Navigation Links
Key feature of immune system survived in humans, other primates for 60 million years
Date:8/18/2009

ch is what you see in sepsis and some autoimmune or degenerative diseases," Gombart said. "This is a very delicate balancing act, and without sufficient levels of vitamin D you may not have an optimal response with either aspect of the immune system."

After years of research, scientists are continuing to find new roles that vitamin D plays in the human body. It can regulate the actions of genes that are important to bone health, calcium uptake, and inhibition of cell growth. It helps regulate cell differentiation and, of course, immune function.

"The antimicrobial peptide that we're studying seems to be involved not just in killing bacteria, but has other biological roles," Gombart said. "It recruits other immune cells and sort of sounds the alarm that something is wrong. It helps promote development of blood vessels, cell growth and healing of wounds. And it seems to have important roles in barrier tissues such as skin and the digestive system. Vitamin D is very important for the health of the skin and digestive system, and putting the cathelicidin antimicrobial peptide gene under its regulation may be important in this function."

Any one, or some combination of those biological roles may be why vitamin D-mediated regulation of the antimicrobial peptide has been conserved in every primate species ever examined for its presence, researchers said, and did not disappear long ago through evolutionary variation and mutation. The evolution of primates into many different families and hundreds of species has been carefully tracked through genetic, molecular sequence and fossil studies, but the presence of this regulatory element in primates is still largely the same as it's been for more than 50 million years.

The evolutionary survival of this genetic element and the placement of the cathelicidin antimicrobial peptide gene under the regulation of the vitamin D pathway "may enable suppression of inflammation while potentiating innate imm
'/>"/>

Contact: Adrian Gombart
adrian.gombart@oregonstate.edu
541-737-8018
Oregon State University
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Methods for gene transfer in stem cells featured in Cold Spring Harbor Protocols
2. Plant microbe shares features with drug-resistant pathogen
3. Recruitment of reproductive features into other cell types may underlie extended lifespan in animals
4. Demonstration Features Commercial Technology for Combating Terrorism
5. Demonstration Features Commercial Technology for Combating Terrorism
6. Protein analysis methods, viral vectors featured in Cold Spring Harbor Protocols
7. ASBMB Annual Meeting to feature talks on the biochemistry of aging
8. Latest research on childrens issues featured at SRCD meeting
9. Basic guides to PCR, labeling neurons featured in Cold Spring Harbor Protocols
10. Protein function and chromatin structure methods featured in Cold Spring Harbor Protocols
11. Toxicology program features wide range of human health and environment topical sessions
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/23/2014)... or simply cli-fi, is a newly coined term for novels ... New research from University of Copenhagen shows how these fictions ... the potential consequences of climate change and imagine other living ... data on changes in the atmosphere; it is also a ... books we read and the films we see. And there ...
(Date:4/23/2014)... HOUSTON, April 23, 2014 A biomedical engineer at ... highly innovative technology to make blood transfusions safer. His ... the National Institutes of Health (NIH). , Blood ... one of modern medicine,s absolute necessities. Without them, for ... mean transfusions are perfect, however. There,s strong evidence that ...
(Date:4/22/2014)... to get your child to behave at the dinner tablecut ... study published in Eating Behaviors , found that when ... with their front teeth such as drumsticks, whole apples, or ... these foods had been cut. "They were twice as ... kids," said Brian Wansink, Professor and Director of the Cornell ...
Breaking Biology News(10 mins):Fiction prepares us for a world changed by global warming 2Fiction prepares us for a world changed by global warming 3UH biomedical engineer works to make blood transfusions safer 2UH biomedical engineer works to make blood transfusions safer 3Biting vs. chewing 2
... our genomes can be traced back to strange rogue sequences known ... mammals. But Johns Hopkins researchers report they have identified a new ... its class found to be active in mammals. The discovery, described ... Proceedings of the National Academy of Sciences , offers a ...
... new research report published in the Journal ... known for causing gum disease-- Porphyromonas gingivalis --manipulates the ... otherwise destroy it. Specifically, the report shows that this ... (IL-10). This, in turn, inhibits the function of T-cells, ...
... carried out at Imperial College London and the University of ... would help prevent miscarriage in women who are particularly vulnerable. ... embed itself in the lining of the uterus. The uterus ... each menstrual cycle, ensuring that embryos can only implant at ...
Cached Biology News:Rare form of active 'jumping genes' found in mammals 2Smile: Gingivitis bacteria manipulate your immune system so they can thrive in your gums 2Scientists pinpoint molecular signals that make some women prone to miscarriage 2
(Date:1/15/2014)... January 15, 2014 The Microcompetition with Foreign ... disease. One of these latent viruses is the Epstein Barr ... (RA). Rheumatoid arthritis (RA) is a chronic inflammatory disease that ... study found that RA patients have high concentrations of EBV ...
(Date:1/15/2014)... (PRWEB) January 15, 2014 AudioNotch is ... new therapy for the treatment of tinnitus. Patients listen ... frequency, and over a period of weeks to months, their ... Therapy in two forms: Notched Music and Notched White Noise. ...
(Date:1/14/2014)... (PRWEB) January 14, 2014 Histogen, Inc., ... products of cells grown under simulated embryonic conditions, today ... agreement with Suneva Medical, Inc. for physician-dispensed aesthetic products ... , This agreement is an amendment to the ...
(Date:1/14/2014)... The largest international professional organization of scientists ... derivatives thereof has endorsed an educational program that ... challenges of adulterated herb and botanical products. ... The Society for Medicinal Plant and Natural Product ...
Breaking Biology Technology:Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 3Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 2Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 3World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 2World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 3World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 4World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 5World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 6World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 7World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 8
... remotes are catching on in large University of Wisconsin-Madison ... mean students are kicking back and watching Comedy Central ... buttons, let them respond instantly to multiple-choice questions posed ... some students who might feel embarrassed to raise their ...
... is an integral place of business, the online reality is ... Web sites. , ,Many Internet surfers often believe they ... intuition is based on a number of surface-level factors. For ... it appears in the natural results of a search engine ...
... says it has bought a new copy machine for $57,000. ... "enlarge" feature than the typical office copier: It makes three-dimensional ... and the Anthrax virus. , ,Using white polymer powder and ... tall one layer at a time. Z-Corp is headquartered in ...
Cached Biology Technology:Many still distrust Web sites is yours credible enough? 2Many still distrust Web sites is yours credible enough? 3
... (Ribonuclease inhibitor) is a 50 ... inhibit RNase activity. It does ... activity. , Inhibits RNase ... template , Lacks DNA ...
... of GC-rich nucleic acids ,The GC-RICH ... Polymerase and a proofreading polymerase, powers through ... amplify with other polymerases and other blends ... blend and the unique GC-RICH Resolution Solution ...
... For nucleofection of optimized cell lines in ... the nucleofection parameters. Nucleofector Kits are only ... Different cell lines can be transfected with ... are given in brackets in percent (Efficiency ...
... PCR Workstation brings together UV irradiation and ... environment against PCR contamination! Quickly inactivate ... Maintain a clean environment with antimicrobial coated ... reagents within minutes with built-in 30-minute timer ...
Biology Products: