Navigation Links
Key feature of immune system survived in humans, other primates for 60 million years
Date:8/18/2009

art of what used to be thought of as "junk DNA" and makes up more than 90 percent of the human genome. That genetic material, however, is now understood to often play important roles in regulating and "turning on" the expression of other genes.

In this case, the genetic element is believed to play a major role in the proper function of the "innate" immune system in primates an ancient, first line of defense against bacteria, viruses and other pathogens, in which the body recognizes something that probably doesn't belong there, even though the specific pathogen may never have been encountered before.

"Many people are familiar with the role of our adaptive immune system, which is what happens when we mount a defense against a new invader and then retain antibodies and immunity in the future," Gombart said. "That's what makes a vaccine work. But also very important is the innate immune system, the almost immediate reaction your body has, for instance, when you get a cut or a skin infection."

In primates, this action of "turning on" an optimal response to microbial attack only works properly in the presence of adequate vitamin D, which is actually a type of hormone that circulates in the blood and signals to cells through a receptor. Vitamin D is produced in large amounts as a result of sun exposure, and is available in much smaller amounts from dietary sources.

Vitamin D prevents the "adaptive" immune response from over-reacting and reduces inflammation, and appears to suppress the immune response. However, the function of the new genetic element this research explored allows vitamin D to boost the innate immune response by turning on an antimicrobial protein. The overall effect may help to prevent the immune system from overreacting.

"It's essential that we have both an innate immune response that provides an immediate and front line of defense, but we also have protection against an overreaction by the immune system, whi
'/>"/>

Contact: Adrian Gombart
adrian.gombart@oregonstate.edu
541-737-8018
Oregon State University
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Methods for gene transfer in stem cells featured in Cold Spring Harbor Protocols
2. Plant microbe shares features with drug-resistant pathogen
3. Recruitment of reproductive features into other cell types may underlie extended lifespan in animals
4. Demonstration Features Commercial Technology for Combating Terrorism
5. Demonstration Features Commercial Technology for Combating Terrorism
6. Protein analysis methods, viral vectors featured in Cold Spring Harbor Protocols
7. ASBMB Annual Meeting to feature talks on the biochemistry of aging
8. Latest research on childrens issues featured at SRCD meeting
9. Basic guides to PCR, labeling neurons featured in Cold Spring Harbor Protocols
10. Protein function and chromatin structure methods featured in Cold Spring Harbor Protocols
11. Toxicology program features wide range of human health and environment topical sessions
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2015)... , June 24, 2015 Biometry authentication ... emerging biometric password solution one face in. ... one face in, entering the expanding ... and affordable multifactor-authentication biometric answer to the password ... provided in partnership with KeyLemon, one face in ...
(Date:6/23/2015)... , June 23, 2015  Crossmatch™, ... and authentication solutions, today announced enhanced functionality of ... authentication solution.  The enhancements build on the ... the DigitalPersona Altus platform and provide expanded ... In today,s environment of increasing ...
(Date:6/17/2015)... , June 17, 2015 QIAGEN ... launched new Investigator ® STR assay kits for analysis ... United States . The new genetic fingerprint kits provide ... (short tandem repeats or STRs) for DNA matching. They incorporate ... of DNA in each sample, a novel QIAGEN technology that ...
Breaking Biology News(10 mins):KeyLemon Announces Partnership With Biometric Password Solution onefacein 2Crossmatch Releases Enhanced DigitalPersona Altus Advanced Authentication Functionality 2QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 2QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 3QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 4QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 5
... monkeys at the Oregon National Primate Research Center, Oregon ... C may have potential to counteract some negative impacts ... thousands of babies born to mothers who continue to ... published in the current edition of the American Journal ...
... track enemy troop movements during the Vietnam war could ... new research published in the British Ecological Society's Journal ... from Stanford University recorded the vibrations from the footfalls ... and humans, using a geophone buried near a path ...
... how the abnormal repetition of a genetic sequence can ... neurons that govern balance and motor coordination. The studies ... caused by having extra copies of a normal protein, ... afflicted with the rare neurodegenerative disorder spinocerebellar ataxia type ...
Cached Biology News:OHSU research shows vitamin C counteracts some negative impacts of smoking on unborn babies 2OHSU research shows vitamin C counteracts some negative impacts of smoking on unborn babies 3Vietnam war technology could aid elephant conservation 2Pinpointing the cause of a neurodegenerative disorder 2Pinpointing the cause of a neurodegenerative disorder 3
(Date:7/1/2015)... ... ... It is now possible to separate two common disorders: post-traumatic stress disorder ... according to researchers from Amen Clinics, UCLA, Thomas Jefferson University, and University of ... to be the largest brain imaging study ever, will be published on July 1, ...
(Date:7/1/2015)... 2015   Neuraltus Pharmaceuticals, Inc. , a privately-held ... drugs to treat neurodegenerative diseases such as amyotrophic ... G. Miller , M.D., Director of the Forbes Norris ... Medical Center in San Francisco, has been awarded a ... to help fund a Phase 2 clinical study ...
(Date:7/1/2015)... ... July 01, 2015 , ... Apex Therapeutics announced today that company CEO, David ... , The presentation took place on Tuesday, June 16 and provided an ... of APX3330 for the treatment of pancreatic cancer. A copy of the company ...
(Date:6/30/2015)... 2015 /PRNewswire/ - Resverlogix Corp. ("Resverlogix") (TSX:RVX) announced ... Resverlogix have approved the resolutions relating to: (i) ... 5,600,000 units at a price of $2.67 per ... comprised of one common share and 0.075358 common ... CAD$15 million; and (ii) the amendment to Resverlogix,s ...
Breaking Biology Technology:Brain Scans Can Tell Post-Traumatic Stress Disorder and Traumatic Brain Injury Apart According to New Research by Amen Clinics 2Brain Scans Can Tell Post-Traumatic Stress Disorder and Traumatic Brain Injury Apart According to New Research by Amen Clinics 3Brain Scans Can Tell Post-Traumatic Stress Disorder and Traumatic Brain Injury Apart According to New Research by Amen Clinics 4Investigator to Receive $1.5 Million Grant from the ALS Association to Help Fund Confirmatory Phase 2 Study of Neuraltus Pharmaceuticals' NP001 2Investigator to Receive $1.5 Million Grant from the ALS Association to Help Fund Confirmatory Phase 2 Study of Neuraltus Pharmaceuticals' NP001 3Investigator to Receive $1.5 Million Grant from the ALS Association to Help Fund Confirmatory Phase 2 Study of Neuraltus Pharmaceuticals' NP001 4Apex Therapeutics Presented Company Overview at This Year’s BIO International Convention in Philadelphia, PA 2Resverlogix Corp. Shareholders Approve Matters Relating to Licensing and Equity Arrangement 2Resverlogix Corp. Shareholders Approve Matters Relating to Licensing and Equity Arrangement 3
... LMNX ) today announced that management will ... Growth Conference to be held,September 20, 2007, in ... Balthrop, president and chief,executive officer, and Harriss T. ... Eastern time on Thursday, September 20, 2007. The,presentation ...
... ... Pathogens, PHILADELPHIA, Sept. ... agreement with the Defense,Threat Reduction Agency (DTRA) of the U.S. Department ... targeting both Gram,negative biothreats and conventional Gram negative hospital pathogens. The,agreement ...
... Intra-Cellular Therapies today,announced it has developed a novel ... treatment of female sexual dysfunction (FSD). These,small molecule ... neuronal activity in selected regions of the brain. ... the treatment of hypoactive,sexual desire disorder (HSDD), a ...
Cached Biology Technology:Luminex Corporation to Present at America's Growth Capital Emerging Growth Conference 2GlaxoSmithKline Awarded U.S. Department of Defense Contract to Pursue Novel Antibacterial Research Program 2GlaxoSmithKline Awarded U.S. Department of Defense Contract to Pursue Novel Antibacterial Research Program 3Intra-Cellular Therapies Provides Overview of its Proprietary Portfolio of Compounds for the Treatment of Female Sexual Dysfunction (FSD) 2Intra-Cellular Therapies Provides Overview of its Proprietary Portfolio of Compounds for the Treatment of Female Sexual Dysfunction (FSD) 3
Rabbit polyclonal to Bag5 ( Abpromise for all tested applications). entrezGeneID: 9529 SwissProtID: Q9UL15...
AADAC Immunogen: AADAC (NP_001077, 201 a.a. ~ 301 a.a) partial recombinant protein with GST tag. Storage: -20 C, Avoid Freeze/Thaw Cycles *Available for distribution in the US only...
RNA polymerase sigma 70 Immunogen: Recombinant, full length protein. Storage: -20 C, Avoid Freeze/Thaw Cycles...
Gamma delta T Lymphocytes Purified Anti-Porcine clone MAC320, Isotype Rat IgG 2a , kappa, 0.1 mg Consult technical datasheet for details....
Biology Products: