Navigation Links
Key feature of immune system survived in humans, other primates for 60 million years
Date:8/18/2009

art of what used to be thought of as "junk DNA" and makes up more than 90 percent of the human genome. That genetic material, however, is now understood to often play important roles in regulating and "turning on" the expression of other genes.

In this case, the genetic element is believed to play a major role in the proper function of the "innate" immune system in primates an ancient, first line of defense against bacteria, viruses and other pathogens, in which the body recognizes something that probably doesn't belong there, even though the specific pathogen may never have been encountered before.

"Many people are familiar with the role of our adaptive immune system, which is what happens when we mount a defense against a new invader and then retain antibodies and immunity in the future," Gombart said. "That's what makes a vaccine work. But also very important is the innate immune system, the almost immediate reaction your body has, for instance, when you get a cut or a skin infection."

In primates, this action of "turning on" an optimal response to microbial attack only works properly in the presence of adequate vitamin D, which is actually a type of hormone that circulates in the blood and signals to cells through a receptor. Vitamin D is produced in large amounts as a result of sun exposure, and is available in much smaller amounts from dietary sources.

Vitamin D prevents the "adaptive" immune response from over-reacting and reduces inflammation, and appears to suppress the immune response. However, the function of the new genetic element this research explored allows vitamin D to boost the innate immune response by turning on an antimicrobial protein. The overall effect may help to prevent the immune system from overreacting.

"It's essential that we have both an innate immune response that provides an immediate and front line of defense, but we also have protection against an overreaction by the immune system, whi
'/>"/>

Contact: Adrian Gombart
adrian.gombart@oregonstate.edu
541-737-8018
Oregon State University
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Methods for gene transfer in stem cells featured in Cold Spring Harbor Protocols
2. Plant microbe shares features with drug-resistant pathogen
3. Recruitment of reproductive features into other cell types may underlie extended lifespan in animals
4. Demonstration Features Commercial Technology for Combating Terrorism
5. Demonstration Features Commercial Technology for Combating Terrorism
6. Protein analysis methods, viral vectors featured in Cold Spring Harbor Protocols
7. ASBMB Annual Meeting to feature talks on the biochemistry of aging
8. Latest research on childrens issues featured at SRCD meeting
9. Basic guides to PCR, labeling neurons featured in Cold Spring Harbor Protocols
10. Protein function and chromatin structure methods featured in Cold Spring Harbor Protocols
11. Toxicology program features wide range of human health and environment topical sessions
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/22/2014)... As President Barack Obama begins a trip to ... strategic pivot to the Pacific, officials at the ... Asia-Pacific Technology and Education Partnership (APTEP) as an ... United States and its allies in the region. ... partnerships across the Asia-Pacific region, supports the development ...
(Date:4/22/2014)... news release is available in French . ... than a month, sequencing of the complete genome and ... Guinea forms a clade (variant) that is distinct from ... and in Gabon. Epidemiological investigations also linked the laboratory ... December 2013 outbreak. , Ebola virus is a lethal, ...
(Date:4/22/2014)... exposure to environmental enrichment can induce neurogenesis ... and memory. Previous studies have demonstrated that ... superficial layer of the cerebral cortex of ... these neurons exhibit very weak properties of ... environmental enrichment has an impact on the ...
Breaking Biology News(10 mins):Full power: Alternative energy partnerships flourish in Asia 2Full power: Alternative energy partnerships flourish in Asia 3Inserm and the Institut Pasteur identify a new variant of Ebola virus in Guinea 2
... damage depends on the balance between the generation of scar ... significant minority of people who get injury to their organs ... to chronic liver disease and cirrhosis where the scarring is ... produce vital hormones and clotting factors. Liver scars also provide ...
... Barbara, Calif.) The National Institutes of Health (NIH) ... engineering, chemistry, and biology researchers to develop a highly ... The technology provides an entirely new method of discovering ... range of applications, including next-generation disease diagnosis at the ...
... (HGNS) produced marked dose-related increases in airflow in obstructive ... according to a new study from the Johns Hopkins ... efficacy of HGNS across a broad range of sleep ... airway pressure (CPAP), the current mainstay of treatment for ...
Cached Biology News:Researchers awarded $3.2 million from NIH to pioneer advanced biomolecule discovery technology 2Researchers awarded $3.2 million from NIH to pioneer advanced biomolecule discovery technology 3Hypoglossal nerve stimulation increases airflow during sleep in obstructive sleep apnea 2
(Date:1/15/2014)... England , January 15, 2014 A ... win races on the Formula 1 track could help to ... McLaren Applied Technologies (MAT), Stowhealth (a GP surgery based in ... by healthcare provider Simplyhealth. Telemetry technology, which is ...
(Date:1/15/2014)... Arizona (PRWEB) January 15, 2014 2013 ... for Scottsdale’s Brain State Technologies®. They saw continued independent ... Medical Center who were awarded a $1 million grant ... published in “Brain and Behavior” a peer reviewed journal, ...
(Date:1/14/2014)... January 14, 2014 Carahsoft and CDS ... January 23, 2014 at 2pm EST (11am PST), “Natural ... topic focuses on how technology can turn raw, heterogeneous ... for government agencies. The online webinar will last approximately ...
(Date:1/14/2014)... Texas , Jan. 14, 2014 The ... and research medicinal plants and therapeutic derivatives thereof ... health professionals, and researchers about the challenges of ... http://photos.prnewswire.com/prnh/20100430/DC95601LOGO ) The Society ...
Breaking Biology Technology:Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 2Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 4Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 2Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 3Webcast - Natural Language Processing: Converting Raw Data into Actionable Knowledge – Hosted by Carahsoft and CDS Federal Services 2World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 2World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 3World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 4World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 5World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 6World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 7World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 8
... NxStage Medical, Inc. (Nasdaq: NXTM ), a ... to release its financial results for the first quarter ... before the opening of the financial markets.NxStage will also ... on Friday, May 8, 2009 to discuss its first ...
... Presentation Highlights Anti-Tumor effects of KRX-0401 (Perifosine)NEW YORK, ... KERX ) today announced multiple presentations of ... (perifosine), the company,s lead anti-cancer compound, at the ... being held in Denver, Colorado. Abstracts selected for ...
... Data demonstrates that ProLindac should provide sustained tumor exposure ... low hematoxicity observed in the clinic -DALLAS, April 21 ... ACCP) announced today that its collaborators at ... on its lead anticancer compound, ProLindac(TM), at the American ...
Cached Biology Technology:NxStage to Report First Quarter 2009 Financial Results 2Keryx Biopharmaceuticals Presents Encouraging Preclinical Data at Annual Meeting of the American Association of Cancer Research 2Keryx Biopharmaceuticals Presents Encouraging Preclinical Data at Annual Meeting of the American Association of Cancer Research 3Keryx Biopharmaceuticals Presents Encouraging Preclinical Data at Annual Meeting of the American Association of Cancer Research 4Access Pharmaceuticals Presents New Data on ProLindac(TM) at the 2009 AACR Annual Meeting 2Access Pharmaceuticals Presents New Data on ProLindac(TM) at the 2009 AACR Annual Meeting 3Access Pharmaceuticals Presents New Data on ProLindac(TM) at the 2009 AACR Annual Meeting 4
...
Mouse monoclonal antibody raised against a partial recombinant L3MBTL2. NCBI Entrez Gene ID = L3MBTL2...
Mouse monoclonal antibody raised against a partial recombinant QARS. NCBI Entrez Gene ID = QARS...
96-well format (For processing samples on microplate-size MALDI target plates such as those from Bruker, Shimadzu, Thermo, and PerkinElmer) Packaging: 2 / pack...
Biology Products: