Navigation Links
Key driver of metastasis identified
Date:10/30/2011

PHILADELPHIA -- Scientists at Dalhousie University in Nova Scotia have identified a key mechanism of metastasis that could lead to blocking tumor growth if their findings are confirmed.

In a recent issue of Cancer Research, a journal of the American Association for Cancer Research, lead researcher David Waisman, Ph.D., professor in the Departments of Biochemistry and Molecular Biology and Pathology, and Canada Research Chair in Cancer Research at Dalhousie University, detailed the key role the macrophage cell surface protein S100A10 plays in allowing macrophages to move to the site of tumor growth a process that is essential to tumor development.

Waisman said the findings are an example of the complicated biology of cancer.

"We used to think that the only cells that mattered in a tumor were the cancer cells, and that's it, but now we are beginning to see that other cells must collaborate with cancer cells to drive tumor growth and permit an evolution of the cancer cells into metastatic cells. This change is what causes poor prognosis and ultimately what kills the patient," he said.

Waisman and colleagues discovered that tumors will not grow without macrophage assistance. These macrophages must come from the blood or from other locations in the tissues. How they are able to move through the tissues or from the blood supply into the tumor had always been a mystery.

These macrophages need to chew their way through the tissue that forms a barrier around the growing tumor in order to move into the tumor site and combine with the cancer cells. The researchers found on the outside surface of the macrophage is a protein called S100A10, which enables the macrophage to remove the tissue barriers retarding migration to the tumor site.

Theoretically, blocking either the macrophages or S100A10 chemically could slow, or even stop, tumor growth.

"We found that the protein, S100A10, acts like a pair o
'/>"/>

Contact: Jeremy Moore
Jeremy.Moore@aacr.org
267-646-0557
American Association for Cancer Research
Source:Eurekalert

Page: 1 2

Related biology news :

1. Research helps drivers cut fuel use
2. Satellites pinpoint drivers of urban heat islands in the northeast
3. Analyzed relation between sleep disorders and risk perception by drivers with disorder
4. Study points to key genetic driver of severe allergic asthma
5. Sorting the drivers from the passengers in the cancer genome
6. Ford and MIT Team Up To Improve Safety by Reducing Driver Stress
7. Futronic Windows 7 Biometric Framework Driver is Signed by Microsoft
8. ELISE ID to Power State Driver Registration Search System
9. Researchers explore new driver of transplant rejection: Platelets
10. L-1 Identity Solutions Awarded New Massachusetts RMV Drivers License Contract Valued at an Estimated $32 Million
11. L-1 Identity Solutions Receives $5.9 Million Drivers License Contract Expansion from the State of Mississippi
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/19/2015)... , May 19, 2015 ... announced the addition of the  "Genetic Testing ... ,     (Logo: http://photos.prnewswire.com/prnh/20130307/600769) , ,A recent report, ... in-depth analysis of the current and future ... gene-based tests, their working principles and types ...
(Date:5/14/2015)... and Markets ( http://www.researchandmarkets.com/research/5whpxg/fingerprint ) has announced ... Smart Mobile Devices " report to their offering. ... watershed year for fingerprint sensors in smartphones and tablets, ... fingerprint sensors a raison d,etre in the mobile milieu ... must-have feature in flagship smartphones. The key ...
(Date:5/11/2015)... 2015  Synaptics Incorporated (NASDAQ: SYNA ), ... announced the appointment of Wajid Ali ... reporting to Rick Bergman , President and ... Officer, Kathleen Bayless , who announced her ... Ali brings extensive financial management expertise to Synaptics, ...
Breaking Biology News(10 mins):Global Genetic Testing Market Outlook 2018 2Global Smart Mobile Devices Fingerprint Sensors Market 2015-2019: Key Vendors are Authentec, Validity Sensors, Fingerprint Cards, Next Biometrics Group. IDEX, and Qualcomm 2Synaptics Appoints Wajid Ali as Senior Vice President and Chief Financial Officer 2
... in the event of a large-scale smallpox bioterrorist attack ... by researchers at Fred Hutchinson Cancer Research Center that ... , Instead, the current U.S. government policy of post-release ... workers and close contacts would be sufficient to thwart ...
... from parents to offspring via sperm or eggs, also known ... genes can be passed to the next generation in spores. ... genetic material after it has been duplicated and then halved ... spores. Near the end of the process, the material ?called ...
... the chromosomes during cell division, first described in the ... movies shown in biology classes, has long fascinated biologists. ... of cell division, the "chromosome-spindle" connection, which is critical ... has remained elusive. , Researchers at the ...
Cached Biology News:Mass vaccination unnecessary in the event of a large bioterrorist US smallpox attack 2Mass vaccination unnecessary in the event of a large bioterrorist US smallpox attack 3Mass vaccination unnecessary in the event of a large bioterrorist US smallpox attack 4Mass vaccination unnecessary in the event of a large bioterrorist US smallpox attack 5Single molecular 'mark' seen as pivotal for genome compaction in spores and sperm 2Two central mysteries in genome inheritance solved at UCSD 2Two central mysteries in genome inheritance solved at UCSD 3
(Date:5/28/2015)... Sunnyvale, Californiaa (PRWEB) May 28, 2015 ... on “ The Changing Landscape of EMR/EHR Clinical Data ... Annual Meeting taking place in Washington, DC on June ... the challenges of integrating EMR/EHR systems with EDC, and ... the opportunities brought by eSource and electronic health records/electronic ...
(Date:5/28/2015)... In two different WPC forums ... Ph.D., will present the company’s unique approach to developing ... talk, he will describe Asymmetrex ’s innovation in ... simulation to produce the first-ever technology for quantitative monitoring ... time in culture. When leading an interactive breakout ...
(Date:5/27/2015)... , May 26, 2015 Research and ... the "Global Breast Cancer Monoclonal Antibodies Market ... Globally, Roche seems to dominate the breast ... Its block buster molecule, Herceptin has been able ... was found that breast cancer cells become recalcitrant ...
(Date:5/27/2015)... The ALS Therapy Development Institute announced ... Anelixis Therapeutics , $1.5 million toward the development ... innate immune system. The funding comes from the $4 ... 2014 social media phenomenon known as the “ALS Ice ... directly by the Institute through last year’s Ice Bucket ...
Breaking Biology Technology:Clinovo Presents at the DIA 2015 51st Annual Meeting in Washington, DC on June 14th-18th 2Asymmetrex Will Discuss the Importance of Adult Tissue Stem Cell Time with 3D Tissue Engineers at the 14th Annual World Preclinical Congress in Boston in June 2Asymmetrex Will Discuss the Importance of Adult Tissue Stem Cell Time with 3D Tissue Engineers at the 14th Annual World Preclinical Congress in Boston in June 3Global Breast Cancer Monoclonal Antibodies Market Outlook 2020 2Global Breast Cancer Monoclonal Antibodies Market Outlook 2020 3Ice Bucket Challenge Advances Antibody Toward Clinical Trial for ALS 2Ice Bucket Challenge Advances Antibody Toward Clinical Trial for ALS 3
... BMP,Sunstone Corporation (Nasdaq: BJGP ) ("BMP Sunstone" ... President of BMP Sunstone,Corporation and a member of ... and Chief Operating Officer of BMP Sunstone Corporation,effective ... of BMP Sunstone since April 2008 and,played an ...
... - Company to Request a Hearing -, MONTVALE, ... ) today announced that on June 6, 2008 it ... the,Company that, because it has not regained compliance with ... 4450(a)(5), its securities,are subject to delisting from The NASDAQ ...
... Requires New Clinical Practices ... and Public Health Costs, SAN FRANCISCO and ... Task Force on Epidemiology and Prevention warned,today that ... sleep apnea (OSA) are closely related, and that ...
Cached Biology Technology:BMP Sunstone Corporation Appoints Zhiqiang Han to President and Chief Operating Officer 2BMP Sunstone Corporation Appoints Zhiqiang Han to President and Chief Operating Officer 3Memory Pharmaceuticals Receives Anticipated NASDAQ Staff Determination Letter 2Memory Pharmaceuticals Receives Anticipated NASDAQ Staff Determination Letter 3IDF Urges Healthcare Providers to Address the Relationship Between Type 2 Diabetes and Sleep Apnea 2IDF Urges Healthcare Providers to Address the Relationship Between Type 2 Diabetes and Sleep Apnea 3IDF Urges Healthcare Providers to Address the Relationship Between Type 2 Diabetes and Sleep Apnea 4
Alexa Fluor 647 anti-mouse Qa-2...
... siRNA Custom Synthesis Service provides ... RNA to knockdown any gene. ... RNA base pairs with terminal ... or other lengths of your ...
Formulation: Phosphate-buffered saline, pH 7.2, containing 0.09% sodium azide....
... The Luminex 100 Instrument System ... multi-analyte assays using Upstate's Beadlyte reagents. ... the Dell computer with software version ... Sheath Delivery System. Upstate offers $2000 ...
Biology Products: