Navigation Links
Key difference in how TB bacteria degrade doomed proteins
Date:10/17/2010

UPTON, NY Scientists at the U.S. Department of Energy's (DOE) Brookhaven National Laboratory and Stony Brook University have discovered a key difference in the way human cells and Mycobacterium tuberculosis bacteria, which cause TB, deliver unwanted proteins marked with a "kiss of death" sequence to their respective cellular recycling factories. This critical difference, described in a paper published online October 17, 2010, in the journal Nature Structural and Molecular Biology, may help scientists design drugs to disable the bacterial system while leaving normal human protein recycling centers intact.

"With tuberculosis infecting a third of the world's population, primarily in developing countries, there is great need for new, effective TB treatments," said study co-author Huilin Li, a Brookhaven biophysicist and associate professor at SBU. "Our research seeks to understand the protein-recycling mechanism of TB bacteria, because it is one of the microbe's keys to survival in human cells.* Targeting this system with small-molecule-based drugs could inhibit the bacteria and effectively treat TB."

The catch is that human cells have a similar protein-recycling system, essential for their survival, which could also be destroyed by inhibitory drugs. "It's important to find differences between the species so we can target features unique to the bacterial system," Li said.

Li has previously looked at differences in the cellular structure known as a proteasome that chops up the unwanted proteins [see links below]. The current study examined the way proteins destined for degradation are recognized by the bacterial proteasome before entering that structure.

Using beams of high-intensity x-rays at the Lab's ["http://www.nsls.bnl.gov/">National Synchrotron Light Source (NSLS), the scientists determined atomic-level structures of the portion of the bacterial proteasome that identifies the unwanted protein's "kiss of death" mar
'/>"/>

Contact: Karen McNulty Walsh
kmcnulty@bnl.gov
631-344-8350
DOE/Brookhaven National Laboratory
Source:Eurekalert

Page: 1 2

Related biology news :

1. Researchers note differences between people and animals on calorie restriction
2. Study sheds light on genetic differences that cause a childhood eye disease
3. Study identifies genetic variants giving rise to differences in metabolism
4. Genetic differences between yeasts greater than those between humans and chimpanzees
5. Red wine vs. white? It makes no difference when it comes to breast-cancer risk
6. Differences in neighborhood food environment may contribute to disparities in obesity
7. The host makes all the difference
8. Difference in fat storage may explain lower rate of liver disease in African-Americans
9. Gene linked to lupus might explain gender difference in disease risk
10. Differences among exercisers and nonexercisers during pregnancy
11. Differences among exercisers and nonexercisers during pregnancy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/20/2015)... Huntington Memorial Hospital is the first facility ... miniaturized, wireless monitoring sensor to manage heart failure (HF). ... FDA-approved heart failure monitoring device that has been proven ... to manage heart failure. The CardioMEMS HF ... pulmonary artery (PA) during a non-surgical procedure to directly ...
(Date:4/13/2015)... 13, 2015 According to ... Biometrics Market Forecast & Opportunities, 2020", the global biometrics ... around 14% till 2020. The biometrics market is ... implementation and review of biometric management systems. The ... products with greater efficiency, are resulting in increasing ...
(Date:4/6/2015)... NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" ... on the growing mobile commerce market, announced today ... MINIATURE, MULTI-PURPOSE ANTENNA METHOD AND SYSTEM FOR ... introduces a new revolutionary method and system to ... of miniature antenna modules for multiple purposes including ...
Breaking Biology News(10 mins):Huntington Memorial Hospital Becomes First in the San Gabriel Valley to Offer Patients a New Heart Failure Monitoring Solution 2Huntington Memorial Hospital Becomes First in the San Gabriel Valley to Offer Patients a New Heart Failure Monitoring Solution 3Global Biometrics Market to Cross US$ 21 Billion by 2020: TechSci Research 2NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 2NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 3NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 4
... of billions of nerve cells enabling to learn, remember ... smell or fear, millions of neurons in our brain ... by chemical and electrical impulses to compute incoming sensory ... 20,000 - 25,000 genes in our genome, most also ...
... NRGX) today announced the publication in the June 23 issue ... first ever gene therapy trial for Parkinson’s disease and the ... brain cells for any adult neurodegenerative disease. , The ... advanced Parkinson’s disease demonstrated both a lack of adverse events ...
... large mammals at the end of the Ice Age may ... To the list of victims such as woolly mammoths and ... more: a highly carnivorous form of wolf that lived in ... generally thought to have survived the end-Pleistocene extinction relatively unscathed. ...
Cached Biology News:Turn-ons and turn-offs for neurons 2Gene therapy study shows safety and statistically significant improvement in Parkinson's disease 2Gene therapy study shows safety and statistically significant improvement in Parkinson's disease 3Gene therapy study shows safety and statistically significant improvement in Parkinson's disease 4Ice Age extinction claimed highly carnivorous Alaskan wolves 2
(Date:5/5/2015)... 2015  Renova™ Therapeutics, a biopharmaceutical company developing ... other chronic diseases, has engaged RAND Health Advisory ... reflect the healthcare patterns of multiple advanced heart ... used to characterize the impact the company,s lead ... groups of patients and the overall health care ...
(Date:5/5/2015)... DIEGO , May 5, 2015  A group ... formation of the Coma Research Institute, a non-profit organization ... patients and families suffering from disorders of consciousness.  ... - http://photos.prnewswire.com/prnh/20150504/213779LOGO   ... disorder of consciousness, in which no voluntary actions can ...
(Date:5/5/2015)... May 05, 2015 Research and Markets ... of the "Clinical Laboratory, Molecular Diagnostics and ... to 2019 - Global Version" report to ... in the area of molecular diagnostics and pharmacogenics ... evolving world market that is moving out of ...
(Date:5/5/2015)... , May 5, 2015  Orexigen Therapeutics, Inc. ... the first quarter 2015 on Friday, May 8 before ... a live webcast and conference call at 8:30 a.m. ... live call may be accessed by phone by calling ... 39586962. The webcast can be accessed live on the ...
Breaking Biology Technology:RAND Health Advisory Services modeling heart failure patient outcomes to inform potential impact of Renova Therapeutics lead product candidate 2RAND Health Advisory Services modeling heart failure patient outcomes to inform potential impact of Renova Therapeutics lead product candidate 3Biotechnology Executives and Medical Doctors Team Up to Tackle Coma and Disorders of Consciousness 2Biotechnology Executives and Medical Doctors Team Up to Tackle Coma and Disorders of Consciousness 3Biotechnology Executives and Medical Doctors Team Up to Tackle Coma and Disorders of Consciousness 4Biotechnology Executives and Medical Doctors Team Up to Tackle Coma and Disorders of Consciousness 5Global Clinical Laboratory, Molecular Diagnostics and Genomic Testing Services Market Trends and Forecast 2015 to 2019 2
... 4 Researchers are taking a closer look at ... demonstrate that inhibiting this biological route suppresses tumor growth, ... The pathway is involved in angiogenesis, cell growth, differentiation, ... PI3/AKT/mTOR pathway, which plays a key role in cancer, ...
... Diagnostic,Systems, Inc., (OTC Bulletin Board: IMDS), a pioneer in ... evaluating the CTLM system as an,adjunct to mammography is ... (Logo: ... a radiologist at Charite Hospital in Berlin,Germany, authored "Near-infrared ...
... Hont, Chairman and Chief Executive Officer of Met-Pro Corporation (NYSE: ... their meeting on December 3, 2008, declared a quarterly dividend of ... record at the close of business on February 26, 2009. ... year. , , This is the ...
Cached Biology Technology:GEN Reports Growing Focus on PI3-Kinase Pathway in Cancer Research 2Imaging Diagnostic Systems CT Laser Mammography (CTLM) Technology Featured in Peer-Reviewed Journal 2Met-Pro Corporation Declares Quarterly Dividend 2
... Goat polyclonal to BRF2 Immunogen ... acids 406-419 of Human BRF2. Reactivity / ... in other species. Background Information BRF2 ... RNA polymerase III transcription factor complex required for ...
... 20X Immunogen Proprietary ... concentration for use in KinEASE™ 645nm ... Quality Assurance Routinely evaluated ... assays. Stability ...
Kinase Buffer can be used to assay protein kinase activity...
Goat polyclonal to SPFH2 ( Abpromise for all tested applications). Antigen: Synthetic peptide: EDEPLETATKEN, corresponding to C terminal amino acids 328-339 of Human SPFH2 Entrez Gene ID: 11...
Biology Products: