Navigation Links
Key enzyme discovered to be master regulator in protein-protein reactions
Date:3/24/2010

f (peer-reviewed) papers out there, but nobody understood how PP1 is regulated," said Peti. "It is in fact a master regulator. We have identified now how it works."

To obtain their results, the team showed for the first time how PP1 is bound to a regulator protein, spinophilin. Using nuclear magnetic resonance spectroscopy and X-ray crystallography, the researchers examined the spinophilin-PP1 complex's structure. The scientists saw that spinophilin had attached itself to one of three substrate binding sites on PP1, called the C-terminal substrate binding groove. Examined at the atomic scale, it appears as if spinophilin is a many-tentacled beast that has woven itself into the C-terminal substrate binding groove, effectively blocking any substrate requiring this groove from interacting with PP1.

That leaves only two other binding sites, the acidic and hydrophobic substrate binding grooves. "Any substrate that needs the C-terminal is out of the game," Peti said.

By narrowing the binding sites from three to two, PP1 is in effect becoming more selective, Peti noted. "What that means is PP1 is equally tightly controlled as kinases are," he said.

"Now we know how PP1 is regulated," Peti added. "What simply happens is we don't create more enzymes. We create more protein complexes (holoenzymes) that increase the specificity of PP1."


'/>"/>

Contact: Richard Lewis
Richard_Lewis@brown.edu
401-863-3766
Brown University
Source:Eurekalert  

Page: 1 2

Related biology news :

1. MSU scientists unlock key enzyme using newly created cool method
2. Enzyme deficiency protects hepatitis C patients from treatment-related anemia
3. Scientists identify critical enzyme in healthy heart function
4. Enzyme necessary for development of healthy immune system
5. Newly identified enzymes help plants sense elevated CO2 and could lead to water-wise crops
6. Tiny particles can deliver antioxidant enzyme to injured heart cells
7. Genencor Wins The American Institute of Chemical Engineers (AIChE) Sustainable Energy Award For Accellerase(R) Cellulosic Ethanol Enzymes
8. UCLA researchers reconstitute enzyme that synthesizes cholesterol drug lovastatin
9. Scientists are first to observe the global motions of an enzyme copying DNA
10. New artificial enzyme safer for nature
11. Developing enzymes to clean up pollution by explosives
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Key enzyme discovered to be master regulator in protein-protein reactions
(Date:7/23/2014)... , , , , ... , , , , ... extend healthy lifespan. The idea, they argue, would be to target the... , , ... , , , , , ... , , , , , , , Medicine focuses almost ...
(Date:7/23/2014)... has the entire country in its grip is affecting more ... responsible for the proliferation of a heat-loving amoeba commonly found ... springs, which the drought has made warmer than usual this ... infection caused by this parasite after swimming in several area ... an individual and travels to the brain. Nose plugs can ...
(Date:7/23/2014)... The planet,s soil releases about 60 billion tons of ... more than that released by burning fossil fuels. This ... release of carbon is balanced by carbon coming into ... matter, as well as by the underground activities of ... that rising temperatures increase the rate of soil respiration. ...
Breaking Biology News(10 mins):Strategy proposed for preventing diseases of aging 2Strategy proposed for preventing diseases of aging 3Strategy proposed for preventing diseases of aging 4Strategy proposed for preventing diseases of aging 5Diseases of another kind 2Climate change and the soil 2
... are ineffective and their continuation endangers ecosystems that ... worlds population depend, United Nations University experts warn ... for sweeping change. In a blunt assessment, ... Headquarters, New York, UNUs Canadian-based International Network on ...
... Biologist John Smol has been named as one of ... Royal Canadian Geographical Society. His half-brother, biologist Jules Blais, ... one of Canada,s most prestigious in the environmental sciences. ... work to Canadian society. Smol is series ...
... Atmel(R) Corporation (Nasdaq:,ATML), an inventor and leading ... that its FingerChip(R) fingerprint sensor,solution has been selected ... PC.,Rise will showcase this biometrics-capable LCD PC during ... as a standard feature enhances consumer,friendliness in the ...
Cached Biology News:Coastal management cooperation, enforcement key to avoid pending crisis for millions: U.N. experts 2Coastal management cooperation, enforcement key to avoid pending crisis for millions: U.N. experts 3Coastal management cooperation, enforcement key to avoid pending crisis for millions: U.N. experts 4Coastal management cooperation, enforcement key to avoid pending crisis for millions: U.N. experts 5Coastal management cooperation, enforcement key to avoid pending crisis for millions: U.N. experts 6Atmel's FingerChip Biometric Sensor Selected by Rise Computer for its Robust Security 2Atmel's FingerChip Biometric Sensor Selected by Rise Computer for its Robust Security 3
(Date:7/23/2014)... (PRWEB) July 23, 2014 StemGenex® ... therapy in the US aimed at improving the lives ... newest clinical study for Parkinson’s disease. StemGenex believes ... stem cell therapy are paramount when providing care to ... study makes stem cell therapy accessible to the millions ...
(Date:7/23/2014)... Iowa (PRWEB) July 23, 2014 DuPont ... the business as vice president of Agricultural Biotechnology (ABT), ... Biotechnology where he served most recently as president, chief ... biotechnology and business leadership in the seed and crop ... said Paul E. Schickler , president of DuPont ...
(Date:7/23/2014)... , July 23, 2014 regulated information -- UCB ... and development pipeline with positive topline results from ... . This study was designed to evaluate the efficacy ... 200 mg/day, without titration) compared to placebo, as ... partial-onset seizures, not fully controlled despite treatment with ...
(Date:7/23/2014)... 23, 2014  GrowBLOX Sciences, Inc. (OTCQB: GBLX), a medical ... filing for two medical marijuana dispensary locations in ... to the Clark County, Nevada dispensary ... as previously announced.  GrowBLOX Sciences, CEO Craig ... new applications for dispensaries in the City of ...
Breaking Biology Technology:StemGenex® Gives Hope to Parkinson’s Patients through New Stem Cell Clinical Study 2StemGenex® Gives Hope to Parkinson’s Patients through New Stem Cell Clinical Study 3DuPont Pioneer Names Neal Gutterson to Lead Agricultural Biotechnology 2DuPont Pioneer Names Neal Gutterson to Lead Agricultural Biotechnology 3Major advance in UCB pipeline: positive topline Phase 3 results for brivaracetam in epilepsy patients with partial-onset seizures 2Major advance in UCB pipeline: positive topline Phase 3 results for brivaracetam in epilepsy patients with partial-onset seizures 3Major advance in UCB pipeline: positive topline Phase 3 results for brivaracetam in epilepsy patients with partial-onset seizures 4Major advance in UCB pipeline: positive topline Phase 3 results for brivaracetam in epilepsy patients with partial-onset seizures 5Major advance in UCB pipeline: positive topline Phase 3 results for brivaracetam in epilepsy patients with partial-onset seizures 6Major advance in UCB pipeline: positive topline Phase 3 results for brivaracetam in epilepsy patients with partial-onset seizures 7GrowBLOX Sciences, Inc. Files for Two Additional Medical Marijuana Dispensaries in Las Vegas 2GrowBLOX Sciences, Inc. Files for Two Additional Medical Marijuana Dispensaries in Las Vegas 3
... Va., June 20 Insmed Inc. (Nasdaq:,INSM), a ... it intends to request a hearing before The ... earlier Staff Determination,to delist the Company,s common stock ... a letter from The NASDAQ Stock Market ("NASDAQ") ...
... June 20, 2008 / b3c newswire / ... organization (CMO) for the development and production of ... 2,500 L multi-process production suite. Hence, Rentschler Biotechnologie ... of 30, 250, 500 and 2,500 liters, allowing ...
... InterMune, Inc.,(Nasdaq: ITMN ) today announced that ... InterMune, will present at the Jefferies 2nd,Annual Healthcare Conference ... p.m. EDT., To access a live audio webcast ... on to the investor relations page of InterMune,s,corporate website ...
Cached Biology Technology:Insmed to Request Hearing Before NASDAQ Panel to Review NASDAQ Staff Determination 2Rentschler Biotechnologie Extends Capacities for Mammalian Cell Culture Manufacturing 2
Reported to support murine B lymphocytes, hematopoietic tissue from bone marrow, B cells stimulated with lipopolysaccharide, T lymphocytes, and a variety of hybrid cells....
... Eagle's medium have been developed ... most widely used modification is ... a modification of Minimum Essential ... a higher concentration of vitamins ...
... a fixative useful for routine procedures. Hollandes ... stable and will decalcify small bone specimens. ... be stained successfully with most stains, and ... red blood cell membranes and cosinophil and ...
... Gas Chromatograph/Mass Spectrometer, utilizing many of ... Plus, offers high throughput and excellent ... performance-to-cost ratio. Like the GCMS-QP2010 Plus, ... velocity for optimum separation, 20 temperature ...
Biology Products: