Navigation Links
Key component of debilitating lung disease identified
Date:9/12/2008

For the first time, researchers have demonstrated a close correlation between the decline in a key component of the lung's antioxidant defense system and the progression of chronic obstructive pulmonary disease (COPD) in humans. COPD is a degenerative condition that decreases the flow of air through the lungs as the lung's air sacs are damaged. A study of lung tissue samples from COPD patients by scientists at the Johns Hopkins Bloomberg School of Public Health found that expression of the regulating gene NRF2 was significantly decreased in smokers with advanced COPD compared to smokers without COPD. The study is published in the September 15, 2008, edition of the American Journal of Respiratory and Critical Care Medicine.

The study team was led by Shyam Biswal, PhD, an associate professor in the Bloomberg School's Department of Environmental Health Sciences and the Division of Pulmonary and Critical Care Medicine at the Johns Hopkins School of Medicine. According to Biswal, NRF2 (nuclear factor erythroid-derived 2-related factor 2) works as a "master gene" to turn on numerous antioxidant and pollutant-detoxifying genes to protect the lungs from environmental pollutants, such as cigarette smoke. Biswal previously identified that disruption of NRF2 expression in mice caused early onset and severe emphysema, which is a major component of COPD in human. However, the status of this critical pathway in humans with COPD was unclear.

"This work clearly demonstrates that decline in our antioxidant system is involved in progression of COPD, which could also be the case for other environmental diseases," said Biswal. "There is no treatment of COPD, but NRF2 could be a novel target for the development of new drug therapies."

Rubin Tuder, MD, a co-author of the study now with the faculty of the University of Colorado, added, "As we learn how the protective actions of NRF2 are decreased in the course of a lifetime of exposure to cigarette smo
'/>"/>

Contact: Tim Parsons
tmparson@jhsph.edu
410-955-7619
Johns Hopkins University Bloomberg School of Public Health
Source:Eurekalert

Page: 1 2

Related biology news :

1. New robot scouts best locations for components of undersea lab
2. A protein sequence associated with Huntington’s disease may become life-saving vaccine component
3. Dissecting the genetic components of adaptation of E. coli to the mouse gut
4. Studying component parts of living cells with carbon nanotube cellular probes
5. A new milestone in the GMES Space Component Program successfully achieved
6. Model for the assembly of advanced, single-molecule-based electronic components developed at Pitt
7. Clemson chemists discover new way antioxidants fight debilitating diseases
8. K-State professors USDA research shows mad cow disease also caused by genetic mutation
9. New studies on the Mediterranean diet confirm its effectiveness for chronic disease prevention
10. African-Americans have unique lung cancer risks from chronic obstructive pulmonary disease
11. Gaining a better understanding of kidney diseases
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2014)... University researchers have completed a 20-year study that ... prairie at different times of the year. It ... spring time frame has no measurable negative consequences ... multiple benefits. , The study was conducted by ... Biological Station fire chief, and Joseph Craine, research ...
(Date:7/31/2014)... percent of animal models against the highly infectious and ... intestinal disease that kills approximately 30,000 Americans annually. The ... and Immunity . , In the study, the ... purified toxins produced by C. difficile , as ... model that mimics the human disease, after only two ...
(Date:7/31/2014)... Alexandre Edmond Becquerel first discovered the photovoltaic effect in ... the power of sunlight for its own purposes. In ... issue of the FASEB Journal , ... the power of sunlight by focusing on a naturally ... throughout evolution. This conservationor persistence over time and across ...
Breaking Biology News(10 mins):Study finds benefits to burning Flint Hills prairie in fall and winter 2Study finds benefits to burning Flint Hills prairie in fall and winter 3C. difficile vaccine proves safe, 100 percent effective in animal models 2Scientists shine bright new light on how living things capture energy from the sun 2
... mice of immune cells that promote the formation of new ... painful condition associated with infertility that affects up to 15 ... of new blood vessels, or angiogenesis, is known to encourage ... led by Ofer Fainaru, MD, PhD, a research associate in ...
... Resilience and Adaptation Program at the University of ... from the National Science Foundation to address questions ... RAP focuses on answering questions of how global ... as indigenous subsistence hunting. Economic, cultural and ecological ...
... Fla. Shiny amber jewelry and a mucky Florida ... ecosystem that could be anywhere from 15 million to ... of Florida and the Museum of Natural History in ... such as beetles and small crustaceans unwittingly swim into ...
Cached Biology News:Immune cells promote blood vessel formation in mouse endometriosis 2Alaska graduate program in sustainability receives $3.2 million award 2Scientists find how amber becomes death trap for watery creatures 2Scientists find how amber becomes death trap for watery creatures 3
(Date:7/31/2014)... mathematician (1912-1954), is famous for a number of breakthroughs, ... 1936 he published a paper, which laid the foundation ... a computer algorithm. He next played a pivotal role ... cracked the German military codes, enabling the Allies to ... the late 1940,s he turned his attention to artificial ...
(Date:7/31/2014)... July 31, 2014 According to ... "Quantum Dots Market - Global Industry Analysis, Size, Share, ... was valued at USD 88.5 million in 2011, which ... growing at a CAGR of 53.8% from 2013 to ... Report at  http://www.transparencymarketresearch.com/quantum-dots.html Increasing demand for ...
(Date:7/31/2014)... DUBLIN , July 31, 2014 ... the "Global Genomics Market 2014-2018" report to ... Genomics is the study of the genetic ... to be a strong basis for the discovery and ... of human diseases or health conditions. Genomics is supported ...
(Date:7/31/2014)... 31, 2014 Held at the Stanford ... an overview of the disease and its treatment. Survivors ... effects, as well as updates on the state-of-the-art with ... Sandy Srinivas for organizing this educational opportunity,” says KCA ... “Sandy and her colleagues have put together a program ...
Breaking Biology Technology:A mathematical theory proposed by Alan Turing in 1952 can explain the formation of fingers 2A mathematical theory proposed by Alan Turing in 1952 can explain the formation of fingers 3Global Quantum Dots Market is Expected to Reach USD 8,246.8 Million in 2023: Transparency Market Research 2Global Quantum Dots Market is Expected to Reach USD 8,246.8 Million in 2023: Transparency Market Research 3Global Quantum Dots Market is Expected to Reach USD 8,246.8 Million in 2023: Transparency Market Research 4Global Genomics Market 2014-2018: Key Vendors are F. Hoffmann-La Roche, Life Technologies, Qiagen and Illumina 2
... PLYMOUTH MEETING, Pa., March 17 /PRNewswire-Asia-FirstCall/ -- BMP,Sunstone Corporation (Nasdaq: ... for the fourth quarter and fiscal year ended,December 31, 2008. , ... -- Fourth quarter revenues increased to $36.6 million, ... fourth quarter of 2007., -- Non-GAAP operating income, ...
... Biotek, an innovative Canadian biotechnology company focusing primarily ... protein purification, today announced the signing of an ... "EXQ") to supply RNA purification kits based on ... Denmark-based company active in the life sciences, diagnostics ...
... of 25 February 2009, Arpida communicated that the Board of ... the company,s future. , In preparation ... to update shareholders as follows: At the shareholders, meeting, the,Board ... following options or a combination thereof: , , ...
Cached Biology Technology:BMP Sunstone Reports Fourth Quarter and Full Year 2008 Financial Results 2BMP Sunstone Reports Fourth Quarter and Full Year 2008 Financial Results 3BMP Sunstone Reports Fourth Quarter and Full Year 2008 Financial Results 4BMP Sunstone Reports Fourth Quarter and Full Year 2008 Financial Results 5BMP Sunstone Reports Fourth Quarter and Full Year 2008 Financial Results 6BMP Sunstone Reports Fourth Quarter and Full Year 2008 Financial Results 7BMP Sunstone Reports Fourth Quarter and Full Year 2008 Financial Results 8BMP Sunstone Reports Fourth Quarter and Full Year 2008 Financial Results 9BMP Sunstone Reports Fourth Quarter and Full Year 2008 Financial Results 10BMP Sunstone Reports Fourth Quarter and Full Year 2008 Financial Results 11BMP Sunstone Reports Fourth Quarter and Full Year 2008 Financial Results 12Norgen Biotek Corp. Announces OEM Manufacturing & Supply Agreement with Exiqon A/S 2Norgen Biotek Corp. Announces OEM Manufacturing & Supply Agreement with Exiqon A/S 3Norgen Biotek Corp. Announces OEM Manufacturing & Supply Agreement with Exiqon A/S 4Board Reviews Strategic Options to Present to Shareholders at Shareholders' Meeting 2
Human VASA Biotinylated Affinity Purified PAb...
[14C]Polyethylene glycol 4000, 9.25 MBq, 250 uCi. Aqueous solution containing 3% ethanol, sterilized. 370-740 MBq/g, 10-20 mCi/g.1.85 MBq/ml, 50 uCi/ml. Category: Radiochemicals &Radiation Safety, ...
... Complete kit for all types of yeast ... Choice of two ... self-activating baits , ... , Complete set ...
Mouse Limitin MAb (Clone 183727)...
Biology Products: