Navigation Links
Key information about breast cancer risk and development is found in 'junk' DNA
Date:12/16/2010

A new genetic biomarker that indicates an increased risk for developing breast cancer can be found in an individual's "junk" (non-coding) DNA, according to a new study featuring work from researchers at the Virginia Bioinformatics Institute (VBI) at Virginia Tech and their colleagues.

The multidisciplinary team found that longer DNA sequences of a repetitive microsatellite were much more likely to be present in breast cancer patients than healthy volunteers. The particular repeated DNA sequence in the control (promoter) region of the estrogen-related receptor gamma (ERR-γ) gene AAAG contains between five and 21 copies and the team found that patients who have more than 13 copies of this repeat have a cancer susceptibility rate that is three times higher than those who do not. They also discovered that this repeat doesn't change the actual protein being reproduced, but likely changes the amount.

The researchers from VBI's Medical Informatics and Systems Division (https://www.vbi.vt.edu/vbi_faculty/vbi_research_group/personal_research_group_page?groupId=6), the University of Texas Southwestern Medical Center and the University of Liverpool, United Kingdom, report their findings in an upcoming edition of the journal Breast Cancer Research and Treatment. The study is currently available online. The group sequenced a specific region of the ERR-γ gene in approximately 500 patient and volunteer samples. While the gene has previously been shown to play a role in breast cancer susceptibility, its mechanism was unknown.

"Creating robust biomarkers to detect disease in their early stages requires access to a large number of clinical samples for analysis. The success of this work hinged on collaborations with clinicians with available samples, as well as researchers with expertise in a variety of areas and access to the latest
'/>"/>

Contact: Susan Bland
subland@vbi.vt.edu
540-231-7912
Virginia Tech
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Can genetic information be controlled by light?
2. TGen spin-off MedTrust Online enables cancer doctors to quickly obtain best-available information
3. SAIC Awarded $37 Million Contract to Support U.S. Army Program Executive Office - Enterprise Information Systems
4. Loggerhead release to provide vital information to scientific community
5. Neuroinformatics special issue spotlights the Neuroscience Information Framework
6. CSHL scientists discover a new way in which epigenetic information is inherited
7. Stevens receives $25,000 grant from the Engineering Information Foundation
8. Sea bed provides information about present climatic change
9. Census of Marine Life and ocean in Google Earth bring ocean information to life
10. QSGI Integrates Fujitsu Mag EraSURE Data Degausser into its Suite of Information Technology Security Services
11. ID Analytics Appoints Chief Information Officer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... France have hit on a novel method to ... correct and most effective treatment possible., Kidney stones ... and developing world. If left untreated, apart from ... failure and other complications. In many patients treated ... a more effective pathological approach to diagnosis and ...
(Date:4/17/2014)... Current Biology on April 17 have discovered ... Brazilian insects, which represent four distinct but related species ... example of an animal with sex-reversed genitalia. , ... animals, Neotrogla is the only example in ... Yoshizawa from Hokkaido University in Japan. , During copulation, ...
(Date:4/17/2014)... at the University of Texas Medical Branch at ... women treated with radiation for cervical cancer should ... , The UTMB researchers, finding a high ... survivors treated with radiation, offer new recommendations that ... cancer screening about eight years after their initial ...
Breaking Biology News(10 mins):In sex-reversed cave insects, females have the penises 2Radiation therapy for cervical cancer increases risk for colorectal cancer 2
... People with high cholesterol in their early 40s are ... low cholesterol, according to research that will be presented ... Annual Meeting in Chicago, April 1219, 2008. "Our ... and patients to attack high cholesterol levels in their,40s ...
... antioxidants as a way to improve health by filling ... studies found no evidence that the nutrition supplements extend ... could increase risk for death. The reviewers want ... researcher with the U.S. Department of Agriculture said that ...
... Fla. University of Florida researchers have identified a gene ... the physical effects of mental stress to the point ... Searching for the presence of this gene may be one ... risk for the phenomenon, said David S. Sheps, M.D., a ...
Cached Biology News:Antioxidant users don't live longer, analysis of studies concludes 2Antioxidant users don't live longer, analysis of studies concludes 3Mental stress reduces blood flow to the heart in patients with gene variation 2Mental stress reduces blood flow to the heart in patients with gene variation 3
(Date:1/15/2014)... interface is the device," Nobel laureate Herbert Kroemer ... be found at the junctures where layers of ... nanotechnology, the interfaces between layers of metal oxides ... high-tech favorites as spintronics, high-temperature superconductors, ferroelectrics and ...
(Date:1/15/2014)... Jan. 15, 2014   Niagara Thermal Products is ... Buffalo BioBlower Technologies LLC ("B3") as the critical thermal ... award from the Army Corps of Engineers.  B3 has ... all biological contaminants and destroys VOCs and other chemical ...
(Date:1/15/2014)... OXFORD, England and SAN JOSE, California ... an international biotechnology company developing antibody-drug conjugates for cancer, today ... its Board of Directors. Dr Reynolds has over 20 years, ... Chief Medical Officer at Seattle Genetics. "I am ...
(Date:1/15/2014)... A study has been launched to test ... track could help to tackle the problem of obesity.  This ... GP surgery based in Stowmarket) and academics at University Campus ... Telemetry technology, which is inspired by equipment used to collect ...
Breaking Biology Technology:A deeper look at interfaces 2Niagara Thermal Products LLC Selected as Critical Supplier for Buffalo BioBlower Air Purification Systems 2Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 2Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 2Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 4
... May 14 Memory Pharmaceuticals,Corp. (Nasdaq: MEMY ... first,quarter ended March 31, 2008., "We had ... with,our collaborations and refocusing our operations to advance ... Chief Executive Officer.,"Roche,s recent decision to license R3487/MEM ...
... Biotech Inc.,("Oncolytics") (TSX:ONC, NASDAQ:ONCY) announced today that ... from the U.K. Medicines and Healthcare,products Regulatory ... (CTA),to begin a Phase II clinical trial ... paclitaxel and carboplatin in patients with,advanced head ...
... China Sky One,Medical, Inc. (OTC Bulletin Board: CSKI; ... marketer and distributor of pharmaceutical,medicinal and diagnostic products, ... were made in conjunction with the Company,filing an ... Stock Exchange., As of May 7, 2008, ...
Cached Biology Technology:Memory Pharmaceuticals Reports First Quarter 2008 Financial Results 2Memory Pharmaceuticals Reports First Quarter 2008 Financial Results 3Memory Pharmaceuticals Reports First Quarter 2008 Financial Results 4Memory Pharmaceuticals Reports First Quarter 2008 Financial Results 5Memory Pharmaceuticals Reports First Quarter 2008 Financial Results 6Memory Pharmaceuticals Reports First Quarter 2008 Financial Results 7Oncolytics Biotech Inc. Announces U.K. Phase II Clinical Trial Investigating REOLYSIN(R) in Combination with Paclitaxel and Carboplatin 2China Sky One Medical, Inc. Changes Management Team 2China Sky One Medical, Inc. Changes Management Team 3
Naked1 Antibody Shipping Temperature: HOT Storage Temperature: -20C...
Rabbit polyclonal to Phosphothreonine-X-Phosphotyrosine (HRP) ( Abpromise for all tested applications)....
Anti-ADAMTS-4, disintegrin-like domain Immunogen: Synthetic peptide - KLH conjugated Available Date: 38569...
Leucine-rich repeat-containing G-protein coupled receptor 4...
Biology Products: