Navigation Links
Key function of protein discovered for obtaining blood stem cells as source for transplants
Date:7/25/2012

Researchers from IMIM (Hospital del Mar Medical Research Institute) have deciphered the function executed by a protein called β-catenin in generating blood tissue stem cells. These cells, also called haematopoietic, are used as a source for transplants that form part of the therapies to fight different types of leukaemia. The results obtained will open the doors to produce these stem cells in the laboratory and, thus, improve the quality and quantity of these surgical procedures. This will let patients with no compatible donors be able to benefit from this discovery in the future.

The study, executed jointly with the Erasmus Medical Center Stem Cell of Rotterdam and published in the Journal of Experimental Medicine, analysed a chain of molecular reactions that are produced inside some embryonic cells and that play a role in the creation of a haematopoietic stem cells. 'Our study contributes to deciphering the code that makes a precursor cell that is only found in the embryo become a haematopoietic stem cell. In order for that to happen, the β-catenin protein must be activated for a while and with a specific dosage' explains Dr Anna Bigas, head of the IMIM Stem Cells & Cancer Group and lead researcher.

This protein also plays a fundamental role in the cells that originate and maintain some types of leukaemia. 'The parallelisms between normal and leukaemia stem cells prove to us that the molecular pathways that regulate both populations are the same. For this reason, our work will help us understand the origin of these diseases', argues Dr Bigas.

In addition to embryonic stem cells, each of our body's organs has another type of stem cell that has the capacity to regenerate all the cells for the tissue in question. However, they are only formed in the embryonic stage and are maintained for the rest of our lives. Haematopoietic stem cells are part of the blood and, when they are transplanted, they are the inception for all of this tissue's cells.

At present, transplanting these cells is dependent on the availability of compatible donors. Nonetheless, there is still a high percentage of patients with no donors and that, therefore, cannot be submitted to this procedure. The results of this article lay the foundations so that, in the future, these patients can benefit from a source of laboratory-generated haematopoietic stem cells created from compatible embryonic cells or other types of expressly transformed cells.


'/>"/>
Contact: Marta Calsina
mcalsina@imim.es
34-933-160-680
IMIM (Hospital del Mar Research Institute)
Source:Eurekalert  

Related biology news :

1. Study demonstrates cells can acquire new functions through transcriptional regulatory network
2. Has modern science become dysfunctional?
3. Second-generation drug used for hypertension aids heart function independent of blood pressure
4. Key proteins newly discovered form and function may provide novel cancer treatment target
5. Discovery of a new family of key mitochondrial proteins for the function and viability of the brain
6. New study discovers powerful function of single protein that controls neurotransmission
7. Heart Damage Repaired By Reprogramming Resident Fibroblasts into Functioning Heart Cells
8. Training cells to perform Boolean functions? Its logical
9. Regenerated cells may restore vision after corneal dysfunction
10. Mild thyroid dysfunction in early pregnancy linked to serious complications
11. Researchers develop new method for analyzing cell function
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Key function of protein discovered for obtaining blood stem cells as source for transplants
(Date:5/23/2017)... 2017  Hunova, the first robotic gym for the rehabilitation and functional ... in Genoa, Italy . The first 30 robots will ... USA . The technology was developed and patented at ... IIT spin-off Movendo Technology thanks to a 10 million euro investment from ... click: ...
(Date:5/16/2017)... 2017   Bridge Patient Portal , an ... MD EMR Systems , an electronic medical record ... have established a partnership to build an interface ... GE Centricity™ products, including Centricity Practice Solution (CPS), ... These new integrations will allow healthcare delivery networks ...
(Date:4/24/2017)... , April 24, 2017 ... and partner with  Identity Strategy Partners, LLP (IdSP) ... "With or without President Trump,s March 6, 2017 ... Terrorist Entry , refugee vetting can be instilled with ... resettlement. (Right now, all refugee applications are suspended ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... ... 2017 , ... For the second time in three years, ... Award. Representatives of the FirstHand program travelled to Washington, D.C. Tuesday, October 10th, ... mission is to change the trajectory of STEM education in America by dramatically ...
(Date:10/10/2017)... ... October 10, 2017 , ... ... business process optimization firm for the life sciences and healthcare industries, announces a ... in San Francisco. , The presentation, “Automating GxP Validation for Agile Cloud Platforms,” ...
(Date:10/9/2017)... ... 09, 2017 , ... At its national board meeting in North Carolina, ... University’s Departments of Physics and Astronomy, has been selected for membership in ARCS ... for the 2015 Breakthrough Prize in Fundamental physics for the discovery of the accelerating ...
(Date:10/7/2017)... ... October 06, 2017 , ... ... its ProxiMeta™ Hi-C metagenome deconvolution product, featuring the first commercially available Hi-C ... software to perform Hi-C metagenome deconvolution using their own facilities, supplementing the ...
Breaking Biology Technology: