biology Technology:Reed Tech Announces FDA Lot Distribution Report (LDR) Service for Manufacturers of Biologic Products 2Reed Tech Announces FDA Lot Distribution Report (LDR) Service for Manufacturers of Biologic Products 3Guggenheim Securities Hires Biotech Analyst William Tanner in Expansion of Healthcare Coverage 2LC Sciences Seeks Beta Testers of Targeted Sequencing Method Ahead of Q4 Launch 2LC Sciences Seeks Beta Testers of Targeted Sequencing Method Ahead of Q4 Launch 3CiRA and Takeda Enter 10-year Collaboration on iPS Cell Research 2CiRA and Takeda Enter 10-year Collaboration on iPS Cell Research 3
... March 25 InNexus Biotechnology Inc., (OTC Bulletin Board: ... development company commercializing the next generation of monoclonal antibodies ... pleased to announce that the Company has entered into ... an aggregate amount of up to USD$2.5 million. The ...
... TORONTO, March 25 /PRNewswire-FirstCall/ - Spectral Diagnostics Inc. ... of sepsis, today announced that the 29th International ... Brussels, Belgium from March 24-27, 2009 will feature ... Endotoxin", that will include presentations from six thought ...
... $50 Million Potential Milestones plus Double Digit Royalties on ... at 11:00 a.m. ET Today - EMERYVILLE, Calif., March ... NBY ), a mid-stage biopharmaceutical company developing first-in-class anti-infective ... range of infections without causing resistance, today announced that ...
Cached Biology Technology:InNexus Biotechnology Announces a Loan Facility of up to USD$2.5 Million 2Spectral announces presentations at the 29TH International Symposium on Intensive Care and Emergency Medicine focusing on the role of endotoxin 2NovaBay and Galderma Enter Into Global Agreement to Develop and Commercialize NovaBay's Novel Aganocide Drugs for Major Dermatological Conditions 2NovaBay and Galderma Enter Into Global Agreement to Develop and Commercialize NovaBay's Novel Aganocide Drugs for Major Dermatological Conditions 3NovaBay and Galderma Enter Into Global Agreement to Develop and Commercialize NovaBay's Novel Aganocide Drugs for Major Dermatological Conditions 4NovaBay and Galderma Enter Into Global Agreement to Develop and Commercialize NovaBay's Novel Aganocide Drugs for Major Dermatological Conditions 5NovaBay and Galderma Enter Into Global Agreement to Develop and Commercialize NovaBay's Novel Aganocide Drugs for Major Dermatological Conditions 6
in vitro Translation, Accessory Products...
... strains are K-12 derivatives that have mutations ... glutathione reductase (gor) genes, which greatly enhances ... have shown that expression in Origami(DE3) yielded ... host even though overall expression levels were ...
Mouse Aminopeptidase P2/XPNPEP2 Affinity Purified PAb Protein Family: Aminopeptidases, Metalloproteases...
Donor Horse Serum US Origin...
Biology Products: