Navigation Links
Kessler Foundation researchers study impact of head movement on fMRI data
Date:2/19/2014

West Orange, NJ. February 19, 2014. Kessler Foundation researchers have shown that discarding data from subjects with multiple sclerosis (MS) who exhibit head movement during functional magnetic resonance imaging (fMRI) may bias sampling away from subjects with lower cognitive ability. The study was published in the January issue of Human Brain Mapping. (Wylie GR, Genova H, DeLuca J, Chiaravalloti N, Sumowski JF. Functional MRI movers and shakers: Does subject-movement cause sampling bias.) Glenn Wylie, DPhil, is associate director of Neuroscience in Neuropsychology & Neuroscience Research at Kessler Foundation. He is also associate director of the Neuroimaging Center at Kessler Foundation, and an associate professor at Rutgers - New Jersey Medical School.

Because head movement during fMRI degrades data quality, data associated with severe movement is frequently discarded as a source of random error. Kessler Foundation scientists tested this assumption in 34 persons with MS by examining whether head movement was related to task difficulty and cognitive status. Cognitive status was assessed by combining performance on a working memory and processing speed task.

"We found an interaction between task difficulty and cognitive status," explained Dr. Wylie. "As task difficulty increased, there was a linear increase in movement that was larger among subjects with lower cognitive ability." Healthy controls showed similar, though far smaller, effects. This finding indicates that discarding data with severe movement artifact may bias MS samples such that only subjects with less-severe cognitive impairment are included in the analyses. However, even if such data are not discarded outright, subjects who move more will contribute less to the group-level results because of the poor quality of their data.

It is important for researchers to be aware of this potential bias. "Some newer scanners can correct for motion," noted Dr. Wylie. "Another approach is to monitor each subject's motion parameters and ensure that an adequate number of subjects with low cognition are included. Recruiting a large number of subjects may ensure inclusion of a sufficient number of people with low cognition/low movement. It is however, a costly option."


'/>"/>

Contact: Carolann Murphy
cmurphy@kesslerfoundaiton.org
973-324-8382
Kessler Foundation
Source:Eurekalert  

Related biology news :

1. Kessler Foundation neuroimaging study sheds light on mechanisms of cognitive fatigue in MS
2. Kessler Foundation awarded more than $1.2 million in grants by the NJ Commission on Sci Research
3. Kessler Foundation implements Ekso Bionics first commercial robotic exoskeleton
4. Two NYU faculty win Sloan Foundation research fellowships
5. Price Family Foundation funds research collaboration between Albert Einstein College of Medicine and University of Oklahoma
6. Price Family Foundation gift will create groundbreaking structural biology institute
7. Vilcek Foundation honors renowned neuroscientist and young researchers with creative promise
8. Damon Runyon Cancer Research Foundation grants prestigious awards to 20 top young scientists
9. E.O. Wilson Biodiversity Foundation moving to Duke
10. AgriLife researcher Xiuren Zhang receives National Science Foundation CAREER grant
11. Prostate Cancer Foundation announces new urine test for prostate cancer available
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Kessler Foundation researchers study impact of head movement on fMRI data
(Date:6/16/2016)... SAN FRANCISCO , June 16, 2016 /PRNewswire/ ... Market size is expected to reach USD ... report by Grand View Research, Inc. Technological proliferation ... and banking applications are expected to drive the ... ) , The development of ...
(Date:6/9/2016)... , June 9, 2016 ... deploy Teleste,s video security solution to ensure the safety of ... during the major tournament Teleste, an ... systems and services, announced today that its video security solution ... to back up public safety across the country. The ...
(Date:6/2/2016)... , June 2, 2016 The Department ... has awarded the 44 million US Dollar project, for the ... Vehicle Plates including Personalization, Enrolment, and IT Infrastructure , ... in the production and implementation of Identity Management Solutions. Numerous ... however Decatur was selected for the ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... Houston Methodist Willowbrook Hospital has signed ... to serve as their official health care provider. ... will provide sponsorship support, athletic training services, and ... volunteers, athletes and families. "We are ... and to bring Houston Methodist quality services and ...
(Date:6/23/2016)... , June, 23, 2016  The Biodesign Challenge (BDC), ... new ways to harness living systems and biotechnology, announced ... (MoMA) in New York City . ... participating students, showcased projects at MoMA,s Celeste Bartos Theater ... Antonelli , MoMA,s senior curator of architecture and design, ...
(Date:6/23/2016)... ... ... STACS DNA Inc., the sample tracking software company, today announced that Dr. ... STACS DNA as a Field Application Specialist. , “I am thrilled that Dr. ... STACS DNA. “In further expanding our capacity as a scientific integrator, Hays brings a ...
(Date:6/23/2016)... 23, 2016  Blueprint Bio, a company dedicated to ... medical community, has closed its Series A funding round, ... "We have received a commitment from Forentis ... need to meet our current goals," stated Matthew ... runway to complete validation on the current projects in ...
Breaking Biology Technology: