Navigation Links
Kessler Foundation researchers publish first study of brain activation in MS using fNIRS
Date:8/27/2014

West Orange, NJ. August 27, 2014. Using functional near infrared spectroscopy (fNIRS), Kessler Foundation researchers have shown differential brain activation patterns between people with multiple sclerosis (MS) and healthy controls. This is the first MS study in which brain activation was studied using fNIRS while participants performed a cognitive task. The article, "Neuroimaging and cognition using functional near infrared spectroscopy (fNIRS) in multiple sclerosis," was published online on June 11 by Brain Imaging and Behavior. Authors are Jelena Stojanovic-Radic, PhD, Glenn Wylie, DPhil, Gerald Voelbel, PhD, Nancy Chiaravalloti, PhD, and John DeLuca, PhD.

Researchers compared 13 individuals with MS with 12 controls for their performance on a working memory task with four levels of difficulty. Most such studies have employed functional magnetic resonance imaging (fMRI); fNIRS has been used infrequently in clinical populations, and has not been applied previously to neuroimaging research in MS. Studies comparing fMRI findings with those of fNIRS, however, show broad agreement in terms of activation patterns.

Results showed differences in activation between the groups that were dependent on task load. The MS group had an increase in activation at low task difficulty and a decrease in activation at high task difficulty. Conversely, in the control group, activation decreased with low task difficulty and increased with high task difficulty. Performance accuracy was lower in the MS group for low task load; there were no differences between the groups at the higher task loads.

"The data we obtained via fNIRS are consistent with fMRI data for clinical populations. We demonstrated that fNIRS is capable of detecting neuronal activation with a reasonable degree of detail," noted Glenn Wylie, DPhil, associate director of Neuroscience Research and the Neuroimaging Center at Kessler Foundation. "We attribute the differences in brain activation patterns to the effort expended during the working memory task rather than to differences in speed of processing," he added. "Because fNIRS is more portable and easier to use that fMRI, it may offer advantages in monitoring cognitive interventions that require frequent scans."

In addition to working memory, future research in clinical populations should focus on processing speed and episodic memory, cognitive functions that are also affected in MS.


'/>"/>

Contact: Carolann Murphy
CMurphy@KesslerFoundation.org
973-324-8382
Kessler Foundation
Source:Eurekalert  

Related biology news :

1. Kessler Foundation awarded Department of Defense grant for spinal cord injury research
2. Kessler Foundation researchers study impact of head movement on fMRI data
3. Kessler Foundation neuroimaging study sheds light on mechanisms of cognitive fatigue in MS
4. Kessler Foundation awarded more than $1.2 million in grants by the NJ Commission on Sci Research
5. Kessler Foundation implements Ekso Bionics first commercial robotic exoskeleton
6. Berger Foundation funds innovative scholarship at UCR School of Medicine
7. Rossi Foundation pledges $1M for JAX neurobehavioral research center
8. The Brain & Behavior Research Foundation names winners of Klerman and Freedman Prizes
9. Albert Einstein College of Medicine receives grant from the Michael J. Fox Foundation to fund drug discovery project targeting Parkinsons
10. NYSCF partners with Beyond Batten Disease Foundation to fight juvenile Batten disease
11. Damon Runyon Cancer Research Foundation grants fellowship awards to 16 young scientists
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Kessler Foundation researchers publish first study of brain activation in MS using fNIRS
(Date:6/23/2020)... FREDERICK, Md. (PRWEB) , ... ... ... a leading provider of gene-to-protein and monoclonal antibody development services, today announced ... of protein-based products and services to the pharmaceutical, diagnostics, and research industries. ...
(Date:6/23/2020)... ... June 23, 2020 , ... ... pleased to announce the next event in a series of TOPIQ webinars, which ... TOPIQ series of webinars was developed in response to social distancing measures that ...
(Date:6/19/2020)... ... June 18, 2020 , ... ... Your Lab with Software for Data Decisions,” for pharmaceutical and biotech executives, ... integrate and automate cutting-edge scientific instruments and laboratory equipment from dozens of ...
Breaking Biology News(10 mins):
(Date:7/22/2020)... ... 2020 , ... Join experts from Reed Tech , Gary Saner, Sr. ... one hour live webinar on Thursday, August 13, 2020 at 11am EDT ... medical devices. Specifically, for medical devices, the NMPA has departments dealing with medical device ...
(Date:7/10/2020)... LORTON, Va. (PRWEB) , ... July 08, 2020 ... ... laboratory testing services and products, announces a significant expansion of laboratory operations through ... robust collection for agencies implementing testing programs. , Bode-CARES provides ...
(Date:7/7/2020)... ... , ... Bio-IT World has announced the winners of the ... of Chicago, Massachusetts General Hospital, Mission: Cure, and the Pistoia Alliance were honored. ... examples of how technology innovations and strategic initiatives can be powerful forces for ...
(Date:6/28/2020)... ... June 25, 2020 , ... With ... a vaccine or drug treatment. In an effort to better understand the cellular ... the world’s largest imaging dataset portraying therapeutic compound effects from over 1,600 approved ...
Breaking Biology Technology: